Kei Tobiume

5.5k total citations · 3 hit papers
45 papers, 4.6k citations indexed

About

Kei Tobiume is a scholar working on Molecular Biology, Oncology and Cancer Research. According to data from OpenAlex, Kei Tobiume has authored 45 papers receiving a total of 4.6k indexed citations (citations by other indexed papers that have themselves been cited), including 30 papers in Molecular Biology, 15 papers in Oncology and 9 papers in Cancer Research. Recurrent topics in Kei Tobiume's work include Cancer-related Molecular Pathways (8 papers), Cancer Cells and Metastasis (7 papers) and Redox biology and oxidative stress (6 papers). Kei Tobiume is often cited by papers focused on Cancer-related Molecular Pathways (8 papers), Cancer Cells and Metastasis (7 papers) and Redox biology and oxidative stress (6 papers). Kei Tobiume collaborates with scholars based in Japan, United States and Indonesia. Kei Tobiume's co-authors include Hidenori Ichijo, Kohsuke Takeda, Atsushi Matsuzawa, Hideki Nishitoh, Keiko Kawauchi, Nobuyuki Tanaka, Keigo Araki, Masao Saitoh, Seiji Hori and Kaoru Saegusa and has published in prestigious journals such as Proceedings of the National Academy of Sciences, Journal of Biological Chemistry and Genes & Development.

In The Last Decade

Kei Tobiume

44 papers receiving 4.6k citations

Hit Papers

align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

ASK1 is essential for endoplasmic reticulum stress-induced neuronal cell death triggered by expanded polyglutamine repeats

2002 1.1k citations Hideki Nishitoh, Atsushi Matsuzawa et al. Genes & Development profile →
ASK1 is required for sustained activations of JNK/p38 MAP kinases and apoptosis

2001 1.0k citations Kei Tobiume, Atsushi Matsuzawa et al. EMBO Reports profile →
p53 regulates glucose metabolism through an IKK-NF-κB pathway and inhibits cell transformation

2008 539 citations Keiko Kawauchi, Keigo Araki et al. profile →

Peers

Countries citing papers authored by Kei Tobiume

Since Specialization

Citations

This map shows the geographic impact of Kei Tobiume's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Kei Tobiume with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Kei Tobiume more than expected).

Fields of papers citing papers by Kei Tobiume

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Kei Tobiume. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Kei Tobiume. The network helps show where Kei Tobiume may publish in the future.

Co-authorship network of co-authors of Kei Tobiume

This figure shows the co-authorship network connecting the top 25 collaborators of Kei Tobiume. A scholar is included among the top collaborators of Kei Tobiume based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Kei Tobiume. Kei Tobiume is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

#	Work	Indexed citations
1	Anticancer effect of the antirheumatic drug leflunomide on oral squamous cell carcinoma by the inhibition of tumor angiogenesis 2025 ·Discover Oncology ·(unknown), Takayuki Nakagawa, (unknown), (unknown), (unknown), (unknown), Shigehiro Ono, Kei Tobiume, Jing Gao, Eijiro Jimi, Kouji Ohta, Tomonao Aikawa	0
2	Immune response to cytosolic DNA via intercellular receptor modulation in oral keratinocytes and fibroblasts 2020 ·Oral Diseases ·(unknown), Kouji Ohta, Hiroki Kato, Yoko Ishida, Hideo Shigeishi, (unknown), Akiko Fukui, Takayuki Nakagawa, Kei Tobiume, Hiromi Nishi, Masaaki Takechi	5
3	D-Alanine Is Reduced by Ocular Hypertension in the Rat Retina 2019 ·Current Eye Research ·Takashi Kanamoto, (unknown), Yasushi Kitaoka, Ryo Asaoka, Kei Tobiume, Yoshiaki Kiuchi	2
4	D-Serine Induced by Ocular Hypertension is Associated with Retinal Cell Death 2018 ·Takashi Kanamoto, Yasushi Kitaoka, (unknown), Yusuke Murakami, Yasuhiro Ikeda, Kei Tobiume, Yoshiaki Kiuchi	1
5	Snail-induced CD44high cells in HNSCC with high ABC transporter capacity exhibit potent resistance to cisplatin and docetaxel 2016 ·International Journal of Clinical and Experimental Pathology ·(unknown), Hideo Shigeishi, (unknown), Kazuhiro Yamamoto, Kei Tobiume, (unknown), (unknown), Hiroki Kato, (unknown), Shigehiro Ono, Kouji Ohta, Koichiro Higashikawa, Masaaki Takechi, Masaru Sugiyama	5
6	Expression and Function of RIG-I in Oral Keratinocytes and Fibroblasts 2014 ·Cellular Physiology and Biochemistry ·Kouji Ohta, Akiko Fukui, Hideo Shigeishi, Yoko Ishida, Hiromi Nishi, Kei Tobiume, Masaaki Takechi, Nobuyuki Kamata	15
7	AKT primes snail‐induced EMT concomitantly with the collective migration of squamous cell carcinoma cells 2013 ·Journal of Cellular Biochemistry ·(unknown), Kei Tobiume, (unknown), Kazuhiro Yamamoto, Hideo Shigeishi, Shigehiro Ono, Koichiro Higashikawa, Nobuyuki Kamata	20
8	Autocrine galectin-1 promotes collective cell migration of squamous cell carcinoma cells through up-regulation of distinct integrins 2013 ·Biochemical and Biophysical Research Communications ·(unknown), Kei Tobiume, (unknown), Kazuhiro Yamamoto, Hideo Shigeishi, Shigehiro Ono, (unknown), Masaaki Takechi, Koichiro Higashikawa, Nobuyuki Kamata	21
9	RHAMM/ERK interaction induces proliferative activities of cementifying fibroma cells through a mechanism based on the CD44–EGFR 2010 ·Laboratory Investigation ·Hiroko Hatano, Hideo Shigeishi, Yasusei Kudo, Koichiro Higashikawa, Kei Tobiume, Takashi Takata, Nobuyuki Kamata	54
10	ΔNp63α‐dependent expression of Id‐3 distinctively suppresses the invasiveness of human squamous cell carcinoma 2009 ·International Journal of Cancer ·Koichiro Higashikawa, (unknown), Kei Tobiume, Masao Saitoh, Masayuki Taki, Yoshitsugu Mitani, Hideo Shigeishi, Shigehiro Ono, Nobuyuki Kamata	38
11	Hedgehog signaling overrides p53-mediated tumor suppression by activating Mdm2 2008 ·Proceedings of the National Academy of Sciences ·Yoshinori Abe, (unknown), Kei Tobiume, Keiko Kawauchi, Yoichi Taya, Koji Okamoto, Moshe Oren, Nobuyuki Tanaka	113
12	Gene expression profiling to identify genes associated with high-invasiveness in human squamous cell carcinoma with epithelial-to-mesenchymal transition 2008 ·Cancer Letters ·Koichiro Higashikawa, (unknown), Masayuki Taki, Hideo Shigeishi, Shigehiro Ono, Kei Tobiume, Nobuyuki Kamata	22
13	Activated p53 induces NF-κB DNA binding but suppresses its transcriptional activation 2008 ·Biochemical and Biophysical Research Communications ·Keiko Kawauchi, Keigo Araki, Kei Tobiume, Nobuyuki Tanaka	58
14	Snail-Induced Down-Regulation of ΔNp63α Acquires Invasive Phenotype of Human Squamous Cell Carcinoma 2007 ·Cancer Research ·Koichiro Higashikawa, (unknown), Kei Tobiume, Masayuki Taki, Hideo Shigeishi, Nobuyuki Kamata	76
15	Apoptosis Signal-regulating Kinase (ASK) 2 Functions as a Mitogen-activated Protein Kinase Kinase Kinase in a Heteromeric Complex with ASK1 2007 ·Journal of Biological Chemistry ·Kohsuke Takeda, (unknown), Takuya Noguchi, Tsuyoshi Umeda, Yoshifumi Morimoto, Isao Naguro, Kei Tobiume, Masao Saitoh, Atsushi Matsuzawa, Hidenori Ichijo	100
16	The negative regulation of p53 by hedgehog signaling 2006 ·Cancer Research ·Yoshinori Abe, (unknown), Kei Tobiume, Keiko Kawauchi, Koji Okamoto, Yoichi Taya, Nobuyuki Tanaka	1
17	Involvement of ASK1 in Ca ²⁺ ‐induced p38 MAP kinase activation 2004 ·EMBO Reports ·Kohsuke Takeda, Atsushi Matsuzawa, Hideki Nishitoh, Kei Tobiume, Satoshi Kishida, Jun Ninomiya‐Tsuji, Kunihiro Matsumoto, Hidenori Ichijo	156
18	ASK1 is essential for endoplasmic reticulum stress-induced neuronal cell death triggered by expanded polyglutamine repeats breakdown → 2002 ·Genes & Development ·Hideki Nishitoh, Atsushi Matsuzawa, Kei Tobiume, Kaoru Saegusa, Kohsuke Takeda, Kiyoshi Inoue, Seiji Hori, Akira Kakizuka, Hidenori Ichijo	1134
19	ASK1 is required for sustained activations of JNK/p38 MAP kinases and apoptosis breakdown → 2001 ·EMBO Reports ·Kei Tobiume, Atsushi Matsuzawa, Takumi Takahashi, Hideki Nishitoh, Keiichi Morita, Kohsuke Takeda, Osamu Minowa, Kohei Miyazono, Tetsuo Noda, Hidenori Ichijo	1042
20	Characterization of Mouse Apoptosis Signal-regulating Kinase 1. 1998 ·THE JOURNAL OF THE STOMATOLOGICAL SOCIETY JAPAN ·Kei Tobiume	3

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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