Hilal A. Lashuel

27.7k citations

227 papers · 20.9k indexed · 9 hit papers · h-index 82

Molecular Biology top 0.2%
Physiology top 0.05%
Neurology top 0.05%
Cellular and Molecular Neuroscience top 0.2%
Cell Biology top 0.2%

Co-authors: Peter T. Lansbury Abid Oueslati Thomas Walz Eliezer Masliah Jeffery W. Kelly Dean M. Hartley Benjamin M. Petre Cassia Overk
Topics: Alzheimer's disease research and treatments (89 papers)Parkinson's Disease Mechanisms and Treatments (85 papers)Neurological disorders and treatments (40 papers)
Cited by: Neurology Physiology
Journals: Nature Cell Proceedings of the National Academy of Sciences
Partner nations: Switzerland United States United Kingdom

In The Last Decade

Hilal A. Lashuel

223 papers receiving 20.6k citations

Hit Papers

5 papers align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

The many faces of α-synuclein: from structure and toxicity to therapeutic target

2012 1.3k citations Hilal A. Lashuel, Cassia Overk et al. Nature reviews. Neuroscience profile →
Amyloid pores from pathogenic mutations

2002 1.1k citations Hilal A. Lashuel, Thomas Walz et al. profile →
α-Synuclein, Especially the Parkinson's Disease-associated Mutants, Forms Pore-like Annular and Tubular Protofibrils

2002 662 citations Hilal A. Lashuel, Thomas Walz et al. profile →
The UCH-L1 Gene Encodes Two Opposing Enzymatic Activities that Affect α-Synuclein Degradation and Parkinson's Disease Susceptibility

2002 652 citations Hilal A. Lashuel, Peter T. Lansbury et al. profile →
A century-old debate on protein aggregation and neurodegeneration enters the clinic

2006 572 citations Peter T. Lansbury, Hilal A. Lashuel profile →
Amyloidogenic Protein–Membrane Interactions: Mechanistic Insight from Model Systems

2010 507 citations Hilal A. Lashuel et al. Angewandte Chemie International Edition profile →
The process of Lewy body formation, rather than simply α-synuclein fibrillization, is one of the major drivers of neurodegeneration

2020 463 citations Anne‐Laure Mahul‐Mellier, Johannes Burtscher et al. Proceedings of the National Academy of Sciences profile →
α-Synuclein in Central Nervous System and from Erythrocytes, Mammalian Cells, and Escherichia coli Exists Predominantly as Disordered Monomer

2012 450 citations Bruno Fauvet, Martial Mbefo et al. Journal of Biological Chemistry profile →
Half a century of amyloids: past, present and future

2020 425 citations Hilal A. Lashuel, Marcus Fändrich et al. profile →

Peers

Countries citing papers authored by Hilal A. Lashuel

Since Specialization

Citations

This map shows the geographic impact of Hilal A. Lashuel's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Hilal A. Lashuel with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Hilal A. Lashuel more than expected).

Fields of papers citing papers by Hilal A. Lashuel

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Hilal A. Lashuel. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Hilal A. Lashuel. The network helps show where Hilal A. Lashuel may publish in the future.

Co-authorship network of co-authors of Hilal A. Lashuel

This figure shows the co-authorship network connecting the top 25 collaborators of Hilal A. Lashuel. A scholar is included among the top collaborators of Hilal A. Lashuel based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Hilal A. Lashuel. Hilal A. Lashuel is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

#	Work	Indexed citations
1	O-GlcNAc forces an α-synuclein amyloid strain with notably diminished seeding and pathology 2024 ·Nature Chemical Biology ·Aaron T. Balana,Anne‐Laure Mahul‐Mellier,Binh A. Nguyen,(unknown),(unknown),(unknown),(unknown),Preeti Singh,Shumaila Afrin,(unknown),Virender Singh,Virginia M.‐Y. Lee,Kelvin C. Luk,Lorena Saelices,Hilal A. Lashuel,Matthew R. Pratt	40
2	Label-free identification of protein aggregates using deep learning 2023 ·Nature Communications ·(unknown),Kristin S. Grußmayer,(unknown),(unknown),Hilal A. Lashuel,Aleksandra Rađenović	8
3	Overexpression of human alpha-Synuclein leads to dysregulated microbiome/metabolites with ageing in a rat model of Parkinson disease 2023 ·Molecular Neurodegeneration ·Yogesh Singh,Christoph Trautwein,J. Romaní,Madhuri S. Salker,Peter H. Neckel,(unknown),(unknown),(unknown),Jakob Admard,Achal Dhariwal,Morten Simonsen Dueholm,Karl‐Herbert Schäfer,Florian Läng,Daniel E. Otzen,Hilal A. Lashuel,Olaf Rieß,Nicolas Casadei	22
4	Effective Inhibition of TDP‐43 Aggregation by Native State Stabilization 2023 ·Angewandte Chemie ·Lixin Yang,(unknown),Agnès Zettor,Oscar Vadas,Jeanne Chiaravalli,Fabrice Agou,Hilal A. Lashuel	3
5	Deep Learning-Assisted Single-Molecule Detection of Protein Post-translational Modifications with a Biological Nanopore 2023 ·ACS Nano ·Chan Cao,Pedro Magalhães,Lucien F. Krapp,Juan F. Bada Juarez,(unknown),(unknown),Anass Chiki,Hilal A. Lashuel,Matteo Dal Peraro	32
6	Effective Inhibition of TDP‐43 Aggregation by Native State Stabilization 2023 ·Angewandte Chemie International Edition ·Lixin Yang,(unknown),Agnès Zettor,Oscar Vadas,Jeanne Chiaravalli,Fabrice Agou,Hilal A. Lashuel	9
7	Fully co-factor-free ClearTau platform produces seeding-competent Tau fibrils for reconstructing pathological Tau aggregates 2023 ·Nature Communications ·Galina Limorenko,Meltem Tatlı,Kolla Rajasekhar,Sergey Nazarov,Marie‐Theres Weil,David C. Schöndorf,(unknown),Peter Reinhardt,Dagmar E. Ehrnhoefer,Henning Stahlberg,Laura Gasparini,Hilal A. Lashuel	7
8	Revisiting the specificity and ability of phospho-S129 antibodies to capture alpha-synuclein biochemical and pathological diversity 2022 ·npj Parkinson s Disease ·Hilal A. Lashuel,Anne‐Laure Mahul‐Mellier,Salvatore Novello,(unknown),(unknown),(unknown),Sonia Donzelli,Sean M. DeGuire,Ritwik Burai,Pedro Magalhães,Anass Chiki,(unknown),(unknown),(unknown),Erik Stoops,Christian Iseli,Nicolas Guex	33
9	Alpha-synuclein research: defining strategic moves in the battle against Parkinson’s disease 2021 ·npj Parkinson s Disease ·Luís M. A. Oliveira,Thomas Gasser,Robert H. Edwards,Markus Zweckstetter,Ronald Melki,Leonidas Stefanis,Hilal A. Lashuel,David Sulzer,Kostas Vekrellis,Glenda M. Halliday,Julianna J. Tomlinson,Michael G. Schlossmacher,Poul Henning Jensen,Julia M. Schulze‐Hentrich,Olaf Rieß,Warren D. Hirst,Omar M. A. El‐Agnaf,Brit Mollenhauer,Peter T. Lansbury,Tiago F. Outeiro	96
10	The process of Lewy body formation, rather than simply α-synuclein fibrillization, is one of the major drivers of neurodegenerationbreakdown → 2020 ·Proceedings of the National Academy of Sciences ·Anne‐Laure Mahul‐Mellier,Johannes Burtscher,Niran Maharjan,(unknown),Marie Croisier,Fabien Kuttler,Marion Leleu,Graham Knott,Hilal A. Lashuel	463
11	Unraveling the complexity of amyloid polymorphism using gold nanoparticles and cryo-EM 2020 ·Proceedings of the National Academy of Sciences ·Urszula Cendrowska,Paulo Jacob Silva,Nadine Ait‐Bouziad,Marie Müller,(unknown),Sophie Vieweg,Anass Chiki,Lynn Radamaker,Senthil T. Kumar,Marcus Fändrich,Francesco Tavanti,Maria Cristina Menziani,Alfredo Alexander‐Katz,Francesco Stellacci,Hilal A. Lashuel	55
12	A simple, versatile and robust centrifugation‐based filtration protocol for the isolation and quantification of α‐synuclein monomers, oligomers and fibrils: Towards improving experimental reproducibility in α‐synuclein research 2020 ·Journal of Neurochemistry ·Senthil T. Kumar,Sonia Donzelli,Anass Chiki,(unknown),Hilal A. Lashuel	50
13	Monitoring alpha‐synuclein oligomerization and aggregation using bimolecular fluorescence complementation assays: What you see is not always what you get 2020 ·Journal of Neurochemistry ·(unknown),(unknown),M P Jackson,(unknown),James A. Duce,Hilal A. Lashuel	19
14	Mental Health in Academia: What about faculty? 2020 ·eLife ·Hilal A. Lashuel	2
15	Membrane scission driven by the PROPPIN Atg18 2017 ·The EMBO Journal ·Navin Gopaldass,Bruno Fauvet,Hilal A. Lashuel,Aurélien Roux,Andreas Mayer	59
16	Synthetic polyubiquitinated α-Synuclein reveals important insights into the roles of the ubiquitin chain in regulating its pathophysiology 2013 ·Proceedings of the National Academy of Sciences ·Mahmood Haj‐Yahya,Bruno Fauvet,(unknown),Mirva Hejjaoui,Sudhir N. Bavikar,Subramanian Vedhanarayanan Karthikeyan,Aaron Ciechanover,Hilal A. Lashuel,Ashraf Brik	130
17	The many faces of α-synuclein: from structure and toxicity to therapeutic targetbreakdown → 2012 ·Nature reviews. Neuroscience ·Hilal A. Lashuel,Cassia Overk,Abid Oueslati,Eliezer Masliah	1254
18	Novel chemical tools to facilitate the synthesis and control the folding and Self-assembly of amyloid-forming polypeptides 2011 ·Biopolymers ·(unknown),(unknown),Ashraf Brik,Hilal A. Lashuel	1
19	Phosphorylation of Synucleins by Members of the Polo-like Kinase Family 2009 ·Journal of Biological Chemistry ·Martial Mbefo,Katerina E. Paleologou,Ahmed Boucharaba,Abid Oueslati,Heinrich Schell,Margot Fournier,Diana Olschewski,Guowei Yin,Markus Zweckstetter,Eliezer Masliah,Philipp J. Kahle,Harald Hirling,Hilal A. Lashuel	205
20	Quaternary Structure, Protein Dynamics, and Synaptic Function of SAP97 Controlled by L27 Domain Interactions 2004 ·Neuron ·Terunaga Nakagawa,Kensuke Futai,Hilal A. Lashuel,Irene M.C. Lo,Kenichi Okamoto,Thomas Walz,Yasunori Hayashi,Morgan Sheng	205

About Hilal A. Lashuel

Hilal A. Lashuel is a scholar working on Neurology, Physiology and Cellular and Molecular Neuroscience, having authored 227 papers that have together received 20.9k indexed citations. Recurring topics across this work include Alzheimer's disease research and treatments (89 papers), Parkinson's Disease Mechanisms and Treatments (85 papers) and Neurological disorders and treatments (40 papers). The work is most often cited by research in Neurology (7.4k citations), Physiology (8.6k citations) and Neurology (1.8k citations). Hilal A. Lashuel has collaborated with scholars based in Switzerland, United States and United Kingdom. Frequent co-authors include Peter T. Lansbury, Abid Oueslati, Thomas Walz, Eliezer Masliah, Jeffery W. Kelly, Dean M. Hartley, Benjamin M. Petre, Cassia Overk, Sara M. Butterfield and Bruno Fauvet. Their work appears in journals such as Nature, Cell and Proceedings of the National Academy of Sciences.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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