Chuan He

130.4k total citations · 48 hit papers
541 papers, 76.8k citations indexed

About

Chuan He is a scholar working on Molecular Biology, Cancer Research and Genetics. According to data from OpenAlex, Chuan He has authored 541 papers receiving a total of 76.8k indexed citations (citations by other indexed papers that have themselves been cited), including 444 papers in Molecular Biology, 131 papers in Cancer Research and 45 papers in Genetics. Recurrent topics in Chuan He's work include RNA modifications and cancer (273 papers), Epigenetics and DNA Methylation (145 papers) and Cancer-related gene regulation (118 papers). Chuan He is often cited by papers focused on RNA modifications and cancer (273 papers), Epigenetics and DNA Methylation (145 papers) and Cancer-related gene regulation (118 papers). Chuan He collaborates with scholars based in United States, China and Germany. Chuan He's co-authors include Qing Dai, Tao Pan, Zhike Lu, Ian A. Roundtree, Ye Fu, Boxuan Zhao, Hailing Shi, Xiao Wang, Guifang Jia and Dali Han and has published in prestigious journals such as Nature, Science and Cell.

In The Last Decade

Chuan He

517 papers receiving 76.3k citations

Hit Papers

N6-methyladenosine-dependent regulation of messenger RNA ... 2010 2026 2015 2020 2013 2011 2015 2011 2013 1000 2.0k 3.0k
What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

  1. N6-methyladenosine-dependent regulation of messenger RNA stability
    2013 3.3k citations Zhike Lu, Dali Han et al. profile →
  2. N6-Methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO
    2011 3.1k citations Xu Zhao, Qing Dai et al. profile →
  3. N6-methyladenosine Modulates Messenger RNA Translation Efficiency
    2015 2.6k citations Zhike Lu, Dali Han et al. Cell profile →
  4. Tet Proteins Can Convert 5-Methylcytosine to 5-Formylcytosine and 5-Carboxylcytosine
    2011 2.6k citations Qing Dai, Chuan He et al. Science profile →
  5. A METTL3–METTL14 complex mediates mammalian nuclear RNA N6-adenosine methylation
    2013 2.5k citations Dali Han, Liang Zhang et al. profile →
  6. Dynamic RNA Modifications in Gene Expression Regulation
    2017 2.4k citations Chuan He et al. Cell profile →
  7. Tet-Mediated Formation of 5-Carboxylcytosine and Its Excision by TDG in Mammalian DNA
    2011 2.1k citations Qing Dai, Chun‐Xiao Song et al. Science profile →
  8. Post-transcriptional gene regulation by mRNA modifications
    2016 1.7k citations Chuan He et al. profile →
  9. N6-methyladenosine-dependent RNA structural switches regulate RNA–protein interactions
    2015 1.5k citations Qing Dai, Chuan He et al. profile →
  10. Gene expression regulation mediated through reversible m6A RNA methylation
    2014 1.5k citations Chuan He et al. profile →
  11. YTHDF3 facilitates translation and decay of N6-methyladenosine-modified RNA
    2017 1.4k citations Hailing Shi, Zhike Lu et al. profile →
  12. Where, When, and How: Context-Dependent Functions of RNA Methylation Writers, Readers, and Erasers
    2019 1.3k citations Hailing Shi, Jiangbo Wei et al. Molecular Cell profile →
  13. m 6 A Demethylase ALKBH5 Maintains Tumorigenicity of Glioblastoma Stem-like Cells by Sustaining FOXM1 Expression and Cell Proliferation Program
    2017 1.1k citations Zhike Lu, Chuan He et al. profile →
  14. YTHDC1 mediates nuclear export of N6-methyladenosine methylated mRNAs
    2017 985 citations Zijie Zhang, Bin Shen et al. profile →
  15. m6A RNA Methylation Regulates the Self-Renewal and Tumorigenesis of Glioblastoma Stem Cells
    2017 967 citations Hailing Shi, Zhike Lu et al. profile →
  16. RNA modifications modulate gene expression during development
    2018 866 citations Michaela Frye, Bryan T. Harada et al. Science profile →
  17. Selective chemical labeling reveals the genome-wide distribution of 5-hydroxymethylcytosine
    2010 818 citations Chun‐Xiao Song, Keith E. Szulwach et al. Nature Biotechnology profile →
  18. Ythdc2 is an N6-methyladenosine binding protein that regulates mammalian spermatogenesis
    2017 804 citations Zhike Lu, Hailing Shi et al. profile →
  19. Base-Resolution Analysis of 5-Hydroxymethylcytosine in the Mammalian Genome
    2012 798 citations Keith E. Szulwach, Chun‐Xiao Song et al. Cell profile →
  20. The dynamic N1-methyladenosine methylome in eukaryotic messenger RNA
    2016 766 citations Qing Dai, Dali Han et al. profile →
  21. VIRMA mediates preferential m6A mRNA methylation in 3′UTR and near stop codon and associates with alternative polyadenylation
    2018 755 citations Jun Liu, Xiaolong Cui et al. profile →
  22. Anti-tumour immunity controlled through mRNA m6A methylation and YTHDF1 in dendritic cells
    2019 737 citations Dali Han, Jun Liu et al. profile →
  23. RNA N6-methyladenosine methylation in post-transcriptional gene expression regulation
    2015 725 citations Chuan He et al. profile →
  24. RNA m6A methylation regulates the ultraviolet-induced DNA damage response
    2017 683 citations Zhike Lu, Chuan He et al. profile →
  25. 5-hmC–mediated epigenetic dynamics during postnatal neurodevelopment and aging
    2011 638 citations Keith E. Szulwach, Xuekun Li et al. Nature Neuroscience profile →
  26. Differential m6A, m6Am, and m1A Demethylation Mediated by FTO in the Cell Nucleus and Cytoplasm
    2018 606 citations Jiangbo Wei, Zhike Lu et al. Molecular Cell profile →
  27. m6A mRNA methylation regulates AKT activity to promote the proliferation and tumorigenicity of endometrial cancer
    2018 603 citations Jun Liu, Bryan T. Harada et al. profile →
  28. Structural basis for selective binding of m6A RNA by the YTHDC1 YTH domain
    2014 568 citations Zhike Lu, Chuan He et al. profile →
  29. m6A mRNA demethylase FTO regulates melanoma tumorigenicity and response to anti-PD-1 blockade
    2019 565 citations Jiangbo Wei, Zhike Lu et al. Nature Communications profile →
  30. Temporal Control of Mammalian Cortical Neurogenesis by m6A Methylation
    2017 551 citations Ki‐Jun Yoon, Francisca Rojas et al. Cell profile →
  31. DNA Methylation on N6-Adenine in C. elegans
    2015 507 citations Chuan He et al. Cell profile →
  32. m 6 A RNA methylation: from mechanisms to therapeutic potential
    2021 505 citations Chuan He et al. profile →
  33. N 6 -methyladenosine of chromosome-associated regulatory RNA regulates chromatin state and transcription
    2020 495 citations Jun Liu, Xiaoyang Dou et al. Science profile →
  34. Selective fluorescent probes for live-cell monitoring of sulphide
    2011 476 citations Chuan He et al. Nature Communications profile →
  35. N6-Methyladenine DNA Modification in Drosophila
    2015 471 citations Chuan He et al. Cell profile →
  36. ALKBH1-Mediated tRNA Demethylation Regulates Translation
    2016 439 citations Jiangbo Wei, Ziyang Hao et al. Cell profile →
  37. m6A-dependent maternal mRNA clearance facilitates zebrafish maternal-to-zygotic transition
    2017 430 citations Zhike Lu, Hailing Shi et al. profile →
  38. N6-methyladenosine (m6A) recruits and repels proteins to regulate mRNA homeostasis
    2017 427 citations Hailing Shi, Zhike Lu et al. profile →
  39. Programming and Inheritance of Parental DNA Methylomes in Mammals
    2014 394 citations Chuan He et al. Cell profile →
  40. Transcriptome-wide Mapping of Internal N7-Methylguanosine Methylome in Mammalian mRNA
    2019 357 citations Lisheng Zhang, Chang Liu et al. Molecular Cell profile →
  41. YTHDF3 Induces the Translation of m6A-Enriched Gene Transcripts to Promote Breast Cancer Brain Metastasis
    2020 298 citations Hailing Shi, Chuan He et al. profile →
  42. EGFR/SRC/ERK-stabilized YTHDF2 promotes cholesterol dysregulation and invasive growth of glioblastoma
    2021 231 citations Hailing Shi, Zhongyu Zou et al. Nature Communications profile →
  43. m6A RNA modifications are measured at single-base resolution across the mammalian transcriptome
    2022 176 citations Lulu Hu, Shun Liu et al. Nature Biotechnology profile →
  44. Quantitative sequencing using BID-seq uncovers abundant pseudouridines in mammalian mRNA at base resolution
    2022 144 citations Qing Dai, Lisheng Zhang et al. Nature Biotechnology profile →
  45. YTHDF2 orchestrates tumor-associated macrophage reprogramming and controls antitumor immunity through CD8+ T cells
    2023 143 citations Chuan He, Jianjun Chen et al. profile →
  46. Exon architecture controls mRNA m 6 A suppression and gene expression
    2023 134 citations Jiangbo Wei, Xiaoyang Dou et al. Science profile →
  47. Transcriptome-wide profiling and quantification of N6-methyladenosine by enzyme-assisted adenosine deamination
    2023 124 citations Shun Liu, Ruiqi Ge et al. Nature Biotechnology profile →
  48. Ultrafast bisulfite sequencing detection of 5-methylcytosine in DNA and RNA
    2024 74 citations Qing Dai, Chang Ye et al. Nature Biotechnology profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name h Career Trend Papers Cites
Chuan He United States 127 69.7k 25.1k 7.4k 4.6k 4.4k 541 76.8k
Stuart L. Schreiber United States 139 66.7k 1.0× 9.4k 0.4× 856 0.1× 4.7k 1.0× 11.3k 2.5× 600 91.9k
Tomas Lindahl Sweden 101 32.3k 0.5× 8.2k 0.3× 871 0.1× 5.1k 1.1× 7.0k 1.6× 364 42.7k
Qing Dai United States 59 28.0k 0.4× 9.6k 0.4× 2.5k 0.3× 2.0k 0.4× 1.2k 0.3× 160 30.1k
Stephen P. Jackson United Kingdom 119 56.5k 0.8× 9.8k 0.4× 636 0.1× 7.3k 1.6× 20.9k 4.7× 350 66.5k
J. Silvio Gutkind United States 121 33.7k 0.5× 5.8k 0.2× 857 0.1× 2.9k 0.6× 11.5k 2.6× 582 52.2k
Jinsong Liu China 81 11.8k 0.2× 4.4k 0.2× 1.7k 0.2× 1.6k 0.4× 4.8k 1.1× 630 25.5k
Christopher J. Schofield United Kingdom 96 27.9k 0.4× 15.3k 0.6× 333 0.0× 4.5k 1.0× 3.2k 0.7× 803 45.6k
Daniel A. Haber United States 106 35.1k 0.5× 14.0k 0.6× 587 0.1× 5.9k 1.3× 26.3k 5.9× 286 63.7k
Toren Finkel United States 97 30.3k 0.4× 5.2k 0.2× 554 0.1× 2.4k 0.5× 4.9k 1.1× 211 55.4k
Lin Zhang China 84 21.4k 0.3× 6.5k 0.3× 462 0.1× 3.5k 0.8× 7.8k 1.8× 811 34.4k

Countries citing papers authored by Chuan He

Since Specialization
Citations

This map shows the geographic impact of Chuan He's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Chuan He with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Chuan He more than expected).

Fields of papers citing papers by Chuan He

Since Specialization
Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Chuan He. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Chuan He. The network helps show where Chuan He may publish in the future.

Co-authorship network of co-authors of Chuan He

This figure shows the co-authorship network connecting the top 25 collaborators of Chuan He. A scholar is included among the top collaborators of Chuan He based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Chuan He. Chuan He is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

20 of 20 papers shown
1.
Liu, Youhua, et al.. (2025). Quercetin‐Driven Akkermansia Muciniphila Alleviates Obesity by Modulating Bile Acid Metabolism via an ILA/m6A/CYP8B1 Signaling. Advanced Science. 12(12). e2412865–e2412865. 9 indexed citations
2.
Huang, Chia‐Yi, Zhong Zheng, Wei Zhao, et al.. (2025). The motor neuron m6A repertoire governs neuronal homeostasis and FTO inhibition mitigates ALS symptom manifestation. Nature Communications. 16(1). 4063–4063. 2 indexed citations
3.
Zhang, Feng, Yao Fu, Ting Zhao, et al.. (2024). m6A/YTHDF2-mediated mRNA decay targets TGF-β signaling to suppress the quiescence acquisition of early postnatal mouse hippocampal NSCs. Cell stem cell. 32(1). 144–156.e8. 6 indexed citations
4.
Zou, Zhongyu, Chang Ye, Xiaoyang Dou, et al.. (2024). Profiling of RNA-binding protein binding sites by in situ reverse transcription-based sequencing. Nature Methods. 21(2). 247–258. 16 indexed citations
5.
Yu, Fang, Allen Zhu, Shun Liu, et al.. (2023). RBM33 is a unique m6A RNA-binding protein that regulates ALKBH5 demethylase activity and substrate selectivity. Molecular Cell. 83(12). 2003–2019.e6. 31 indexed citations
6.
Li, Yini, Xiaoyang Dou, Jun Liu, et al.. (2023). Globally reduced N6-methyladenosine (m6A) in C9ORF72-ALS/FTD dysregulates RNA metabolism and contributes to neurodegeneration. Nature Neuroscience. 26(8). 1328–1338. 38 indexed citations
7.
Jiang, Bochen, Zhenhui Zhong, Lianfeng Gu, et al.. (2023). Light-induced LLPS of the CRY2/SPA1/FIO1 complex regulating mRNA methylation and chlorophyll homeostasis in Arabidopsis. Nature Plants. 9(12). 2042–2058. 42 indexed citations
8.
Hu, Lulu, Shun Liu, Yong Peng, et al.. (2022). m6A RNA modifications are measured at single-base resolution across the mammalian transcriptome. Nature Biotechnology. 40(8). 1210–1219. 176 indexed citations breakdown →
9.
Lu, Mijia, Miaoge Xue, Haitao Wang, et al.. (2021). Nonsegmented Negative-Sense RNA Viruses Utilize N 6 -Methyladenosine (m 6 A) as a Common Strategy To Evade Host Innate Immunity. Journal of Virology. 95(9). 37 indexed citations
10.
Olazagoitia‐Garmendia, Ane, Linda Zhang, Paula Mera, et al.. (2021). Gluten-induced RNA methylation changes regulate intestinal inflammation via allele-specific XPO1 translation in epithelial cells. Gut. 71(1). 68–76. 34 indexed citations
11.
Zhao, Fanpeng, Ying Xu, Shichao Gao, et al.. (2021). METTL3-dependent RNA m6A dysregulation contributes to neurodegeneration in Alzheimer’s disease through aberrant cell cycle events. Molecular Neurodegeneration. 16(1). 70–70. 132 indexed citations
12.
Yu, Fang, Jiangbo Wei, Xiaolong Cui, et al.. (2021). Post-translational modification of RNA m6A demethylase ALKBH5 regulates ROS-induced DNA damage response. Nucleic Acids Research. 49(10). 5779–5797. 169 indexed citations
13.
Liu, Jun, Xiaoyang Dou, Chuanyuan Chen, et al.. (2020). N 6 -methyladenosine of chromosome-associated regulatory RNA regulates chromatin state and transcription. Science. 367(6477). 580–586. 495 indexed citations breakdown →
14.
Shi, Hailing, Jiangbo Wei, & Chuan He. (2019). Where, When, and How: Context-Dependent Functions of RNA Methylation Writers, Readers, and Erasers. Molecular Cell. 74(4). 640–650. 1319 indexed citations breakdown →
15.
Liu, Liping, Pan Xu, Lin Zhang, et al.. (2019). Thymine DNA glycosylase recognizes the geometry alteration of minor grooves induced by 5-formylcytosine and 5-carboxylcytosine. Chemical Science. 10(31). 7407–7417. 18 indexed citations
16.
Li, Miaomiao, Xu Zhao, Wei Wang, et al.. (2018). Ythdf2-mediated m6A mRNA clearance modulates neural development in mice. Genome biology. 19(1). 69–69. 257 indexed citations
17.
Frye, Michaela, Bryan T. Harada, Mikaela Behm, & Chuan He. (2018). RNA modifications modulate gene expression during development. Science. 361(6409). 1346–1349. 866 indexed citations breakdown →
18.
Yoon, Ki‐Jun, Francisca Rojas, Caroline Vissers, et al.. (2017). Temporal Control of Mammalian Cortical Neurogenesis by m6A Methylation. Cell. 171(4). 877–889.e17. 551 indexed citations breakdown →
19.
Ji, Quanjiang, Liang Zhang, Marcus B. Jones, et al.. (2013). Molecular mechanism of quinone signaling mediated through S-quinonization of a YodB family repressor QsrR. Proceedings of the National Academy of Sciences. 110(13). 5010–5015. 37 indexed citations
20.
Wang, Tao, Qian Pan, Lin Li, et al.. (2012). Genome-wide DNA hydroxymethylation changes are associated with neurodevelopmental genes in the developing human cerebellum. Human Molecular Genetics. 21(26). 5500–5510. 131 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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