Jens C. Brüning

38.9k total citations · 19 hit papers
217 papers, 28.0k citations indexed

About

Jens C. Brüning is a scholar working on Physiology, Endocrine and Autonomic Systems and Molecular Biology. According to data from OpenAlex, Jens C. Brüning has authored 217 papers receiving a total of 28.0k indexed citations (citations by other indexed papers that have themselves been cited), including 88 papers in Physiology, 85 papers in Endocrine and Autonomic Systems and 79 papers in Molecular Biology. Recurrent topics in Jens C. Brüning's work include Regulation of Appetite and Obesity (81 papers), Adipose Tissue and Metabolism (65 papers) and Pancreatic function and diabetes (43 papers). Jens C. Brüning is often cited by papers focused on Regulation of Appetite and Obesity (81 papers), Adipose Tissue and Metabolism (65 papers) and Pancreatic function and diabetes (43 papers). Jens C. Brüning collaborates with scholars based in Germany, United States and United Kingdom. Jens C. Brüning's co-authors include C. Ronald Kahn, A. Christine Könner, F. Thomas Wunderlich, Jonathon N. Winnay, Markus Schubert, Katharina Timper, Jan Mauer, Bengt‐Frederik Belgardt, Alexander Jaïs and Wilhelm Krone and has published in prestigious journals such as Nature, Science and Cell.

In The Last Decade

Jens C. Brüning

215 papers receiving 27.7k citations

Hit Papers

5 papers align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Role of Brain Insulin Receptor in Control of Body Weight and Reproduction

2000 1.7k citations Jens C. Brüning, Markus Schubert et al. profile →
Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene

1994 1.0k citations Jens C. Brüning et al. profile →
A Muscle-Specific Insulin Receptor Knockout Exhibits Features of the Metabolic Syndrome of NIDDM without Altering Glucose Tolerance

1998 939 citations Jens C. Brüning, Jonathon N. Winnay et al. profile →
Tissue-Specific Knockout of the Insulin Receptor in Pancreatic β Cells Creates an Insulin Secretory Defect Similar to that in Type 2 Diabetes

1999 918 citations Jens C. Brüning, Jonathon N. Winnay et al. profile →
Interleukin-10 Signaling in Regulatory T Cells Is Required for Suppression of Th17 Cell-Mediated Inflammation

2011 740 citations F. Thomas Wunderlich, Jens C. Brüning et al. profile →
Agouti-related peptide–expressing neurons are mandatory for feeding

2005 616 citations Brigitte Hampel, Ari Waisman et al. profile →
Insulin Receptor Signaling in Osteoblasts Regulates Postnatal Bone Acquisition and Body Composition

2010 603 citations Jens C. Brüning et al. profile →
Signaling by IL-6 promotes alternative activation of macrophages to limit endotoxemia and obesity-associated resistance to insulin

2014 573 citations Jan Mauer, F. Thomas Wunderlich et al. profile →
Overexpression of Fto leads to increased food intake and results in obesity

2010 556 citations Jens C. Brüning et al. profile →
Hypothalamic circuits regulating appetite and energy homeostasis: pathways to obesity

2017 546 citations Jens C. Brüning et al. profile →
Insulin Action in AgRP-Expressing Neurons Is Required for Suppression of Hepatic Glucose Production

2007 538 citations Sabine D. Jordan, Eva Rother et al. Cell Metabolism profile →
Role for neuronal insulin resistance in neurodegenerative diseases

2004 517 citations Markus Schubert, Jens C. Brüning et al. Proceedings of the National Academy of Sciences profile →
FOXO1 couples metabolic activity and growth state in the vascular endothelium

2016 429 citations Jens C. Brüning et al. profile →
NK cells link obesity-induced adipose stress to inflammation and insulin resistance

2015 386 citations F. Thomas Wunderlich, Jens C. Brüning et al. profile →
Hypothalamic inflammation in obesity and metabolic disease

2017 344 citations Jens C. Brüning et al. profile →
Mitochondrial metabolism coordinates stage-specific repair processes in macrophages during wound healing

2021 183 citations Jens C. Brüning et al. Cell Metabolism profile →
Arcuate Nucleus-Dependent Regulation of Metabolism—Pathways to Obesity and Diabetes Mellitus

2021 148 citations Jens C. Brüning et al. profile →
Integrative neurocircuits that control metabolism and food intake

2023 96 citations Jens C. Brüning, Henning Fenselau profile →
A comprehensive spatio-cellular map of the human hypothalamus

2025 29 citations Lukas Steuernagel, Paul Klemm et al. profile →

Peers

Countries citing papers authored by Jens C. Brüning

Since Specialization

Citations

This map shows the geographic impact of Jens C. Brüning's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Jens C. Brüning with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Jens C. Brüning more than expected).

Fields of papers citing papers by Jens C. Brüning

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Jens C. Brüning. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Jens C. Brüning. The network helps show where Jens C. Brüning may publish in the future.

Co-authorship network of co-authors of Jens C. Brüning

This figure shows the co-authorship network connecting the top 25 collaborators of Jens C. Brüning. A scholar is included among the top collaborators of Jens C. Brüning based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Jens C. Brüning. Jens C. Brüning is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

#	Work	Indexed citations
1	Neuroprotective effect of neuron‐specific deletion of the C16 ceramide synthetic enzymes in an animal model of multiple sclerosis 2024 ·Glia ·(unknown), Damien Maréchal, Mar Gacias, (unknown), Sarah M. Turpin-Nolan, Johannes Morstein, Mohammed Moniruzzaman, Jens C. Brüning, Norman J. Haughey, Dirk Trauner, Patrizia Casaccia	5
2	Reciprocal activity of AgRP and POMC neurons governs coordinated control of feeding and metabolism 2024 ·Nature Metabolism ·Alain J. De Solís, (unknown), (unknown), Weiyi Chen, Lukas Steuernagel, Corinna A. Bauder, (unknown), Donald A. Morgan, (unknown), Michael Sué, (unknown), Christian Kukat, Stefan Vollmar, Heiko Backes, Kamal Rahmouni, Peter Kloppenburg, Jens C. Brüning	41
3	An Approach to Intersectionally Target Mature Enteroendocrine Cells in the Small Intestine of Mice 2024 ·Cells ·(unknown), (unknown), Claudia M. Wunderlich, Melanie J. Mittenbühler, (unknown), (unknown), (unknown), (unknown), (unknown), Kat Folz‐Donahue, Christian Kukat, Ingo Voigt, Jens C. Brüning, Henning Fenselau, F. Thomas Wunderlich	1
4	CerS6-dependent ceramide synthesis in hypothalamic neurons promotes ER/mitochondrial stress and impairs glucose homeostasis in obese mice 2023 ·Nature Communications ·Philipp Hammerschmidt, Sophie M. Steculorum, (unknown), (unknown), Lukas Steuernagel, (unknown), (unknown), Luis Varela, (unknown), (unknown), R. Klar, Corinna A. Bauder, (unknown), (unknown), Nasim Biglari, (unknown), Tamás L. Horváth, Thorsten Hornemann, Susanne Brodesser, Jens C. Brüning	21
5	Habitual daily intake of a sweet and fatty snack modulates reward processing in humans 2023 ·Cell Metabolism ·Sharmili Edwin Thanarajah, Alexandra G. DiFeliceantonio, Kerstin Albus, Bojana Kuzmanovic, Lionel Rigoux, Sandra Iglesias, Ruth Hanßen, Marc Schlamann, Oliver A. Cornely, Jens C. Brüning, Marc Tittgemeyer, Dana M. Small	42
6	An antisense transcript transcribed from Irs2 locus contributes to the pathogenesis of hepatic steatosis in insulin resistance 2022 ·Cell chemical biology ·(unknown), Motoharu Awazawa, Naoki Kobayashi, (unknown), (unknown), Miwa Tamura‐Nakano, Masafumi Muratani, Kenta Kobayashi, Matthias Blüher, Jens C. Brüning, Kohjiro Ueki	1
7	Early microglial response, myelin deterioration and lethality in mice deficient for very long chain ceramide synthesis in oligodendrocytes 2022 ·Glia ·Jonathan D. Teo, (unknown), Alanna G. Spiteri, (unknown), (unknown), (unknown), Holly P. McEwen, (unknown), Monokesh K. Sen, Laura Piccio, Jessica L. Fletcher, Nicholas J. C. King, Simon S. Murray, Jens C. Brüning, Anthony S. Don	20
8	Dopamine-inhibited POMCDrd2+ neurons in the ARC acutely regulate feeding and body temperature 2022 ·JCI Insight ·(unknown), (unknown), Nasim Biglari, (unknown), (unknown), Tamara Sotelo-Hitschfeld, Paul Klemm, Lukas Steuernagel, Alain J. De Solís, Weiyi Chen, F. Thomas Wunderlich, Peter Kloppenburg, Jens C. Brüning	9
9	POMC neuronal heterogeneity in energy balance and beyond: an integrated view 2021 ·Nature Metabolism ·Carmelo Quarta, Marc Claret, Lori M. Zeltser, Kevin W. Williams, Giles S.H. Yeo, Matthias H. Tschöp, Sabrina Diano, Jens C. Brüning, Daniela Cota	115
10	Modulation of Endocannabinoids by Caloric Restriction Is Conserved in Mice but Is Not Required for Protection from Acute Kidney Injury 2021 ·International Journal of Molecular Sciences ·(unknown), Martin R. Späth, Ruth Hanßen, (unknown), Susanne Brodesser, (unknown), (unknown), Felix C. Koehler, Heike Göbel, Torsten Kubacki, Franziska Grundmann, Bernhard Schermer, Jens C. Brüning, Thomas Benzing, Volker Burst, Roman‐Ulrich Müller	1
11	NPY mediates the rapid feeding and glucose metabolism regulatory functions of AgRP neurons 2020 ·Nature Communications ·Linda Engström, (unknown), Alain J. De Solís, Henning Fenselau, Jens C. Brüning	73
12	Antagonistic modulation of NPY/AgRP and POMC neurons in the arcuate nucleus by noradrenalin 2017 ·eLife ·Lars Paeger, Ismene Karakasilioti, Janine Altmüller, Peter Frommolt, Jens C. Brüning, Peter Kloppenburg	38
13	Energy imbalance alters Ca2+ handling and excitability of POMC neurons 2017 ·eLife ·Lars Paeger, (unknown), Simon Heß, (unknown), Andreas Klein, Andreas Husch, Christophe Pouzat, Jens C. Brüning, Peter Kloppenburg	44
14	Insulin controls food intake and energy balance via NPY neurons 2017 ·Molecular Metabolism ·Kim Loh, Lei Zhang, Amanda E. Brandon, Qiao‐Ping Wang, Denovan P. Begg, Yue Qi, (unknown), Rishikesh N. Kulkarni, Jonathan D. Teo, Paul A. Baldock, Jens C. Brüning, Gregory J. Cooney, G. Gregory Neely, Herbert Herzog	122
15	Acute selective ablation of rat insulin promoter-expressing (RIP _HER ) neurons defines their orexigenic nature 2012 ·Proceedings of the National Academy of Sciences ·Eva Rother, Bengt‐Frederik Belgardt, Eva Tsaousidou, Brigitte Hampel, Ari Waisman, Martin G. Myers, Jens C. Brüning	26
16	Dwarfism in Mice Lacking Collagen-binding Integrins α2β1 and α11β1 Is Caused by Severely Diminished IGF-1 Levels 2011 ·Journal of Biological Chemistry ·Katrin Blumbach, Anja Niehoff, Bengt‐Frederik Belgardt, Harald W.A. Ehlen, (unknown), (unknown), Jan-Niklas Schulz, Jens C. Brüning, Thomas Krieg, Markus Schubert, Donald Gullberg, Beate Eckes	26
17	Hepatic Bax Inhibitor-1 Inhibits IRE1α and Protects from Obesity-associated Insulin Resistance and Glucose Intolerance 2009 ·Journal of Biological Chemistry ·Béatrice Bailly‐Maitre, Bengt‐Frederik Belgardt, Sabine D. Jordan, Beatrice Coornaert, (unknown), André Kleinridders, Jan Mauer, Michael Cuddy, Christina Kress, Diana M. Willmes, (unknown), Brigitte Hampel, Ulrike Protzer, John C. Reed, Jens C. Brüning	97
18	Hepatic NF-κB essential modulator deficiency prevents obesity-induced insulin resistance but synergizes with high-fat feeding in tumorigenesis 2008 ·Proceedings of the National Academy of Sciences ·F. Thomas Wunderlich, Tom Luedde, Stephan Singer, Marc Schmidt‐Supprian, (unknown), Peter Schirmacher, Manolis Pasparakis, Jens C. Brüning	90
19	Das pädagogische Jahrhundert in der Praxis : Schulwandel in Stadt und Land in den preußischen Westprovinzen Minden und Ravensberg 1648 - 1816 1998 ·DUNCKER UND HUMBLOT eBooks ·Jens C. Brüning	1
20	Differential Signaling by Insulin Receptor Substrate 1 (IRS-1) and IRS-2 in IRS-1-Deficient Cells 1997 ·Molecular and Cellular Biology ·Jens C. Brüning, Jonathon N. Winnay, Bentley Cheatham, C. Ronald Kahn	184

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