Dario A.A. Vignali

50.6k citations
242 papers · 33.4k indexed · 27 hit papers · h-index 85
Co-authors
Creg J. WorkmanLauren W. CollisonKate M. VignaliVijay K. KuchrooLawrence P. AndrewsRichard T. CarsonCharles G. DrakeTullia C. Bruno
Topics
Immune Cell Function and Interaction (147 papers)T-cell and B-cell Immunology (109 papers)Cancer Immunotherapy and Biomarkers (74 papers)
Cited by
ImmunologyOncologyCancer Research
Journals
NatureScienceCell
Partner nations
United StatesUnited KingdomGermany

In The Last Decade

Dario A.A. Vignali

237 papers receiving 33.0k citations

Hit Papers

How regulatory T cells work19922026200320142008200820071996201250010001.5k2.0k
What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

  1. How regulatory T cells work
    2008 2.5k citations Dario A.A. Vignali, Creg J. Workman et al. profile →
  2. Coregulation of CD8+ T cell exhaustion by multiple inhibitory receptors during chronic viral infection
    2008 1.6k citations Creg J. Workman, Gordon J. Freeman et al. Nature Immunology profile →
  3. The inhibitory cytokine IL-35 contributes to regulatory T-cell function
    2007 1.6k citations Creg J. Workman, Kate M. Vignali et al. Nature profile →
  4. Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted State6 gene
    1996 1.1k citations Dario A.A. Vignali et al. Nature profile →
  5. IL-12 family cytokines: immunological playmakers
    2012 1.0k citations Dario A.A. Vignali et al. Nature Immunology profile →
  6. Role of LAG-3 in Regulatory T Cells
    2004 993 citations Creg J. Workman, Dario A.A. Vignali et al. profile →
  7. Requirement for Stat4 in interleukin-12-mediated responses of natural killer and T cells
    1996 976 citations Dario A.A. Vignali et al. Nature profile →
  8. Metabolic support of tumour-infiltrating regulatory T cells by lactic acid
    2021 817 citations McLane J. Watson, Paolo Vignali et al. Nature profile →
  9. Specificity and promiscuity among naturally processed peptides bound to HLA-DR alleles.
    1993 742 citations Dario A.A. Vignali et al. The Journal of Experimental Medicine profile →
  10. Multiplexed particle-based flow cytometric assays
    2000 738 citations Dario A.A. Vignali profile →
  11. LAG3 (CD223) as a cancer immunotherapy target
    2017 684 citations Dario A.A. Vignali et al. profile →
  12. IL-35-mediated induction of a potent regulatory T cell population
    2010 676 citations Creg J. Workman, Dario A.A. Vignali et al. Nature Immunology profile →
  13. Predominant naturally processed peptides bound to HLA-DR1 are derived from MHC-related molecules and are heterogeneous in size
    1992 633 citations Dario A.A. Vignali et al. Nature profile →
  14. Immune Landscape of Viral- and Carcinogen-Driven Head and Neck Cancer
    2020 452 citations Anthony R. Cillo, Tracy Tabib et al. profile →
  15. Stability and function of regulatory T cells is maintained by a neuropilin-1–semaphorin-4a axis
    2013 445 citations Greg M. Delgoffe, Abigail E. Overacre-Delgoffe et al. Nature profile →
  16. Interferon-γ Drives Treg Fragility to Promote Anti-tumor Immunity
    2017 432 citations Abigail E. Overacre-Delgoffe, Maria Chikina et al. profile →
  17. Inhibitory receptors and ligands beyond PD-1, PD-L1 and CTLA-4: breakthroughs or backups
    2019 401 citations Dario A.A. Vignali et al. Nature Immunology profile →
  18. The plasticity and stability of regulatory T cells
    2013 392 citations Dario A.A. Vignali et al. profile →
  19. Adaptive plasticity of IL-10+ and IL-35+ Treg cells cooperatively promotes tumor T cell exhaustion
    2019 388 citations Maria Chikina, Qianxia Zhang et al. Nature Immunology profile →
  20. Interferon-γ: teammate or opponent in the tumour microenvironment?
    2021 343 citations Creg J. Workman, Dario A.A. Vignali et al. profile →
  21. B cell signatures and tertiary lymphoid structures contribute to outcome in head and neck squamous cell carcinoma
    2021 230 citations Anthony R. Cillo, Tracy Tabib et al. profile →
  22. Microbiota-specific T follicular helper cells drive tertiary lymphoid structures and anti-tumor immunity against colorectal cancer
    2021 202 citations Abigail E. Overacre-Delgoffe, Anthony R. Cillo et al. profile →
  23. LAG-3 as the third checkpoint inhibitor
    2023 184 citations Creg J. Workman, Dario A.A. Vignali et al. Nature Immunology profile →
  24. Therapeutic targeting of regulatory T cells in cancer
    2022 143 citations Feng Shan, Ashwin Somasundaram et al. profile →
  25. T Cell Exhaustion
    2024 121 citations Dario A.A. Vignali et al. profile →
  26. LAG-3 and PD-1 synergize on CD8+ T cells to drive T cell exhaustion and hinder autocrine IFN-γ-dependent anti-tumor immunity
    2024 110 citations Jian Cui, Anthony R. Cillo et al. profile →
  27. Blockade of LAG-3 and PD-1 leads to co-expression of cytotoxic and exhaustion gene modules in CD8+ T cells to promote antitumor immunity
    2024 75 citations Anthony R. Cillo, Carly Cardello et al. profile →

Peers

Dario A.A. Vignali
Comparison fields: 5 of 156
  • Immunology 22.9k
  • Oncology 12.2k
  • Molecular Biology 7.0k
  • Genetics 2.5k
  • Epidemiology 2.4k
Replace Yang‐Xin Fu with:
Yang‐Xin Fu United States
Gwendalyn J. Randolph United States
Éric Vivier France
Lieping Chen United States
John J. O’Shea United States
Laurie H. Glimcher United States
Miyuki Azuma Japan
Kenneth M. Murphy United States
Pamela S. Ohashi Canada
Lorenzo Moretta Italy
Dario A.A. Vignali relative to Yang‐Xin Fu United States Yang‐Xin Fu's profile →
Citations per field
00.5×1.5×
Yang‐Xin Fu · 1×
Citations per year

Countries citing papers authored by Dario A.A. Vignali

Since Specialization
Citations

This map shows the geographic impact of Dario A.A. Vignali's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Dario A.A. Vignali with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Dario A.A. Vignali more than expected).

Fields of papers citing papers by Dario A.A. Vignali

Since Specialization
Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Dario A.A. Vignali. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Dario A.A. Vignali. The network helps show where Dario A.A. Vignali may publish in the future.

Co-authorship network of co-authors of Dario A.A. Vignali

This figure shows the co-authorship network connecting the top 25 collaborators of Dario A.A. Vignali. A scholar is included among the top collaborators of Dario A.A. Vignali based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Dario A.A. Vignali. Dario A.A. Vignali is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

20 of 20 papers shown
#WorkIndexed citations
1
Tim-3 Is Required for Regulatory T Cell–Mediated Promotion of T Cell Exhaustion and Viral Persistence during Chronic Lymphocytic Choriomeningitis Virus Infection
2024 ·The Journal of Immunology ·(unknown),(unknown),(unknown),(unknown),(unknown),(unknown),Bingxian Xie,(unknown),Jishnu Das,Dario A.A. Vignali,Greg M. Delgoffe,Larry Kane
1
2
Immune infiltration correlates with transcriptomic subtypes in primary estrogen receptor positive invasive lobular breast cancer
2024 ·npj Precision Oncology ·Fangyuan Chen,Sayali Onkar,Jian Zou,Yujia Li,(unknown),(unknown),George C. Tseng,Peter C. Lucas,Tullia C. Bruno,Dario A.A. Vignali,Julia Foldi,Marija Balić,Adrian V. Lee,Steffi Oesterreich
1
3
IFNγ-induction of TH1-like regulatory T cells controls antiviral responses
2023 ·Nature Immunology ·(unknown),Jian Cui,Andrea L. Szymczak-Workman,Kate M. Vignali,(unknown),(unknown),(unknown),Lyndsay Avery,(unknown),Brydie R. Huckestein,(unknown),Marlies Meisel,John F. Alcorn,Larry Kane,Creg J. Workman,Dario A.A. Vignali
37
4
Integrated BATF transcriptional network regulates suppressive intratumoral regulatory T cells
2023 ·Science Immunology ·Feng Shan,Anthony R. Cillo,Carly Cardello,(unknown),Sheryl Kunning,Jian Cui,Caleb Lampenfeld,(unknown),(unknown),Arjun Pennathur,James D. Luketich,John M. Kirkwood,Robert L. Ferris,Tullia C. Bruno,Creg J. Workman,Panayiotis V. Benos,Dario A.A. Vignali
16
5
End-Stage Idiopathic Pulmonary Fibrosis Lung Microenvironment Promotes Impaired NK Activity
2023 ·The Journal of Immunology ·Tamara Cruz,(unknown),(unknown),(unknown),Nilay Mitash,John Sembrat,Tracy Tabib,Wenping Zhang,(unknown),Victor Peters,(unknown),Dario A.A. Vignali,Ana L. Mora,Robert Lafyatis,Mauricio Rojas
8
6
Autoreactive CD8+ T cells are restrained by an exhaustion-like program that is maintained by LAG3
2022 ·Nature Immunology ·Stephanie Grebinoski,Qianxia Zhang,Anthony R. Cillo,Sasikanth Manne,Hanxi Xiao,Erin A. Brunazzi,Tracy Tabib,Carly Cardello,Christine G. Lian,George F. Murphy,Robert Lafyatis,E. John Wherry,Jishnu Das,Creg J. Workman,Dario A.A. Vignali
70
7
Systemic Immune Dysfunction in Cancer Patients Driven by IL6 Induction of LAG3 in Peripheral CD8+ T Cells
2022 ·Cancer Immunology Research ·Ashwin Somasundaram,Anthony R. Cillo,Caleb Lampenfeld,Creg J. Workman,Sheryl Kunning,(unknown),Maria A. Velez,Sonali Joyce,Michael Calderon,Rebekah Dadey,Dhivyaa Rajasundaram,Daniel P. Normolle,Simon C. Watkins,James G. Herman,John M. Kirkwood,Evan J. Lipson,Robert L. Ferris,Tullia C. Bruno,Dario A.A. Vignali
18
8
Ewing Sarcoma and Osteosarcoma Have Distinct Immune Signatures and Intercellular Communication Networks
2022 ·Clinical Cancer Research ·Anthony R. Cillo,(unknown),Nathanael G. Bailey,Sayali Onkar,(unknown),Cláudia Salgado,(unknown),(unknown),Sarangarajan Ranganathan,Melissa Burgess,John Sembrat,Kurt R. Weiss,Rebecca Watters,Tullia C. Bruno,Dario A.A. Vignali,Kelly M. Bailey
51
9
Antibodies targeting conserved non-canonical antigens and endemic coronaviruses associate with favorable outcomes in severe COVID-19
2022 ·Cell Reports ·(unknown),Syed A. Rahman,Anthony R. Cillo,(unknown),Ashwin Somasundaram,Creg J. Workman,William Bain,Bryan J. McVerry,Barbara A. Methé,Janet Lee,Prabir Ray,Anuradha Ray,Tullia C. Bruno,Dario A.A. Vignali,Georgios D. Kitsios,Alison Morris,Harinder Singh,Aniruddh Sarkar,Jishnu Das
12
10
The Great Immune Escape: Understanding the Divergent Immune Response in Breast Cancer Subtypes
2022 ·Cancer Discovery ·Sayali Onkar,Neil Carleton,Peter C. Lucas,Tullia C. Bruno,Adrian V. Lee,Dario A.A. Vignali,Steffi Oesterreich
133
11
Metabolic support of tumour-infiltrating regulatory T cells by lactic acidbreakdown →
2021 ·Nature ·McLane J. Watson,Paolo Vignali,Steven J. Mullett,Abigail E. Overacre-Delgoffe,Ronal M. Peralta,Stephanie Grebinoski,Ashley V. Menk,Natalie Rittenhouse,Kristin DePeaux,Ryan D. Whetstone,Dario A.A. Vignali,Timothy W. Hand,Amanda C. Poholek,Brett M. Morrison,Jeffrey D. Rothstein,Stacy G. Wendell,Greg M. Delgoffe
817
12
Cancer-associated MSC drive tumor immune exclusion and resistance to immunotherapy, which can be overcome by Hedgehog inhibition
2021 ·Science Advances ·Sandra Cascio,Chelsea Chandler,(unknown),(unknown),Bingsi Gao,Sayali Onkar,Tullia C. Bruno,Dario A.A. Vignali,Haider Mahdi,Hatice U. Osmanbeyoglu,Anda Vlad,Lan Coffman,Ronald J. Buckanovich
54
13
B cell–Derived IL35 Drives STAT3-Dependent CD8+ T-cell Exclusion in Pancreatic Cancer
2020 ·Cancer Immunology Research ·Bhalchandra Mirlekar,Daniel Michaud,Samuel Lee,Nancy P. Kren,(unknown),Kevin G. Greene,Emily C. Goldman,Gaorav P. Gupta,Ryan C. Fields,William G. Hawkins,David G. DeNardo,Naim U. Rashid,Jen Jen Yeh,Autumn J. McRee,Benjamin G. Vincent,Dario A.A. Vignali,Yuliya Pylayeva‐Gupta
92
14
Interleukin-33 activates regulatory T cells to suppress innate γδ T cell responses in the lung
2020 ·Nature Immunology ·Lucas Faustino,Jason W. Griffith,Rod A. Rahimi,(unknown),Daniel L. Hamilos,(unknown),Benjamin D. Medoff,James J. Moon,Dario A.A. Vignali,Andrew D. Luster
76
15
PD-1 restraint of regulatory T cell suppressive activity is critical for immune tolerance
2020 ·The Journal of Experimental Medicine ·(unknown),Juhi R. Kuchroo,Peter T. Sage,Dan Liang,Loise M. Francisco,Jessica N. Buck,Youg Raj Thaker,Qianxia Zhang,Shannon McArdel,Vikram R. Juneja,Sun Jung Lee,Scott B. Lovitch,Christine G. Lian,George F. Murphy,Bruce R. Blazar,Dario A.A. Vignali,Gordon J. Freeman,Arlene H. Sharpe
181
16
LAG3 limits regulatory T cell proliferation and function in autoimmune diabetes
2017 ·Science Immunology ·Qianxia Zhang,Maria Chikina,Andrea L. Szymczak-Workman,William Horne,Jay K. Kolls,Kate M. Vignali,Daniel P. Normolle,Maria Bettini,Creg J. Workman,Dario A.A. Vignali
120
17
Cutting Edge: CD3 ITAM Diversity Is Required for Optimal TCR Signaling and Thymocyte Development
2017 ·The Journal of Immunology ·Matthew L. Bettini,(unknown),Clifford S. Guy,Thomas Lee,Kate M. Vignali,Dario A.A. Vignali
35
18
Prevention of Autoimmune Diabetes by Ectopic Pancreatic β-Cell Expression of Interleukin-35
2012 ·Diabetes ·Maria Bettini,Ashley Castellaw,Greig P. Lennon,Amanda R. Burton,Dario A.A. Vignali
100
19
PD-L1 blockade effectively restores strong graft-versus-leukemia effects without graft-versus-host disease after delayed adoptive transfer of T-cell receptor gene-engineered allogeneic CD8+ T cells
2010 ·Blood ·(unknown),Martin Hapke,Jessica Herbst,Christoph Klein,Karl Welte,(unknown),Andrew Flatley,Dario A.A. Vignali,Matthias Hardtke‐Wolenski,Elmar Jaeckel,Bruce R. Blazar,Martin G. Sauer
63
20
Essential Cytoplasmic Translocation of a Cytokine Receptor–Assembled Signaling Complex
2008 ·Science ·Atsushi Matsuzawa,Ping‐Hui Tseng,Sivakumar Vallabhapurapu,Jun‐Li Luo,Weizhou Zhang,Haopeng Wang,Dario A.A. Vignali,Ewen Gallagher,Michael Karin
179

About Dario A.A. Vignali

Dario A.A. Vignali is a scholar working on Immunology, Oncology and Parasitology, having authored 242 papers that have together received 33.4k indexed citations. Recurring topics across this work include Immune Cell Function and Interaction (147 papers), T-cell and B-cell Immunology (109 papers) and Cancer Immunotherapy and Biomarkers (74 papers). The work is most often cited by research in Immunology (22.9k citations), Oncology (12.2k citations) and Cancer Research (2.4k citations). Dario A.A. Vignali has collaborated with scholars based in United States, United Kingdom and Germany. Frequent co-authors include Creg J. Workman, Lauren W. Collison, Kate M. Vignali, Vijay K. Kuchroo, Lawrence P. Andrews, Richard T. Carson, Charles G. Drake, Tullia C. Bruno, Andrea L. Szymczak-Workman and Greg M. Delgoffe. Their work appears in journals such as Nature, Science and Cell.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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