Hergen Spits

51.2k total citations · 20 hit papers
336 papers, 39.1k citations indexed

About

Hergen Spits is a scholar working on Immunology, Oncology and Radiology, Nuclear Medicine and Imaging. According to data from OpenAlex, Hergen Spits has authored 336 papers receiving a total of 39.1k indexed citations (citations by other indexed papers that have themselves been cited), including 281 papers in Immunology, 63 papers in Oncology and 62 papers in Radiology, Nuclear Medicine and Imaging. Recurrent topics in Hergen Spits's work include Immune Cell Function and Interaction (176 papers), T-cell and B-cell Immunology (167 papers) and Immunotherapy and Immune Responses (89 papers). Hergen Spits is often cited by papers focused on Immune Cell Function and Interaction (176 papers), T-cell and B-cell Immunology (167 papers) and Immunotherapy and Immune Responses (89 papers). Hergen Spits collaborates with scholars based in Netherlands, United States and France. Hergen Spits's co-authors include J E de Vries, David Artis, James P. Di Santo, Hans Yssel, Tom Cupedo, Bianca Blom, Kees Weijer, Jenny Mjösberg, Andrew N. J. McKenzie and René de Waal Malefyt and has published in prestigious journals such as Nature, Science and Cell.

In The Last Decade

Hergen Spits

334 papers receiving 38.2k citations

Hit Papers

5 papers align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Innate lymphoid cells — a proposal for uniform nomenclature

2013 1.8k citations Hergen Spits et al. profile →
Interleukin 10 (IL-10) and viral IL-10 strongly reduce antigen-specific human T cell proliferation by diminishing the antigen-presenting capacity of monocytes via downregulation of class II major histocompatibility complex expression.

1991 1.7k citations René de Waal Malefyt, Hergen Spits et al. The Journal of Experimental Medicine profile →
Innate Lymphoid Cells: 10 Years On

2018 1.5k citations Hergen Spits et al. profile →
Radiation modulates the peptide repertoire, enhances MHC class I expression, and induces successful antitumor immunotherapy

2006 1.3k citations Eric A. Reits, James W. Hodge et al. The Journal of Experimental Medicine profile →
The biology of innate lymphoid cells

2015 1.2k citations Hergen Spits et al. profile →
Human IL-25- and IL-33-responsive type 2 innate lymphoid cells are defined by expression of CRTH2 and CD161

2011 931 citations Jenny Mjösberg, Cornelis M. van Drunen et al. Nature Immunology profile →
IgE production by normal human lymphocytes is induced by interleukin 4 and suppressed by interferons gamma and alpha and prostaglandin E2.

1988 802 citations Hergen Spits et al. Proceedings of the National Academy of Sciences profile →
Human type 1 innate lymphoid cells accumulate in inflamed mucosal tissues

2013 775 citations Jochem H. Bernink, Kees Weijer et al. Nature Immunology profile →
Normal viability and altered pharmacokinetics in mice lacking mdr1-type (drug-transporting) P-glycoproteins

1997 771 citations Alfred H. Schinkel, Ulrich Mayer et al. Proceedings of the National Academy of Sciences profile →
Identification of a human helper T cell population that has abundant production of interleukin 22 and is distinct from TH-17, TH1 and TH2 cells

2009 771 citations Hergen Spits et al. Nature Immunology profile →
The expanding family of innate lymphoid cells: regulators and effectors of immunity and tissue remodeling

2010 638 citations Hergen Spits et al. Nature Immunology profile →
Human fetal lymphoid tissue–inducer cells are interleukin 17–producing precursors to RORC+ CD127+ natural killer–like cells

2008 542 citations Kees Weijer, Willem E. Fibbe et al. Nature Immunology profile →
Innate Lymphoid Cells: Emerging Insights in Development, Lineage Relationships, and Function

2012 530 citations Hergen Spits et al. profile →
High-throughput epitope discovery reveals frequent recognition of neo-antigens by CD4+ T cells in human melanoma

2014 527 citations Remko Schotte, Hergen Spits et al. profile →
The Transcription Factor GATA3 Is Essential for the Function of Human Type 2 Innate Lymphoid Cells

2012 518 citations Jenny Mjösberg, Jochem H. Bernink et al. profile →
Interleukin-12 and -23 Control Plasticity of CD127+ Group 1 and Group 3 Innate Lymphoid Cells in the Intestinal Lamina Propria

2015 492 citations Jochem H. Bernink, Lisette Krabbendam et al. profile →
Prostaglandin D2 activates group 2 innate lymphoid cells through chemoattractant receptor-homologous molecule expressed on TH2 cells

2014 384 citations Jenny Mjösberg, Hergen Spits et al. Journal of Allergy and Clinical Immunology profile →
IL-1β, IL-4 and IL-12 control the fate of group 2 innate lymphoid cells in human airway inflammation in the lungs

2016 371 citations Suzanne M. Bal, Jochem H. Bernink et al. Nature Immunology profile →
Serum-free medium for generation and propagation of functional human cytotoxic and helper T cell clones

1984 346 citations J E de Vries, Hergen Spits et al. profile →
NK cells and type 1 innate lymphoid cells: partners in host defense

2016 340 citations Hergen Spits, Jochem H. Bernink et al. Nature Immunology profile →

Peers

Countries citing papers authored by Hergen Spits

Since Specialization

Citations

This map shows the geographic impact of Hergen Spits's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Hergen Spits with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Hergen Spits more than expected).

Fields of papers citing papers by Hergen Spits

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Hergen Spits. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Hergen Spits. The network helps show where Hergen Spits may publish in the future.

Co-authorship network of co-authors of Hergen Spits

This figure shows the co-authorship network connecting the top 25 collaborators of Hergen Spits. A scholar is included among the top collaborators of Hergen Spits based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Hergen Spits. Hergen Spits is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

#	Work	Indexed citations
1	Characterization of human FDCs reveals regulation of T cells and antigen presentation to B cells 2021 ·The Journal of Experimental Medicine ·Balthasar A. Heesters, (unknown), Ilhan Tomris, Robert P. de Vries, Giuliana Magri, Hergen Spits	40
2	Innate lymphoid cells: The missing part of a puzzle in food allergy 2021 ·Allergy ·Ümit Murat Şahiner, Janice A. Layhadi, Korneliusz Golebski, Zsolt István Komlósi, Yaqi Peng, Bülent Enis Şekerel, Stephen R. Durham, Helen A. Brough, Hideaki Morita, Mübeccel Akdiş, Paul Turner, Kari C. Nadeau, Hergen Spits, Cezmi A. Akdiş, Mohamed H. Shamji	21
3	Persistently activated, proliferative memory autoreactive B cells promote inflammation in rheumatoid arthritis 2020 ·Science Translational Medicine ·Hendy Kristyanto, (unknown), Linda M. Slot, Ellen I. H. van der Voort, Priscilla F. Kerkman, Aleida M. Bakker, L.E. Burgers, Robin M. ten Brinck, Annette H M van der Helm–van Mil, Hergen Spits, Dominique Baeten, T. Huizinga, René E. M. Toes, Hans Ulrich Scherer	73
4	Cytokines regulate the antigen-presenting characteristics of human circulating and tissue-resident intestinal ILCs 2020 ·Nature Communications ·Anna Rao, Otto Strauß, Efthymia Kokkinou, Mélanie Bruchard, Kumar Parijat Tripathi, Heinrich Schlums, Anna Carrasco, Luca Mazzurana, Viktória Kónya, Eduardo J. Villablanca, Niklas K. Björkström, Ulrik Lindforss, Hergen Spits, Jenny Mjösberg	50
5	A Chemo-enzymatically Linked Bispecific Antibody Retargets T Cells to a Sialylated Epitope on CD43 in Acute Myeloid Leukemia 2019 ·Cancer Research ·(unknown), (unknown), (unknown), Etsuko Yasuda, (unknown), (unknown), (unknown), (unknown), (unknown), Gemma Moiset, Arjen Q. Bakker, Pauline M. van Helden, Julien Villaudy, Mette D. Hazenberg, Hergen Spits, Koen Wagner	14
6	New insights into the function, development, and plasticity of type 2 innate lymphoid cells 2018 ·Immunological Reviews ·Lisette Krabbendam, Suzanne M. Bal, Hergen Spits, Korneliusz Golebski	66
7	Human innate lymphoid cells 2016 ·Journal of Allergy and Clinical Immunology ·Jenny Mjösberg, Hergen Spits	174
8	IL-1β, IL-4 and IL-12 control the fate of group 2 innate lymphoid cells in human airway inflammation in the lungs breakdown → 2016 ·Nature Immunology ·Suzanne M. Bal, Jochem H. Bernink, Maho Nagasawa, (unknown), Medya Shikhagaie, Korneliusz Golebski, Cornelis M. van Drunen, René Lutter, René E. Jonkers, Pleun Hombrink, Mélanie Bruchard, Julien Villaudy, J. Marius Munneke, (unknown), Jonas S. Erjefält, Hergen Spits, Xavier Romero Ros	371
9	Effective Inhibition of Bone Morphogenetic Protein Function by Highly Specific Llama-Derived Antibodies 2015 ·Molecular Cancer Therapeutics ·Silvia Calpe, Koen Wagner, Mohamed El Khattabi, Lucy Rutten, Cheryl Zimberlin, Edward Dolk, C. Theo Verrips, Jan Paul Medema, Hergen Spits, Kausilia K. Krishnadath	16
10	Synergy between IL-15 and Id2 Promotes the Expansion of Human NK Progenitor Cells, Which Can Be Counteracted by the E Protein HEB Required To Drive T Cell Development 2010 ·The Journal of Immunology ·Remko Schotte, Wendy Dontje, Maho Nagasawa, Yuko Yasuda, Arjen Q. Bakker, Hergen Spits, Bianca Blom	35
11	Radiation modulates the peptide repertoire, enhances MHC class I expression, and induces successful antitumor immunotherapy breakdown → 2006 ·The Journal of Experimental Medicine ·Eric A. Reits, James W. Hodge, Carla Herberts, Tom A. Groothuis, Mala Chakraborty, Elizabeth K. Wansley, Kevin Camphausen, Rosalie M. Luiten, (unknown), Joost Neijssen, Alexander Griekspoor, Elly Mesman, Frank A. W. Verreck, Hergen Spits, Jeffrey Schlom, Peter A. van Veelen, Jacques Neefjes	1346
12	Experimental Models to Study Development and Function of the Human Immune System In Vivo 2006 ·The Journal of Immunology ·Nicolas Legrand, Kees Weijer, Hergen Spits	135
13	Human Thymic Stromal Lymphopoietin Preferentially Stimulates Myeloid Cells 2001 ·The Journal of Immunology ·Pedro A. Reche, Vassili Soumelis, Daniel M. Gorman, (unknown), Man-Ru Liu, Marilyn Travis, Sandra Zurawski, (unknown), Yong-Jun Liu, Hergen Spits, René de Waal Malefyt, Robert A. Kastelein, J. Fernando Bazán	338
14	Immortalization of Human CD8+ T Cell Clones by Ectopic Expression of Telomerase Reverse Transcriptase 2000 ·The Journal of Immunology ·Erik Hooijberg, Janneke J. Ruizendaal, Peter J.F. Snijders, Esther W. M. Kueter, Jan M.M. Walboomers, Hergen Spits	144
15	Normal viability and altered pharmacokinetics in mice lacking mdr1-type (drug-transporting) P-glycoproteins breakdown → 1997 ·Proceedings of the National Academy of Sciences ·Alfred H. Schinkel, Ulrich Mayer, Els Wagenaar, Carla A.A.M. Mol, Liesbeth van Deemter, (unknown), Martin A. van der Valk, Arie C. Voordouw, Hergen Spits, Olaf van Tellingen, J. M. J. M. Zijlmans, Willem E. Fibbe, Piet Borst	771
16	Prethymic CD34+ progenitors capable of developing into T cells are not committed to the T cell lineage 1997 ·The Journal of Immunology ·Bianca Blom, (unknown), (unknown), Kees Weijer, Hergen Spits	53
17	Use of bicistronic retroviral vectors encoding the LacZ gene together with a gene of interest: a method to select producer cells and follow transduced target cells. 1996 ·Data Archiving and Networked Services (DANS) ·Frank J. T. Staal, (unknown), (unknown), (unknown), Hergen Spits	25
18	Polymorphism of Human Fc-Receptors for Mouse Igg1 and Igg2b 1985 ·Transplantation Proceedings ·W.J.M. Tax, Hergen Spits, H. F. M. Hermes, H.W. Willems, P J Capel, R. A. P. Koene	6
19	Characterization of Monoclonal Antibodies Against Cell Surface Molecules Associated with Cytotoxic Activity of Natural and Activated Killer Cells and Cloned CTL Lines 1983 ·Hybridoma ·Hergen Spits, (unknown), Jannie Borst, Cox Terhorst, Annemarie Hekman, J E de Vries	137
20	Comparison of Target Antigens of Monoclonal Reagents OKT5, OKT8, and Leu2A, which Inhibit Effector Function of Human Cytotoxic T Lymphocytes 1983 ·Hybridoma ·Peter M. Snow, Hergen Spits, Jan de Vries, Cox Terhorst	21

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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