Lyle W. Ostrow

6.5k citations

33 papers · 2.8k indexed · 4 hit papers · h-index 18

Molecular Biology top 5%
Neurology top 1%
Genetics top 1%
Cellular and Molecular Neuroscience top 5%
Neurology top 2%

Co-authors: Jeffrey D. Rothstein Frederick Sachs Avindra Nath Timothy M. Miller Masahiro Fukaya Shin Hyeok Kang Ileana Lorenzini Don W. Cleveland
Topics: Amyotrophic Lateral Sclerosis Research (15 papers)Neurogenetic and Muscular Disorders Research (9 papers)Nitric Oxide and Endothelin Effects (4 papers)
Cited by: Neurology Genetics
Journals: Proceedings of the National Academy of Sciences Nature Communications Neuron
Partner nations: United States United Kingdom Argentina

In The Last Decade

Lyle W. Ostrow

33 papers receiving 2.7k citations

Hit Papers

align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

RAN proteins and RNA foci from antisense transcripts in C9ORF72 ALS and frontotemporal dementia

2013 577 citations Timothy M. Miller, Lyle W. Ostrow et al. profile →
An antisense oligonucleotide against SOD1 delivered intrathecally for patients with SOD1 familial amyotrophic lateral sclerosis: a phase 1, randomised, first-in-man study

2013 492 citations Timothy M. Miller, Alan Pestronk et al. The Lancet Neurology profile →
Degeneration and impaired regeneration of gray matter oligodendrocytes in amyotrophic lateral sclerosis

2013 449 citations Lyle W. Ostrow, Jeffrey D. Rothstein et al. Nature Neuroscience profile →
Human endogenous retrovirus-K contributes to motor neuron disease

2015 340 citations Andrew L. Mammen, Lyle W. Ostrow et al. Science Translational Medicine profile →

Peers

Countries citing papers authored by Lyle W. Ostrow

Since Specialization

Citations

This map shows the geographic impact of Lyle W. Ostrow's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Lyle W. Ostrow with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Lyle W. Ostrow more than expected).

Fields of papers citing papers by Lyle W. Ostrow

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Lyle W. Ostrow. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Lyle W. Ostrow. The network helps show where Lyle W. Ostrow may publish in the future.

Co-authorship network of co-authors of Lyle W. Ostrow

This figure shows the co-authorship network connecting the top 25 collaborators of Lyle W. Ostrow. A scholar is included among the top collaborators of Lyle W. Ostrow based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Lyle W. Ostrow. Lyle W. Ostrow is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

#	Work	Indexed citations
1	Clinical assessment and interpretation of dysarthria in ALS using attention based deep learning AI models 2025 ·npj Digital Medicine ·Michele Merler,Carla Agurto,(unknown),(unknown),(unknown),Marcos A. Trevisan,(unknown),James D. Berry,Ernest Fraenkel,Lyle W. Ostrow,Guillermo Cecchi,Raquel Norel	1
2	Harnessing Remote Speech Tasks for Early ALS Biomarker Identification 2024 ·Carla Agurto,Michele Merler,(unknown),(unknown),Marcos A. Trevisan,Diego E. Shalóm,(unknown),Lyle W. Ostrow,(unknown),Ernest Fraenkel,James Berry,Guillermo Cecchi,Raquel Norel	1
3	TDP43 aggregation at ER-exit sites impairs ER-to-Golgi transport 2024 ·Nature Communications ·(unknown),Loo Chien Wang,(unknown),(unknown),Jin Zhu,(unknown),Kathleen Wilsbach,(unknown),Lyle W. Ostrow,Crystal Jing Jing Yeo,Radoslaw M. Sobota,Rong Li	4
4	Distinct transcriptomic profile of satellite cells contributes to preservation of neuromuscular junctions in extraocular muscles of ALS mice 2024 ·eLife ·Ang Li,Jianxun Yi,Xuejun Li,Li Dong,Lyle W. Ostrow,Jianjie Ma,Jingsong Zhou	2
5	Globally reduced N6-methyladenosine (m6A) in C9ORF72-ALS/FTD dysregulates RNA metabolism and contributes to neurodegeneration 2023 ·Nature Neuroscience ·Yini Li,Xiaoyang Dou,Jun Liu,Yu Xiao,Zhe Zhang,Lindsey R. Hayes,Rong Wu,Xiujuan Fu,(unknown),Bing Yang,Lyle W. Ostrow,Chuan He,Shuying Sun	38
6	Distinct transcriptomic profile of satellite cells contributes to preservation of neuromuscular junctions in extraocular muscles of ALS mice 2023 ·eLife ·Ang Li,Jianxun Yi,Xuejun Li,Li Dong,Lyle W. Ostrow,Jianjie Ma,Jingsong Zhou	3
7	Loss of TDP-43 function and rimmed vacuoles persist after T cell depletion in a xenograft model of sporadic inclusion body myositis 2022 ·Science Translational Medicine ·Kyla A. Britson,Jonathan P. Ling,Kerstin E. Braunstein,Janelle M. Montagne,Jenna M. Kastenschmidt,Andrew D. Wilson,Chiseko Ikenaga,William Tsao,Iago Pinal‐Fernandez,K. Russell,Nicole Reed,Tahseen Mozaffar,Kathryn R. Wagner,Lyle W. Ostrow,Andrea M. Corse,Andrew L. Mammen,S. Armando Villalta,H. Benjamin Larman,Philip C. Wong,Thomas E. Lloyd	34
8	Nuclear export and translation of circular repeat-containing intronic RNA in C9ORF72-ALS/FTD 2021 ·Nature Communications ·Shaopeng Wang,(unknown),Zhe Zhang,Bo Huang,Dmitriy G. Bobrovnikov,Daoyuan Dong,Nathan M. Livingston,(unknown),Lindsey R. Hayes,Jeffrey D. Rothstein,Lyle W. Ostrow,Bin Wu,Shuying Sun	48
9	Transcriptional profiling of HERV-K(HML-2) in amyotrophic lateral sclerosis and potential implications for expression of HML-2 proteins 2018 ·Molecular Neurodegeneration ·Jens Mayer,(unknown),Laura Sánchez,Gavin Pereira,Esther Maldener,Sara R. Heras,Lyle W. Ostrow,John Ravits,Ranjan Batra,Eckart Meese,José L. García-Pérez,John L. Goodier	47
10	Properties of LINE-1 proteins and repeat element expression in the context of amyotrophic lateral sclerosis 2018 ·Mobile DNA ·Gavin Pereira,Laura Sánchez,Paul Schaughency,Alejandro Rubio-Roldán,(unknown),Evarist Planet,Ranjan Batra,Priscilla Turelli,Didier Trono,Lyle W. Ostrow,John Ravits,Haig H. Kazazian,Sarah J. Wheelan,Sara R. Heras,Jens Mayer,José L. García-Pérez,John L. Goodier	38
11	S-acylation of SOD1, CCS, and a stable SOD1-CCS heterodimer in human spinal cords from ALS and non-ALS subjects 2017 ·Scientific Reports ·Sarah E. Antinone,Ghanashyam D. Ghadge,Lyle W. Ostrow,Raymond P. Roos,William N. Green	17
12	Distinct conformers of transmissible misfolded SOD1 distinguish human SOD1-FALS from other forms of familial and sporadic ALS 2016 ·Acta Neuropathologica ·Jacob I. Ayers,(unknown),(unknown),Susan Fromholt,Ahmad Galaleldeen,Lyle W. Ostrow,Jonathan D. Glass,P. John Hart,David Borchelt	38
13	Loss of RAD-23 Protects Against Models of Motor Neuron Disease by Enhancing Mutant Protein Clearance 2015 ·Journal of Neuroscience ·(unknown),Todd Lamitina,Nicole F. Liachko,Mariangela Sabatella,Jiayin Lu,Lei Zhang,Lyle W. Ostrow,Preetika Gupta,(unknown),Shachee Doshi,Jelena Mojsilovic‐Petrovic,Hannes Lans,Jiou Wang,Brian C. Kraemer,Robert G. Kalb	20
14	An antisense oligonucleotide against SOD1 delivered intrathecally for patients with SOD1 familial amyotrophic lateral sclerosis: a phase 1, randomised, first-in-man studybreakdown → 2013 ·The Lancet Neurology ·Timothy M. Miller,Alan Pestronk,William David,Jeffrey Rothstein,Ericka Simpson,Stanley H. Appel,Patricia L. Andres,Katy Mahoney,Peggy Allred,K. Alexander,Lyle W. Ostrow,David Schoenfeld,Eric A. Macklin,Daniel A. Norris,Georgios Manousakis,Matthew J. Crisp,Richard Smith,C. Frank Bennett,Kathie M. Bishop,Merit Cudkowicz	492
15	Expanding the spectrum of monoclonal light chain deposition disease in muscle 2012 ·Muscle & Nerve ·Lyle W. Ostrow,Andrea M. Corse,Brett M. Morrison,Carol Ann Huff,John A. Carrino,Ahmet Höke,Andrew L. Mammen	13
16	Immunohistochemistry of affected tissue may guide cGVHD treatment decisions 2011 ·Bone Marrow Transplantation ·Kirsten M. Williams,Lyle W. Ostrow,David M. Loeb,Tae Chung,Ronald D. Cohn,Andrea M. Corse,Andrew L. Mammen,Allen Chen	4
17	PML-IRIS in patients with HIV infection 2009 ·Neurology ·Kevin Tan,(unknown),Lyle W. Ostrow,Justin C. McArthur,Avindra Nath	259
18	Mechanosensitive Ion Channels as Drug Targets 2004 ·PubMed ·Philip A. Gottlieb,Thomas M. Suchyna,Lyle W. Ostrow,Frederick Sachs	36
19	Mechanosensation and endothelin in astrocytes—hypothetical roles in CNS pathophysiology 2004 ·Brain Research Reviews ·Lyle W. Ostrow,Frederick Sachs	78
20	Stretch-Induced Endothelin-1 Production by Astrocytes 2000 ·Journal of Cardiovascular Pharmacology ·Lyle W. Ostrow,Thomas J. Langan,Frederick Sachs	32

About Lyle W. Ostrow

Lyle W. Ostrow is a scholar working on Neurology, Genetics and Developmental Neuroscience, having authored 33 papers that have together received 2.8k indexed citations. Recurring topics across this work include Amyotrophic Lateral Sclerosis Research (15 papers), Neurogenetic and Muscular Disorders Research (9 papers) and Nitric Oxide and Endothelin Effects (4 papers). The work is most often cited by research in Neurology (1.2k citations), Genetics (795 citations) and Neurology (359 citations). Lyle W. Ostrow has collaborated with scholars based in United States, United Kingdom and Argentina. Frequent co-authors include Jeffrey D. Rothstein, Frederick Sachs, Avindra Nath, Timothy M. Miller, Masahiro Fukaya, Shin Hyeok Kang, Ileana Lorenzini, Don W. Cleveland, Dwight E. Bergles and Ying Li. Their work appears in journals such as Proceedings of the National Academy of Sciences, Nature Communications and Neuron.

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