Benjamin P. Kleinstiver

14.0k citations

66 papers · 8.7k indexed · 8 hit papers · h-index 28

Molecular Biology top 0.5%
Genetics top 0.5%
Business and International Management top 0.05%
Plant Science top 2%
Insect Science top 1%

Co-authors: J. Keith Joung Shengdar Q. Tsai Michelle S. Prew Nathalie T. Nguyen Zongli Zheng Vikram Pattanayak Russell T. Walton Martin J. Aryee
Topics: CRISPR and Genetic Engineering (53 papers)RNA and protein synthesis mechanisms (22 papers)Advanced biosensing and bioanalysis techniques (21 papers)
Cited by: Business and International Management Aging Molecular Biology
Journals: Nature Science Proceedings of the National Academy of Sciences
Partner nations: United States Canada Switzerland

In The Last Decade

Benjamin P. Kleinstiver

64 papers receiving 8.6k citations

Hit Papers

5 papers align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

High-fidelity CRISPR–Cas9 nucleases with no detectable genome-wide off-target effects

2016 2.0k citations Benjamin P. Kleinstiver, Michelle S. Prew et al. profile →
Engineered CRISPR-Cas9 nucleases with altered PAM specificities

2015 1.3k citations Benjamin P. Kleinstiver, Michelle S. Prew et al. profile →
Enhanced proofreading governs CRISPR–Cas9 targeting accuracy

2017 872 citations Benjamin P. Kleinstiver, Alexander A. Sousa et al. profile →
Unconstrained genome targeting with near-PAMless engineered CRISPR-Cas9 variants

2020 805 citations Russell T. Walton, Kathleen A. Christie et al. Science profile →
Genome-wide specificities of CRISPR-Cas Cpf1 nucleases in human cells

2016 509 citations Benjamin P. Kleinstiver, Shengdar Q. Tsai et al. Nature Biotechnology profile →
Broadening the targeting range of Staphylococcus aureus CRISPR-Cas9 by modifying PAM recognition

2015 466 citations Benjamin P. Kleinstiver, Michelle S. Prew et al. Nature Biotechnology profile →
Engineered CRISPR–Cas12a variants with increased activities and improved targeting ranges for gene, epigenetic and base editing

2019 453 citations Benjamin P. Kleinstiver, Alexander A. Sousa et al. Nature Biotechnology profile →
High levels of AAV vector integration into CRISPR-induced DNA breaks

2019 289 citations Killian S. Hanlon, Benjamin P. Kleinstiver et al. Nature Communications profile →

Peers

Countries citing papers authored by Benjamin P. Kleinstiver

Since Specialization

Citations

This map shows the geographic impact of Benjamin P. Kleinstiver's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Benjamin P. Kleinstiver with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Benjamin P. Kleinstiver more than expected).

Fields of papers citing papers by Benjamin P. Kleinstiver

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Benjamin P. Kleinstiver. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Benjamin P. Kleinstiver. The network helps show where Benjamin P. Kleinstiver may publish in the future.

Co-authorship network of co-authors of Benjamin P. Kleinstiver

This figure shows the co-authorship network connecting the top 25 collaborators of Benjamin P. Kleinstiver. A scholar is included among the top collaborators of Benjamin P. Kleinstiver based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Benjamin P. Kleinstiver. Benjamin P. Kleinstiver is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

Sort: Min cites: Since: Top N: Style:

20 of 20 papers shown

#	Work	Indexed citations
1	Exploring the potential of cell-derived vesicles for transient delivery of gene editing payloads 2024 ·Advanced Drug Delivery Reviews ·Kevin Leandro,David Rufino‐Ramos,Koen Breyne,Emilio Di Ianni,Sara Lopes,Rui Jorge Nobre,Benjamin P. Kleinstiver,(unknown),Xandra O. Breakefield,Luís Pereira de Almeida	13
2	High-fidelity PAMless base editing of hematopoietic stem cells to treat chronic granulomatous disease 2024 ·Science Translational Medicine ·(unknown),Linyuan Ma,Siyuan Liu,(unknown),Madelynn N. Whittaker,Ronald J. Meis,Uimook Choi,A. A. H. Lawson,(unknown),Narda Theobald,Sandra Burkett,Colin L. Sweeney,Cícera R. Lazzarotto,Shengdar Q. Tsai,Justin Lack,Xiaolin Wu,Gary A. Dahl,Harry L. Malech,Benjamin P. Kleinstiver,Suk See De Ravin	7
3	CRISPR-Cas Genome Editing in Ex Vivo Human Lungs to Rewire the Translational Path of Genome-Targeting Therapeutics 2024 ·Human Gene Therapy ·Kumi Mesaki,(unknown),S. Juvet,Jonathan Yeung,Zehong Guan,(unknown),(unknown),(unknown),(unknown),Aizhou Wang,Gavin W. Wilson,Andrea Mariscal,Jim Hu,Alan R. Davidson,Benjamin P. Kleinstiver,Marcelo Cypel,Mingyao Liu,Shaf Keshavjee	2
4	Sniper2L is a high-fidelity Cas9 variant with high activity 2023 ·Nature Chemical Biology ·Young-hoon Kim,Nahye Kim,(unknown),(unknown),Seonwoo Min,Joonsun Lee,(unknown),(unknown),(unknown),(unknown),Young-Ho Kim,Jin‐Soo Kim,Benjamin P. Kleinstiver,Jungjoon K. Lee,Taekjip Ha,Seokjoong Kim	33
5	Treatment of monogenic and digenic dominant genetic hearing loss by CRISPR-Cas9 ribonucleoprotein delivery in vivo 2023 ·Nature Communications ·Yong Tao,Verónica Lamas,Wan Du,Wenliang Zhu,Yiran Li,Madelynn N. Whittaker,John A. Zuris,David B. Thompson,Arun Prabhu Rameshbabu,Yilai Shu,Xue Gao,Johnny H. Hu,(unknown),Weijia Kong,Xuezhong Liu,Hao Wu,Benjamin P. Kleinstiver,David R. Liu,Zheng‐Yi Chen	29
6	Immunomodulation of the donor lung with CRISPR-mediated activation of IL-10 expression 2023 ·The Journal of Heart and Lung Transplantation ·Kumi Mesaki,S. Juvet,Jonathan Yeung,Zehong Guan,Gavin W. Wilson,Jim Hu,Alan R. Davidson,Benjamin P. Kleinstiver,Marcelo Cypel,Mingyao Liu,Shaf Keshavjee	13
7	Precise DNA cleavage using CRISPR-SpRYgests 2022 ·Nature Biotechnology ·Kathleen A. Christie,Jimmy A. Guo,Rachel A. Silverstein,(unknown),Megumu Mabuchi,(unknown),Jiecong Lin,Linyuan Ma,Russell T. Walton,Luca Pinello,G. Brett Robb,Benjamin P. Kleinstiver	35
8	Allele-specific silencing of the gain-of-function mutation in Huntington’s disease using CRISPR/Cas9 2022 ·JCI Insight ·Jun Wan Shin,Eun Pyo Hong,(unknown),(unknown),Ihn Sik Seong,Madelynn N. Whittaker,Benjamin P. Kleinstiver,(unknown),Jong‐Min Lee	17
9	Lack of Cas13a inhibition by anti-CRISPR proteins from Leptotrichia prophages 2022 ·Molecular Cell ·Matthew C. Johnson,(unknown),Benjamin P. Kleinstiver,Alexander J. Meeske,Joseph Bondy‐Denomy	10
10	Genome editing in animals with minimal PAM CRISPR-Cas9 enzymes 2022 ·Nature Communications ·(unknown),(unknown),Ismael Moreno-Sánchez,(unknown),Charles E. Vejnar,(unknown),(unknown),(unknown),(unknown),Natalia Rodrigo Melero,(unknown),Carlo Carolis,Antonio J. Pérez‐Pulido,Antonio J. Giráldez,Benjamin P. Kleinstiver,Julián Cerón,Miguel A. Moreno-Mateos	33
11	In vivo engineering of lymphocytes after systemic exosome-associated AAV delivery 2020 ·Scientific Reports ·(unknown),Killian S. Hanlon,(unknown),Adrienn Volak,Amine Meliani,Federico Mingozzi,Benjamin P. Kleinstiver,James J. Moon,Casey A. Maguire	25
12	Cell-based artificial APC resistant to lentiviral transduction for efficient generation of CAR-T cells from various cell sources 2020 ·Journal for ImmunoTherapy of Cancer ·Andrea Schmidts,(unknown),(unknown),Amanda A. Bouffard,Angela C. Boroughs,Irene Scarfò,Rebecca C. Larson,Felipe Bedoya,Bryan D. Choi,Matthew J. Frigault,Stefanie R. Bailey,Mark B. Leick,(unknown),Michael C. Kann,Michelle S. Prew,Benjamin P. Kleinstiver,J. Keith Joung,Marcela V. Maus	18
13	enAsCas12a Enables CRISPR-Directed Evolution to Screen for Functional Drug Resistance Mutations in Sequences Inaccessible to SpCas9 2020 ·Molecular Therapy ·Jasper E. Neggers,Maarten Jacquemyn,Tim Dierckx,Benjamin P. Kleinstiver,Hendrik Jan Thibaut,Dirk Daelemans	13
14	Unconstrained genome targeting with near-PAMless engineered CRISPR-Cas9 variantsbreakdown → 2020 ·Science ·Russell T. Walton,Kathleen A. Christie,Madelynn N. Whittaker,Benjamin P. Kleinstiver	805
15	Broad-spectrum anti-CRISPR proteins facilitate horizontal gene transfer 2020 ·Nature Microbiology ·Caroline Mahendra,Kathleen A. Christie,Beatriz A. Osuna,Rafael Pinilla‐Redondo,Benjamin P. Kleinstiver,Joseph Bondy‐Denomy	79
16	Optimization of AsCas12a for combinatorial genetic screens in human cells 2020 ·Nature Biotechnology ·Peter C. DeWeirdt,Kendall R Sanson,Annabel K. Sangree,Mudra Hegde,Ruth E. Hanna,Marissa N. Feeley,Audrey L Griffith,Teng Teng,(unknown),Christine Strand,J. Keith Joung,Benjamin P. Kleinstiver,Xuewen Pan,Alan Huang,John G. Doench	110
17	Scripts for analyzing High-Throughput PAM Determination Assay (HT-PAMDA) experimental data for CRISPR enzymes 2020 ·Zenodo (CERN European Organization for Nuclear Research) ·Russell T. Walton,Benjamin P. Kleinstiver	1
18	Allele-specific gene disruption through discrimination of a single base change by S. aureus Cas9-KKH prevents progressive hearing loss after AAV-mediated gene delivery 2019 ·Human Gene Therapy ·Bence György,Carl Nist-Lund,Bifeng Pan,Yuki Asai,K. Domenica Karavitaki,Benjamin P. Kleinstiver,Sara P. Garcia,Mikołaj Piotr Zaborowski,Paola Solanes,(unknown),Brandt L. Schneider,J. Keith Joung,Gwenaëlle S. G. Géléoc,Jeffrey R. Holt,David P. Corey	1
19	Discovery of widespread type I and type V CRISPR-Cas inhibitors 2018 ·Science ·Nicole D. Marino,Jenny Y. Zhang,Adair L. Borges,Alexander A. Sousa,Lina M León,Benjamin J. Rauch,Russell T. Walton,Joel Berry,J. Keith Joung,Benjamin P. Kleinstiver,Joseph Bondy‐Denomy	192
20	DNA hydrolysis and genome editing applications of GIY-YIG family homing endonucleases 2013 ·Scholarship@Western (Western University) ·Benjamin P. Kleinstiver	1

About Benjamin P. Kleinstiver

Benjamin P. Kleinstiver is a scholar working on Aging, Business and International Management and Chemical Health and Safety, having authored 66 papers that have together received 8.7k indexed citations. Recurring topics across this work include CRISPR and Genetic Engineering (53 papers), RNA and protein synthesis mechanisms (22 papers) and Advanced biosensing and bioanalysis techniques (21 papers). The work is most often cited by research in Business and International Management (1.0k citations), Aging (663 citations) and Molecular Biology (8.4k citations). Benjamin P. Kleinstiver has collaborated with scholars based in United States, Canada and Switzerland. Frequent co-authors include J. Keith Joung, Shengdar Q. Tsai, Michelle S. Prew, Nathalie T. Nguyen, Zongli Zheng, Vikram Pattanayak, Russell T. Walton, Martin J. Aryee, Kathleen A. Christie and Madelynn N. Whittaker. Their work appears in journals such as Nature, Science and Proceedings of the National Academy of Sciences.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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