Roel Nusse

71.6k citations

208 papers · 55.1k indexed · 27 hit papers · h-index 99

Impact in

Molecular Biology top 0.01%
- Wnt/β-catenin signaling in development and cancer
- Cancer-related gene regulation
- Developmental Biology and Gene Regulation
- Epigenetics and DNA Methylation
- Kruppel-like factors research
- Pluripotent Stem Cells Research
Aging top 0.1%

Papers in

Molecular Biology 177
- Wnt/β-catenin signaling in development and cancer 114
- Cancer-related gene regulation 75
- Developmental Biology and Gene Regulation 41
- Epigenetics and DNA Methylation 23
- RNA Research and Splicing 13
- Kruppel-like factors research 12
- RNA modifications and cancer 12
Genetics 43
- Virus-based gene therapy research 15

Co-authors: Hans Clevers Catriona Y. Logan Ken M. Cadigan Harold Varmus Karl Willert W. James Nelson Renée van Amerongen Andreas Wodarz
Journals: Development (16 papers)Cell (12 papers)Nature (11 papers)Molecular and Cellular Biology (9 papers)Genes & Development (8 papers)
Partner nations: United States Netherlands United Kingdom

In The Last Decade

Roel Nusse

206 papers receiving 54.0k citations

Hit Papers

15 papers align trajectories log scale

The Wnt Pathway: From Signaling Mechanisms to Synthetic Modulators 2022 · 285 citations

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if any of the following hold:

it has ≥500 total citations;
it reaches ≥1.5× the top-1% citation threshold for papers in the same subfield and year (the threshold is the minimum needed to enter the top 1%, not the average within it);
it reaches the top citation threshold in at least one of its specific research topics.

2022 Annual Review of Biochemistry
2018 Cell
2017 Cell
2015 Nature
2014 Science
2013 Science
2012 Cell
2009 Development
2009 Nature
2006 PLoS Biology
2006 Journal of Biological Chemistry
2005 Cell Research
2004 Annual Review of Cell and Developmental Biology
2004 Science
2003 Nature
2003 Nature
2002 Science
1999 Nature
1998 Annual Review of Cell and Developmental Biology
1998 Current Opinion in Genetics & Development
1997 Genes & Development
1996 Nature
1992 Cell
1988 New England Journal of Medicine
1987 Cell
1984 Nature
1982 Cell

Peers

Countries citing papers authored by Roel Nusse

Since Specialization

Citations

This map shows the geographic impact of Roel Nusse's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Roel Nusse with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Roel Nusse more than expected).

Fields of papers citing papers by Roel Nusse

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Roel Nusse. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Roel Nusse. The network helps show where Roel Nusse may publish in the future.

Co-authorship network

The 25 scholars most cited alongside Roel Nusse, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Roel Nusse Line = papers co-authored together Roel Nusse links everyone, so they are left out of the graph.

All Works

Sort: Min cites: Since: Top N: Style:

20 of 20 papers shown

#	Work
1	Deletion of an enhancer that controls Wnt gene expression following tissue injury produces increased adipogenesis in regenerated muscle Development ·Catriona Y. Logan, Xinhong Lim, 佐々木威治, Makiko Mizutani, Francisco Javier Vázquez Mojarro, Roel Nusse	2025	0
2	An integral program for tissue renewal and regeneration: Wnt signaling and stem cell control Science ·Hans Clevers, Kyle M. Loh, Roel Nusse Hit paper breakdown →	2014	1034
3	Interfollicular Epidermal Stem Cells Self-Renew via Autocrine Wnt Signaling Science ·Xinhong Lim, Si Hui Tan, Winston Koh, Rosanna Man Wah Chau, Kelley S. Yan, Calvin J. Kuo, Renée van Amerongen, Allon M. Klein, Roel Nusse	2013	275
4	Wnt signaling : a subject collection from Cold Spring Harbor Perspectives in Biology Roel Nusse, Xi He, Renée van Amerongen	2013	12
5	ROR2 is a novel prognostic biomarker and a potential therapeutic target in leiomyosarcoma and gastrointestinal stromal tumour The Journal of Pathology ·Badreddin Edris, Íñigo Espinosa, Thomas Mühlenberg, Amanda Mikels, Cheng‐Han Lee, Sonja E. Steigen, Shirley Zhu, Kelli Montgomery, Alexander J. Lazar, Dina Lev, Jonathan A. Fletcher, Andrew H. Beck, Robert B. West, Roel Nusse, Matt van de Rijn	2012	66
6	Illegitimate WNT Pathway Activation by β-Catenin Mutation or Autocrine Stimulation in T-Cell Malignancies Cancer Research ·Richard W.J. Groen, Monique E.C.M. Oud, Esther J.M. Schilder-Tol, Marije B. Overdijk, Derk ten Berge, Roel Nusse, Marcel Spaargaren, Steven T. Pals	2008	38
7	Asymmetric Homotypic Interactions of the Atypical Cadherin Flamingo Mediate Intercellular Polarity Signaling Cell ·Alberty Fragoso, Dragana Antic, Maja Matis, Catriona Y. Logan, Michael Povelones, Graham A. Anderson, Roel Nusse, Jeffrey D. Axelrod	2008	195
8	A Dedicated Wnt Secretion Factor Cell ·Т.Я. Кузнецова, Roel Nusse	2006	44
9	Analysis of the role of Sfrps in modulating Wnt-3a activity. Developmental Biology ·Tiffany Barnes, Lisa M. Galli, 直実貴嶋, Philippa H. Francis‐West, Karl Willert, Roel Nusse, Paola Bovolenta, Laura W. Burrus	2004	1
10	Dishevelled 2 Recruits ß-Arrestin 2 to Mediate Wnt5A-Stimulated Endocytosis of Frizzled 4 Science ·Wei Chen, Derk ten Berge, LI Lv-bing, Seungkirl Ahn, Liaoyuan A. Hu, William E. Miller, Marc G. Caron, Larry S. Barak, Roel Nusse, Robert J. Lefkowitz	2003	281
11	Wnt proteins are lipid-modified and can act as stem cell growth factors Nature ·Karl Willert, Jeffrey D. Brown, Esther Danenberg, Andrew W. Duncan, Irving L. Weissman, Tannishtha Reya, John R. Yates, Roel Nusse Hit paper breakdown →	2003	1760
12	Ablation of Insulin-Producing Neurons in Flies: Growth and Diabetic Phenotypes Science ·Eric Rulifson, Seung K. Kim, Roel Nusse Hit paper breakdown →	2002	854
13	Wingless blocks bristle formation and morphogenetic furrow progression in the eye through repression of Daughterless Development ·Ken M. Cadigan, Elena Espinosa Mangana, Roel Nusse	2002	49
14	Pathway Specificity by the Bifunctional Receptor Frizzled Is Determined by Affinity for Wingless Molecular Cell ·Eric Rulifson, M. Westhoff-Bleck, Roel Nusse	2000	113
15	MECHANISMS OF WNT SIGNALING IN DEVELOPMENT Annual Review of Cell and Developmental Biology ·Andreas Wodarz, Roel Nusse Hit paper breakdown →	1998	1673
16	β-catenin: a key mediator of Wnt signaling Current Opinion in Genetics & Development ·Karl Willert, Roel Nusse Hit paper breakdown →	1998	641
17	A novel human homologue of the Drosophila frizzled wnt receptor gene binds wingless protein and is in the Williams syndrome deletion at 7q11.23 Human Molecular Genetics ·Ariana F. VanDillen, N. Lagakos, Risa Peoples, Luis A. Pérez‐Jurado, Roel Nusse, Uta Francke	1997	132
18	The Drosophila Wnt Protein DWnt-3 Is a Secreted Glycoprotein Localized on the Axon Tracts of the Embryonic CNS Developmental Biology ·Lee G. Fradkin, Jasprien Noordermeer, Roel Nusse	1995	57
19	Amplification of the neu (c- erbB-2 ) Oncogene in Human Mammmary Tumors is Relatively Frequent and is Often Accompanied by Amplification of the Linked c- erbA Oncogene Molecular and Cellular Biology ·Marc J. van de Vijver, Junhua Chen, Peter Devilee, Cornelisse Cj, Johannes L. Peterse, Roel Nusse	1987	73
20	Retroviral insertional mutagenesis in murine mammary cancer Proceedings of the Royal Society of London. Series B, Biological sciences ·Roel Nusse, Albert van Ooyen, F.A.M. Rijsewijk, Maarten van Lohuizen, Ed Schuuring, K-P. Guenther	1985	14

About Roel Nusse

Roel Nusse is a scholar working on Molecular Biology, Genetics, Cell Biology, Aging and Developmental Neuroscience, having authored 208 papers that have together received 55.1k indexed citations. Recurring topics across this work include Wnt/β-catenin signaling in development and cancer (114 papers), Cancer-related gene regulation (75 papers), Developmental Biology and Gene Regulation (41 papers), Epigenetics and DNA Methylation (23 papers), Virus-based gene therapy research (15 papers), RNA Research and Splicing (13 papers), Kruppel-like factors research (12 papers) and RNA modifications and cancer (12 papers). The work is most often cited by research in Molecular Biology (43.6k citations), Aging (925 citations), Cell Biology (6.3k citations), Genetics (8.1k citations) and Developmental Neuroscience (1.2k citations). Roel Nusse has collaborated with scholars based in United States, Netherlands and United Kingdom. Frequent co-authors include Hans Clevers, Catriona Y. Logan, Ken M. Cadigan, Harold Varmus, Karl Willert, W. James Nelson, Renée van Amerongen, Andreas Wodarz, Amanda Mikels and Michael D. Gordon. Their work appears in journals such as Development, Cell, Nature, Molecular and Cellular Biology and Genes & Development.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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