Jeffrey D. Rothstein

54.2k total citations · 24 hit papers
235 papers, 37.2k citations indexed

About

Jeffrey D. Rothstein is a scholar working on Cellular and Molecular Neuroscience, Molecular Biology and Neurology. According to data from OpenAlex, Jeffrey D. Rothstein has authored 235 papers receiving a total of 37.2k indexed citations (citations by other indexed papers that have themselves been cited), including 121 papers in Cellular and Molecular Neuroscience, 108 papers in Molecular Biology and 94 papers in Neurology. Recurrent topics in Jeffrey D. Rothstein's work include Neuroscience and Neuropharmacology Research (97 papers), Amyotrophic Lateral Sclerosis Research (89 papers) and Neurogenetic and Muscular Disorders Research (53 papers). Jeffrey D. Rothstein is often cited by papers focused on Neuroscience and Neuropharmacology Research (97 papers), Amyotrophic Lateral Sclerosis Research (89 papers) and Neurogenetic and Muscular Disorders Research (53 papers). Jeffrey D. Rothstein collaborates with scholars based in United States, Japan and United Kingdom. Jeffrey D. Rothstein's co-authors include Nicholas J. Maragakis, Ralph W. Kuncl, Lee J. Martin, Don W. Cleveland, Margaret Dykes‐Hoberg, Dwight E. Bergles, Jin Li, Thomas Philips, Lynn A. Bristol and Allan I. Levey and has published in prestigious journals such as Nature, Science and New England Journal of Medicine.

In The Last Decade

Jeffrey D. Rothstein

230 papers receiving 36.7k citations

Hit Papers

5 papers align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Knockout of Glutamate Transporters Reveals a Major Role for Astroglial Transport in Excitotoxicity and Clearance of Glutamate

1996 2.1k citations Jeffrey D. Rothstein, Margaret Dykes‐Hoberg et al. profile →
Identification of a unique TGF-β–dependent molecular and functional signature in microglia

2013 1.9k citations Jeffrey D. Rothstein et al. profile →
Oligodendroglia metabolically support axons and contribute to neurodegeneration

2012 1.2k citations Brett M. Morrison, Mohamed H. Farah et al. Nature profile →
β-Lactam antibiotics offer neuroprotection by increasing glutamate transporter expression

2005 1.2k citations Jeffrey D. Rothstein, Yanhua H. Huang et al. Nature profile →
Selective loss of glial glutamate transporter GLT‐1 in amyotrophic lateral sclerosis

1995 1.2k citations Jeffrey D. Rothstein, Lee J. Martin et al. Annals of Neurology profile →
From charcot to lou gehrig: deciphering selective motor neuron death in als

2001 1.1k citations Don W. Cleveland, Jeffrey D. Rothstein Nature reviews. Neuroscience profile →
ALS-Linked SOD1 Mutant G85R Mediates Damage to Astrocytes and Promotes Rapidly Progressive Disease with SOD1-Containing Inclusions

1997 1.1k citations Jeffrey D. Rothstein, Donald L. Price et al. profile →
Decreased Glutamate Transport by the Brain and Spinal Cord in Amyotrophic Lateral Sclerosis

1992 967 citations Jeffrey D. Rothstein, Lee J. Martin et al. profile →
Metabolic support of tumour-infiltrating regulatory T cells by lactic acid

2021 817 citations McLane J. Watson, Paolo Vignali et al. Nature profile →
C9orf72 nucleotide repeat structures initiate molecular cascades of disease

2014 730 citations Nicholas J. Maragakis, Jeffrey D. Rothstein et al. Nature profile →
Retrograde Viral Delivery of IGF-1 Prolongs Survival in a Mouse ALS Model

2003 689 citations Jeffrey D. Rothstein et al. profile →
RNA Toxicity from the ALS/FTD C9ORF72 Expansion Is Mitigated by Antisense Intervention

2013 670 citations Jeffrey D. Rothstein et al. profile →
Focal loss of the glutamate transporter EAAT2 in a transgenic rat model of SOD1 mutant-mediated amyotrophic lateral sclerosis (ALS)

2002 660 citations Nicholas J. Maragakis, Don W. Cleveland et al. profile →
Mechanisms of Disease: astrocytes in neurodegenerative disease

2006 655 citations Nicholas J. Maragakis, Jeffrey D. Rothstein profile →
NG2+ CNS Glial Progenitors Remain Committed to the Oligodendrocyte Lineage in Postnatal Life and following Neurodegeneration

2010 601 citations Jeffrey D. Rothstein, Dwight E. Bergles et al. profile →
RAN proteins and RNA foci from antisense transcripts in C9ORF72 ALS and frontotemporal dementia

2013 577 citations Lyle W. Ostrow, Jeffrey D. Rothstein et al. profile →
Aberrant RNA Processing in a Neurodegenerative Disease: the Cause for Absent EAAT2, a Glutamate Transporter, in Amyotrophic Lateral Sclerosis

1998 549 citations Margaret Dykes‐Hoberg, Jeffrey D. Rothstein et al. profile →
Current hypotheses for the underlying biology of amyotrophic lateral sclerosis

2009 538 citations Jeffrey D. Rothstein Annals of Neurology profile →
Chronic inhibition of glutamate uptake produces a model of slow neurotoxicity.

1993 528 citations Jeffrey D. Rothstein, Margaret Dykes‐Hoberg et al. profile →
Abnormal excitatory amino acid metabolism in amyotrophic lateral sclerosis

1990 509 citations Jeffrey D. Rothstein et al. Annals of Neurology profile →
The blood-brain barrier: an engineering perspective

2013 498 citations Jeffrey D. Rothstein, Dwight E. Bergles et al. profile →
Degeneration and impaired regeneration of gray matter oligodendrocytes in amyotrophic lateral sclerosis

2013 449 citations Don W. Cleveland, Lyle W. Ostrow et al. profile →
Human endogenous retrovirus-K contributes to motor neuron disease

2015 340 citations Lyle W. Ostrow, Jeffrey D. Rothstein et al. profile →
Stress Granule Assembly Disrupts Nucleocytoplasmic Transport

2018 279 citations Ke Zhang, Alyssa N. Coyne et al. profile →

Peers

Countries citing papers authored by Jeffrey D. Rothstein

Since Specialization

Citations

This map shows the geographic impact of Jeffrey D. Rothstein's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Jeffrey D. Rothstein with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Jeffrey D. Rothstein more than expected).

Fields of papers citing papers by Jeffrey D. Rothstein

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Jeffrey D. Rothstein. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Jeffrey D. Rothstein. The network helps show where Jeffrey D. Rothstein may publish in the future.

Co-authorship network of co-authors of Jeffrey D. Rothstein

This figure shows the co-authorship network connecting the top 25 collaborators of Jeffrey D. Rothstein. A scholar is included among the top collaborators of Jeffrey D. Rothstein based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Jeffrey D. Rothstein. Jeffrey D. Rothstein is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

#	Work	Indexed citations
1	Identification of a Subpopulation of Astrocyte Progenitor Cells in the Neonatal Subventricular Zone: Evidence that Migration is Regulated by Glutamate Signaling 2025 ·Neurochemical Research ·Zila Martínez‐Lozada, Alain M. Guillem, In‐Ae Song, Michael V. Gonzalez, Hajime Takano, (unknown), Jeffrey D. Rothstein, Mary Putt, Michael B. Robinson	0
2	Visualizing nuclear pore complex plasticity with pan-expansion microscopy 2025 ·The Journal of Cell Biology ·(unknown), (unknown), Alyssa N. Coyne, Jeffrey D. Rothstein, C. Patrick Lusk, Megan C. King	1
3	Monocarboxylate transporters facilitate succinate uptake into brown adipocytes 2024 ·Nature Metabolism ·Anita Reddy, Sally Winther, Nhien Tran, Haopeng Xiao, (unknown), Ryan Garrity, (unknown), (unknown), Dina Laznik-Bogoslavski, Jeffrey D. Rothstein, Evanna L. Mills, Edward T. Chouchani	15
4	Identification of Therapeutic Targets for Amyotrophic Lateral Sclerosis Using PandaOmics – An AI-Enabled Biological Target Discovery Platform 2022 ·Frontiers in Aging Neuroscience ·Frank W. Pun, Bonnie Hei Man Liu, Xi Long, Hoi-Wing Leung, (unknown), (unknown), Junli Gao, Anastasia Shneyderman, Ivan V. Ozerov, Ju Wang, Feng Ren, Alexander Aliper, Evelyne Bischof, Evgeny Izumchenko, (unknown), Ke Zhang, (unknown), Jeffrey D. Rothstein, Merit Cudkowicz, Alex Zhavoronkov	59
5	Metabolic support of tumour-infiltrating regulatory T cells by lactic acid breakdown → 2021 ·Nature ·McLane J. Watson, Paolo Vignali, Steven J. Mullett, Abigail E. Overacre-Delgoffe, Ronal M. Peralta, Stephanie Grebinoski, Ashley V. Menk, Natalie Rittenhouse, Kristin DePeaux, Ryan D. Whetstone, Dario A.A. Vignali, Timothy W. Hand, Amanda C. Poholek, Brett M. Morrison, Jeffrey D. Rothstein, Stacy G. Wendell, Greg M. Delgoffe	817
6	Nuclear export and translation of circular repeat-containing intronic RNA in C9ORF72-ALS/FTD 2021 ·Nature Communications ·Shaopeng Wang, (unknown), Zhe Zhang, Bo Huang, Dmitriy G. Bobrovnikov, Daoyuan Dong, Nathan M. Livingston, (unknown), Lindsey R. Hayes, Jeffrey D. Rothstein, Lyle W. Ostrow, Bin Wu, Shuying Sun	48
7	Increased synthesis of pro-inflammatory cytokines in C9ORF72 patients 2021 ·Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration ·(unknown), Anupama Kumar, (unknown), Carlos A. Pardo, Jeffrey D. Rothstein, Hristelina Ilieva	10
8	Derivation of Glial Restricted Precursors from E13 mice 2012 ·Journal of Visualized Experiments ·André W. Phillips, (unknown), (unknown), Irina Shats, (unknown), Edwin Araúz, Douglas A. Kerr, Jeffrey D. Rothstein, Michael V. Johnston, Ali Fatemi	17
9	Motor Neuron Disease Occurring in a Mutant Dynactin Mouse Model Is Characterized by Defects in Vesicular Trafficking 2008 ·Journal of Neuroscience ·Fiona M. Laird, Mohamed H. Farah, Steven Ackerley, Ahmet Höke, Nicholas J. Maragakis, Jeffrey D. Rothstein, John H. Griffin, Donald L. Price, Lee J. Martin, Philip C. Wong	143
10	Glutamate mediates platelet activation through the AMPA receptor 2008 ·The Journal of Experimental Medicine ·Craig N. Morrell, Henry Sun, Masahiro Ikeda, Jean‐Claude Béïque, (unknown), (unknown), (unknown), Laura E. Thompson, Oğuz Gözen, (unknown), Rolf Sprengel, Jeffrey D. Rothstein, Nauder Faraday, Richard L. Huganir, Charles J. Lowenstein	81
11	Climbing Fiber Activation of EAAT4 Transporters and Kainate Receptors in Cerebellar Purkinje Cells 2004 ·Journal of Neuroscience ·Yanhua H. Huang, Margaret Dykes‐Hoberg, Kohichi Tanaka, Jeffrey D. Rothstein, Dwight E. Bergles	87
12	Preclinical studies: how much can we rely on? 2004 ·Amyotrophic Lateral Sclerosis and Other Motor Neuron Disorders ·Jeffrey D. Rothstein	6
13	Glutamate receptor antagonists protect from virus‐induced neural degeneration 2004 ·Annals of Neurology ·(unknown), (unknown), Ming Zhang, David N. Irani, Jeffrey D. Rothstein, Diane E. Griffin	51
14	Glutamate Transporters in Neurologic Disease 2001 ·Archives of Neurology ·Nicholas J. Maragakis, Jeffrey D. Rothstein	258
15	From charcot to lou gehrig: deciphering selective motor neuron death in als breakdown → 2001 ·Nature reviews. Neuroscience ·Don W. Cleveland, Jeffrey D. Rothstein	1137
16	Cytotoxicity by Matrix Metalloprotease-1 in Organotypic Spinal Cord and Dissociated Neuronal Cultures 2000 ·Experimental Neurology ·Catharina M.P. Vos, Lucas Sjulson, Avindra Nath, Justin C. McArthur, Carlos A. Pardo, Jeffrey D. Rothstein, Katherine Conant	69
17	Cultured motor neurons possess calcium-permeable AMPA/kainate receptors 1999 ·Neuroreport ·Osnat Bar-Peled, Richard O’Brien, John H. Morrison, Jeffrey D. Rothstein	58
18	Activity and protein localization of multiple glutamate transporters in gestationday 14vs.day 20rat placenta 1998 ·American Journal of Physiology-Cell Physiology ·J. C. Matthews, Mark Beveridge, Marc S. Malandro, Jeffrey D. Rothstein, Martha Campbell‐Thompson, Jill W. Verlander, Michael S. Kilberg, Donald A. Novak	59
19	Glutamate transport in cultures from developing avian cerebellum: Presence of GLT-1 immunoreactivity in Purkinje neurons 1998 ·Journal of Neuroscience Research ·(unknown), Vladimír J. Balcar, Jeffrey D. Rothstein, Peter L. Jeffrey	19
20	Comparison of Na+-dependent glutamate transport activity in synaptosomes, C6 glioma, and Xenopus oocytes expressing excitatory amino acid carrier 1 (EAAC1). 1996 ·Molecular Pharmacology ·(unknown), (unknown), Jeffrey D. Rothstein, Dolan B. Pritchett, Michael B. Robinson	104

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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