Jon C. Aster

52.5k total citations · 11 hit papers
278 papers, 32.0k citations indexed

About

Jon C. Aster is a scholar working on Molecular Biology, Hematology and Oncology. According to data from OpenAlex, Jon C. Aster has authored 278 papers receiving a total of 32.0k indexed citations (citations by other indexed papers that have themselves been cited), including 178 papers in Molecular Biology, 59 papers in Hematology and 53 papers in Oncology. Recurrent topics in Jon C. Aster's work include Developmental Biology and Gene Regulation (67 papers), Cancer-related gene regulation (46 papers) and Epigenetics and DNA Methylation (39 papers). Jon C. Aster is often cited by papers focused on Developmental Biology and Gene Regulation (67 papers), Cancer-related gene regulation (46 papers) and Epigenetics and DNA Methylation (39 papers). Jon C. Aster collaborates with scholars based in United States, France and Japan. Jon C. Aster's co-authors include Stephen C. Blacklow, Warren S. Pear, Andrew P. Weng, A. Thomas Look, Lanwei Xu, Cheryll Sanchez-Irizarry, Adolfo A. Ferrando, Jeffery L. Kutok, Lewis B. Silverman and John P. Morris and has published in prestigious journals such as Nature, Science and New England Journal of Medicine.

In The Last Decade

Jon C. Aster

275 papers receiving 31.6k citations

Hit Papers

5 papers align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Activating Mutations of NOTCH1 in Human T Cell Acute Lymphoblastic Leukemia

2004 2.0k citations Andrew P. Weng, Adolfo A. Ferrando et al. Science profile →
Comprehensive analyses of tumor immunity: implications for cancer immunotherapy

2016 1.6k citations Jon C. Aster, Scott J. Rodig et al. profile →
Notch1 Expression in Early Lymphopoiesis Influences B versus T Lineage Determination

1999 766 citations David Allman, Lanwei Xu et al. profile →
c-Myc is an important direct target of Notch1 in T-cell acute lymphoblastic leukemia/lymphoma

2006 673 citations Andrew P. Weng, Yumi Yashiro–Ohtani et al. profile →
NOTCH1 directly regulates c-MYC and activates a feed-forward-loop transcriptional network promoting leukemic cell growth

2006 639 citations Teresa Palomero, Wei Keat Lim et al. Proceedings of the National Academy of Sciences profile →
Efficient and Rapid Induction of a Chronic Myelogenous Leukemia-Like Myeloproliferative Disease in Mice Receiving P210 bcr/abl-Transduced Bone Marrow

1998 627 citations Warren S. Pear, Lanwei Xu et al. Blood profile →
Direct inhibition of the NOTCH transcription factor complex

2009 619 citations Jon C. Aster, Stephen C. Blacklow et al. Nature profile →
Single-Cell RNA-Seq Reveals AML Hierarchies Relevant to Disease Progression and Immunity

2019 613 citations Gabriel K. Griffin, Jason Stephansky et al. profile →
Exclusive development of T cell neoplasms in mice transplanted with bone marrow expressing activated Notch alleles.

1996 570 citations Warren S. Pear, Jon C. Aster et al. profile →
SCFFBW7 regulates cellular apoptosis by targeting MCL1 for ubiquitylation and destruction

2011 537 citations Amanda L. Christie, Jon C. Aster et al. Nature profile →
The Varied Roles of Notch in Cancer

2016 494 citations Jon C. Aster, Warren S. Pear et al. profile →

Peers

Countries citing papers authored by Jon C. Aster

Since Specialization

Citations

This map shows the geographic impact of Jon C. Aster's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Jon C. Aster with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Jon C. Aster more than expected).

Fields of papers citing papers by Jon C. Aster

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Jon C. Aster. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Jon C. Aster. The network helps show where Jon C. Aster may publish in the future.

Co-authorship network of co-authors of Jon C. Aster

This figure shows the co-authorship network connecting the top 25 collaborators of Jon C. Aster. A scholar is included among the top collaborators of Jon C. Aster based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Jon C. Aster. Jon C. Aster is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

#	Work	Indexed citations
1	A spatiotemporal Notch interaction map from plasma membrane to nucleus 2023 ·Science Signaling ·Alexandre Martin, Gary A. Bradshaw, (unknown), Emily D. Egan, (unknown), Julia M. Rogers, (unknown), (unknown), Jon C. Aster, Tomas Kirchhausen, Marian Kalocsay, Stephen C. Blacklow	9
2	Gamma Secretase Inhibition for a Child With Metastatic Glomus Tumor and Activated NOTCH1 2022 ·JCO Precision Oncology ·Ellen Zhang, Amber Miller, Catherine Clinton, (unknown), Stephan D. Voss, Jon C. Aster, Alanna J. Church, Reza Rahbar, (unknown), Katherine A. Janeway, Steven G. DuBois	3
3	Pre-T cell receptor self-MHC sampling restricts thymocyte dedifferentiation 2022 ·Nature ·Jonathan S. Duke‐Cohan, Aoi Akitsu, Robert J. Mallis, (unknown), Patrick H. Lizotte, Jon C. Aster, Wonmuk Hwang, Matthew J. Lang, Ellis L. Reinherz	13
4	p53 Pathway Inactivation Drives SMARCB1 -deficient p53 -wildtype Epithelioid Sarcoma Onset Indicating Therapeutic Vulnerability Through MDM2 Inhibition 2022 ·Molecular Cancer Therapeutics ·Felix Oppel, (unknown), (unknown), Mark W. Zimmerman, Matthias Schürmann, (unknown), Peter Goon, Susan Chi, Jon C. Aster, Holger Sudhoff, A. Thomas Look	4
5	MAML1-Dependent Notch-Responsive Genes Exhibit Differing Cofactor Requirements for Transcriptional Activation 2020 ·Molecular and Cellular Biology ·Julia M. Rogers, Bingqian Guo, Emily D. Egan, Jon C. Aster, Karen Adelman, Stephen C. Blacklow	7
6	Proteogenomic Analysis of Salivary Adenoid Cystic Carcinomas Defines Molecular Subtypes and Identifies Therapeutic Targets 2020 ·Clinical Cancer Research ·Renata Ferrarotto, Yoshitsugu Mitani, Daniel J. McGrail, Kaiyi Li, Tatiana V. Karpinets, Diana Bell, Steven J. Frank, Xingzhi Song, Michael E. Kupferman, Bin Liu, J. Jack Lee, Bonnie S. Glisson, Jianhua Zhang, Jon C. Aster, Shiaw‐Yih Lin, P. Andrew Futreal, John V. Heymach, Adel K. El‐Naggar	87
7	Anti-CD37 chimeric antigen receptor T cells are active against B- and T-cell lymphomas 2018 ·Blood ·Irene Scarfò, Maria Ormhøj, Matthew J. Frigault, Ana P. Castaño, Selena Lorrey, Amanda A. Bouffard, Alexandria Van Scoyk, Scott J. Rodig, (unknown), Jon C. Aster, Frederic I. Preffer, David M. Weinstock, Marcela V. Maus	105
8	Blastic Plasmacytoid Dendritic Cell Neoplasm Is Dependent on BCL2 and Sensitive to Venetoclax 2016 ·Cancer Discovery ·Joan Montero, Jason Stephansky, Tianyu Cai, Gabriel K. Griffin, Lucía Cabal‐Hierro, Katsuhiro Togami, Leah J. Hogdal, Ilene Galinsky, Elizabeth A. Morgan, Jon C. Aster, Matthew S. Davids, Nicole R. LeBoeuf, Richard M. Stone, Marina Konopleva, Naveen Pemmaraju, (unknown), Andrew A. Lane	144
9	Long-range enhancer activity determines Myc sensitivity to Notch inhibitors in T cell leukemia 2014 ·Proceedings of the National Academy of Sciences ·Yumi Yashiro–Ohtani, Hongfang Wang, Chongzhi Zang, Kelly L. Arnett, Will Bailis, Yugong Ho, Birgit Knoechel, Claudia Lanauze, (unknown), Katherine S. Forsyth, Sujun Chen, (unknown), Jonathan Schug, Gerd A. Blobel, Stephen A. Liebhaber, B Bernstein, Stephen C. Blacklow, Xiaole Shirley Liu, Jon C. Aster, Warren S. Pear	133
10	Targeted Imaging of Ewing Sarcoma in Preclinical Models Using a 64Cu-Labeled Anti-CD99 Antibody 2013 ·Clinical Cancer Research ·Allison F. O’Neill, Jason L.J. Dearling, Yuchuan Wang, Tanya Tupper, Yanping Sun, Jon C. Aster, Monica L. Calicchio, Antonio R. Pérez‐Atayde, Alan B. Packard, Andrew L. Kung	17
11	Jagged2 acts as a Delta-like Notch ligand during early hematopoietic cell fate decisions 2011 ·Blood ·Inge Van de Walle, Greet De Smet, (unknown), Magda De Smedt, (unknown), Bart Vandekerckhove, Georges Leclercq, Jean Plum, Jon C. Aster, Irwin D. Bernstein, Cynthia J. Guidos, Bruno Kyewski, Tom Taghon	67
12	Differentiation of NUT Midline Carcinoma by Epigenomic Reprogramming 2011 ·Cancer Research ·Brian E. Schwartz, Matthias D. Hofer, Madeleine E. Lemieux, (unknown), Michael J. Cameron, Nathan West, Elin S. Agoston, Nicolas Reynoird, Saadi Khochbin, Tan A. Ince, Amanda L. Christie, Katherine A. Janeway, Sara O. Vargas, Antonio R. Pérez‐Atayde, Jon C. Aster, Stephen E. Sallan, Andrew L. Kung, James E. Bradner, Christopher A. French	156
13	Oncogenic activation of the Notch1 gene by deletion of its promoter in Ikaros-deficient T-ALL 2010 ·Blood ·Robin Jeannet, Jérôme Mastio, (unknown), Attila Oravecz, Todd Ashworth, (unknown), Bernard Jost, Stéphanie Le Gras, Jacques Ghysdael, Thomas Gridley, Tasuku Honjo, Freddy Radtke, Jon C. Aster, Susan Chan, Philippe Kastner	65
14	Cooperative assembly of higher-order Notch complexes functions as a switch to induce transcription 2007 ·Proceedings of the National Academy of Sciences ·Yunsun Nam, Piotr Sliz, Warren S. Pear, Jon C. Aster, Stephen C. Blacklow	130
15	NOTCH1 directly regulates c-MYC and activates a feed-forward-loop transcriptional network promoting leukemic cell growth breakdown → 2006 ·Proceedings of the National Academy of Sciences ·Teresa Palomero, Wei Keat Lim, Duncan T. Odom, Maria Luisa Sulis, Pedro J. Real, Adam A. Margolin, Kelly Barnes, Jennifer O’Neil, Donna Neuberg, Andrew P. Weng, Jon C. Aster, François Sigaux, Jean Soulier, A. Thomas Look, Richard A. Young, Andrea Califano, Adolfo A. Ferrando	639
16	Mastermind critically regulates Notch-mediated lymphoid cell fate decisions 2004 ·Blood ·Ivan Maillard, Andrew P. Weng, Andrea C. Carpenter, Carlos G. Rodríguez, Hong Sai, Lanwei Xu, David Allman, Jon C. Aster, Warren S. Pear	235
17	JAGGED1 Expression Is Associated with Prostate Cancer Metastasis and Recurrence 2004 ·Cancer Research ·Sandro Santagata, Francesca Demichelis, Alberto Riva, Sooryanarayana Varambally, Matthias D. Hofer, Jeffery L. Kutok, Robert Kim, Jeffery Tang, James E. Montie, Arul M. Chinnaiyan, Mark A. Rubin, Jon C. Aster	271
18	Activating Mutations of NOTCH1 in Human T Cell Acute Lymphoblastic Leukemia breakdown → 2004 ·Science ·Andrew P. Weng, Adolfo A. Ferrando, Woojoong Lee, John P. Morris, Lewis B. Silverman, Cheryll Sanchez-Irizarry, Stephen C. Blacklow, A. Thomas Look, Jon C. Aster	2013
19	Notch Subunit Heterodimerization and Prevention of Ligand-Independent Proteolytic Activation Depend, Respectively, on a Novel Domain and the LNR Repeats 2004 ·Molecular and Cellular Biology ·Cheryll Sanchez-Irizarry, Andrea C. Carpenter, Andrew P. Weng, Warren S. Pear, Jon C. Aster, Stephen C. Blacklow	163
20	Myc-Induced T Cell Leukemia in Transgenic Zebrafish 2003 ·Science ·David M. Langenau, David Traver, Adolfo A. Ferrando, Jeffery L. Kutok, Jon C. Aster, John P. Kanki, Shuo Lin, (unknown), Nikolaus S. Trede, Leonard I. Zon, A. Thomas Look	432

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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