Dario A.A. Vignali

50.6k citations

242 papers · 33.4k indexed · 27 hit papers · h-index 85

Immunology top 0.01%
- Immune Cell Function and Interaction 147
- T-cell and B-cell Immunology 109
- Immunotherapy and Immune Responses 67
- Immune Response and Inflammation 14
Oncology top 0.05%
- Cancer Immunotherapy and Biomarkers 74
- CAR-T cell therapy research 44
- Cytokine Signaling Pathways and Interactions 11
Cancer Research top 0.5%
Immunology and Allergy top 0.5%
Molecular Biology top 0.5%
Genetics
- Diabetes and associated disorders 22

Co-authors: Creg J. Workman Lauren W. Collison Kate M. Vignali Vijay K. Kuchroo Lawrence P. Andrews Richard T. Carson Charles G. Drake Tullia C. Bruno
Cited by: Immunology Oncology Cancer Research
Partner nations: United States United Kingdom Germany

In The Last Decade

Dario A.A. Vignali

237 papers receiving 33.0k citations

Hit Papers

15 papers align trajectories log scale

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

2024 T Cell Exhaustion
2024 LAG-3 and PD-1 synergize on CD8+ T cells to drive T cell exhaustion and hinder autocrine IFN-γ-dependent anti-tumor immunity
2024 Blockade of LAG-3 and PD-1 leads to co-expression of cytotoxic and exhaustion gene modules in CD8+ T cells to promote antitumor immunity
2023 LAG-3 as the third checkpoint inhibitor
2022 Therapeutic targeting of regulatory T cells in cancer
2021 Interferon-γ: teammate or opponent in the tumour microenvironment?
2021 B cell signatures and tertiary lymphoid structures contribute to outcome in head and neck squamous cell carcinoma
2021 Microbiota-specific T follicular helper cells drive tertiary lymphoid structures and anti-tumor immunity against colorectal cancer
2021 Metabolic support of tumour-infiltrating regulatory T cells by lactic acid
2020 Immune Landscape of Viral- and Carcinogen-Driven Head and Neck Cancer
2019 Inhibitory receptors and ligands beyond PD-1, PD-L1 and CTLA-4: breakthroughs or backups
2019 Adaptive plasticity of IL-10+ and IL-35+ Treg cells cooperatively promotes tumor T cell exhaustion
2017 LAG3 (CD223) as a cancer immunotherapy target
2017 Interferon-γ Drives Treg Fragility to Promote Anti-tumor Immunity
2013 Stability and function of regulatory T cells is maintained by a neuropilin-1–semaphorin-4a axis
2013 The plasticity and stability of regulatory T cells
2012 IL-12 family cytokines: immunological playmakers
2010 IL-35-mediated induction of a potent regulatory T cell population
2008 How regulatory T cells work
2008 Coregulation of CD8+ T cell exhaustion by multiple inhibitory receptors during chronic viral infection
2007 The inhibitory cytokine IL-35 contributes to regulatory T-cell function
2004 Role of LAG-3 in Regulatory T Cells
2000 Multiplexed particle-based flow cytometric assays
1996 Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted State6 gene
1996 Requirement for Stat4 in interleukin-12-mediated responses of natural killer and T cells
1993 Specificity and promiscuity among naturally processed peptides bound to HLA-DR alleles.
1992 Predominant naturally processed peptides bound to HLA-DR1 are derived from MHC-related molecules and are heterogeneous in size

Peers

Countries citing papers authored by Dario A.A. Vignali

Since Specialization

Citations

This map shows the geographic impact of Dario A.A. Vignali's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Dario A.A. Vignali with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Dario A.A. Vignali more than expected).

Fields of papers citing papers by Dario A.A. Vignali

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Dario A.A. Vignali. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Dario A.A. Vignali. The network helps show where Dario A.A. Vignali may publish in the future.

Co-authorship network

The 25 scholars most cited alongside Dario A.A. Vignali, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Dario A.A. Vignali Line = papers co-authored together Dario A.A. Vignali links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

#	Work
1	Tim-3 Is Required for Regulatory T Cell–Mediated Promotion of T Cell Exhaustion and Viral Persistence during Chronic Lymphocytic Choriomeningitis Virus Infection Hector Nieves-Rosado,Hridesh Banerjee,Angela Gocher-Demske,Priyanka Manandhar,Isha Mehta,Ogechukwu Ezenwa,Bingxian Xie,Benjamin Murter,Jishnu Das,Dario A.A. Vignali,Greg M. Delgoffe,Larry Kane	2024	1
2	Immune infiltration correlates with transcriptomic subtypes in primary estrogen receptor positive invasive lobular breast cancer Fangyuan Chen,Sayali Onkar,Jian Zou,Yujia Li,Haley Arbore,Sai Maley,George C. Tseng,Peter C. Lucas,Tullia C. Bruno,Dario A.A. Vignali,Julia Foldi,Marija Balić,Adrian V. Lee,Steffi Oesterreich	2024	1
3	IFNγ-induction of TH1-like regulatory T cells controls antiviral responses Angela M. Gocher-Demske,Jian Cui,Andrea L. Szymczak-Workman,Kate M. Vignali,Julianna Latini,Gwen P. Pieklo,Jesse C. Kimball,Lyndsay Avery,Ellyse Cipolla,Brydie R. Huckestein,Lee Hedden,Marlies Meisel,John F. Alcorn,Larry Kane,Creg J. Workman,Dario A.A. Vignali	2023	37
4	Integrated BATF transcriptional network regulates suppressive intratumoral regulatory T cells Feng Shan,Anthony R. Cillo,Carly Cardello,Daniel Y. Yuan,Sheryl Kunning,Jian Cui,Caleb Lampenfeld,Asia M. Williams,Alexandra P. McDonough,Arjun Pennathur,James D. Luketich,John M. Kirkwood,Robert L. Ferris,Tullia C. Bruno,Creg J. Workman,Panayiotis V. Benos,Dario A.A. Vignali	2023	16
5	End-Stage Idiopathic Pulmonary Fibrosis Lung Microenvironment Promotes Impaired NK Activity Tamara Cruz,Paula A. Agudelo Garcia,Julián A. Chamucero-Millares,Anna Bondonese,Nilay Mitash,John Sembrat,Tracy Tabib,Wenping Zhang,Nouraie Seyed,Victor Peters,Sean D. Stacey,Dario A.A. Vignali,Ana L. Mora,Robert Lafyatis,Mauricio Rojas	2023	8
6	Autoreactive CD8+ T cells are restrained by an exhaustion-like program that is maintained by LAG3 Stephanie Grebinoski,Qianxia Zhang,Anthony R. Cillo,Sasikanth Manne,Hanxi Xiao,Erin A. Brunazzi,Tracy Tabib,Carly Cardello,Christine G. Lian,George F. Murphy,Robert Lafyatis,E. John Wherry,Jishnu Das,Creg J. Workman,Dario A.A. Vignali	2022	70
7	Systemic Immune Dysfunction in Cancer Patients Driven by IL6 Induction of LAG3 in Peripheral CD8+ T Cells Ashwin Somasundaram,Anthony R. Cillo,Caleb Lampenfeld,Creg J. Workman,Sheryl Kunning,Lauren Oliveri,Maria A. Velez,Sonali Joyce,Michael Calderon,Rebekah Dadey,Dhivyaa Rajasundaram,Daniel P. Normolle,Simon C. Watkins,James G. Herman,John M. Kirkwood,Evan J. Lipson,Robert L. Ferris,Tullia C. Bruno,Dario A.A. Vignali	2022	18
8	Ewing Sarcoma and Osteosarcoma Have Distinct Immune Signatures and Intercellular Communication Networks Anthony R. Cillo,Elina Mukherjee,Nathanael G. Bailey,Sayali Onkar,Jessica D. Daley,Cláudia Salgado,Xiang Li,Dongyan Liu,Sarangarajan Ranganathan,Melissa Burgess,John Sembrat,Kurt R. Weiss,Rebecca Watters,Tullia C. Bruno,Dario A.A. Vignali,Kelly M. Bailey	2022	51
9	Antibodies targeting conserved non-canonical antigens and endemic coronaviruses associate with favorable outcomes in severe COVID-19 Sai Preetham Peddireddy,Syed A. Rahman,Anthony R. Cillo,Godhev Manakkat Vijay,Ashwin Somasundaram,Creg J. Workman,William Bain,Bryan J. McVerry,Barbara A. Methé,Janet Lee,Prabir Ray,Anuradha Ray,Tullia C. Bruno,Dario A.A. Vignali,Georgios D. Kitsios,Alison Morris,Harinder Singh,Aniruddh Sarkar,Jishnu Das	2022	12
10	The Great Immune Escape: Understanding the Divergent Immune Response in Breast Cancer Subtypes Sayali Onkar,Neil Carleton,Peter C. Lucas,Tullia C. Bruno,Adrian V. Lee,Dario A.A. Vignali,Steffi Oesterreich	2022	133
11	Metabolic support of tumour-infiltrating regulatory T cells by lactic acidbreakdown → McLane J. Watson,Paolo Vignali,Steven J. Mullett,Abigail E. Overacre-Delgoffe,Ronal M. Peralta,Stephanie Grebinoski,Ashley V. Menk,Natalie Rittenhouse,Kristin DePeaux,Ryan D. Whetstone,Dario A.A. Vignali,Timothy W. Hand,Amanda C. Poholek,Brett M. Morrison,Jeffrey D. Rothstein,Stacy G. Wendell,Greg M. Delgoffe	2021	817
12	Cancer-associated MSC drive tumor immune exclusion and resistance to immunotherapy, which can be overcome by Hedgehog inhibition Sandra Cascio,Chelsea Chandler,Linan Zhang,Sarah Sinno,Bingsi Gao,Sayali Onkar,Tullia C. Bruno,Dario A.A. Vignali,Haider Mahdi,Hatice U. Osmanbeyoglu,Anda Vlad,Lan Coffman,Ronald J. Buckanovich	2021	54
13	B cell–Derived IL35 Drives STAT3-Dependent CD8+ T-cell Exclusion in Pancreatic Cancer Bhalchandra Mirlekar,Daniel Michaud,Samuel Lee,Nancy P. Kren,Cameron Harris,Kevin G. Greene,Emily C. Goldman,Gaorav P. Gupta,Ryan C. Fields,William G. Hawkins,David G. DeNardo,Naim U. Rashid,Jen Jen Yeh,Autumn J. McRee,Benjamin G. Vincent,Dario A.A. Vignali,Yuliya Pylayeva‐Gupta	2020	92
14	Interleukin-33 activates regulatory T cells to suppress innate γδ T cell responses in the lung Lucas Faustino,Jason W. Griffith,Rod A. Rahimi,Keshav Nepal,Daniel L. Hamilos,(unknown),Benjamin D. Medoff,James J. Moon,Dario A.A. Vignali,Andrew D. Luster	2020	76
15	PD-1 restraint of regulatory T cell suppressive activity is critical for immune tolerance Catherine L. Tan,Juhi R. Kuchroo,Peter T. Sage,Dan Liang,Loise M. Francisco,Jessica N. Buck,Youg Raj Thaker,Qianxia Zhang,Shannon McArdel,Vikram R. Juneja,Sun Jung Lee,Scott B. Lovitch,Christine G. Lian,George F. Murphy,Bruce R. Blazar,Dario A.A. Vignali,Gordon J. Freeman,Arlene H. Sharpe	2020	181
16	LAG3 limits regulatory T cell proliferation and function in autoimmune diabetes Qianxia Zhang,Maria Chikina,Andrea L. Szymczak-Workman,William Horne,Jay K. Kolls,Kate M. Vignali,Daniel P. Normolle,Maria Bettini,Creg J. Workman,Dario A.A. Vignali	2017	120
17	Cutting Edge: CD3 ITAM Diversity Is Required for Optimal TCR Signaling and Thymocyte Development Matthew L. Bettini,Po-Chein Chou,Clifford S. Guy,Thomas Lee,Kate M. Vignali,Dario A.A. Vignali	2017	35
18	Prevention of Autoimmune Diabetes by Ectopic Pancreatic β-Cell Expression of Interleukin-35 Maria Bettini,Ashley Castellaw,Greig P. Lennon,Amanda R. Burton,Dario A.A. Vignali	2012	100
19	PD-L1 blockade effectively restores strong graft-versus-leukemia effects without graft-versus-host disease after delayed adoptive transfer of T-cell receptor gene-engineered allogeneic CD8+ T cells Wolfgang Koestner,Martin Hapke,Jessica Herbst,Christoph Klein,Karl Welte,Joerg Fruehauf,Andrew Flatley,Dario A.A. Vignali,Matthias Hardtke‐Wolenski,Elmar Jaeckel,Bruce R. Blazar,Martin G. Sauer	2010	63
20	Essential Cytoplasmic Translocation of a Cytokine Receptor–Assembled Signaling Complex Atsushi Matsuzawa,Ping‐Hui Tseng,Sivakumar Vallabhapurapu,Jun‐Li Luo,Weizhou Zhang,Haopeng Wang,Dario A.A. Vignali,Ewen Gallagher,Michael Karin	2008	179

About Dario A.A. Vignali

Dario A.A. Vignali is a scholar working on Immunology, Oncology and Parasitology, having authored 242 papers that have together received 33.4k indexed citations. Recurring topics across this work include Immune Cell Function and Interaction (147 papers), T-cell and B-cell Immunology (109 papers), Cancer Immunotherapy and Biomarkers (74 papers), Immunotherapy and Immune Responses (67 papers), CAR-T cell therapy research (44 papers), Diabetes and associated disorders (22 papers), Immune Response and Inflammation (14 papers) and Cytokine Signaling Pathways and Interactions (11 papers). The work is most often cited by research in Immunology (22.9k citations), Oncology (12.2k citations) and Cancer Research (2.4k citations). Dario A.A. Vignali has collaborated with scholars based in United States, United Kingdom and Germany. Frequent co-authors include Creg J. Workman, Lauren W. Collison, Kate M. Vignali, Vijay K. Kuchroo, Lawrence P. Andrews, Richard T. Carson, Charles G. Drake, Tullia C. Bruno, Andrea L. Szymczak-Workman and Greg M. Delgoffe.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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