Jens C. Brüning

38.9k total citations · 19 hit papers
217 papers, 28.0k citations indexed

About

Jens C. Brüning is a scholar working on Physiology, Endocrine and Autonomic Systems and Molecular Biology. According to data from OpenAlex, Jens C. Brüning has authored 217 papers receiving a total of 28.0k indexed citations (citations by other indexed papers that have themselves been cited), including 88 papers in Physiology, 85 papers in Endocrine and Autonomic Systems and 79 papers in Molecular Biology. Recurrent topics in Jens C. Brüning's work include Regulation of Appetite and Obesity (81 papers), Adipose Tissue and Metabolism (65 papers) and Pancreatic function and diabetes (43 papers). Jens C. Brüning is often cited by papers focused on Regulation of Appetite and Obesity (81 papers), Adipose Tissue and Metabolism (65 papers) and Pancreatic function and diabetes (43 papers). Jens C. Brüning collaborates with scholars based in Germany, United States and United Kingdom. Jens C. Brüning's co-authors include C. Ronald Kahn, A. Christine Könner, F. Thomas Wunderlich, Jonathon N. Winnay, Markus Schubert, Katharina Timper, Jan Mauer, Bengt‐Frederik Belgardt, Alexander Jaïs and Wilhelm Krone and has published in prestigious journals such as Nature, Science and Cell.

In The Last Decade

Jens C. Brüning

215 papers receiving 27.7k citations

Hit Papers

Role of Brain Insulin Rec... 1994 2026 2004 2015 2000 1994 1998 1999 2011 500 1000 1.5k
What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

  1. Role of Brain Insulin Receptor in Control of Body Weight and Reproduction
    2000 1.7k citations Jens C. Brüning, Markus Schubert et al. profile →
  2. Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene
    1994 1.0k citations Jens C. Brüning et al. profile →
  3. A Muscle-Specific Insulin Receptor Knockout Exhibits Features of the Metabolic Syndrome of NIDDM without Altering Glucose Tolerance
    1998 939 citations Jens C. Brüning et al. profile →
  4. Tissue-Specific Knockout of the Insulin Receptor in Pancreatic β Cells Creates an Insulin Secretory Defect Similar to that in Type 2 Diabetes
    1999 918 citations Jens C. Brüning et al. profile →
  5. Interleukin-10 Signaling in Regulatory T Cells Is Required for Suppression of Th17 Cell-Mediated Inflammation
    2011 740 citations F. Thomas Wunderlich, Jens C. Brüning et al. profile →
  6. Agouti-related peptide–expressing neurons are mandatory for feeding
    2005 616 citations Brigitte Hampel, Ari Waisman et al. profile →
  7. Insulin Receptor Signaling in Osteoblasts Regulates Postnatal Bone Acquisition and Body Composition
    2010 603 citations Jens C. Brüning et al. profile →
  8. Signaling by IL-6 promotes alternative activation of macrophages to limit endotoxemia and obesity-associated resistance to insulin
    2014 573 citations Jan Mauer, F. Thomas Wunderlich et al. profile →
  9. Overexpression of Fto leads to increased food intake and results in obesity
    2010 556 citations Jens C. Brüning et al. profile →
  10. Hypothalamic circuits regulating appetite and energy homeostasis: pathways to obesity
    2017 546 citations Jens C. Brüning et al. profile →
  11. Insulin Action in AgRP-Expressing Neurons Is Required for Suppression of Hepatic Glucose Production
    2007 538 citations Sabine D. Jordan, Eva Rother et al. Cell Metabolism profile →
  12. Role for neuronal insulin resistance in neurodegenerative diseases
    2004 517 citations Markus Schubert, Jens C. Brüning et al. Proceedings of the National Academy of Sciences profile →
  13. FOXO1 couples metabolic activity and growth state in the vascular endothelium
    2016 429 citations Jens C. Brüning et al. profile →
  14. NK cells link obesity-induced adipose stress to inflammation and insulin resistance
    2015 386 citations F. Thomas Wunderlich, Jens C. Brüning et al. profile →
  15. Hypothalamic inflammation in obesity and metabolic disease
    2017 344 citations Jens C. Brüning et al. profile →
  16. Mitochondrial metabolism coordinates stage-specific repair processes in macrophages during wound healing
    2021 183 citations Jens C. Brüning et al. Cell Metabolism profile →
  17. Arcuate Nucleus-Dependent Regulation of Metabolism—Pathways to Obesity and Diabetes Mellitus
    2021 148 citations Jens C. Brüning et al. profile →
  18. Integrative neurocircuits that control metabolism and food intake
    2023 96 citations Jens C. Brüning, Henning Fenselau profile →
  19. A comprehensive spatio-cellular map of the human hypothalamus
    2025 29 citations Lukas Steuernagel, Paul Klemm et al. profile →

Author Peers

Peers are selected by citation overlap in the author's most active subfields. citations · hero ref

Author Last Decade Papers Cites
Jens C. Brüning 11.0k 9.0k 7.4k 4.9k 4.2k 217 28.0k
Martin G. Myers 8.9k 0.8× 7.7k 0.9× 11.5k 1.6× 3.9k 0.8× 6.2k 1.5× 332 27.9k
Tamás L. Horváth 8.2k 0.7× 11.9k 1.3× 15.8k 2.1× 2.2k 0.4× 3.8k 0.9× 328 34.7k
Jason K. Kim 13.5k 1.2× 9.4k 1.0× 1.8k 0.2× 3.6k 0.7× 6.6k 1.6× 197 25.4k
Rexford S. Ahima 6.9k 0.6× 13.8k 1.5× 13.9k 1.9× 2.7k 0.5× 10.4k 2.5× 238 32.2k
Bernard Thorens 14.1k 1.3× 5.2k 0.6× 2.9k 0.4× 10.4k 2.1× 2.4k 0.6× 261 28.2k
Masashi Yanagisawa 18.7k 1.7× 27.6k 3.1× 19.4k 2.6× 4.9k 1.0× 2.1k 0.5× 527 64.7k
Stephen O’Rahilly 16.7k 1.5× 16.2k 1.8× 14.4k 1.9× 6.0k 1.2× 9.8k 2.3× 429 46.8k
Morris J. Birnbaum 27.6k 2.5× 9.9k 1.1× 2.2k 0.3× 8.3k 1.7× 5.7k 1.3× 243 41.3k
Bradford B. Lowell 16.4k 1.5× 24.2k 2.7× 18.9k 2.6× 4.6k 0.9× 8.3k 2.0× 200 50.5k
Domenico Accili 18.8k 1.7× 7.8k 0.9× 1.9k 0.3× 10.0k 2.0× 4.7k 1.1× 271 31.5k

Countries citing papers authored by Jens C. Brüning

Since Specialization
Citations

This map shows the geographic impact of Jens C. Brüning's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Jens C. Brüning with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Jens C. Brüning more than expected).

Fields of papers citing papers by Jens C. Brüning

Since Specialization
Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Jens C. Brüning. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Jens C. Brüning. The network helps show where Jens C. Brüning may publish in the future.

Co-authorship network of co-authors of Jens C. Brüning

This figure shows the co-authorship network connecting the top 25 collaborators of Jens C. Brüning. A scholar is included among the top collaborators of Jens C. Brüning based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Jens C. Brüning. Jens C. Brüning is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

20 of 20 papers shown
1.
Maréchal, Damien, Mar Gacias, Sarah M. Turpin-Nolan, et al.. (2024). Neuroprotective effect of neuron‐specific deletion of the C16 ceramide synthetic enzymes in an animal model of multiple sclerosis. Glia. 73(2). 271–290. 5 indexed citations
2.
Wunderlich, Claudia M., Melanie J. Mittenbühler, Kat Folz‐Donahue, et al.. (2024). An Approach to Intersectionally Target Mature Enteroendocrine Cells in the Small Intestine of Mice. Cells. 13(1). 102–102. 1 indexed citations
3.
Solís, Alain J. De, Weiyi Chen, Lukas Steuernagel, et al.. (2024). Reciprocal activity of AgRP and POMC neurons governs coordinated control of feeding and metabolism. Nature Metabolism. 6(3). 473–493. 41 indexed citations
4.
Thanarajah, Sharmili Edwin, Alexandra G. DiFeliceantonio, Kerstin Albus, et al.. (2023). Habitual daily intake of a sweet and fatty snack modulates reward processing in humans. Cell Metabolism. 35(4). 571–584.e6. 42 indexed citations
5.
Hammerschmidt, Philipp, Sophie M. Steculorum, Lukas Steuernagel, et al.. (2023). CerS6-dependent ceramide synthesis in hypothalamic neurons promotes ER/mitochondrial stress and impairs glucose homeostasis in obese mice. Nature Communications. 14(1). 7824–7824. 21 indexed citations
6.
Awazawa, Motoharu, Naoki Kobayashi, Miwa Tamura‐Nakano, et al.. (2022). An antisense transcript transcribed from Irs2 locus contributes to the pathogenesis of hepatic steatosis in insulin resistance. Cell chemical biology. 29(4). 680–689.e6. 1 indexed citations
7.
Teo, Jonathan D., Alanna G. Spiteri, Holly P. McEwen, et al.. (2022). Early microglial response, myelin deterioration and lethality in mice deficient for very long chain ceramide synthesis in oligodendrocytes. Glia. 71(4). 1120–1141. 20 indexed citations
8.
Biglari, Nasim, Tamara Sotelo-Hitschfeld, Paul Klemm, et al.. (2022). Dopamine-inhibited POMCDrd2+ neurons in the ARC acutely regulate feeding and body temperature. JCI Insight. 7(21). 9 indexed citations
9.
Quarta, Carmelo, Marc Claret, Lori M. Zeltser, et al.. (2021). POMC neuronal heterogeneity in energy balance and beyond: an integrated view. Nature Metabolism. 3(3). 299–308. 115 indexed citations
10.
Späth, Martin R., Ruth Hanßen, Susanne Brodesser, et al.. (2021). Modulation of Endocannabinoids by Caloric Restriction Is Conserved in Mice but Is Not Required for Protection from Acute Kidney Injury. International Journal of Molecular Sciences. 22(11). 5485–5485. 1 indexed citations
11.
Engström, Linda, et al.. (2020). NPY mediates the rapid feeding and glucose metabolism regulatory functions of AgRP neurons. Nature Communications. 11(1). 73 indexed citations
12.
Paeger, Lars, Simon Heß, Andreas Klein, et al.. (2017). Energy imbalance alters Ca2+ handling and excitability of POMC neurons. eLife. 6. 44 indexed citations
13.
Paeger, Lars, Ismene Karakasilioti, Janine Altmüller, et al.. (2017). Antagonistic modulation of NPY/AgRP and POMC neurons in the arcuate nucleus by noradrenalin. eLife. 6. 38 indexed citations
14.
Braune, Julia, U. Weyer, Constance Hobusch, et al.. (2017). IL-6 Regulates M2 Polarization and Local Proliferation of Adipose Tissue Macrophages in Obesity. The Journal of Immunology. 198(7). 2927–2934. 195 indexed citations
15.
Loh, Kim, Lei Zhang, Amanda E. Brandon, et al.. (2017). Insulin controls food intake and energy balance via NPY neurons. Molecular Metabolism. 6(6). 574–584. 122 indexed citations
16.
Rother, Eva, Bengt‐Frederik Belgardt, Eva Tsaousidou, et al.. (2012). Acute selective ablation of rat insulin promoter-expressing (RIP HER ) neurons defines their orexigenic nature. Proceedings of the National Academy of Sciences. 109(44). 18132–18137. 26 indexed citations
17.
Blumbach, Katrin, Anja Niehoff, Bengt‐Frederik Belgardt, et al.. (2011). Dwarfism in Mice Lacking Collagen-binding Integrins α2β1 and α11β1 Is Caused by Severely Diminished IGF-1 Levels. Journal of Biological Chemistry. 287(9). 6431–6440. 26 indexed citations
18.
Bailly‐Maitre, Béatrice, Bengt‐Frederik Belgardt, Sabine D. Jordan, et al.. (2009). Hepatic Bax Inhibitor-1 Inhibits IRE1α and Protects from Obesity-associated Insulin Resistance and Glucose Intolerance. Journal of Biological Chemistry. 285(9). 6198–6207. 97 indexed citations
19.
Wunderlich, F. Thomas, Tom Luedde, Stephan Singer, et al.. (2008). Hepatic NF-κB essential modulator deficiency prevents obesity-induced insulin resistance but synergizes with high-fat feeding in tumorigenesis. Proceedings of the National Academy of Sciences. 105(4). 1297–1302. 90 indexed citations
20.
Brüning, Jens C.. (1998). Das pädagogische Jahrhundert in der Praxis : Schulwandel in Stadt und Land in den preußischen Westprovinzen Minden und Ravensberg 1648 - 1816. DUNCKER UND HUMBLOT eBooks. 1 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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