Kun‐Liang Guan

131.1k total citations · 51 hit papers
422 papers, 89.1k citations indexed

About

Kun‐Liang Guan is a scholar working on Molecular Biology, Cell Biology and Cancer Research. According to data from OpenAlex, Kun‐Liang Guan has authored 422 papers receiving a total of 89.1k indexed citations (citations by other indexed papers that have themselves been cited), including 297 papers in Molecular Biology, 142 papers in Cell Biology and 56 papers in Cancer Research. Recurrent topics in Kun‐Liang Guan's work include Hippo pathway signaling and YAP/TAZ (112 papers), PI3K/AKT/mTOR signaling in cancer (73 papers) and Protein Kinase Regulation and GTPase Signaling (54 papers). Kun‐Liang Guan is often cited by papers focused on Hippo pathway signaling and YAP/TAZ (112 papers), PI3K/AKT/mTOR signaling in cancer (73 papers) and Protein Kinase Regulation and GTPase Signaling (54 papers). Kun‐Liang Guan collaborates with scholars based in United States, China and Japan. Kun‐Liang Guan's co-authors include Ken Inoki, Joungmok Kim, Bin Zhao, Fa‐Xing Yu, Yue Xiong, Benoı̂t Viollet, Mondira Kundu, Tianqing Zhu, Young Chul Kim and Zhipeng Meng and has published in prestigious journals such as Nature, Science and Cell.

In The Last Decade

Kun‐Liang Guan

413 papers receiving 88.3k citations

Hit Papers

AMPK and mTOR regulate au... 1991 2026 2002 2014 2011 2003 2007 2002 2008 1000 2.0k 3.0k 4.0k 5.0k
What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

  1. AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1
    2011 5.6k citations Kun‐Liang Guan et al. profile →
  2. TSC2 Mediates Cellular Energy Response to Control Cell Growth and Survival
    2003 3.1k citations Ken Inoki, Kun‐Liang Guan et al. profile →
  3. Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control
    2007 2.4k citations Bin Zhao, Tsuneo Ikenoue et al. Genes & Development profile →
  4. TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling
    2002 2.4k citations Ken Inoki, Yong Li et al. profile →
  5. TEAD mediates YAP-dependent gene induction and growth control
    2008 1.9k citations Bin Zhao, Cun-Yu Wang et al. Genes & Development profile →
  6. Eukaryotic proteins expressed in Escherichia coli: An improved thrombin cleavage and purification procedure of fusion proteins with glutathione S-transferase
    1991 1.7k citations Kun‐Liang Guan et al. profile →
  7. Hippo Pathway in Organ Size Control, Tissue Homeostasis, and Cancer
    2015 1.7k citations Fa‐Xing Yu, Bin Zhao et al. profile →
  8. mTOR: a pharmacologic target for autophagy regulation
    2015 1.6k citations Kun‐Liang Guan et al. profile →
  9. Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling
    2003 1.5k citations Ken Inoki, Yong Li et al. Genes & Development profile →
  10. Regulation of the Hippo-YAP Pathway by G-Protein-Coupled Receptor Signaling
    2012 1.3k citations Fa‐Xing Yu, Bin Zhao et al. profile →
  11. ULK1 induces autophagy by phosphorylating Beclin-1 and activating VPS34 lipid kinase
    2013 1.3k citations Ryan C. Russell, Hyun Woo Park et al. profile →
  12. Mechanisms of Hippo pathway regulation
    2016 1.2k citations Zhipeng Meng, Toshiro Moroishi et al. Genes & Development profile →
  13. A coordinated phosphorylation by Lats and CK1 regulates YAP stability through SCFβ-TRCP
    2010 1.1k citations Bin Zhao, Kun‐Liang Guan et al. Genes & Development profile →
  14. TSC2 Integrates Wnt and Energy Signals via a Coordinated Phosphorylation by AMPK and GSK3 to Regulate Cell Growth
    2006 1.1k citations Ken Inoki, Cun-Yu Wang et al. profile →
  15. Regulation of TORC1 by Rag GTPases in nutrient response
    2008 1.0k citations Kun‐Liang Guan et al. profile →
  16. The Hippo pathway: regulators and regulations
    2013 980 citations Fa‐Xing Yu, Kun‐Liang Guan Genes & Development profile →
  17. The Hippo pathway in organ size control, tissue regeneration and stem cell self-renewal
    2011 941 citations Bin Zhao, Kun‐Liang Guan et al. profile →
  18. The Hippo–YAP pathway in organ size control and tumorigenesis: an updated version
    2010 935 citations Bin Zhao, Qun‐Ying Lei et al. Genes & Development profile →
  19. The emerging roles of YAP and TAZ in cancer
    2015 921 citations Toshiro Moroishi, Kun‐Liang Guan et al. profile →
  20. The Hippo Pathway: Biology and Pathophysiology
    2018 911 citations Zhipeng Meng, Kun‐Liang Guan et al. profile →
  21. Glioma-Derived Mutations in IDH1 Dominantly Inhibit IDH1 Catalytic Activity and Induce HIF-1α
    2009 896 citations Shimin Zhao, Yan Lin et al. Science profile →
  22. Acetylation of Metabolic Enzymes Coordinates Carbon Source Utilization and Metabolic Flux
    2010 812 citations Yan Lin, Yue Xiong et al. Science profile →
  23. TAZ Promotes Cell Proliferation and Epithelial-Mesenchymal Transition and Is Inhibited by the Hippo Pathway
    2008 785 citations Qun‐Ying Lei, Bin Zhao et al. Molecular and Cellular Biology profile →
  24. Dysregulation of the TSC-mTOR pathway in human disease
    2004 775 citations Ken Inoki, Kun‐Liang Guan et al. profile →
  25. mTOR as a central hub of nutrient signalling and cell growth
    2018 757 citations Kun‐Liang Guan et al. profile →
  26. Amino acid signalling upstream of mTOR
    2013 694 citations Ryan C. Russell, Kun‐Liang Guan et al. profile →
  27. Negative Regulation of the Forkhead Transcription Factor FKHR by Akt
    1999 656 citations Eric Tang, Gabriel Núñez et al. Journal of Biological Chemistry profile →
  28. Differential Regulation of Distinct Vps34 Complexes by AMPK in Nutrient Stress and Autophagy
    2013 642 citations Ryan C. Russell, Kun‐Liang Guan et al. profile →
  29. Cell detachment activates the Hippo pathway via cytoskeleton reorganization to induce anoikis
    2012 632 citations Bin Zhao, Cun-Yu Wang et al. Genes & Development profile →
  30. AMPK and mTOR in Cellular Energy Homeostasis and Drug Targets
    2011 629 citations Ken Inoki, Kun‐Liang Guan et al. profile →
  31. Growth suppression by p18, a p16INK4/MTS1- and p14INK4B/MTS2-related CDK6 inhibitor, correlates with wild-type pRb function.
    1994 610 citations Kun‐Liang Guan, Yue Xiong et al. Genes & Development profile →
  32. The role of YAP transcription coactivator in regulating stem cell self-renewal and differentiation
    2010 605 citations Bin Zhao, Kun‐Liang Guan et al. Genes & Development profile →
  33. ATM signals to TSC2 in the cytoplasm to regulate mTORC1 in response to ROS
    2010 576 citations Ken Inoki, Kun‐Liang Guan et al. Proceedings of the National Academy of Sciences profile →
  34. Differential regulation of mTORC1 by leucine and glutamine
    2015 572 citations Ryan C. Russell, Fa‐Xing Yu et al. Science profile →
  35. Targeting the Hippo pathway in cancer, fibrosis, wound healing and regenerative medicine
    2020 566 citations Kun‐Liang Guan et al. profile →
  36. Autophagy regulation by nutrient signaling
    2013 557 citations Ryan C. Russell, Kun‐Liang Guan et al. profile →
  37. TSC–mTOR maintains quiescence and function of hematopoietic stem cells by repressing mitochondrial biogenesis and reactive oxygen species
    2008 556 citations Tsuneo Ikenoue, Kun‐Liang Guan et al. profile →
  38. Alternative Wnt Signaling Activates YAP/TAZ
    2015 554 citations Hyun Woo Park, Toshiro Moroishi et al. profile →
  39. Angiomotin is a novel Hippo pathway component that inhibits YAP oncoprotein
    2011 543 citations Bin Zhao, Qun‐Ying Lei et al. Genes & Development profile →
  40. The Hippo signaling pathway in stem cell biology and cancer
    2014 519 citations Hyun Woo Park, Kun‐Liang Guan et al. profile →
  41. A gp130–Src–YAP module links inflammation to epithelial regeneration
    2015 502 citations Fa‐Xing Yu, Kun‐Liang Guan et al. profile →
  42. The autophagy initiating kinase ULK1 is regulated via opposing phosphorylation by AMPK and mTOR
    2011 493 citations Kun‐Liang Guan et al. profile →
  43. YAP and TAZ: a nexus for Hippo signaling and beyond
    2015 464 citations Toshiro Moroishi, Kun‐Liang Guan et al. profile →
  44. Cellular energy stress induces AMPK-mediated regulation of YAP and the Hippo pathway
    2015 443 citations Zhipeng Meng, Hyun Woo Park et al. profile →
  45. mTORC1 activation in podocytes is a critical step in the development of diabetic nephropathy in mice
    2011 438 citations Ken Inoki, Tsuneo Ikenoue et al. profile →
  46. MAP4K family kinases act in parallel to MST1/2 to activate LATS1/2 in the Hippo pathway
    2015 406 citations Zhipeng Meng, Toshiro Moroishi et al. Nature Communications profile →
  47. The Hippo signalling pathway and its implications in human health and diseases
    2022 358 citations Kun‐Liang Guan et al. profile →
  48. Flow-dependent YAP/TAZ activities regulate endothelial phenotypes and atherosclerosis
    2016 347 citations Kun‐Liang Guan et al. Proceedings of the National Academy of Sciences profile →
  49. Interplay between YAP/TAZ and Metabolism
    2018 317 citations Kun‐Liang Guan et al. profile →
  50. The multifaceted role of autophagy in cancer
    2022 139 citations Ryan C. Russell, Kun‐Liang Guan The EMBO Journal profile →
  51. Insights into recent findings and clinical application of YAP and TAZ in cancer
    2023 120 citations Kun‐Liang Guan et al. profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name h Career Trend Papers Cites
Kun‐Liang Guan United States 148 57.9k 32.0k 14.3k 10.2k 10.0k 422 89.1k
David M. Sabatini United States 129 71.6k 1.2× 13.4k 0.4× 13.8k 1.0× 12.9k 1.3× 9.5k 1.0× 257 101.0k
Steven P. Gygi United States 166 88.4k 1.5× 18.1k 0.6× 14.5k 1.0× 11.7k 1.1× 12.4k 1.2× 695 121.5k
Michael P. Lisanti United States 144 47.5k 0.8× 33.5k 1.0× 4.9k 0.3× 15.4k 1.5× 9.1k 0.9× 573 70.7k
Randal J. Kaufman United States 146 42.0k 0.7× 39.1k 1.2× 21.4k 1.5× 3.8k 0.4× 3.8k 0.4× 466 82.2k
Keiji Tanaka Japan 112 37.9k 0.7× 11.5k 0.4× 19.9k 1.4× 4.0k 0.4× 7.5k 0.7× 428 55.1k
David Ron United States 118 40.5k 0.7× 45.4k 1.4× 22.2k 1.6× 3.5k 0.3× 2.9k 0.3× 266 74.6k
Dario R. Alessi United Kingdom 124 50.6k 0.9× 10.1k 0.3× 5.1k 0.4× 5.6k 0.6× 7.7k 0.8× 313 65.6k
Alfred L. Goldberg United States 138 49.6k 0.9× 17.3k 0.5× 10.2k 0.7× 2.8k 0.3× 9.1k 0.9× 369 67.3k
Nahum Sonenberg Canada 160 77.5k 1.3× 7.9k 0.2× 6.5k 0.5× 12.8k 1.3× 7.1k 0.7× 673 97.8k
Paul Tempst United States 143 62.1k 1.1× 8.7k 0.3× 4.9k 0.3× 7.6k 0.7× 8.3k 0.8× 320 80.8k

Countries citing papers authored by Kun‐Liang Guan

Since Specialization
Citations

This map shows the geographic impact of Kun‐Liang Guan's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Kun‐Liang Guan with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Kun‐Liang Guan more than expected).

Fields of papers citing papers by Kun‐Liang Guan

Since Specialization
Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Kun‐Liang Guan. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Kun‐Liang Guan. The network helps show where Kun‐Liang Guan may publish in the future.

Co-authorship network of co-authors of Kun‐Liang Guan

This figure shows the co-authorship network connecting the top 25 collaborators of Kun‐Liang Guan. A scholar is included among the top collaborators of Kun‐Liang Guan based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Kun‐Liang Guan. Kun‐Liang Guan is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

20 of 20 papers shown
1.
Chen, Hang, Biao Wu, Kun‐Liang Guan, et al.. (2025). Identification of lipid metabolism related immune markers in atherosclerosis through machine learning and experimental analysis. Frontiers in Immunology. 16. 1549150–1549150. 7 indexed citations
2.
Han, Han, Zhen Huang, Congsheng Xu, et al.. (2024). Functional annotation of the Hippo pathway somatic mutations in human cancers. Nature Communications. 15(1). 10106–10106. 4 indexed citations
3.
Russell, Ryan C. & Kun‐Liang Guan. (2022). The multifaceted role of autophagy in cancer. The EMBO Journal. 41(13). e110031–e110031. 139 indexed citations breakdown →
4.
Tang, Tracy, Andrei W. Konradi, Ying Feng, et al.. (2021). Small Molecule Inhibitors of TEAD Auto-palmitoylation Selectively Inhibit Proliferation and Tumor Growth of NF2 -deficient Mesothelioma. Molecular Cancer Therapeutics. 20(6). 986–998. 147 indexed citations
5.
Lin, Zhijie, Ruiling Xie, Kun‐Liang Guan, & Mingjie Zhang. (2020). A WW Tandem-Mediated Dimerization Mode of SAV1 Essential for Hippo Signaling. Cell Reports. 32(10). 108118–108118. 17 indexed citations
6.
Meng, Zhipeng, et al.. (2020). Critical roles of phosphoinositides and NF2 in Hippo pathway regulation. Genes & Development. 34(7-8). 511–525. 49 indexed citations
7.
Akgül, Seçkin, Yinghua Li, Siyuan Zheng, et al.. (2018). Opposing Tumor-Promoting and -Suppressive Functions of Rictor/mTORC2 Signaling in Adult Glioma and Pediatric SHH Medulloblastoma. Cell Reports. 24(2). 463–478.e5. 20 indexed citations
8.
Cosset, Érika, Sten Ilmjärv, Valérie Dutoit, et al.. (2017). Glut3 Addiction Is a Druggable Vulnerability for a Molecularly Defined Subpopulation of Glioblastoma. Cancer Cell. 32(6). 856–868.e5. 128 indexed citations
9.
Strnádel, Ján, Sunkyu Choi, Ken Fujimura, et al.. (2017). eIF5A-PEAK1 Signaling Regulates YAP1/TAZ Protein Expression and Pancreatic Cancer Cell Growth. Cancer Research. 77(8). 1997–2007. 68 indexed citations
10.
Wang, Zhen, Peng Liu, Xin Zhou, et al.. (2017). Endothelin Promotes Colorectal Tumorigenesis by Activating YAP/TAZ. Cancer Research. 77(9). 2413–2423. 69 indexed citations
11.
Diao, Yarui, Rongxin Fang, Bin Li, et al.. (2017). A tiling-deletion-based genetic screen for cis-regulatory element identification in mammalian cells. Nature Methods. 14(6). 629–635. 169 indexed citations
12.
Song, Lei, Wei‐Ren Liu, Minbiao Ji, et al.. (2016). Destabilization of Fatty Acid Synthase by Acetylation Inhibits De Novo Lipogenesis and Tumor Cell Growth. Cancer Research. 76(23). 6924–6936. 100 indexed citations
13.
Yang, Hui, Lisha Zhou, Qian Shi, et al.. (2015). SIRT 3‐dependent GOT 2 acetylation status affects the malate–aspartate NADH shuttle activity and pancreatic tumor growth. The EMBO Journal. 34(8). 1110–1125. 155 indexed citations
14.
Xu, Yanping, Fulong Li, Lei Lv, et al.. (2014). Oxidative Stress Activates SIRT2 to Deacetylate and Stimulate Phosphoglycerate Mutase. Cancer Research. 74(13). 3630–3642. 128 indexed citations
15.
Xie, Xiaoduo, Denghong Zhang, Bin Zhao, et al.. (2011). IκB kinase ε and TANK-binding kinase 1 activate AKT by direct phosphorylation. Proceedings of the National Academy of Sciences. 108(16). 6474–6479. 169 indexed citations
16.
Zhao, Shimin, Yan Lin, Wei Xu, et al.. (2009). Glioma-Derived Mutations in IDH1 Dominantly Inhibit IDH1 Catalytic Activity and Induce HIF-1α. Science. 324(5924). 261–265. 896 indexed citations breakdown →
17.
Guan, Kun‐Liang, et al.. (2009). AMP‐activated protein kinase and cancer. Acta Physiologica. 196(1). 55–63. 141 indexed citations
18.
Gan, Boyi, Zara Melkoumian, Xiaoyang Wu, Kun‐Liang Guan, & Jun‐Lin Guan. (2005). Identification of FIP200 interaction with the TSC1–TSC2 complex and its role in regulation of cell size control. The Journal of Cell Biology. 170(3). 379–389. 74 indexed citations
19.
Li, Yong, Ken Inoki, & Kun‐Liang Guan. (2004). Biochemical and Functional Characterizations of Small GTPase Rheb and TSC2 GAP Activity. Molecular and Cellular Biology. 24(18). 7965–7975. 198 indexed citations
20.
Tang, Eric, Gabriel Núñez, Frederic G. Barr, & Kun‐Liang Guan. (1999). Negative Regulation of the Forkhead Transcription Factor FKHR by Akt. Journal of Biological Chemistry. 274(24). 16741–16746. 656 indexed citations breakdown →

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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