George R. Stark

65.2k citations

349 papers · 54.9k indexed · 21 hit papers · h-index 112

Molecular Biology top 0.05%
Oncology top 0.01%
Immunology top 0.02%
Cancer Research top 0.05%
Genetics top 0.1%

Co-authors: James Darnell Ian M. Kerr Geoffrey M. Wahl Michael Stern Robert D. Schreiber Robert H. Silverman James C. Alwine Bryan Williams
Topics: Cytokine Signaling Pathways and Interactions (107 papers)interferon and immune responses (84 papers)NF-κB Signaling Pathways (65 papers)
Cited by: Immunology Oncology Cancer Research
Journals: Nature Science Cell
Partner nations: United States United Kingdom China

In The Last Decade

George R. Stark

347 papers receiving 51.8k citations

Hit Papers

5 papers align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Jak-STAT Pathways and Transcriptional Activation in Response to IFNs and Other Extracellular Signaling Proteins

1994 5.1k citations George R. Stark et al. profile →
HOW CELLS RESPOND TO INTERFERONS

1998 3.3k citations George R. Stark, Ian M. Kerr et al. profile →
Efficient transfer of large DNA fragments from agarose gels to diazobenzyloxymethyl-paper and rapid hybridization by using dextran sulfate.

1979 3.2k citations George R. Stark et al. Proceedings of the National Academy of Sciences profile →
Method for detection of specific RNAs in agarose gels by transfer to diazobenzyloxymethyl-paper and hybridization with DNA probes.

1977 1.7k citations George R. Stark et al. Proceedings of the National Academy of Sciences profile →
Regulation of the G2/M transition by p53

2001 1.3k citations George R. Stark et al. profile →
Interferons at age 50: past, current and future impact on biomedicine

2007 904 citations Ernest C. Borden, Ganes C. Sen et al. Nature Reviews Drug Discovery profile →
Use of Dimethyl Suberimidate, a Cross-Linking Reagent, in Studying the Subunit Structure of Oligomeric Proteins

1970 760 citations George R. Stark et al. Proceedings of the National Academy of Sciences profile →
p53 controls both the G2/M and the G1 cell cycle checkpoints and mediates reversible growth arrest in human fibroblasts.

1995 715 citations George R. Stark et al. Proceedings of the National Academy of Sciences profile →
A Single Phosphotyrosine Residue of Stat91 Required for Gene Activation by Interferon-γ

1993 706 citations George R. Stark et al. profile →
Transcriptional and posttranscriptional regulation of interferon-induced gene expression in human cells

1984 671 citations Ian M. Kerr, George R. Stark et al. profile →
The p53 Network

1998 645 citations Munna L. Agarwal, Olga Chernova et al. Journal of Biological Chemistry profile →
Regulation of Simian Virus 40 Transcription: Sensitive Analysis of the RNA Species Present Early in Infections by Virus or Viral DNA

1979 592 citations George R. Stark et al. profile →
Activation of Phosphatidylinositol 3-Kinase in Response to Interleukin-1 Leads to Phosphorylation and Activation of the NF-κB p65/RelA Subunit

1999 580 citations Nywana Sizemore, George R. Stark et al. Molecular and Cellular Biology profile →
Reactions of the Cyanate Present in Aqueous Urea with Amino Acids and Proteins

1960 563 citations George R. Stark et al. Journal of Biological Chemistry profile →
Transfer of proteins from gels to diazobenzyloxymethyl-paper and detection with antisera: a method for studying antibody specificity and antigen structure.

1979 542 citations George R. Stark et al. Proceedings of the National Academy of Sciences profile →
Unphosphorylated STAT3 accumulates in response to IL-6 and activates transcription by binding to NFκB

2007 513 citations George R. Stark et al. profile →
CARD4/Nod1 mediates NF‐κB and JNK activation by invasive Shigella flexneri

2001 503 citations Stephen E. Girardin, Régis Tournebize et al. EMBO Reports profile →
[15] Detection of specific RNAs or specific fragments of DNA by fractionation in gels and transfer to diazobenzyloxymethyl paper

1979 502 citations George R. Stark et al. Methods in enzymology on CD-ROM/Methods in enzymology profile →
Gene amplification causes overproduction of the first three enzymes of UMP synthesis in N-(phosphonacetyl)-L-aspartate-resistant hamster cells.

1979 431 citations George R. Stark et al. Journal of Biological Chemistry profile →
The JAK-STAT pathway at 30: Much learned, much more to do

2022 385 citations HyeonJoo Cheon, George R. Stark et al. profile →
IFNβ-dependent increases in STAT1, STAT2, and IRF9 mediate resistance to viruses and DNA damage

2013 254 citations HyeonJoo Cheon, Elise Holvey-Bates et al. profile →

Peers

Countries citing papers authored by George R. Stark

Since Specialization

Citations

This map shows the geographic impact of George R. Stark's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by George R. Stark with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites George R. Stark more than expected).

Fields of papers citing papers by George R. Stark

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by George R. Stark. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by George R. Stark. The network helps show where George R. Stark may publish in the future.

Co-authorship network of co-authors of George R. Stark

This figure shows the co-authorship network connecting the top 25 collaborators of George R. Stark. A scholar is included among the top collaborators of George R. Stark based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with George R. Stark. George R. Stark is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

#	Work	Indexed citations
1	H3K9 methylation drives resistance to androgen receptor–antagonist therapy in prostate cancer 2022 ·Proceedings of the National Academy of Sciences ·Mehdi Baratchian,Ritika Tiwari,Sirvan Khalighi,Ankur Chakravarthy,Wei Yuan,(unknown),Jianneng Li,(unknown),Johann S. de Bono,Vladimir Makarov,Timothy A. Chan,Robert H. Silverman,George R. Stark,Vinay Varadan,(unknown),Abhishek A. Chakraborty,Nima Sharifi	35
2	OAS-RNase L innate immune pathway mediates the cytotoxicity of a DNA-demethylating drug 2019 ·Proceedings of the National Academy of Sciences ·Shuvojit Banerjee,Elona Gusho,Christina Gaughan,Beihua Dong,Xiaorong Gu,Elise Holvey-Bates,Manisha Talukdar,Yize Li,Susan R. Weiss,Frank Sicheri,Yogen Saunthararajah,George R. Stark,Robert H. Silverman	50
3	The FACT inhibitor CBL0137 Synergizes with Cisplatin in Small-Cell Lung Cancer by Increasing NOTCH1 Expression and Targeting Tumor-Initiating Cells 2018 ·Cancer Research ·Sarmishtha De,Daniel J. Lindner,(unknown),Gary Wildey,Afshin Dowlati,George R. Stark	37
4	IFNL4 -ΔG Allele Is Associated with an Interferon Signature in Tumors and Survival of African-American Men with Prostate Cancer 2018 ·Clinical Cancer Research ·Wei Tang,Tiffany A. Wallace,Ming Yi,Cristina Magi‐Galluzzi,Tiffany H. Dorsey,Olusegun O. Onabajo,Adeola Obajemu,(unknown),Christopher A. Loffredo,Robert M. Stephens,Robert H. Silverman,George R. Stark,Eric A. Klein,Ludmila Prokunina‐Olsson,Stefan Ambs	38
5	Pharmacological Targeting of the Histone Chaperone Complex FACT Preferentially Eliminates Glioblastoma Stem Cells and Prolongs Survival in Preclinical Models 2016 ·Cancer Research ·Josephine Kam Tai Dermawan,Masahiro Hitomi,Daniel J. Silver,Qiulian Wu,Poorva Sandlesh,Andrew E. Sloan,Andrei A. Purmal,Katerina V. Gurova,Jeremy N. Rich,Justin D. Lathia,George R. Stark,Monica Venere	55
6	NF-κB: Regulation by Methylation 2015 ·Cancer Research ·Tao Lu,George R. Stark	83
7	Quinacrine Overcomes Resistance to Erlotinib by Inhibiting FACT, NF-κB, and Cell-Cycle Progression in Non–Small Cell Lung Cancer 2014 ·Molecular Cancer Therapeutics ·Josephine Kam Tai Dermawan,Katerina V. Gurova,John J. Pink,Afshin Dowlati,Sarmishtha De,Goutham Narla,Neelesh Sharma,George R. Stark	55
8	Unphosphorylated STAT1 prolongs the expression of interferon-induced immune regulatory genes 2009 ·Proceedings of the National Academy of Sciences ·HyeonJoo Cheon,George R. Stark	249
9	p53-Mediated Growth Suppression in Response to Nutlin-3 in Cyclin D1–Transformed Cells Occurs Independently of p21 2007 ·Cancer Research ·(unknown),John T. Patton,George R. Stark,Mark W. Jackson	22
10	Interferons at age 50: past, current and future impact on biomedicinebreakdown → 2007 ·Nature Reviews Drug Discovery ·Ernest C. Borden,Ganes C. Sen,Gilles Uzé,Robert H. Silverman,Richard M. Ransohoff,Graham R. Foster,George R. Stark	904
11	Levels of HdmX Expression Dictate the Sensitivity of Normal and Transformed Cells to Nutlin-3 2006 ·Cancer Research ·John T. Patton,Lindsey D. Mayo,Aatur D. Singhi,Andrei V. Gudkov,George R. Stark,Mark W. Jackson	147
12	Inhibitor of κB kinase is required to activate a subset of interferon γ-stimulated genes 2004 ·Proceedings of the National Academy of Sciences ·Nywana Sizemore,Anju Agarwal,Kingshuk Das,Natalia Lerner,Michael Sulak,Sandhya Rani,Richard M. Ransohoff,David Shultz,George R. Stark	49
13	CARD4/Nod1 mediates NF‐κB and JNK activation by invasive Shigella flexneribreakdown → 2001 ·EMBO Reports ·Stephen E. Girardin,Régis Tournebize,Maria Mavris,Anne‐Laure Page,Xiaoxia Li,George R. Stark,John Bertin,Peter S. DiStefano,Moshé Yaniv,Philippe Sansonetti,Dana J. Philpott	503
14	Roles of Phosphatidylinositol 3-Kinase in Interferon-γ-dependent Phosphorylation of STAT1 on Serine 727 and Activation of Gene Expression 2001 ·Journal of Biological Chemistry ·Hannah Nguyen,Chilakamarti V. Ramana,(unknown),George R. Stark	211
15	MYC Abrogates p53-Mediated Cell Cycle Arrest in N -(Phosphonacetyl)- l -Aspartate-Treated Cells, Permitting CAD Gene Amplification 1998 ·Molecular and Cellular Biology ·Olga Chernova,(unknown),Yukihito Ishizaka,Munna L. Agarwal,George R. Stark	54
16	The Antiviral Effects of the Interferons and Their Inhibition 1992 ·Journal of Interferon Research ·Ian M. Kerr,George R. Stark	56
17	Interferon-Dependent Signaling Pathways: DNA Elements, Transcription Factors, Mutations, and Effects of Viral Proteins 1992 ·Journal of Interferon Research ·George R. Stark,Ian M. Kerr	71
18	Expression of the terminal protein region of hepatitis B virus inhibits cellular responses to interferons alpha and gamma and double-stranded RNA. 1991 ·Proceedings of the National Academy of Sciences ·Graham R. Foster,Andrew M. Ackrill,Robert Goldin,Ian M. Kerr,Howard C. Thomas,George R. Stark	128
19	Properties of Single-Step Mutants of Syrian Hamster Cell Lines Resistant to N -(Phosphonacetyl)-L-Aspartate 1983 ·Molecular and Cellular Biology ·Janine Zieg,Christine Clayton,Feroza Ardeshir,Elena Giulotto,Elizabeth A. Swyryd,George R. Stark	17
20	[14] Isolation of specific RNAs using DNA covalently linked to diazobenzyloxymethyl cellulose or paper 1979 ·Methods in enzymology on CD-ROM/Methods in enzymology ·Michael L. Goldberg,Richard P. Lifton,George R. Stark,Jeffrey G. Williams	86

About George R. Stark

George R. Stark is a scholar working on Oncology, Immunology and Cancer Research, having authored 349 papers that have together received 54.9k indexed citations. Recurring topics across this work include Cytokine Signaling Pathways and Interactions (107 papers), interferon and immune responses (84 papers) and NF-κB Signaling Pathways (65 papers). The work is most often cited by research in Immunology (19.8k citations), Oncology (20.9k citations) and Cancer Research (7.3k citations). George R. Stark has collaborated with scholars based in United States, United Kingdom and China. Frequent co-authors include James Darnell, Ian M. Kerr, Geoffrey M. Wahl, Michael Stern, Robert D. Schreiber, Robert H. Silverman, James C. Alwine, Bryan Williams, Xiaoxia Li and William R. Taylor. Their work appears in journals such as Nature, Science and Cell.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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