Daniel E. Otzen

25.9k total citations · 7 hit papers
435 papers, 20.9k citations indexed

About

Daniel E. Otzen is a scholar working on Molecular Biology, Physiology and Neurology. According to data from OpenAlex, Daniel E. Otzen has authored 435 papers receiving a total of 20.9k indexed citations (citations by other indexed papers that have themselves been cited), including 298 papers in Molecular Biology, 123 papers in Physiology and 66 papers in Neurology. Recurrent topics in Daniel E. Otzen's work include Alzheimer's disease research and treatments (116 papers), Protein Structure and Dynamics (107 papers) and Parkinson's Disease Mechanisms and Treatments (66 papers). Daniel E. Otzen is often cited by papers focused on Alzheimer's disease research and treatments (116 papers), Protein Structure and Dynamics (107 papers) and Parkinson's Disease Mechanisms and Treatments (66 papers). Daniel E. Otzen collaborates with scholars based in Denmark, United States and United Kingdom. Daniel E. Otzen's co-authors include Sven Frøkjær, Laura S. Itzhaki, Gunna Christiansen, Mikael Oliveberg, Per Halkjær Nielsen, Alan R. Fersht, Jan Skov Pedersen, Lise Giehm, Jesper Søndergaard Pedersen and Jesper E. Mogensen and has published in prestigious journals such as Proceedings of the National Academy of Sciences, Journal of the American Chemical Society and Chemical Society Reviews.

In The Last Decade

Daniel E. Otzen

426 papers receiving 20.6k citations

Hit Papers

Proliferation of amyloid-β42 aggreg... 1995 2026 2005 2015 2013 2005 1995 2011 2020 250 500 750 1000
What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

  1. Proliferation of amyloid-β42 aggregates occurs through a secondary nucleation mechanism
    2013 1.1k citations Daniel E. Otzen, Tuomas P. J. Knowles et al. Proceedings of the National Academy of Sciences profile →
  2. Protein drug stability: a formulation challenge
    2005 896 citations Daniel E. Otzen et al. profile →
  3. The Structure of the Transition State for Folding of Chymotrypsin Inhibitor 2 Analysed by Protein Engineering Methods: Evidence for a Nucleation-condensation Mechanism for Protein Folding
    1995 631 citations Daniel E. Otzen et al. profile →
  4. Protein–surfactant interactions: A tale of many states
    2011 517 citations Daniel E. Otzen Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics profile →
  5. Half a century of amyloids: past, present and future
    2020 425 citations Tuomas P. J. Knowles, Hilal A. Lashuel et al. profile →
  6. ThT 101: a primer on the use of thioflavin T to investigate amyloid formation
    2017 324 citations Johannes Büchner, Daniel E. Otzen et al. profile →
  7. α‐synuclein oligomers and fibrils: a spectrum of species, a spectrum of toxicities
    2019 224 citations Daniel E. Otzen et al. profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name h Career Trend Papers Cites
Daniel E. Otzen Denmark 73 13.5k 5.8k 3.3k 2.4k 2.3k 435 20.9k
M.R. Sawaya United States 84 21.3k 1.6× 7.4k 1.3× 4.4k 1.3× 3.4k 1.4× 1.7k 0.7× 243 27.9k
Yuji Goto Japan 79 15.7k 1.2× 6.0k 1.0× 4.2k 1.3× 1.8k 0.8× 800 0.3× 377 21.7k
Sheena E. Radford United Kingdom 84 18.7k 1.4× 7.4k 1.3× 6.2k 1.9× 3.1k 1.3× 901 0.4× 355 25.2k
Sara Linse Sweden 79 14.6k 1.1× 9.2k 1.6× 5.4k 1.6× 6.6k 2.8× 1.9k 0.8× 340 27.6k
Anthony L. Fink United States 86 17.8k 1.3× 9.1k 1.6× 4.7k 1.4× 1.7k 0.7× 7.0k 3.0× 231 28.7k
Tuomas P. J. Knowles United Kingdom 88 19.2k 1.4× 14.8k 2.6× 4.0k 1.2× 7.8k 3.3× 4.0k 1.8× 465 32.9k
Ayyalusamy Ramamoorthy United States 86 14.4k 1.1× 6.2k 1.1× 4.0k 1.2× 3.4k 1.4× 325 0.1× 426 26.6k
Jeffery W. Kelly United States 106 29.0k 2.2× 11.7k 2.0× 3.4k 1.0× 2.3k 1.0× 1.5k 0.7× 424 39.8k
Witold K. Surewicz United States 65 11.3k 0.8× 3.1k 0.5× 1.5k 0.5× 982 0.4× 510 0.2× 174 13.9k
David Schubert United States 73 11.0k 0.8× 6.8k 1.2× 947 0.3× 1.1k 0.5× 894 0.4× 196 20.4k

Countries citing papers authored by Daniel E. Otzen

Since Specialization
Citations

This map shows the geographic impact of Daniel E. Otzen's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Daniel E. Otzen with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Daniel E. Otzen more than expected).

Fields of papers citing papers by Daniel E. Otzen

Since Specialization
Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Daniel E. Otzen. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Daniel E. Otzen. The network helps show where Daniel E. Otzen may publish in the future.

Co-authorship network of co-authors of Daniel E. Otzen

This figure shows the co-authorship network connecting the top 25 collaborators of Daniel E. Otzen. A scholar is included among the top collaborators of Daniel E. Otzen based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Daniel E. Otzen. Daniel E. Otzen is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

20 of 20 papers shown
1.
2.
Panigrahi, Rajlaxmi, Arpit Mehrotra, Janni Nielsen, et al.. (2025). Sulfamerazine as a Potential Modulator against α-Synuclein Aggregation and Associated Toxicity. ACS Chemical Neuroscience. 16(5). 880–894. 1 indexed citations
3.
Zhang, Xialin, et al.. (2025). Single-vesicle Tracking of α-Synuclein Oligomers Reveals Pore Formation by a Three-Stage Model. Europe PMC (PubMed Central). 19(36). 32108–32122. 2 indexed citations
4.
Aliakbari, Farhang, et al.. (2025). The neuroprotective effect of human umbilical cord MSCs-derived secretome against α-synuclein aggregates on the blood-brain barrier. International Journal of Biological Macromolecules. 304(Pt 1). 140387–140387. 2 indexed citations
5.
Peña‐Díaz, Samuel, et al.. (2024). Functional Amyloids: The Biomaterials of Tomorrow?. Advanced Materials. 36(18). e2312823–e2312823. 25 indexed citations
6.
Kumar, Rakesh, Luis Enrique Arroyo‐García, Azad Farzadfard, et al.. (2024). Specific inhibition of α‐synuclein oligomer generation and toxicity by the chaperone domain Bri2 BRICHOS. Protein Science. 33(8). e5091–e5091. 4 indexed citations
7.
Mamashli, Fatemeh, Faezeh Moosavi-Movahedi, Ahmad Amiri, et al.. (2024). Cell-Penetrating Peptides: Promising Therapeutics and Drug-Delivery Systems for Neurodegenerative Diseases. Molecular Pharmaceutics. 21(5). 2097–2117. 23 indexed citations
8.
Singh, Yogesh, Christoph Trautwein, J. Romaní, et al.. (2023). Overexpression of human alpha-Synuclein leads to dysregulated microbiome/metabolites with ageing in a rat model of Parkinson disease. Molecular Neurodegeneration. 18(1). 44–44. 22 indexed citations
9.
Aliakbari, Farhang, et al.. (2022). The impact of α-synuclein aggregates on blood-brain barrier integrity in the presence of neurovascular unit cells. International Journal of Biological Macromolecules. 229. 305–320. 21 indexed citations
10.
Otzen, Daniel E., Jannik Nedergaard Pedersen, Helena Østergaard Rasmussen, & Jan Skov Pedersen. (2022). How do surfactants unfold and refold proteins?. Advances in Colloid and Interface Science. 308. 102754–102754. 34 indexed citations
11.
Yamaguchi, K., Masatomo So, Eri Chatani, et al.. (2021). Breakdown of supersaturation barrier links protein folding to amyloid formation. Communications Biology. 4(1). 120–120. 47 indexed citations
12.
Otzen, Daniel E., et al.. (2021). In situ Sub‐Cellular Identification of Functional Amyloids in Bacteria and Archaea by Infrared Nanospectroscopy. Small Methods. 5(6). e2001002–e2001002. 21 indexed citations
13.
Otzen, Daniel E., Alexander K. Buell, & Henrik Jensen. (2021). Microfluidics and the quantification of biomolecular interactions. Current Opinion in Structural Biology. 70. 8–15. 24 indexed citations
14.
Aliakbari, Farhang, Hossein Mohammad‐Beigi, Nasrollah Rezaei‐Ghaleh, et al.. (2020). Multiple Protective Roles of Nanoliposome‐Incorporated Baicalein against Alpha‐Synuclein Aggregates. Advanced Functional Materials. 31(7). 22 indexed citations
15.
Pedersen, Jannik Nedergaard, et al.. (2019). Bacterial amphiphiles as amyloid inducers: Effect of Rhamnolipid and Lipopolysaccharide on FapC fibrillation. Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics. 1867(11). 140263–140263. 25 indexed citations
16.
Mohammad‐Beigi, Hossein, Jannik Nedergaard Pedersen, Gunna Christiansen, et al.. (2019). Plant Polyphenols Inhibit Functional Amyloid and Biofilm Formation in Pseudomonas Strains by Directing Monomers to Off-Pathway Oligomers. Biomolecules. 9(11). 659–659. 36 indexed citations
17.
Lam, Hoa A., Michael Helwig, Nikolai Lorenzen, et al.. (2016). The neural chaperone proSAAS blocks α-synuclein fibrillation and neurotoxicity. Proceedings of the National Academy of Sciences. 113(32). E4708–15. 35 indexed citations
18.
Hein, Kim L., Ulrich Kragh‐Hansen, Jens Preben Morth, et al.. (2010). Crystallographic analysis reveals a unique lidocaine binding site on human serum albumin. Journal of Structural Biology. 171(3). 353–360. 99 indexed citations
19.
Mogensen, Jesper E., et al.. (2005). Barriers to Folding of the Transmembrane Domain of the Escherichia coli Autotransporter Adhesin Involved in Diffuse Adherence. Biochemistry. 44(11). 4533–4545. 25 indexed citations
20.
Umakoshi, Hiroshi, Josefine Persson, Hans-Olof Johansson, et al.. (2000). Model process for separation based on unfolding and refolding of chymotrypsin inhibitor 2 in thermoseparating polymer two-phase systems. Journal of Chromatography B Biomedical Sciences and Applications. 743(1-2). 13–19. 8 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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