James Darnell

87.7k total citations · 32 hit papers
453 papers, 73.6k citations indexed

About

James Darnell is a scholar working on Molecular Biology, Oncology and Genetics. According to data from OpenAlex, James Darnell has authored 453 papers receiving a total of 73.6k indexed citations (citations by other indexed papers that have themselves been cited), including 275 papers in Molecular Biology, 109 papers in Oncology and 75 papers in Genetics. Recurrent topics in James Darnell's work include Cytokine Signaling Pathways and Interactions (98 papers), RNA Research and Splicing (97 papers) and RNA and protein synthesis mechanisms (88 papers). James Darnell is often cited by papers focused on Cytokine Signaling Pathways and Interactions (98 papers), RNA Research and Splicing (97 papers) and RNA and protein synthesis mechanisms (88 papers). James Darnell collaborates with scholars based in United States, United Kingdom and Canada. James Darnell's co-authors include George R. Stark, David T. Levy, Zhong Zhong, Zilong Wen, Jacqueline Bromberg, Christian Schindler, Ke Shuai, Curt M. Horvath, Vincent R. Prezioso and George R. Stark and has published in prestigious journals such as Nature, Science and Cell.

In The Last Decade

James Darnell

445 papers receiving 69.9k citations

Hit Papers

Jak-STAT Pathways and Transcriptional Activ... 1962 2026 1983 2004 1994 1997 2002 1999 1994 1000 2.0k 3.0k 4.0k 5.0k
What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

  1. Jak-STAT Pathways and Transcriptional Activation in Response to IFNs and Other Extracellular Signaling Proteins
    1994 5.1k citations James Darnell et al. profile →
  2. STATs and Gene Regulation
    1997 3.4k citations James Darnell profile →
  3. STATs: transcriptional control and biological impact
    2002 2.6k citations David T. Levy, James Darnell profile →
  4. Stat3 as an Oncogene
    1999 2.5k citations Jacqueline Bromberg, James Darnell et al. profile →
  5. Stat3: a STAT Family Member Activated by Tyrosine Phosphorylation in Response to Epidermal Growth Factor and Interleukin-6
    1994 1.8k citations Zilong Wen, James Darnell et al. profile →
  6. Maximal activation of transcription by statl and stat3 requires both tyrosine and serine phosphorylation
    1995 1.7k citations Zilong Wen, James Darnell et al. profile →
  7. TRANSCRIPTIONAL RESPONSES TO POLYPEPTIDE LIGANDS: The JAK-STAT Pathway
    1995 1.6k citations James Darnell et al. profile →
  8. The JAK-STAT Pathway at Twenty
    2012 1.2k citations James Darnell et al. profile →
  9. The role of STATs in transcriptional control and their impact on cellular function
    2000 1.0k citations Jacqueline Bromberg, James Darnell profile →
  10. Transcription factors as targets for cancer therapy
    2002 947 citations James Darnell profile →
  11. Liver-enriched transcription factor HNF-4 is a novel member of the steroid hormone receptor superfamily.
    1990 934 citations Frances M. Sladek, James Darnell et al. profile →
  12. Sedimentation characteristics of rapidly labelled RNA from HeLa cells
    1962 926 citations James Darnell et al. profile →
  13. Leptin activation of Stat3 in the hypothalamus of wild–type and ob/ob mice but not db/db mice
    1996 922 citations Curt M. Horvath, James Darnell et al. profile →
  14. Choice of STATs and Other Substrates Specified by Modular Tyrosine-Based Motifs in Cytokine Receptors
    1995 840 citations James Darnell et al. profile →
  15. Interferon-Dependent Tyrosine Phosphorylation of a Latent Cytoplasmic Transcription Factor
    1992 776 citations Chris Schindler, Ke Shuai et al. profile →
  16. Interferon activation of the transcription factor Stat91 involves dimerization through SH2-phosphotyrosyl peptide interactions
    1994 709 citations Ke Shuai, Curt M. Horvath et al. profile →
  17. A Single Phosphotyrosine Residue of Stat91 Required for Gene Activation by Interferon-γ
    1993 706 citations Ke Shuai, James Darnell et al. profile →
  18. Activation of Transcription by IFN-γ: Tyrosine Phosphorylation of a 91-kD DNA Binding Protein
    1992 693 citations Ke Shuai, Chris Schindler et al. profile →
  19. The winged-helix transcription factor HNF-3β is required for notochord development in the mouse embryo
    1994 672 citations Vincent R. Prezioso, James Darnell et al. profile →
  20. A majority of m6A residues are in the last exons, allowing the potential for 3′ UTR regulation
    2015 649 citations James Darnell et al. profile →
  21. Variety in the level of gene control in eukaryotic cells
    1982 631 citations James Darnell profile →
  22. Interleukin 12 signaling in T helper type 1 (Th1) cells involves tyrosine phosphorylation of signal transducer and activator of transcription (Stat)3 and Stat4.
    1995 574 citations James Darnell et al. profile →
  23. Crystal Structure of a Tyrosine Phosphorylated STAT-1 Dimer Bound to DNA
    1998 571 citations Xiaohong Chen, James Darnell et al. profile →
  24. Stat3 Activation Is Required for Cellular Transformation by v- src
    1998 553 citations Jacqueline Bromberg, Curt M. Horvath et al. Molecular and Cellular Biology profile →
  25. Transcriptional control in the production of liver-specific mRNAs
    1981 547 citations Kenneth Krauter, James Darnell et al. profile →
  26. Interferon-induced nuclear factors that bind a shared promoter element correlate with positive and negative transcriptional control.
    1988 515 citations David T. Levy, Richard Pine et al. profile →
  27. Polyadenylic Acid Sequences: Role in Conversion of Nuclear RNA into Messenger RNA
    1971 508 citations James Darnell et al. profile →
  28. Signal Transduction and the Control of Gene Expression
    2002 501 citations James Darnell et al. profile →
  29. m6A mRNA modifications are deposited in nascent pre-mRNA and are not required for splicing but do specify cytoplasmic turnover
    2017 425 citations James Darnell et al. profile →
  30. Rapidly labeled HeLa cell nuclear RNA
    1966 416 citations James Darnell et al. Journal of Molecular Biology profile →
  31. POLYRIBOSOMES IN NORMAL AND POLIOVIRUS-INFECTED HELA CELLS AND THEIR RELATIONSHIP TO MESSENGER-RNA
    1963 400 citations James Darnell et al. Proceedings of the National Academy of Sciences profile →
  32. The JAK-STAT pathway at 30: Much learned, much more to do
    2022 385 citations Curt M. Horvath, James Darnell et al. profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name h Career Trend Papers Cites
James Darnell United States 133 40.4k 30.8k 22.7k 9.1k 8.3k 453 73.6k
Ira Pastan United States 146 45.5k 1.1× 30.0k 1.0× 20.3k 0.9× 10.2k 1.1× 3.7k 0.4× 1.2k 90.1k
George R. Stark United States 112 27.8k 0.7× 20.9k 0.7× 19.8k 0.9× 5.3k 0.6× 7.3k 0.9× 349 54.9k
Robert D. Schreiber United States 119 20.7k 0.5× 33.6k 1.1× 48.3k 2.1× 4.6k 0.5× 7.5k 0.9× 385 79.6k
John C. Reed United States 161 73.3k 1.8× 21.4k 0.7× 20.4k 0.9× 6.1k 0.7× 12.2k 1.5× 799 107.5k
Tak W. Mak Canada 156 49.6k 1.2× 22.6k 0.7× 34.0k 1.5× 5.8k 0.6× 17.0k 2.0× 710 96.1k
Shigekazu Nagata Japan 119 42.4k 1.0× 10.8k 0.4× 32.9k 1.5× 5.1k 0.6× 6.6k 0.8× 615 76.5k
Tadatsugu Taniguchi Japan 113 22.8k 0.6× 18.8k 0.6× 34.7k 1.5× 3.9k 0.4× 7.4k 0.9× 285 58.6k
David V. Goeddel United States 106 34.7k 0.9× 12.4k 0.4× 24.1k 1.1× 4.8k 0.5× 16.6k 2.0× 194 64.8k
Tony Hunter United States 155 77.6k 1.9× 23.2k 0.8× 11.8k 0.5× 9.5k 1.0× 8.6k 1.0× 504 103.8k
Vishva M. Dixit United States 141 62.4k 1.5× 13.0k 0.4× 32.9k 1.5× 4.1k 0.5× 15.7k 1.9× 315 88.1k

Countries citing papers authored by James Darnell

Since Specialization
Citations

This map shows the geographic impact of James Darnell's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by James Darnell with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites James Darnell more than expected).

Fields of papers citing papers by James Darnell

Since Specialization
Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by James Darnell. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by James Darnell. The network helps show where James Darnell may publish in the future.

Co-authorship network of co-authors of James Darnell

This figure shows the co-authorship network connecting the top 25 collaborators of James Darnell. A scholar is included among the top collaborators of James Darnell based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with James Darnell. James Darnell is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

20 of 20 papers shown
1.
Schindler, Chris, Ke Shuai, Vincent R. Prezioso, & James Darnell. (2011). Pillars article: Interferon-dependent tyrosine phosphorylation of a latent cytoplasmic transcription factor. Science. 1992. 257: 809-813.. PubMed. 187(11). 5489–94. 5 indexed citations
2.
Zhong, Minghao, Melissa A. Henriksen, Kenji Takeuchi, et al.. (2005). Implications of an antiparallel dimeric structure of nonphosphorylated STAT1 for the activation–inactivation cycle. Proceedings of the National Academy of Sciences. 102(11). 3966–3971. 126 indexed citations
3.
Besser, Daniel, Jacqueline Bromberg, James Darnell, & Hidesaburô Hanafusa. (1999). A Single Amino Acid Substitution in the v-Eyk Intracellular Domain Results in Activation of Stat3 and Enhances Cellular Transformation. Molecular and Cellular Biology. 19(2). 1401–1409. 114 indexed citations
4.
Bromberg, Jacqueline, Curt M. Horvath, Daniel Besser, Wyndham W. Lathem, & James Darnell. (1998). Stat3 Activation Is Required for Cellular Transformation by v- src. Molecular and Cellular Biology. 18(5). 2553–2558. 553 indexed citations breakdown →
5.
Zhu, Xuejun, Zilong Wen, Liang Xu, & James Darnell. (1997). Stat1 Serine Phosphorylation Occurs Independently of Tyrosine Phosphorylation and Requires an Activated Jak2 Kinase. Molecular and Cellular Biology. 17(11). 6618–6623. 144 indexed citations
6.
Sladek, Frances M. & James Darnell. (1992). Mechanisms of liver-specific gene expression. Current Opinion in Genetics & Development. 2(2). 256–259. 56 indexed citations
7.
Mirkovitch, Jovan, Thomas Decker, & James Darnell. (1992). Interferon Induction of Gene Transcription Analyzed by In Vivo Footprinting. Molecular and Cellular Biology. 12(1). 1–9. 23 indexed citations
8.
Veals, Susan A., Chris Schindler, Debra G. B. Leonard, et al.. (1992). Subunit of an Alpha-Interferon-Responsive Transcription Factor Is Related to Interferon Regulatory Factor and Myb Families of DNA-Binding Proteins. Molecular and Cellular Biology. 12(8). 3315–3324. 114 indexed citations
9.
Decker, Thomas, Daniel J. Lew, & James Darnell. (1991). Two Distinct Alpha-Interferon-Dependent Signal Transduction Pathways May Contribute to Activation of Transcription of the Guanylate-Binding Protein Gene. Molecular and Cellular Biology. 11(10). 5147–5153. 14 indexed citations
10.
Lew, Daniel J., Thomas Decker, Inga Strehlow, & James Darnell. (1991). Overlapping Elements in the Guanylate-Binding Protein Gene Promoter Mediate Transcriptional Induction by Alpha and Gamma Interferons. Molecular and Cellular Biology. 11(1). 182–191. 31 indexed citations
11.
Pine, Richard, David T. Levy, Nancy C. Reich, & James Darnell. (1988). Transcriptional stimulation by CaPO4-DNA precipitates. Nucleic Acids Research. 16(4). 1371–1378. 45 indexed citations
12.
Kuo, C. Frank, K. Eric Paulson, & James Darnell. (1988). Positional and Developmental Regulation of Glutamine Synthetase Expression in Mouse Liver. Molecular and Cellular Biology. 8(11). 4966–4971. 22 indexed citations
13.
Georgoff, Ingo, Harriet C. Isom, M. Salditt-Georgieff, & James Darnell. (1986). Liver-specific RNA metabolism in hepatocytes in long-term culture. Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States). 1 indexed citations
14.
Krauter, Kenneth, et al.. (1986). Isolation and Characterization of the α 1 -Antitrypsin Gene of Mice. DNA. 5(1). 29–36. 41 indexed citations
15.
16.
Friedman, Jan M., Lee E. Babiss, David F. Clayton, & James Darnell. (1986). Cellular Promoters Incorporated into the Adenovirus Genome: Cell Specificity of Albumin and Immunoglobulin Expression. Molecular and Cellular Biology. 6(11). 3791–3797. 30 indexed citations
17.
Clayton, David F., Mary C. Weiss, & James Darnell. (1985). Liver-Specific RNA Metabolism in Hepatoma Cells: Variations in Transcription Rates and mRNA Levels. Molecular and Cellular Biology. 5(10). 2633–2641. 84 indexed citations
18.
Babiss, L E, H S Ginsberg, & James Darnell. (1985). Adenovirus E1B Proteins Are Required for Accumulation of Late Viral mRNA and for Effects on Cellular mRNA Translation and Transport. Molecular and Cellular Biology. 5(10). 2552–2558. 120 indexed citations
19.
Nevins, Joseph R., Jean‐Marie Blanchard, & James Darnell. (1980). Transcription units of adenovirus type 2. Journal of Molecular Biology. 144(3). 377–386. 83 indexed citations
20.
Darnell, James. (1979). Transcription Units for mRNA Production in Eukaryotic Cells and Their DNA Viruses. Progress in nucleic acid research and molecular biology. 22. 327–353. 127 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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