Rob Kastelein

7.7k total citations · 4 hit papers
38 papers, 6.4k citations indexed

About

Rob Kastelein is a scholar working on Immunology, Molecular Biology and Oncology. According to data from OpenAlex, Rob Kastelein has authored 38 papers receiving a total of 6.4k indexed citations (citations by other indexed papers that have themselves been cited), including 21 papers in Immunology, 16 papers in Molecular Biology and 12 papers in Oncology. Recurrent topics in Rob Kastelein's work include RNA and protein synthesis mechanisms (8 papers), Immune Cell Function and Interaction (6 papers) and Bacteriophages and microbial interactions (5 papers). Rob Kastelein is often cited by papers focused on RNA and protein synthesis mechanisms (8 papers), Immune Cell Function and Interaction (6 papers) and Bacteriophages and microbial interactions (5 papers). Rob Kastelein collaborates with scholars based in United States, Netherlands and France. Rob Kastelein's co-authors include René de Waal Malefyt, Kevin W. Moore, J E de Vries, Hergen Spits, Hans Yssel, Carl G. Figdor, John B.A.G. Haanen, Maria Grazia Roncarolo, Keith Johnson and Tim R. Mosmann and has published in prestigious journals such as Nature, Proceedings of the National Academy of Sciences and The Journal of Experimental Medicine.

In The Last Decade

Rob Kastelein

37 papers receiving 6.2k citations

Hit Papers

align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Interleukin 10 (IL-10) and viral IL-10 strongly reduce antigen-specific human T cell proliferation by diminishing the antigen-presenting capacity of monocytes via downregulation of class II major histocompatibility complex expression.

1991 1.7k citations René de Waal Malefyt, John B.A.G. Haanen et al. The Journal of Experimental Medicine profile →
Interleukin 10 is a potent growth and differentiation factor for activated human B lymphocytes.

1992 1.1k citations Rob Kastelein, Kevin W. Moore et al. profile →
Isolation and expression of human cytokine synthesis inhibitory factor cDNA clones: homology to Epstein-Barr virus open reading frame BCRFI.

1991 627 citations René de Waal Malefyt, Rob Kastelein et al. profile →
IGIF Does Not Drive Th1 Development but Synergizes with IL-12 for Interferon-γ Production and Activates IRAK and NFκB

1997 620 citations Douglas S. Robinson, Kazuko Shibuya et al. Immunity profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name	h						Papers	Cites
Rob Kastelein United States	24	4.0k	1.3k	1.3k	1.0k	526	38	6.4k
David H. Presky United States	33	4.3k 1.1×	1.4k 1.1×	1.1k 0.9×	776 0.8×	498 0.9×	53	6.1k
John S. Abrams United States	31	2.9k 0.7×	1.2k 0.9×	1.4k 1.1×	684 0.7×	463 0.9×	36	5.6k
Maria Wysocka United States	36	5.6k 1.4×	1.6k 1.3×	1.3k 1.0×	2.1k 2.1×	464 0.9×	59	8.7k
Christoph Mueller Switzerland	49	3.6k 0.9×	1.1k 0.9×	1.8k 1.4×	882 0.9×	1.2k 2.2×	145	6.9k
Maria‐Grazia Roncarolo Italy	29	4.4k 1.1×	1.3k 1.0×	736 0.6×	686 0.7×	614 1.2×	59	6.0k
Thomas A. Fleisher United States	53	5.6k 1.4×	1.8k 1.4×	1.4k 1.1×	1.0k 1.0×	1.0k 2.0×	163	8.1k
Grant Gallagher United Kingdom	35	3.9k 1.0×	1.4k 1.1×	857 0.7×	1.4k 1.4×	442 0.8×	96	6.3k
Clifford M. Snapper United States	47	6.1k 1.5×	902 0.7×	1.7k 1.4×	1.7k 1.7×	412 0.8×	122	9.1k
Carol Clayberger United States	52	7.4k 1.9×	1.4k 1.1×	2.0k 1.6×	1.3k 1.3×	610 1.2×	156	10.7k
Willi K. Born United States	53	8.5k 2.1×	1.1k 0.9×	1.3k 1.0×	1.1k 1.1×	496 0.9×	182	10.5k

Countries citing papers authored by Rob Kastelein

Since Specialization

Citations

This map shows the geographic impact of Rob Kastelein's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Rob Kastelein with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Rob Kastelein more than expected).

Fields of papers citing papers by Rob Kastelein

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Rob Kastelein. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Rob Kastelein. The network helps show where Rob Kastelein may publish in the future.

Co-authorship network of co-authors of Rob Kastelein

This figure shows the co-authorship network connecting the top 25 collaborators of Rob Kastelein. A scholar is included among the top collaborators of Rob Kastelein based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Rob Kastelein. Rob Kastelein is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

Oft, Martin, Navneet Ratti, Sandro Vivona, et al.. (2023). Abstract 1801: STK-012, an a/b-selective IL-2 activates tumor antigen specific CD25+ CD8 T cells to reject tumors without acute vascular toxicity. Cancer Research. 83(7_Supplement). 1801–1801. 1 indexed citations

Aspuria, Paul‐Joseph, Sandro Vivona, Navneet Ratti, et al.. (2022). Abstract 2824: Engineered human IL-2/IL-2Rb orthogonal pairs selectively enhance anti-GPC3 CAR T cells to drive complete responses in solid epithelial tumor models. Cancer Research. 82(12_Supplement). 2824–2824.

Aspuria, Paul‐Joseph, Sandro Vivona, Michele Bauer, et al.. (2021). An orthogonal IL-2 and IL-2Rβ system drives persistence and activation of CAR T cells and clearance of bulky lymphoma. Science Translational Medicine. 13(625). eabg7565–eabg7565. 61 indexed citations

Hunter, Christopher A. & Rob Kastelein. (2012). Interleukin-27: Balancing Protective and Pathological Immunity. Immunity. 37(6). 960–969. 220 indexed citations

Rankin, Andrew L., John B. Mumm, Erin Murphy, et al.. (2009). IL-33 Induces IL-13–Dependent Cutaneous Fibrosis. The Journal of Immunology. 184(3). 1526–1535. 181 indexed citations

Hillyer, Philippa, Maggie Larché, Edward P. Bowman, et al.. (2009). Investigating the role of the interleukin-23/-17A axis in rheumatoid arthritis. Lara D. Veeken. 48(12). 1581–1589. 47 indexed citations

Kleinschek, Melanie A., Uwe Müller, Norbert Schütze, et al.. (2009). Administration of IL-23 engages innate and adaptive immune mechanisms during fungal infection. International Immunology. 22(2). 81–90. 22 indexed citations

Larousserie, Fréderique, Émilie Bardel, Stefan Pflanz, et al.. (2005). Analysis of Interleukin-27 (EBI3/p28) Expression in Epstein-Barr Virus- and Human T-Cell Leukemia Virus Type 1-Associated Lymphomas. American Journal Of Pathology. 166(4). 1217–1228. 59 indexed citations

Larousserie, Fréderique, Stefan Pflanz, Aurore Coulomb L’Herminé, et al.. (2004). Expression of IL‐27 in human Th1‐associated granulomatous diseases. The Journal of Pathology. 202(2). 164–171. 111 indexed citations

10.

Robinson, Douglas S., Kazuko Shibuya, Alice Mui, et al.. (1997). IGIF Does Not Drive Th1 Development but Synergizes with IL-12 for Interferon-γ Production and Activates IRAK and NFκB. Immunity. 7(4). 571–581. 620 indexed citations breakdown →

11.

Rock, Fernando, S. Altmann, Margaret van Heek, Rob Kastelein, & J. Fernando Bazán. (1996). The Liptin Haemopoietic Cytokine Fold is Stabilized by an Intrachain Disulfide Bond. Hormone and Metabolic Research. 28(12). 649–652. 46 indexed citations

12.

Rock, Fernando, D L Peterson, Blair Weig, Rob Kastelein, & J. Fernando Bazán. (1996). Binding of Leptin to the Soluble Ectodomain of Recombinant Leptin Receptor. Hormone and Metabolic Research. 28(12). 748–750. 20 indexed citations

13.

Hon, Floris D. de, Edwin ten Boekel, Claude Clément, et al.. (1995). Functional distinction of two regions of human interleukin 6 important for signal transduction via gp130. Cytokine. 7(5). 398–407. 11 indexed citations

14.

Malefyt, René de Waal, John B.A.G. Haanen, Hergen Spits, et al.. (1991). Interleukin 10 (IL-10) and viral IL-10 strongly reduce antigen-specific human T cell proliferation by diminishing the antigen-presenting capacity of monocytes via downregulation of class II major histocompatibility complex expression.. The Journal of Experimental Medicine. 174(4). 915–924. 1685 indexed citations breakdown →

15.

Lundell, D J, Charles A. Lunn, Robert S. Greenberg, et al.. (1990). Exploiting the cell membrane for the production of heterologous proteins in Escherichia coli. Biotechnology and Applied Biochemistry. 12(5). 567–578. 3 indexed citations

16.

Lundell, Daniel, Robert S. Greenberg, James Fossetta, et al.. (1990). Cytoplasmic and periplasmic expression of a highly basic protein, human interleukin 4, inEscherichia coli. Journal of Industrial Microbiology & Biotechnology. 5(4). 215–227. 13 indexed citations

17.

Go, Ning, Brian E. Castle, Rachel Barrett, et al.. (1990). Interleukin 10, a novel B cell stimulatory factor: unresponsiveness of X chromosome-linked immunodeficiency B cells.. The Journal of Experimental Medicine. 172(6). 1625–1631. 423 indexed citations

18.

Bond, M W, et al.. (1988). Expression, renaturation and purification of recombinant human interleukin 4 from Escherichia coli. European Journal of Biochemistry. 173(1). 109–114. 53 indexed citations

19.

Spits, Hergen, Hans Yssel, Xavier Paliard, et al.. (1988). IL-4 inhibits IL-2-mediated induction of human lymphokine-activated killer cells, but not the generation of antigen-specific cytotoxic T lymphocytes in mixed leukocyte cultures.. The Journal of Immunology. 141(1). 29–36. 143 indexed citations

20.

Kastelein, Rob, Ben Berkhout, & Jan van Duin. (1983). Opening the closed ribosome-binding site of the lysis cistron of bacteriophage MS2. Nature. 305(5936). 741–743. 28 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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