James S. Fraser

23.3k total citations · 3 hit papers
113 papers, 7.0k citations indexed

About

James S. Fraser is a scholar working on Molecular Biology, Materials Chemistry and Computational Theory and Mathematics. According to data from OpenAlex, James S. Fraser has authored 113 papers receiving a total of 7.0k indexed citations (citations by other indexed papers that have themselves been cited), including 93 papers in Molecular Biology, 46 papers in Materials Chemistry and 10 papers in Computational Theory and Mathematics. Recurrent topics in James S. Fraser's work include Protein Structure and Dynamics (52 papers), Enzyme Structure and Function (46 papers) and RNA and protein synthesis mechanisms (26 papers). James S. Fraser is often cited by papers focused on Protein Structure and Dynamics (52 papers), Enzyme Structure and Function (46 papers) and RNA and protein synthesis mechanisms (26 papers). James S. Fraser collaborates with scholars based in United States, Canada and France. James S. Fraser's co-authors include Henry van den Bedem, Tom Alber, Nathaniel Echols, Benjamin A. Barad, James M. Holton, Ray Yu‐Ruei Wang, Frank DiMaio, Yifan Cheng, Paul D. Adams and P. Therese Lang and has published in prestigious journals such as Nature, Science and Cell.

In The Last Decade

James S. Fraser

103 papers receiving 6.9k citations

Hit Papers

align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

EMRinger: side chain–directed model and map validation for 3D cryo-electron microscopy

2015 568 citations Benjamin A. Barad, Nathaniel Echols et al. Nature Methods profile →
Discovery and Characterization of Gut Microbiota Decarboxylases that Can Produce the Neurotransmitter Tryptamine

2014 519 citations A.H. Van Benschoten, James S. Fraser et al. profile →
Large language models generate functional protein sequences across diverse families

2023 487 citations James M. Holton, James S. Fraser et al. profile →

Peers

Countries citing papers authored by James S. Fraser

Since Specialization

Citations

This map shows the geographic impact of James S. Fraser's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by James S. Fraser with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites James S. Fraser more than expected).

Fields of papers citing papers by James S. Fraser

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by James S. Fraser. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by James S. Fraser. The network helps show where James S. Fraser may publish in the future.

Co-authorship network of co-authors of James S. Fraser

This figure shows the co-authorship network connecting the top 25 collaborators of James S. Fraser. A scholar is included among the top collaborators of James S. Fraser based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with James S. Fraser. James S. Fraser is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

Sort: Min cites: Since: Top N: Style:

20 of 20 papers shown

#	Work	Indexed citations
1	Expanding automated multiconformer ligand modeling to macrocycles and fragments 2025 ·eLife ·(unknown), Nathaniel Echols, G.J. Correy, (unknown), (unknown), Adam R. Renslo, Henry van den Bedem, James S. Fraser, Stephanie A. Wankowicz	2
2	The impact of library size and scale of testing on virtual screening 2025 ·Nature Chemical Biology ·Fangyu Liu, Olivier Mailhot, (unknown), (unknown), (unknown), Xinyu Xu, (unknown), (unknown), Dmytro S. Radchenko, James S. Fraser, Yurii S. Moroz, John J. Irwin, Brian K. Shoichet	12
3	Exploration of structure-activity relationships for the SARS-CoV-2 macrodomain from shape-based fragment linking and active learning 2025 ·Science Advances ·G.J. Correy, (unknown), (unknown), Stefan Gahbauer, (unknown), (unknown), Priyadarshini Jaishankar, (unknown), Brian Goldman, (unknown), (unknown), Dmytro S. Radchenko, Yurii S. Moroz, Alan Ashworth, Patrick Riley, Brian K. Shoichet, Adam R. Renslo, W. Patrick Walters, James S. Fraser	2
4	Rosace: a robust deep mutational scanning analysis framework employing position and mean-variance shrinkage 2024 ·Genome biology ·J. N. K. Rao, (unknown), Christian B. Macdonald, (unknown), (unknown), Sook Wah Yee, (unknown), James S. Fraser, Willow Coyote‐Maestas, Harold Pimentel	10
5	Automated multiconformer model building for X-ray crystallography and cryo-EM 2024 ·eLife ·Stephanie A. Wankowicz, (unknown), (unknown), Blake T. Riley, (unknown), (unknown), (unknown), Henry van den Bedem, D.A. Keedy, James S. Fraser	5
6	Conserved regulatory motifs in the juxtamembrane domain and kinase N-lobe revealed through deep mutational scanning of the MET receptor tyrosine kinase domain 2023 ·eLife ·(unknown), Edmond M. Linossi, Christian B. Macdonald, (unknown), Jennifer M. Michaud, Willow Coyote‐Maestas, Eric A. Collisson, Natalia Jura, James S. Fraser	6
7	Automated multiconformer model building for X-ray crystallography and cryo-EM 2023 ·eLife ·Stephanie A. Wankowicz, (unknown), (unknown), Blake T. Riley, (unknown), (unknown), (unknown), Henry van den Bedem, D.A. Keedy, James S. Fraser	13
8	Structural characterization of ligand binding and pH-specific enzymatic activity of mouse Acidic Mammalian Chitinase 2023 ·eLife ·Roberto Efraín Díaz, (unknown), G.J. Correy, (unknown), I.D. Young, Bryan Faust, Michael C. Thompson, Ian B. Seiple, Steven J. Van Dyken, Richard M. Locksley, James S. Fraser	1
9	The mechanisms of catalysis and ligand binding for the SARS-CoV-2 NSP3 macrodomain from neutron and x-ray diffraction at room temperature 2022 ·Science Advances ·G.J. Correy, Daniel W. Kneller, G.N. Phillips, Swati Pant, Silvia Russi, Aina E. Cohen, G. Meigs, James M. Holton, Stefan Gahbauer, Michael C. Thompson, Alan Ashworth, Leighton Coates, Andrey Kovalevsky, Flora Meilleur, James S. Fraser	24
10	Directed evolution of the rRNA methylating enzyme Cfr reveals molecular basis of antibiotic resistance 2021 ·eLife ·(unknown), Vanja Stojković, Lianet Noda‐García, I.D. Young, Alexander G. Myasnikov, (unknown), Ali Palla, Stephen N. Floor, Adam Frost, James S. Fraser, Dan S. Tawfik, Danica Galonić Fujimori	17
11	State of the structure address on MET receptor activation by HGF 2021 ·Biochemical Society Transactions ·Edmond M. Linossi, (unknown), Masaya Oshima, James S. Fraser, Eric A. Collisson, Natalia Jura	11
12	Assessment of enzyme active site positioning and tests of catalytic mechanisms through X-ray–derived conformational ensembles 2020 ·Proceedings of the National Academy of Sciences ·Filip Yabukarski, J.T. Biel, Margaux M. Pinney, Tzanko Doukov, Alexander S. Powers, James S. Fraser, Daniel Herschlag	51
13	Expanding the space of protein geometries by computational design of de novo fold families 2020 ·Science ·Xingjie Pan, Michael C. Thompson, Sunny Zhang, Lin Liu, James S. Fraser, Mark J. S. Kelly, Tanja Kortemme	58
14	Differences in the chitinolytic activity of mammalian chitinases on soluble and insoluble substrates 2020 ·Protein Science ·Benjamin A. Barad, Lin Liu, Roberto Efraín Díaz, (unknown), Steven J. Van Dyken, Richard M. Locksley, James S. Fraser	19
15	Computational design of a modular protein sense-response system 2019 ·Science ·Anum Glasgow, Yao-Ming Huang, Daniel J. Mandell, Michael C. Thompson, Ryan Ritterson, Amanda L. Loshbaugh, J. Pellegrino, (unknown), Roland A. Pache, Kyle A. Barlow, Noah Ollikainen, (unknown), Mark J. S. Kelly, James S. Fraser, Tanja Kortemme	92
16	Measuring and modeling diffuse scattering in protein X-ray crystallography 2016 ·Proceedings of the National Academy of Sciences ·A.H. Van Benschoten, Lin Liu, Ana González, Aaron S. Brewster, Nicholas K. Sauter, James S. Fraser, Michael E. Wall	27
17	Conformational variation of proteins at room temperature is not dominated by radiation damage 2016 ·Journal of Synchrotron Radiation ·Silvia Russi, Ana González, Lukas Kenner, D.A. Keedy, James S. Fraser, Henry van den Bedem	47
18	Automated structure refinement of macromolecular assemblies from cryo-EM maps using Rosetta 2016 ·eLife ·Ray Yu‐Ruei Wang, Yifan Song, Benjamin A. Barad, Yifan Cheng, James S. Fraser, Frank DiMaio	298
19	EMRinger: side chain–directed model and map validation for 3D cryo-electron microscopy breakdown → 2015 ·Nature Methods ·Benjamin A. Barad, Nathaniel Echols, Ray Yu‐Ruei Wang, Yifan Cheng, Frank DiMaio, Paul D. Adams, James S. Fraser	568
20	Integrated description of protein dynamics from room-temperature X-ray crystallography and NMR 2014 ·Proceedings of the National Academy of Sciences ·R. Bryn Fenwick, Henry van den Bedem, James S. Fraser, Peter E. Wright	126

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

Explore authors with similar magnitude of impact