John M. Sedivy

32.5k citations

161 papers · 20.2k indexed · 10 hit papers · h-index 69

Molecular Biology top 0.1%
Physiology top 0.2%
Oncology top 0.2%
Cancer Research top 0.5%
Immunology top 1%

Co-authors: Utz Herbig Wenyi Wei Jeremy Brown Annie Dutriaux Bert Vogelstein Kenneth W. Kinzler Jessie C. Jeyapalan Christoph Lengauer
Topics: Telomeres, Telomerase, and Senescence (44 papers)Cancer-related Molecular Pathways (28 papers)CRISPR and Genetic Engineering (20 papers)
Cited by: Aging Molecular Biology Physiology
Journals: Nature Science Cell
Partner nations: United States United Kingdom Japan

In The Last Decade

John M. Sedivy

157 papers receiving 19.9k citations

Hit Papers

5 papers align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Requirement for p53 and p21 to Sustain G ₂ Arrest After DNA Damage

1998 2.5k citations John M. Sedivy et al. Science profile →
Mitochondrial DNA Mutations, Oxidative Stress, and Apoptosis in Mammalian Aging

2005 1.7k citations Holly Van Remmen, John M. Sedivy et al. Science profile →
Telomere Shortening Triggers Senescence of Human Cells through a Pathway Involving ATM, p53, and p21CIP1, but Not p16INK4a

2004 990 citations Utz Herbig, John M. Sedivy et al. profile →
Cellular Senescence in Aging Primates

2006 824 citations Utz Herbig, John M. Sedivy et al. Science profile →
Suppression of Raf-1 kinase activity and MAP kinase signalling by RKIP

1999 706 citations Kam C. Yeung, Petra Janosch et al. Nature profile →
Bypass of Senescence After Disruption of p21 ^CIP1/WAF1 Gene in Normal Diploid Human Fibroblasts

1997 653 citations Wenyi Wei, John M. Sedivy et al. Science profile →
Dissociation among in vitro telomerase activity, telomere maintenance, and cellular immortalization

1998 533 citations William C. Hahn, Wenyi Wei et al. profile →
LINE1 Derepression in Aged Wild-Type and SIRT6-Deficient Mice Drives Inflammation

2019 305 citations Marco De Cecco, Stephen L. Helfand et al. profile →
The role of retrotransposable elements in ageing and age-associated diseases

2021 232 citations Vera Gorbunova, Andrei Seluanov et al. Nature profile →
Inflammation, epigenetics, and metabolism converge to cell senescence and ageing: the regulation and intervention

2021 214 citations John M. Sedivy et al. profile →

Peers

Countries citing papers authored by John M. Sedivy

Since Specialization

Citations

This map shows the geographic impact of John M. Sedivy's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by John M. Sedivy with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites John M. Sedivy more than expected).

Fields of papers citing papers by John M. Sedivy

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by John M. Sedivy. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by John M. Sedivy. The network helps show where John M. Sedivy may publish in the future.

Co-authorship network of co-authors of John M. Sedivy

This figure shows the co-authorship network connecting the top 25 collaborators of John M. Sedivy. A scholar is included among the top collaborators of John M. Sedivy based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with John M. Sedivy. John M. Sedivy is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

#	Work	Indexed citations
1	RNA transcripts in salivary extracellular vesicle cargo isolated from aged populations 2026 ·Frontiers in Aging ·Sicheng Wen,(unknown),(unknown),(unknown),(unknown),(unknown),(unknown),(unknown),(unknown),John M. Sedivy,(unknown),P. J. Quesenberry,Jill A. Kreiling	0
2	TE-Seq: a transposable element annotation and RNA-Seq pipeline 2025 ·Mobile DNA ·(unknown),Radha L. Kalekar,John M. Sedivy	0
3	Rapid DNA cleavage by the LINE-1 endonuclease proximal to DNA ends and at mismatches 2025 ·Journal of Biological Chemistry ·(unknown),(unknown),Trevor van Eeuwen,(unknown),(unknown),Hua Jiang,Alison D. O’Brien,Nan Dai,Robert J. Trachman,Shengxi Guan,Jennifer Flynn,Wen‐Chih Cheng,John M. Sedivy,G. Jogl,Michael P. Rout,John LaCava,Kathleen H. Burns,Martin S. Taylor	1
4	LINE-1 retrotransposon expression in cancerous, epithelial and neuronal cells revealed by 5′ single-cell RNA-Seq 2023 ·Nucleic Acids Research ·Wilson McKerrow,(unknown),Nicole Doudican,(unknown),(unknown),Shane A. Evans,Azucena Rocha,John M. Sedivy,Nicola Neretti,John A. Carucci,Jef D. Boeke,David Fenyö	12
5	Proceedings of the inaugural Dark Genome Symposium: November 2022 2023 ·Mobile DNA ·Jef D. Boeke,Kathleen H. Burns,Katherine B. Chiappinelli,Marie Classon,John M. Coffin,(unknown),Joseph Dukes,Benjamin D. Greenbaum,George Kassiotis,Sarah K. Knutson,Arnold J. Levine,Avindra Nath,Sophie Papa,Daniel Ríos,John M. Sedivy,David T. Ting	3
6	The role of retrotransposable elements in ageing and age-associated diseasesbreakdown → 2021 ·Nature ·Vera Gorbunova,Andrei Seluanov,Paolo Mita,Wilson McKerrow,David Fenyö,Jef D. Boeke,Sara B. Linker,Fred H. Gage,Jill A. Kreiling,Anna P. Petrashen,(unknown),Jackson Taylor,Stephen L. Helfand,John M. Sedivy	232
7	Reduced Expression of MYC Increases Longevity and Enhances Healthspan 2015 ·Cell ·Jeffrey W. Hofmann,Xiaoai Zhao,Marco De Cecco,(unknown),Luca Pagliaroli,(unknown),Gene B. Hubbard,Yuji Ikeno,Yongqing Zhang,Bin Feng,Xiaxi Li,T. Serre,Wenbo Qi,Holly Van Remmen,Richard A. Miller,Kevin G. Bath,Rafael de Cabo,Haiyan Xu,Nicola Neretti,John M. Sedivy	203
8	Postnatal liver growth and regeneration are independent of c-myc in a mouse model of conditional hepatic c-myc deletion 2012 ·BMC Physiology ·Jennifer A. Sanders,Christoph Schorl,(unknown),John M. Sedivy,Philip A. Gruppuso	30
9	Proteomic profiling of Myc-associated proteins 2010 ·Cell Cycle ·Pooja Agrawal,Kebing Yu,Arthur R. Salomon,John M. Sedivy	52
10	How Does Proliferative Homeostasis Change With Age? What Causes It and How Does It Contribute to Aging? 2009 ·The Journals of Gerontology Series A ·J. Campisi,John M. Sedivy	37
11	8 Cellular Senescence: A Link between Tumor Suppression and Organismal Aging? 2008 ·Cold Spring Harbor Monograph Archive ·John M. Sedivy,Ursula Muñoz-Nájar,Jessie C. Jeyapalan,Judith Campisi	8
12	Reconstructing networks of pathways via significance analysis of their intersections 2008 ·BMC Bioinformatics ·Mirko Francesconi,Daniel Remondini,Nicola Neretti,John M. Sedivy,Leon N. Cooper,E. Verondini,Luciano Milanesi,Gastone Castellani	41
13	Microarray analysis of glial cells resistant to JCV infection suggests a correlation between viral infection and inflammatory cytokine gene expression 2007 ·Virology ·Kate Manley,Gretchen V. Gee,Carl P. Simkevich,John M. Sedivy,Walter J. Atwood	8
14	Cellular Senescence in Aging Primatesbreakdown → 2006 ·Science ·Utz Herbig,(unknown),(unknown),(unknown),John M. Sedivy	824
15	C-Myc–Independent Restoration of Multiple Phenotypes by Two C-Myc Target Genes with Overlapping Functions 2005 ·Cancer Research ·(unknown),Kenneth Rogulski,(unknown),Amy B. Heagle,John M. Sedivy,Lixia Pu,Edward V. Prochownik	55
16	Abolition of Cyclin-Dependent Kinase Inhibitor p16 ^Ink4a and p21 ^Cip1/Waf1 Functions Permits Ras-Induced Anchorage-Independent Growth in Telomerase-Immortalized Human Fibroblasts 2003 ·Molecular and Cellular Biology ·Wenyi Wei,(unknown),Wen Chen,William C. Hahn,John M. Sedivy	58
17	Involvement of the INK4a/Arf gene locus in senescence 2003 ·Aging Cell ·Carol Collins,John M. Sedivy	84
18	Myc Potentiates Apoptosis by Stimulating Bax Activity at the Mitochondria 2001 ·Molecular and Cellular Biology ·Erinn Soucié,Matthew G. Annis,John M. Sedivy,Jorge Filmus,Brian Leber,David W. Andrews,Linda Z. Penn	120
19	Mechanism of Suppression of the Raf/MEK/Extracellular Signal-Regulated Kinase Pathway by the Raf Kinase Inhibitor Protein 2000 ·Molecular and Cellular Biology ·Kam C. Yeung,Petra Janosch,Brian W. McFerran,David W. Rose,Harald Mischak,John M. Sedivy,Walter Kölch	304
20	c-Myc Regulates Cyclin D-Cdk4 and -Cdk6 Activity but Affects Cell Cycle Progression at Multiple Independent Points 1999 ·Molecular and Cellular Biology ·Maria K. Mateyak,Álvaro J. Obaya,John M. Sedivy	279

About John M. Sedivy

John M. Sedivy is a scholar working on Aging, Physiology and Molecular Biology, having authored 161 papers that have together received 20.2k indexed citations. Recurring topics across this work include Telomeres, Telomerase, and Senescence (44 papers), Cancer-related Molecular Pathways (28 papers) and CRISPR and Genetic Engineering (20 papers). The work is most often cited by research in Aging (1.5k citations), Molecular Biology (14.6k citations) and Physiology (5.1k citations). John M. Sedivy has collaborated with scholars based in United States, United Kingdom and Japan. Frequent co-authors include Utz Herbig, Wenyi Wei, Jeremy Brown, Annie Dutriaux, Bert Vogelstein, Kenneth W. Kinzler, Jessie C. Jeyapalan, Christoph Lengauer, Fred Bunz and Steven Zhou. Their work appears in journals such as Nature, Science and Cell.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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