Michael S. Wolfe

18.6k total citations · 4 hit papers
168 papers, 14.5k citations indexed

About

Michael S. Wolfe is a scholar working on Physiology, Molecular Biology and Pharmacology. According to data from OpenAlex, Michael S. Wolfe has authored 168 papers receiving a total of 14.5k indexed citations (citations by other indexed papers that have themselves been cited), including 98 papers in Physiology, 89 papers in Molecular Biology and 27 papers in Pharmacology. Recurrent topics in Michael S. Wolfe's work include Alzheimer's disease research and treatments (98 papers), Cholinesterase and Neurodegenerative Diseases (27 papers) and Computational Drug Discovery Methods (25 papers). Michael S. Wolfe is often cited by papers focused on Alzheimer's disease research and treatments (98 papers), Cholinesterase and Neurodegenerative Diseases (27 papers) and Computational Drug Discovery Methods (25 papers). Michael S. Wolfe collaborates with scholars based in United States, Japan and Belgium. Michael S. Wolfe's co-authors include Dennis J. Selkoe, W. Taylor Kimberly, Beth L. Ostaszewski, Weiming Xia, Thekla S. Diehl, Raphael Kopan, Bart De Strooper, William P. Esler, Wenjuan Ye and Alison Goate and has published in prestigious journals such as Nature, Science and Cell.

In The Last Decade

Michael S. Wolfe

165 papers receiving 14.3k citations

Hit Papers

align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

A presenilin-1-dependent γ-secretase-like protease mediates release of Notch intracellular domain

1999 1.7k citations Michael S. Wolfe et al. profile →
Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and γ-secretase activity

1999 1.6k citations Michael S. Wolfe, Weiming Xia et al. profile →
c-Myc is an important direct target of Notch1 in T-cell acute lymphoblastic leukemia/lymphoma

2006 673 citations Michael S. Wolfe et al. profile →
γ-Secretase is a membrane protein complex comprised of presenilin, nicastrin, aph-1, and pen-2

2003 621 citations W. Taylor Kimberly, Beth L. Ostaszewski et al. profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name	h						Papers	Cites
Michael S. Wolfe United States	56	8.2k	8.1k	2.6k	2.3k	1.9k	168	14.5k
Wim Annaert Belgium	51	6.6k 0.8×	7.3k 0.9×	1.7k 0.7×	3.3k 1.4×	2.3k 1.2×	141	13.1k
Koji Takio Japan	76	4.1k 0.5×	13.4k 1.7×	794 0.3×	3.1k 1.3×	2.3k 1.2×	196	20.9k
Gloria Lee United States	56	5.2k 0.6×	6.2k 0.8×	901 0.3×	2.6k 1.1×	2.4k 1.3×	127	12.7k
Anthony H. Futerman Israel	73	6.4k 0.8×	12.8k 1.6×	773 0.3×	5.3k 2.3×	962 0.5×	282	18.3k
Peter J. Parker United Kingdom	95	3.0k 0.4×	25.3k 3.1×	972 0.4×	7.6k 3.3×	3.0k 1.6×	406	33.7k
Kun Ping Lu United States	74	2.8k 0.3×	17.4k 2.1×	697 0.3×	2.6k 1.1×	2.1k 1.1×	208	21.0k
Hiroyoshi Hidaka Japan	59	1.9k 0.2×	9.3k 1.1×	822 0.3×	1.7k 0.7×	2.6k 1.3×	326	14.3k
Per Westermark Sweden	80	9.2k 1.1×	15.6k 1.9×	431 0.2×	3.1k 1.3×	1.3k 0.7×	372	23.1k
Rony Seger Israel	70	1.3k 0.2×	14.9k 1.8×	778 0.3×	3.1k 1.3×	2.7k 1.4×	206	22.2k
Rob Leurs Netherlands	71	2.3k 0.3×	10.9k 1.3×	813 0.3×	294 0.1×	3.8k 2.0×	443	19.1k

Countries citing papers authored by Michael S. Wolfe

Since Specialization

Citations

This map shows the geographic impact of Michael S. Wolfe's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Michael S. Wolfe with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Michael S. Wolfe more than expected).

Fields of papers citing papers by Michael S. Wolfe

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Michael S. Wolfe. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Michael S. Wolfe. The network helps show where Michael S. Wolfe may publish in the future.

Co-authorship network of co-authors of Michael S. Wolfe

This figure shows the co-authorship network connecting the top 25 collaborators of Michael S. Wolfe. A scholar is included among the top collaborators of Michael S. Wolfe based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Michael S. Wolfe. Michael S. Wolfe is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

Sort: Min cites: Since: Top N: Style:

20 of 20 papers shown

Evans, W. Douglas, et al.. (2025). Enhancing college student retention and graduation rates: key findings from a five-year comprehensive approach. Cogent Education. 12(1).

Wolfe, Michael S.. (2025). Presenilin, γ-Secretase, and the Search for Pathogenic Triggers of Alzheimer’s Disease. Biochemistry. 64(8). 1662–1672. 5 indexed citations

Wolfe, Michael S., et al.. (2025). Effects of Transmembrane Phenylalanine Residues on γ-Secretase-Mediated Notch-1 Proteolysis. ACS Chemical Neuroscience. 16(5). 844–855. 2 indexed citations

Zhou, Rui, Masato Maesako, N. Hung, et al.. (2024). Familial Alzheimer mutations stabilize synaptotoxic γ-secretase-substrate complexes. Cell Reports. 43(2). 113761–113761. 15 indexed citations

Wolfe, Michael S., et al.. (2024). Automation of quantum dot measurement analysis via explainable machine learning. Machine Learning Science and Technology. 6(1). 15006–15006. 1 indexed citations

Williams, Emily L., et al.. (2024). Alzheimer-mutant γ-secretase complexes stall amyloid β-peptide production. eLife. 13. 3 indexed citations

Aron, Liviu, Chenxi Qiu, M H Liang, et al.. (2023). A neurodegeneration checkpoint mediated by REST protects against the onset of Alzheimer’s disease. Nature Communications. 14(1). 7030–7030. 4 indexed citations

Bhattarai, Apurba, Hung D. Nguyen, Jinan Wang, et al.. (2022). Mechanism of Tripeptide Trimming of Amyloid β-Peptide 49 by γ-Secretase. Journal of the American Chemical Society. 144(14). 6215–6226. 22 indexed citations

Castro, Manuel, et al.. (2022). Verteporfin is a substrate-selective γ-secretase inhibitor that binds the amyloid precursor protein transmembrane domain. Journal of Biological Chemistry. 298(4). 101792–101792. 10 indexed citations

10.

Williams, Todd D., et al.. (2021). Familial Alzheimer’s disease mutations in amyloid protein precursor alter proteolysis by γ-secretase to increase amyloid β-peptides of ≥45 residues. Journal of Biological Chemistry. 296. 100281–100281. 41 indexed citations

11.

Wolfe, Michael S.. (2019). Substrate recognition and processing by γ-secretase. Biochimica et Biophysica Acta (BBA) - Biomembranes. 1862(1). 183016–183016. 31 indexed citations

12.

Bhattarai, Sanjay, et al.. (2019). Designed Helical Peptides as Functional Probes for γ-Secretase. Biochemistry. 58(44). 4398–4407. 5 indexed citations

13.

Montagna, Daniel R., et al.. (2016). The amyloid-beta forming tripeptide cleavage mechanism of γ-secretase. eLife. 5. 125 indexed citations

14.

Wolfe, Michael S.. (2011). γ‐Secretase inhibitors and modulators for Alzheimer’s disease. Journal of Neurochemistry. 120(s1). 89–98. 107 indexed citations

15.

Osenkowski, Pamela, Hua Li, Wenjuan Ye, et al.. (2008). Cryoelectron Microscopy Structure of Purified γ-Secretase at 12 Å Resolution. Journal of Molecular Biology. 385(2). 642–652. 93 indexed citations

16.

Liao, Yung-Feng, et al.. (2004). P1-295 γ-secretase-mediated cleavage of amyloid precursor protein is stimulated by the cytokine-elicited activation of a JNK-dependent MAPK pathway. Neurobiology of Aging. 25. S180–S180. 1 indexed citations

17.

Campbell, William A., et al.. (2003). Presenilin endoproteolysis mediated by an aspartyl protease activity pharmacologically distinct from γ‐secretase. Journal of Neurochemistry. 85(6). 1563–1574. 32 indexed citations

18.

Esler, William P., W. Taylor Kimberly, Beth L. Ostaszewski, et al.. (2000). Transition-state analogue inhibitors of γ-secretase bind directly to presenilin-1. Nature Cell Biology. 2(7). 428–434. 435 indexed citations

19.

Wolfe, Michael S.. (1997). N-Benzoyl-4-(dimethylamino)pyridinium Chloride: Isolation and Use for the Direct Benzoylation of Alcohols. Synthetic Communications. 27(17). 2975–2984. 13 indexed citations

20.

Wolfe, Michael S. & Rogers E. Harry‐O'kuru. (1995). A concise synthesis of 2′-c-methylribonucleosides. Tetrahedron Letters. 36(42). 7611–7614. 14 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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