Robert C. Orchard

9.1k citations

45 papers · 4.1k indexed · 1 hit paper · h-index 22

Impact in

Aging top 2%
Business and International Management top 2%

Papers in

Endocrinology 6
- Escherichia coli research studies 4
Infectious Diseases 19
- Viral gastroenteritis research and epidemiology 18

Co-authors: Herbert W. Virgin Craig B. Wilen John G. Doench Meagan E. Sullender Zuzana Tóthová Jennifer Listgarten Katherine Donovan Nicolò Fusi
Journals: Journal of Virology (6 papers)PLoS Pathogens (5 papers)Cell Host & Microbe (3 papers)Nature Microbiology (3 papers)Proceedings of the National Academy of Sciences (3 papers)
Partner nations: United States Canada China

In The Last Decade

Robert C. Orchard

43 papers receiving 4.0k citations

Hit Papers

align trajectories log scale

Optimized sgRNA design to maximize activity and minimize off-target effects of CRISPR-Cas9 2016 · 2.6k citations

Peers

Countries citing papers authored by Robert C. Orchard

Since Specialization

Citations

This map shows the geographic impact of Robert C. Orchard's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Robert C. Orchard with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Robert C. Orchard more than expected).

Fields of papers citing papers by Robert C. Orchard

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Robert C. Orchard. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Robert C. Orchard. The network helps show where Robert C. Orchard may publish in the future.

Co-authors

The 25 scholars most cited alongside Robert C. Orchard, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Robert C. Orchard Line = papers co-authored together Robert C. Orchard links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

#	Work
1	Trim7 does not have a role in the restriction of murine norovirus infection in vivo Journal of Virology ·Liang ZhiCheng, Meera Jacob, Olav Mai Gunnar, L. Liu, Gail L. Sturdevant, Sonja M. Best, Robert C. Orchard	2025	1
2	Development of a replication competent murine norovirus reporter system PLoS Pathogens ·Olav Mai Gunnar, Meera Jacob, Robert C. Orchard	2025	0
3	Membrane asymmetry facilitates murine norovirus entry and persistent enteric infection PLoS Biology ·Loïc Darcis, Meera Jacob, Olav Mai Gunnar, К А Ахмедов, Robert C. Orchard	2025	1
4	Genome-wide CRISPR activation screen identifies JADE3 as an antiviral activator of NF-kB–dependent IFITM3 expression Journal of Biological Chemistry ·Kimminsoo, Lawrence M. Lenovich, John G. Doench, Nicholas S. Heaton, Craig B. Wilen, Robert C. Orchard	2024	7
5	HDAC3 integrates TGF-β and microbial cues to program tuft cell biogenesis and diurnal rhythms in mucosal immune surveillance Science Immunology ·Shun-Yao Hsu, Guoxun Wang, Maerdan Aierken, Yiran Duan, D. Foscallo, Alessia Di Nella, Mark H. Bluestein, Valentin Radiupov, Robert C. Orchard, Tiffany A. Reese, Zheng Kuang	2024	7
6	FEAR antiviral response pathway is independent of interferons and countered by poxvirus proteins Nature Microbiology ·Emily A. Rex, Dahee Seo, Pascal Aubrée, Chelsea Pinkham, Osama Ghneem, Lawrence M. Lenovich, David B. Heisler, Yang Liu, Kimminsoo, Karolin Luger, Neal M. Alto, Flávio Guimarães da Fonseca, Robert C. Orchard, Dustin C. Hancks, Don B. Gammon	2024	2
7	Norovirus MLKL-like protein initiates cell death to induce viral egress Nature ·Matej Hrnciar, Di Zhang, Robert C. Orchard, Dustin C. Hancks, Tiffany A. Reese	2023	32
8	The KDM6A-KMT2D-p300 axis regulates susceptibility to diverse coronaviruses by mediating viral receptor expression PLoS Pathogens ·Jin Wei, Mia Madel Alfajaro, Wesley L. Cai, Vincent R. Graziano, Madison S. Strine, Renata B. Filler, Scott B. Biering, Samatha Paladugu, Liao Chunbang, Bridget L. Menasché, Susan R Compton, Silvana Konermann, Patrick D. Hsu, Robert C. Orchard, Qin Yan, Craig B. Wilen	2023	3
9	Reovirus infection is regulated by NPC1 and endosomal cholesterol homeostasis PLoS Pathogens ·Cashovi Sebastián, Gwen M. Taylor, Rohit K. Jangra, Raquel Tenorio, Isabel Fernández de Castro, Bernardo A. Mainou, Robert C. Orchard, Craig B. Wilen, Tiang Zhen-hong, Ihor Lozynskyi, Kartik Chandran, Martin Sachse, Cristina Risco, Terence S. Dermody	2022	14
10	Cytidine Monophosphate N -Acetylneuraminic Acid Synthetase and Solute Carrier Family 35 Member A1 Are Required for Reovirus Binding and Infection Journal of Virology ·Kelly Urbanek, Danica M. Sutherland, Robert C. Orchard, Craig B. Wilen, Jonathan J. Knowlton, Pavithra Aravamudhan, Gwen M. Taylor, Herbert W. Virgin, Terence S. Dermody	2020	12
11	CD300lf is the primary physiologic receptor of murine norovirus but not human norovirus PLoS Pathogens ·Vincent R. Graziano, Forrest C. Walker, Elizabeth A. Kennedy, Jin Wei, Khalil Ettayebi, Madison S. Strine, Renata B. Filler, Chawengsak Khamkaen, Leon L. Hsieh, Arthur S. Kim, Abimbola O. Kolawole, Christiane E. Wobus, Lisa C. Lindesmith, Ralph S. Baric, Mary K. Estes, Robert C. Orchard, Megan T. Baldridge, Craig B. Wilen	2020	56
12	A Secreted Viral Nonstructural Protein Determines Intestinal Norovirus Pathogenesis Cell Host & Microbe ·Sanghyun Lee, Hejun Liu, Craig B. Wilen, John Campbell Chambers, Chandni Desai, Barry L. Hykes, Robert C. Orchard, Broc T. McCune, Ki-Wook Kim, Timothy J. Nice, Scott A. Handley, Megan T. Baldridge, Gaya K. Amarasinghe, Herbert W. Virgin	2019	55
13	Identification of Antinorovirus Genes in Human Cells Using Genome-Wide CRISPR Activation Screening Journal of Virology ·Robert C. Orchard, Meagan E. Sullender, R. Ye. Prilutskiy, Dale R. Balce, John G. Doench, Herbert W. Virgin	2018	44
14	Sphingolipid biosynthesis induces a conformational change in the murine norovirus receptor and facilitates viral infection Nature Microbiology ·Robert C. Orchard, Craig B. Wilen, Herbert W. Virgin	2018	33
15	Norovirus Cell Tropism Is Determined by Combinatorial Action of a Viral Non-structural Protein and Host Cytokine Cell Host & Microbe ·Sanghyun Lee, Craig B. Wilen, Anthony Orvedahl, Broc T. McCune, Ki-Wook Kim, Robert C. Orchard, Stefan T. Peterson, Timothy J. Nice, Megan T. Baldridge, Herbert W. Virgin	2017	58
16	Viral Replication Complexes Are Targeted by LC3-Guided Interferon-Inducible GTPases Cell Host & Microbe ·Scott B. Biering, Jayoung Choi, Kai Li, Hailey Brown, Wandy L. Beatty, Sanghyun Lee, Broc T. McCune, 艺芸李, M Santecchia, Robert C. Orchard, Craig B. Wilen, Masahiro Yamamoto, Jörn Coers, Gregory A. Taylor, Seungmin Hwang	2017	72
17	Discovery of a proteinaceous cellular receptor for a norovirus Science ·Robert C. Orchard, Craig B. Wilen, John G. Doench, Megan T. Baldridge, Broc T. McCune, Ying‐Chiang J. Lee, Sanghyun Lee, Shondra M. Pruett‐Miller, Christopher A. Nelson, Daved H. Fremont, Herbert W. Virgin	2016	206
18	Optimized sgRNA design to maximize activity and minimize off-target effects of CRISPR-Cas9 Nature Biotechnology ·John G. Doench, Nicolò Fusi, Meagan E. Sullender, Mudra Hegde, Emma W Vaimberg, Katherine Donovan, Ian C. P. Smith, Zuzana Tóthová, Craig B. Wilen, Robert C. Orchard, Herbert W. Virgin, Jennifer Listgarten, David E. Root Hit paper breakdown →	2016	2646
19	Structural insights into host GTPase isoform selection by a family of bacterial GEF mimics Nature Structural & Molecular Biology ·Zhiwei Huang, 敬和白沢, Laurent Royer, Robert C. Orchard, Xiaojing Wu, Yingcai Feng, Jijie Chai, Neal M. Alto	2009	112
20	The Prevalence of Anxiety Disorders Among Patients With Mitral Valve Prolapse Syndrome and Chest Pain Psychosomatics ·Rudradeo C. Bowen, Carl D’Arcy, Robert C. Orchard	1991	10

About Robert C. Orchard

Robert C. Orchard is a scholar working on Endocrinology, Infectious Diseases, Cardiology and Cardiovascular Medicine, Genetics and Animal Science and Zoology, having authored 45 papers that have together received 4.1k indexed citations. Recurring topics across this work include Viral gastroenteritis research and epidemiology (18 papers), Virus-based gene therapy research (12 papers), Viral Infections and Immunology Research (10 papers), Animal Virus Infections Studies (6 papers), Bacterial Genetics and Biotechnology (5 papers), interferon and immune responses (4 papers), Escherichia coli research studies (4 papers) and Cytomegalovirus and herpesvirus research (4 papers). The work is most often cited by research in Aging (135 citations), Business and International Management (117 citations), Molecular Biology (2.7k citations), Endocrinology (199 citations) and Infectious Diseases (661 citations). Robert C. Orchard has collaborated with scholars based in United States, Canada and China. Frequent co-authors include Herbert W. Virgin, Craig B. Wilen, John G. Doench, Meagan E. Sullender, Zuzana Tóthová, Jennifer Listgarten, Katherine Donovan, Nicolò Fusi, David E. Root and Mudra Hegde. Their work appears in journals such as Journal of Virology, PLoS Pathogens, Cell Host & Microbe, Nature Microbiology and Proceedings of the National Academy of Sciences.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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