Kohsuke Takeda

23.1k total citations · 8 hit papers
175 papers, 19.4k citations indexed

About

Kohsuke Takeda is a scholar working on Molecular Biology, Immunology and Cell Biology. According to data from OpenAlex, Kohsuke Takeda has authored 175 papers receiving a total of 19.4k indexed citations (citations by other indexed papers that have themselves been cited), including 109 papers in Molecular Biology, 42 papers in Immunology and 26 papers in Cell Biology. Recurrent topics in Kohsuke Takeda's work include Redox biology and oxidative stress (32 papers), Genomics, phytochemicals, and oxidative stress (22 papers) and Endoplasmic Reticulum Stress and Disease (21 papers). Kohsuke Takeda is often cited by papers focused on Redox biology and oxidative stress (32 papers), Genomics, phytochemicals, and oxidative stress (22 papers) and Endoplasmic Reticulum Stress and Disease (21 papers). Kohsuke Takeda collaborates with scholars based in Japan, United States and Germany. Kohsuke Takeda's co-authors include Hidenori Ichijo, Shizuo Akira, Atsushi Matsuzawa, Hideki Nishitoh, Takuya Noguchi, Kei Tobiume, Eiichi Araki, Tomomi Gotoh, Masataka Mori and Seiichi Oyadomari and has published in prestigious journals such as Nature, Proceedings of the National Academy of Sciences and The Lancet.

In The Last Decade

Kohsuke Takeda

170 papers receiving 19.1k citations

Hit Papers

Essential role of Stat6 i... 1996 2026 2006 2016 1996 2002 2001 2002 2002 400 800 1.2k
What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

  1. Essential role of Stat6 in IL-4 signalling
    1996 1.3k citations Kohsuke Takeda, Tadamitsu Kishimoto et al. profile →
  2. ASK1 is essential for endoplasmic reticulum stress-induced neuronal cell death triggered by expanded polyglutamine repeats
    2002 1.1k citations Hideki Nishitoh, Atsushi Matsuzawa et al. Genes & Development profile →
  3. ASK1 is required for sustained activations of JNK/p38 MAP kinases and apoptosis
    2001 1.0k citations Kei Tobiume, Atsushi Matsuzawa et al. profile →
  4. Targeted disruption of the Chop gene delays endoplasmic reticulum stress–mediated diabetes
    2002 760 citations Seiichi Oyadomari, Akio Koizumi et al. Journal of Clinical Investigation profile →
  5. Targeted disruption of the Chop gene delays endoplasmic reticulum stress–mediated diabetes
    2002 682 citations Seiichi Oyadomari, Akio Koizumi et al. Journal of Clinical Investigation profile →
  6. ROS-dependent activation of the TRAF6-ASK1-p38 pathway is selectively required for TLR4-mediated innate immunity
    2005 581 citations Atsushi Matsuzawa, Kaoru Saegusa et al. profile →
  7. ASK1 Is Essential for JNK/SAPK Activation by TRAF2
    1998 566 citations Hideki Nishitoh, Masao Saitoh et al. Molecular Cell profile →
  8. Nitric oxide-induced apoptosis in pancreatic β cells is mediated by the endoplasmic reticulum stress pathway
    2001 509 citations Seiichi Oyadomari, Kohsuke Takeda et al. Proceedings of the National Academy of Sciences profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name h Career Trend Papers Cites
Kohsuke Takeda Japan 68 10.1k 4.8k 4.3k 3.0k 2.3k 175 19.4k
Søren K. Moestrup Denmark 85 7.7k 0.8× 3.9k 0.8× 3.6k 0.8× 2.2k 0.8× 1.8k 0.8× 246 20.0k
Mauro Piacentini Italy 72 8.2k 0.8× 4.2k 0.9× 3.4k 0.8× 6.0k 2.0× 2.3k 1.0× 287 20.1k
Emilio Hirsch Italy 73 9.6k 0.9× 5.4k 1.1× 2.6k 0.6× 1.2k 0.4× 2.9k 1.3× 297 19.0k
Marja Jäättelä Denmark 80 15.2k 1.5× 3.0k 0.6× 4.7k 1.1× 6.2k 2.1× 2.5k 1.1× 182 23.8k
Marek Michalak Canada 75 11.0k 1.1× 5.2k 1.1× 9.3k 2.2× 3.1k 1.1× 1.2k 0.5× 297 20.2k
Yoshihide Tsujimoto Japan 85 18.8k 1.9× 4.0k 0.8× 2.8k 0.7× 4.8k 1.6× 4.3k 1.9× 184 28.6k
Afshin Samali Ireland 64 11.7k 1.2× 2.2k 0.5× 7.3k 1.7× 4.5k 1.5× 1.3k 0.6× 173 19.9k
Clive A. Slaughter United States 70 15.1k 1.5× 3.0k 0.6× 4.3k 1.0× 1.6k 0.5× 3.0k 1.3× 182 20.5k
Kodi S. Ravichandran United States 77 11.0k 1.1× 11.1k 2.3× 2.5k 0.6× 1.8k 0.6× 2.1k 0.9× 208 22.5k
Kinya Otsu Japan 57 10.8k 1.1× 4.2k 0.9× 1.7k 0.4× 4.8k 1.6× 1.1k 0.5× 152 19.5k

Countries citing papers authored by Kohsuke Takeda

Since Specialization
Citations

This map shows the geographic impact of Kohsuke Takeda's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Kohsuke Takeda with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Kohsuke Takeda more than expected).

Fields of papers citing papers by Kohsuke Takeda

Since Specialization
Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Kohsuke Takeda. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Kohsuke Takeda. The network helps show where Kohsuke Takeda may publish in the future.

Co-authorship network of co-authors of Kohsuke Takeda

This figure shows the co-authorship network connecting the top 25 collaborators of Kohsuke Takeda. A scholar is included among the top collaborators of Kohsuke Takeda based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Kohsuke Takeda. Kohsuke Takeda is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

20 of 20 papers shown
1.
Metwally, Hozaifa, Hisako Kayama, Kazuki Okuyama, et al.. (2025). Threonine phosphorylation of STAT1 safeguards gut epithelial integrity and restricts interferon-mediated cytotoxicity. Proceedings of the National Academy of Sciences. 122(30). e2511957122–e2511957122. 2 indexed citations
2.
Sakamoto, Noriho, Hideki Hayashi, Tsutomu Fukuda, et al.. (2025). Lamellarin D Acts as an Inhibitor of Type I Collagen Production. ChemMedChem. 20(9). e202401001–e202401001. 1 indexed citations
3.
Fukuda, Hayato, Kohsuke Takeda, Keijo Fukushima, et al.. (2025). Design and Synthesis of Cyclopropane Congeners of Resolvin E2 with Azidopropoxy Chain toward a Chemical Tool for Probing the Anti-inflammatory Activity. The Journal of Organic Chemistry. 91(1). 466–476.
4.
Uemura, Ryoko, Susumu Tanimura, Nobuo Yamaguchi, et al.. (2025). Expression Analysis of Heavy-Chain-Only Antibodies in Cloudy Catshark and Japanese Bullhead Shark. Marine Drugs. 23(1). 28–28. 1 indexed citations
5.
Oguro-Igashira, Eri, Mari Murakami, Ryota Mori, et al.. (2024). The pyruvate–GPR31 axis promotes transepithelial dendrite formation in human intestinal dendritic cells. Proceedings of the National Academy of Sciences. 121(44). e2318767121–e2318767121. 5 indexed citations
6.
Sugiyama, Takashi, Naoya Murao, Hisae Kadowaki, et al.. (2021). ERAD components Derlin-1 and Derlin-2 are essential for postnatal brain development and motor function. iScience. 24(7). 102758–102758. 15 indexed citations
7.
Matsui, Hiroyuki, Yoshiaki Kanda, Osamu Suzuki, et al.. (2014). The Expression of Fn14 via Mechanical Stress-activated JNK Contributes to Apoptosis Induction in Osteoblasts. Journal of Biological Chemistry. 289(10). 6438–6450. 35 indexed citations
8.
Takeda, Kohsuke, Yosuke Ishida, Takuya Noguchi, et al.. (2009). Mitochondrial phosphoglycerate mutase 5 uses alternate catalytic activity as a protein serine/threonine phosphatase to activate ASK1. Proceedings of the National Academy of Sciences. 106(30). 12301–12305. 118 indexed citations
9.
Nagai, Hiroaki, Takuya Noguchi, Kengo Homma, et al.. (2009). Ubiquitin-like Sequence in ASK1 Plays Critical Roles in the Recognition and Stabilization by USP9X and Oxidative Stress-Induced Cell Death. Molecular Cell. 36(5). 805–818. 122 indexed citations
10.
Sekine, Yusuke, et al.. (2009). Signaling pathways in invertebrate immune and stress response. SHILAP Revista de lepidopterología. 6(1). 32–43. 15 indexed citations
11.
Nagai, Hiroaki, Takuya Noguchi, Kohsuke Takeda, & Hidenori Ichijo. (2007). Pathophysiological Roles of ASK1-MAP Kinase Signaling Pathways. BMB Reports. 40(1). 1–6. 208 indexed citations
12.
Kadowaki, Hisae, Hideki Nishitoh, Fumihiko Urano, et al.. (2004). Amyloid β induces neuronal cell death through ROS-mediated ASK1 activation. Cell Death and Differentiation. 12(1). 19–24. 361 indexed citations
13.
Weiss, David S., Bärbel Raupach, Kohsuke Takeda, Shizuo Akira, & Arturo Zychlinsky. (2004). Toll-Like Receptors Are Temporally Involved in Host Defense. The Journal of Immunology. 172(7). 4463–4469. 176 indexed citations
14.
Inoshita, Seiji, Kohsuke Takeda, Yoshio Terada, et al.. (2002). Phosphorylation and Inactivation of Myeloid Cell Leukemia 1 by JNK in Response to Oxidative Stress. Journal of Biological Chemistry. 277(46). 43730–43734. 188 indexed citations
15.
Nishitoh, Hideki, Atsushi Matsuzawa, Kei Tobiume, et al.. (2002). ASK1 is essential for endoplasmic reticulum stress-induced neuronal cell death triggered by expanded polyglutamine repeats. Genes & Development. 16(11). 1345–1355. 1134 indexed citations breakdown →
16.
Takeda, Kohsuke & Shizuo Akira. (2002). Regulation of Innate Immune Responses by Toll-Like Receptors. Japanese Journal of Infectious Diseases. 54(6). 209–219. 44 indexed citations
17.
Oyadomari, Seiichi, Akio Koizumi, Kohsuke Takeda, et al.. (2002). Targeted disruption of the Chop gene delays endoplasmic reticulum stress–mediated diabetes. Journal of Clinical Investigation. 109(4). 525–532. 760 indexed citations breakdown →
18.
Shi, Fu‐Dong, Kohsuke Takeda, Shizuo Akira, Nora Sarvetnick, & Hans‐Gustaf Ljunggren. (2000). IL-18 Directs Autoreactive T Cells and Promotes Autodestruction in the Central Nervous System Via Induction of IFN-γ by NK Cells. The Journal of Immunology. 165(6). 3099–3104. 152 indexed citations
19.
Takeda, Kohsuke, et al.. (2000). Genetically Resistant Mice Lacking IL-18 Gene Develop Th1 Response and Control Cutaneous Leishmania major Infection. The Journal of Immunology. 164(11). 5890–5893. 73 indexed citations
20.
Takeda, Kohsuke, Hidenori Ichijo, Makiko Fujii, et al.. (1998). Identification of a Novel Bone Morphogenetic Protein-responsive Gene That May Function as a Noncoding RNA. Journal of Biological Chemistry. 273(27). 17079–17085. 50 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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