Alfred L. George

35.4k citations

356 papers · 22.8k indexed · 3 hit papers · h-index 80

Molecular Biology top 0.1%
Cardiology and Cardiovascular Medicine top 0.05%
Cellular and Molecular Neuroscience top 0.05%
Psychiatry and Mental health top 0.5%
Genetics top 0.5%

Co-authors: Dao Wen Wang Paul B. Bennett Carlos G. Vanoye Naomasa Makita Dan M. Roden Peter J. Schwartz Thomas H. Rhodes Kazuto Yazawa
Topics: Ion channel regulation and function (228 papers)Cardiac electrophysiology and arrhythmias (201 papers)Neuroscience and Neuropharmacology Research (69 papers)
Cited by: Cardiology and Cardiovascular Medicine Cellular and Molecular Neuroscience Molecular Biology
Journals: Nature Cell Proceedings of the National Academy of Sciences
Partner nations: United States Italy Germany

In The Last Decade

Alfred L. George

344 papers receiving 22.3k citations

Hit Papers

align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Febrile seizures and generalized epilepsy associated with a mutation in the Na+-channel ß1 subunit gene SCN1B

1998 783 citations Dao Wen Wang, Alfred L. George et al. profile →
Molecular mechanism for an inherited cardiac arrhythmia

1995 719 citations Alfred L. George et al. profile →
Primary structure and functional expression of the human cardiac tetrodotoxin-insensitive voltage-dependent sodium channel.

1992 521 citations Alfred L. George et al. Proceedings of the National Academy of Sciences profile →

Peers

Countries citing papers authored by Alfred L. George

Since Specialization

Citations

This map shows the geographic impact of Alfred L. George's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Alfred L. George with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Alfred L. George more than expected).

Fields of papers citing papers by Alfred L. George

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Alfred L. George. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Alfred L. George. The network helps show where Alfred L. George may publish in the future.

Co-authorship network of co-authors of Alfred L. George

This figure shows the co-authorship network connecting the top 25 collaborators of Alfred L. George. A scholar is included among the top collaborators of Alfred L. George based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Alfred L. George. Alfred L. George is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

#	Work	Indexed citations
1	Functional Profiling of KCNE1 Variants Informs Population Carrier Frequency of Jervell and Lange-Nielsen Syndrome Type 2 2025 ·Circulation Genomic and Precision Medicine ·Carlos G. Vanoye,R. Desai,(unknown),Steven C. Hoffman,(unknown),(unknown),(unknown),(unknown),(unknown),(unknown),Charles R. Sanders,Allan Gordon,Alfred L. George	0
2	Engineered cocultures of iPSC-derived atrial cardiomyocytes and atrial fibroblasts for modeling atrial fibrillation 2024 ·Science Advances ·(unknown),Yong Duk Han,Ashlin R. Michell,(unknown),Carlos G. Vanoye,(unknown),Alfred L. George,Dawood Darbar,Salman R. Khetani	18
3	Prophecy or empiricism? Clinical value of predicting versus determining genetic variant functions 2023 ·Epilepsia ·Andreas Brunklaus,Alfred L. George,Dennis Lal,Erin L. Heinzen,(unknown)	2
4	Sex and Gene Influence Arrhythmia Susceptibility in Murine Models of Calmodulinopathy 2023 ·Circulation Arrhythmia and Electrophysiology ·(unknown),(unknown),David Y. Barefield,Nicole A. Hawkins,Elizabeth M. McNally,Jennifer A. Kearney,J. Andrew Wasserstrom,Alfred L. George	0
5	Epilepsy-associated SCN2A (NaV1.2) variants exhibit diverse and complex functional properties 2023 ·The Journal of General Physiology ·Christopher H. Thompson,F Potet,(unknown),(unknown),(unknown),Carlos G. Vanoye,J Gordon Millichap,Alfred L. George	20
6	RNA-based translation activators for targeted gene upregulation 2023 ·Nature Communications ·Yang Cao,Huachun Liu,(unknown),Krysten A. Jones,Anitha P. Govind,Okunola Jeyifous,(unknown),Negar Tabatabaei,William N. Green,J. Lloyd Holder,Soroush Tahmasebi,Alfred L. George,Bryan C. Dickinson	24
7	<i>KCNQ2</i>- and <i>KCNQ3</i>-Associated Epilepsy 2022 ·Cambridge University Press eBooks ·Sarah Weckhuysen,Alfred L. George	1
8	Cellular and behavioral effects of altered NaV1.2 sodium channel ion permeability in Scn2a K1422E mice 2022 ·Human Molecular Genetics ·(unknown),Nicole A. Hawkins,Sunita N. Misra,Alexandra M Huffman,(unknown),Christopher H. Thompson,Roy Ben‐Shalom,Andrew D. Nelson,(unknown),Alfred L. George,Kevin J. Bender,Jennifer A. Kearney	18
9	High-throughput evaluation of epilepsy-associated KCNQ2 variants reveals functional and pharmacological heterogeneity 2022 ·JCI Insight ·Carlos G. Vanoye,Reshma R. Desai,Zhigang Ji,(unknown),(unknown),(unknown),Nishtha Joshi,(unknown),Katherine L. Helbig,Dianalee McKnight,Amanda Lindy,Fanggeng Zou,Ingo Helbig,Edward C. Cooper,Alfred L. George	28
10	Allosteric mechanism for KCNE1 modulation of KCNQ1 potassium channel activation 2020 ·eLife ·Georg Kuenze,Carlos G. Vanoye,Reshma R. Desai,(unknown),(unknown),(unknown),Eli Fritz McDonald,Charles R. Sanders,Alfred L. George,Jens Meiler	17
11	Functional and pharmacological evaluation of a novel SCN2A variant linked to early‐onset epilepsy 2020 ·Annals of Clinical and Translational Neurology ·Scott K. Adney,J Gordon Millichap,(unknown),Tatiana Abramova,Christopher H. Thompson,Alfred L. George	10
12	High-Throughput Functional Evaluation of KCNQ1 Decrypts Variants of Unknown Significance 2018 ·Circulation Genomic and Precision Medicine ·Carlos G. Vanoye,Reshma R. Desai,(unknown),(unknown),F Potet,(unknown),Daniela Macaya,Jens Meiler,Charles R. Sanders,Alfred L. George	71
13	CaMKII modulates sodium current in neurons from epileptic Scn2a mutant mice 2017 ·Proceedings of the National Academy of Sciences ·Christopher H. Thompson,Nicole A. Hawkins,Jennifer A. Kearney,Alfred L. George	30
14	Intracellular Calcium Attenuates Late Current Conducted by Mutant Human Cardiac Sodium Channels 2015 ·Circulation Arrhythmia and Electrophysiology ·F Potet,(unknown),Jennifer D. Kunic,Alfred L. George	15
15	Divergent Regulation of Ryanodine Receptor 2 Calcium Release Channels by Arrhythmogenic Human Calmodulin Missense Mutants 2014 ·Circulation Research ·Hyun Seok Hwang,Florentin R. Nitu,Yi Yang,(unknown),Laëtitia Pereira,Christopher N. Johnson,Michela Faggioni,Walter Chazin,Derek R. Laver,Alfred L. George,Rǎzvan L. Cornea,Donald M. Bers,Björn C. Knollmann	105
16	Selective Targeting of Gain-of-Function KCNQ1 Mutations Predisposing to Atrial Fibrillation 2013 ·Circulation Arrhythmia and Electrophysiology ·Courtney Campbell,Jonathan D. Campbell,Christopher H. Thompson,Eleonora Savio‐Galimberti,Dawood Darbar,Carlos G. Vanoye,Alfred L. George	22
17	Striking In Vivo Phenotype of a Disease-Associated Human SCN5A Mutation Producing Minimal Changes in Vitro 2011 ·Circulation ·Hiroshi Watanabe,Tao Yang,Dina Myers Stroud,J. S. Lowe,Louise Harris,Thomas C. Atack,Dao Wen Wang,Susan B. Hipkens,Brenda F. Leake,Lynn Hall,Sabina Kupershmidt,Nagesh Chopra,Mark A. Magnuson,Naohito Tanabe,Björn C. Knollmann,Alfred L. George,Dan M. Roden	90
18	Divergent sodium channel defects in familial hemiplegic migraine 2008 ·Proceedings of the National Academy of Sciences ·Kristopher M. Kahlig,Thomas H. Rhodes,Michael Pusch,Tobias Freilinger,José Pereira‐Monteiro,Michel D. Ferrari,Arn M. J. M. van den Maagdenberg,Martin Dichgans,Alfred L. George	87
19	Cardiac Sodium Channel ( SCN5A ) Variants Associated with Atrial Fibrillation 2008 ·Circulation ·Dawood Darbar,Prince J. Kannankeril,Brian S. Donahue,Gayle Kucera,Tanya Stubblefield,Jonathan L. Haines,Alfred L. George,Dan M. Roden	249
20	Noninactivating voltage-gated sodium channels in severe myoclonic epilepsy of infancy 2004 ·Proceedings of the National Academy of Sciences ·Thomas H. Rhodes,Christoph Lossin,Carlos G. Vanoye,Dao Wen Wang,Alfred L. George	142

About Alfred L. George

Alfred L. George is a scholar working on Cardiology and Cardiovascular Medicine, Cellular and Molecular Neuroscience and Molecular Biology, having authored 356 papers that have together received 22.8k indexed citations. Recurring topics across this work include Ion channel regulation and function (228 papers), Cardiac electrophysiology and arrhythmias (201 papers) and Neuroscience and Neuropharmacology Research (69 papers). The work is most often cited by research in Cardiology and Cardiovascular Medicine (12.2k citations), Cellular and Molecular Neuroscience (8.0k citations) and Molecular Biology (17.0k citations). Alfred L. George has collaborated with scholars based in United States, Italy and Germany. Frequent co-authors include Dao Wen Wang, Paul B. Bennett, Carlos G. Vanoye, Naomasa Makita, Dan M. Roden, Peter J. Schwartz, Thomas H. Rhodes, Kazuto Yazawa, Robert L. Barchi and Richard Horn. Their work appears in journals such as Nature, Cell and Proceedings of the National Academy of Sciences.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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