George Thomas

32.7k total citations · 11 hit papers
162 papers, 24.4k citations indexed

About

George Thomas is a scholar working on Molecular Biology, Oncology and Cell Biology. According to data from OpenAlex, George Thomas has authored 162 papers receiving a total of 24.4k indexed citations (citations by other indexed papers that have themselves been cited), including 144 papers in Molecular Biology, 27 papers in Oncology and 19 papers in Cell Biology. Recurrent topics in George Thomas's work include PI3K/AKT/mTOR signaling in cancer (50 papers), Protein Kinase Regulation and GTPase Signaling (39 papers) and RNA modifications and cancer (20 papers). George Thomas is often cited by papers focused on PI3K/AKT/mTOR signaling in cancer (50 papers), Protein Kinase Regulation and GTPase Signaling (39 papers) and RNA modifications and cancer (20 papers). George Thomas collaborates with scholars based in Switzerland, United States and Spain. George Thomas's co-authors include Sara C. Kozma, Patrick B. Dennis, Sung Hee Um, Stefano Fumagalli, Ernst Hafen, Stephen G. Dann, Manel Joaquin, Hugo Stocker, Jacques Montagne and Anand Selvaraj and has published in prestigious journals such as Nature, Science and Cell.

In The Last Decade

George Thomas

162 papers receiving 23.9k citations

Hit Papers

5 papers align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity

2004 1.3k citations Sung Hee Um, Melanie Sticker et al. profile →
Inhibition of mTORC1 leads to MAPK pathway activation through a PI3K-dependent feedback loop in human cancer

2008 1.1k citations Andrea Alimonti, George Thomas et al. profile →
Hypothalamic mTOR Signaling Regulates Food Intake

2006 993 citations Daniela Cota, Karine Proulx et al. Science profile →
Insulin Activation of Rheb, a Mediator of mTOR/S6K/4E-BP Signaling, Is Inhibited by TSC1 and 2

2003 832 citations Takahiro Nobukuni, Sara C. Kozma et al. profile →
Mammalian TOR: A Homeostatic ATP Sensor

2001 795 citations Patrick B. Dennis, Sara C. Kozma et al. Science profile →
Metformin, Independent of AMPK, Inhibits mTORC1 in a Rag GTPase-Dependent Manner

2010 718 citations Anand Selvaraj, Patrick B. Dennis et al. profile →
S6K1 ^−/− / S6K2 ^−/− Mice Exhibit Perinatal Lethality and Rapamycin-Sensitive 5′-Terminal Oligopyrimidine mRNA Translation and Reveal a Mitogen-Activated Protein Kinase-Dependent S6 Kinase Pathway

2004 623 citations Mario Pende, Sung Hee Um et al. Molecular and Cellular Biology profile →
Drosophila S6 Kinase: A Regulator of Cell Size

1999 605 citations Sara C. Kozma, George Thomas et al. Science profile →
Amino acids mediate mTOR/raptor signaling through activation of class 3 phosphatidylinositol 3OH-kinase

2005 590 citations Takahiro Nobukuni, George Thomas et al. profile →
Nutrient overload, insulin resistance, and ribosomal protein S6 kinase 1, S6K1

2006 575 citations Sung Hee Um, George Thomas et al. profile →
mTORC1-Mediated Cell Proliferation, But Not Cell Growth, Controlled by the 4E-BPs

2010 549 citations Ryan J.O. Dowling, Ivan Topisirović et al. Science profile →

Peers

Countries citing papers authored by George Thomas

Since Specialization

Citations

This map shows the geographic impact of George Thomas's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by George Thomas with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites George Thomas more than expected).

Fields of papers citing papers by George Thomas

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by George Thomas. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by George Thomas. The network helps show where George Thomas may publish in the future.

Co-authorship network of co-authors of George Thomas

This figure shows the co-authorship network connecting the top 25 collaborators of George Thomas. A scholar is included among the top collaborators of George Thomas based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with George Thomas. George Thomas is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

Sort: Min cites: Since: Top N: Style:

20 of 20 papers shown

#	Work	Indexed citations
1	Engineering neuronal networks in granular microgels to innervate bioprinted cancer organoids on-a-chip 2025 ·Lab on a Chip ·(unknown), (unknown), Jason Cosgrove, Gülsu Şener, (unknown), (unknown), (unknown), (unknown), George Thomas, (unknown), Luiz E. Bertassoni	4
2	A compound directed against S6K1 hampers fat mass expansion and mitigates diet-induced hepatosteatosis 2022 ·JCI Insight ·(unknown), Sónia R. Veiga, Jèssica Latorre, José María Moreno‐Navarrete, Núria Bonifaci, (unknown), You Zhou, Marcus Höring, Gerhard Liebisch, Vesa M. Olkkonen, David Llobet‐Navàs, George Thomas, Ruth Rodríguez‐Barrueco, José Manuel Fernández‐Real, Sara C. Kozma, Francisco Ortega	6
3	Phenformin-Induced Mitochondrial Dysfunction Sensitizes Hepatocellular Carcinoma for Dual Inhibition of mTOR 2018 ·Clinical Cancer Research ·Sónia R. Veiga, Xuemei Ge, Carol A. Mercer, María Isabel Hernández‐Álvarez, Hala Elnakat Thomas, Javier Hernández‐Losa, Santiago Ramón y Cajal, António Zorzano, George Thomas, Sara C. Kozma	36
4	Involvement of S6K1 in mitochondria function and structure in HeLa cells 2016 ·Cellular Signalling ·Jisoo Park, Quangdon Tran, (unknown), Kouhei Masuda, So Hee Kwon, Seon‐Hwan Kim, Dong Hoon Kim, George Thomas, Jongsun Park	9
5	A Phase I Study of Cixutumumab (IMC-A12) in Combination with Temsirolimus (CCI-779) in Children with Recurrent Solid Tumors: A Children's Oncology Group Phase I Consortium Report 2014 ·Clinical Cancer Research ·Maryam Fouladi, John P. Perentesis, Lars M. Wagner, Alexander A. Vinks, Joel M. Reid, Charlotte H. Ahern, George Thomas, Carol A. Mercer, Darcy A. Krueger, Peter J. Houghton, L. Austin Doyle, Helen Chen, Brenda J. Weigel, Susan M. Blaney	16
6	A Synthetic Lethal Screen Reveals Enhanced Sensitivity to ATR Inhibitor Treatment in Mantle Cell Lymphoma with ATM Loss-of-Function 2014 ·Molecular Cancer Research ·Daniel L. Menezes, (unknown), Yan Tang, Jiajia Feng, Paul A. Barsanti, Yue Pan, Majid Ghoddusi, Wei Zhang, George Thomas, Jocelyn Holash, Emma Lees, Lorena Taricani	78
7	Differential Expression of S6K2 Dictates Tissue-Specific Requirement for S6K1 in Mediating Aberrant mTORC1 Signaling and Tumorigenesis 2011 ·Cancer Research ·Caterina Nardella, Andrea Lunardi, Giuseppe Fedele, John G. Clohessy, Andrea Alimonti, Sara C. Kozma, George Thomas, Massimo Loda, Pier Paolo Pandolfi	17
8	mTORC1-Mediated Cell Proliferation, But Not Cell Growth, Controlled by the 4E-BPs breakdown → 2010 ·Science ·Ryan J.O. Dowling, Ivan Topisirović, Tommy Alain, Michael Bidinosti, Bruno D. Fonseca, Emmanuel Petroulakis, Xiaoshan Wang, Ola Larsson, Anand Selvaraj, Yi Liu, Sara C. Kozma, George Thomas, Nahum Sonenberg	549
9	Effective in vivo targeting of the mammalian target of rapamycin pathway in malignant peripheral nerve sheath tumors 2008 ·Molecular Cancer Therapeutics ·Gunnar Johansson, Yonatan Y. Mahller, Margaret H. Collins, Mi‐Ok Kim, Takahiro Nobukuni, John P. Perentesis, Timothy P. Cripe, Heidi A. Lane, Sara C. Kozma, George Thomas, Nancy Ratner	104
10	Hypothalamic mTOR Signaling Regulates Food Intake breakdown → 2006 ·Science ·Daniela Cota, Karine Proulx, (unknown), Sara C. Kozma, George Thomas, Stephen C. Woods, Randy J. Seeley	993
11	S6K1 ^−/− / S6K2 ^−/− Mice Exhibit Perinatal Lethality and Rapamycin-Sensitive 5′-Terminal Oligopyrimidine mRNA Translation and Reveal a Mitogen-Activated Protein Kinase-Dependent S6 Kinase Pathway breakdown → 2004 ·Molecular and Cellular Biology ·Mario Pende, Sung Hee Um, Virginie Mieulet, Melanie Sticker, Valerie L. Goss, Jürgen Mestan, Matthias Mueller, Stefano Fumagalli, Sara C. Kozma, George Thomas	623
12	Cell growth : control of cell size 2004 ·UCL Discovery (University College London) ·Michael N. Hall, Martin Raff, George Thomas	119
13	23 S6 Phosphorylation and Signal Transduction 2000 ·Cold Spring Harbor Monograph Archive ·Stefano Fumagalli, George Thomas	21
14	p70 ^S6K Controls Selective mRNA Translation during Oocyte Maturation and Early Embryogenesis in Xenopus laevis 1999 ·Molecular and Cellular Biology ·Markus S. Schwab, Sang Ho Kim, Naohiro Terada, (unknown), Sara C. Kozma, George Thomas, James L. Maller	51
15	The Insulin-Induced Signalling Pathway Leading to S6 and Initiation Factor 4E Binding Protein 1 Phosphorylation Bifurcates at a Rapamycin-Sensitive Point Immediately Upstream of p70 ^s6k 1997 ·Molecular and Cellular Biology ·(unknown), Patrick B. Dennis, Nick Pullen, Anne‐Claude Gingras, Nahum Sonenberg, George Thomas	204
16	S6 Phosphorylation and the p70 ^s6k /p85 ^s6k 1994 ·Critical Reviews in Biochemistry and Molecular Biology ·Stefano Ferrari, George Thomas	136
17	[12] Micro- and macropurification methods for protein kinases 1991 ·Methods in enzymology on CD-ROM/Methods in enzymology ·Stefano Ferrari, George Thomas	13
18	[22] Purification and properties of mitogen-activated S6 kinase from rat liver and 3T3 cells 1991 ·Methods in enzymology on CD-ROM/Methods in enzymology ·(unknown), George Thomas	29
19	[39] Analysis of 40S ribosomal protein S6 phosphorylation during the mitogenic response 1988 ·Methods in enzymology on CD-ROM/Methods in enzymology ·Joachim Krieg, Andrée R. Olivier, George Thomas	24
20	[34] Separation of multiple phosphorylated forms of 40 S ribosomal protein S6 by two-dimensional polyacrylamide gel electrophoresis 1987 ·Methods in enzymology on CD-ROM/Methods in enzymology ·Michel Siegmann, George Thomas	32

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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