Dario A.A. Vignali

50.6k total citations · 27 hit papers
242 papers, 33.4k citations indexed

About

Dario A.A. Vignali is a scholar working on Immunology, Oncology and Molecular Biology. According to data from OpenAlex, Dario A.A. Vignali has authored 242 papers receiving a total of 33.4k indexed citations (citations by other indexed papers that have themselves been cited), including 195 papers in Immunology, 111 papers in Oncology and 30 papers in Molecular Biology. Recurrent topics in Dario A.A. Vignali's work include Immune Cell Function and Interaction (147 papers), T-cell and B-cell Immunology (109 papers) and Cancer Immunotherapy and Biomarkers (74 papers). Dario A.A. Vignali is often cited by papers focused on Immune Cell Function and Interaction (147 papers), T-cell and B-cell Immunology (109 papers) and Cancer Immunotherapy and Biomarkers (74 papers). Dario A.A. Vignali collaborates with scholars based in United States, United Kingdom and Germany. Dario A.A. Vignali's co-authors include Creg J. Workman, Lauren W. Collison, Kate M. Vignali, Vijay K. Kuchroo, Lawrence P. Andrews, Richard T. Carson, Charles G. Drake, Tullia C. Bruno, Andrea L. Szymczak-Workman and Greg M. Delgoffe and has published in prestigious journals such as Nature, Science and Cell.

In The Last Decade

Dario A.A. Vignali

237 papers receiving 33.0k citations

Hit Papers

5 papers align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

How regulatory T cells work

2008 2.5k citations Dario A.A. Vignali, Creg J. Workman et al. profile →
Coregulation of CD8+ T cell exhaustion by multiple inhibitory receptors during chronic viral infection

2008 1.6k citations Creg J. Workman, Gordon J. Freeman et al. Nature Immunology profile →
The inhibitory cytokine IL-35 contributes to regulatory T-cell function

2007 1.6k citations Creg J. Workman, Kate M. Vignali et al. Nature profile →
Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted State6 gene

1996 1.1k citations Dario A.A. Vignali et al. Nature profile →
IL-12 family cytokines: immunological playmakers

2012 1.0k citations Dario A.A. Vignali et al. Nature Immunology profile →
Role of LAG-3 in Regulatory T Cells

2004 993 citations Creg J. Workman, Dario A.A. Vignali et al. profile →
Requirement for Stat4 in interleukin-12-mediated responses of natural killer and T cells

1996 976 citations Dario A.A. Vignali et al. Nature profile →
Metabolic support of tumour-infiltrating regulatory T cells by lactic acid

2021 817 citations McLane J. Watson, Paolo Vignali et al. Nature profile →
Specificity and promiscuity among naturally processed peptides bound to HLA-DR alleles.

1993 742 citations Dario A.A. Vignali et al. The Journal of Experimental Medicine profile →
Multiplexed particle-based flow cytometric assays

2000 738 citations Dario A.A. Vignali profile →
LAG3 (CD223) as a cancer immunotherapy target

2017 684 citations Dario A.A. Vignali et al. profile →
IL-35-mediated induction of a potent regulatory T cell population

2010 676 citations Creg J. Workman, Dario A.A. Vignali et al. Nature Immunology profile →
Predominant naturally processed peptides bound to HLA-DR1 are derived from MHC-related molecules and are heterogeneous in size

1992 633 citations Dario A.A. Vignali et al. Nature profile →
Immune Landscape of Viral- and Carcinogen-Driven Head and Neck Cancer

2020 452 citations Anthony R. Cillo, Tracy Tabib et al. profile →
Stability and function of regulatory T cells is maintained by a neuropilin-1–semaphorin-4a axis

2013 445 citations Greg M. Delgoffe, Abigail E. Overacre-Delgoffe et al. Nature profile →
Interferon-γ Drives Treg Fragility to Promote Anti-tumor Immunity

2017 432 citations Abigail E. Overacre-Delgoffe, Maria Chikina et al. profile →
Inhibitory receptors and ligands beyond PD-1, PD-L1 and CTLA-4: breakthroughs or backups

2019 401 citations Dario A.A. Vignali et al. Nature Immunology profile →
The plasticity and stability of regulatory T cells

2013 392 citations Dario A.A. Vignali et al. profile →
Adaptive plasticity of IL-10+ and IL-35+ Treg cells cooperatively promotes tumor T cell exhaustion

2019 388 citations Maria Chikina, Qianxia Zhang et al. Nature Immunology profile →
Interferon-γ: teammate or opponent in the tumour microenvironment?

2021 343 citations Creg J. Workman, Dario A.A. Vignali et al. profile →
B cell signatures and tertiary lymphoid structures contribute to outcome in head and neck squamous cell carcinoma

2021 230 citations Anthony R. Cillo, Tracy Tabib et al. profile →
Microbiota-specific T follicular helper cells drive tertiary lymphoid structures and anti-tumor immunity against colorectal cancer

2021 202 citations Abigail E. Overacre-Delgoffe, Anthony R. Cillo et al. profile →
LAG-3 as the third checkpoint inhibitor

2023 184 citations Creg J. Workman, Dario A.A. Vignali et al. Nature Immunology profile →
Therapeutic targeting of regulatory T cells in cancer

2022 143 citations Feng Shan, Ashwin Somasundaram et al. profile →
T Cell Exhaustion

2024 121 citations Dario A.A. Vignali et al. profile →
LAG-3 and PD-1 synergize on CD8+ T cells to drive T cell exhaustion and hinder autocrine IFN-γ-dependent anti-tumor immunity

2024 110 citations Jian Cui, Anthony R. Cillo et al. profile →
Blockade of LAG-3 and PD-1 leads to co-expression of cytotoxic and exhaustion gene modules in CD8+ T cells to promote antitumor immunity

2024 75 citations Anthony R. Cillo, Carly Cardello et al. profile →

Peers

Countries citing papers authored by Dario A.A. Vignali

Since Specialization

Citations

This map shows the geographic impact of Dario A.A. Vignali's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Dario A.A. Vignali with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Dario A.A. Vignali more than expected).

Fields of papers citing papers by Dario A.A. Vignali

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Dario A.A. Vignali. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Dario A.A. Vignali. The network helps show where Dario A.A. Vignali may publish in the future.

Co-authorship network of co-authors of Dario A.A. Vignali

This figure shows the co-authorship network connecting the top 25 collaborators of Dario A.A. Vignali. A scholar is included among the top collaborators of Dario A.A. Vignali based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Dario A.A. Vignali. Dario A.A. Vignali is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

Sort: Min cites: Since: Top N: Style:

20 of 20 papers shown

#	Work	Indexed citations
1	Tim-3 Is Required for Regulatory T Cell–Mediated Promotion of T Cell Exhaustion and Viral Persistence during Chronic Lymphocytic Choriomeningitis Virus Infection 2024 ·The Journal of Immunology ·(unknown), (unknown), (unknown), (unknown), (unknown), (unknown), Bingxian Xie, (unknown), Jishnu Das, Dario A.A. Vignali, Greg M. Delgoffe, Larry Kane	1
2	Immune infiltration correlates with transcriptomic subtypes in primary estrogen receptor positive invasive lobular breast cancer 2024 ·npj Precision Oncology ·Fangyuan Chen, Sayali Onkar, Jian Zou, Yujia Li, (unknown), (unknown), George C. Tseng, Peter C. Lucas, Tullia C. Bruno, Dario A.A. Vignali, Julia Foldi, Marija Balić, Adrian V. Lee, Steffi Oesterreich	1
3	IFNγ-induction of TH1-like regulatory T cells controls antiviral responses 2023 ·Nature Immunology ·(unknown), Jian Cui, Andrea L. Szymczak-Workman, Kate M. Vignali, (unknown), (unknown), (unknown), Lyndsay Avery, (unknown), Brydie R. Huckestein, (unknown), Marlies Meisel, John F. Alcorn, Larry Kane, Creg J. Workman, Dario A.A. Vignali	37
4	Integrated BATF transcriptional network regulates suppressive intratumoral regulatory T cells 2023 ·Science Immunology ·Feng Shan, Anthony R. Cillo, Carly Cardello, (unknown), Sheryl Kunning, Jian Cui, Caleb Lampenfeld, (unknown), (unknown), Arjun Pennathur, James D. Luketich, John M. Kirkwood, Robert L. Ferris, Tullia C. Bruno, Creg J. Workman, Panayiotis V. Benos, Dario A.A. Vignali	16
5	End-Stage Idiopathic Pulmonary Fibrosis Lung Microenvironment Promotes Impaired NK Activity 2023 ·The Journal of Immunology ·Tamara Cruz, (unknown), (unknown), (unknown), Nilay Mitash, John Sembrat, Tracy Tabib, Wenping Zhang, (unknown), Victor Peters, (unknown), Dario A.A. Vignali, Ana L. Mora, Robert Lafyatis, Mauricio Rojas	8
6	Autoreactive CD8+ T cells are restrained by an exhaustion-like program that is maintained by LAG3 2022 ·Nature Immunology ·Stephanie Grebinoski, Qianxia Zhang, Anthony R. Cillo, Sasikanth Manne, Hanxi Xiao, Erin A. Brunazzi, Tracy Tabib, Carly Cardello, Christine G. Lian, George F. Murphy, Robert Lafyatis, E. John Wherry, Jishnu Das, Creg J. Workman, Dario A.A. Vignali	70
7	Systemic Immune Dysfunction in Cancer Patients Driven by IL6 Induction of LAG3 in Peripheral CD8+ T Cells 2022 ·Cancer Immunology Research ·Ashwin Somasundaram, Anthony R. Cillo, Caleb Lampenfeld, Creg J. Workman, Sheryl Kunning, (unknown), Maria A. Velez, Sonali Joyce, Michael Calderon, Rebekah Dadey, Dhivyaa Rajasundaram, Daniel P. Normolle, Simon C. Watkins, James G. Herman, John M. Kirkwood, Evan J. Lipson, Robert L. Ferris, Tullia C. Bruno, Dario A.A. Vignali	18
8	Ewing Sarcoma and Osteosarcoma Have Distinct Immune Signatures and Intercellular Communication Networks 2022 ·Clinical Cancer Research ·Anthony R. Cillo, (unknown), Nathanael G. Bailey, Sayali Onkar, (unknown), Cláudia Salgado, (unknown), (unknown), Sarangarajan Ranganathan, Melissa Burgess, John Sembrat, Kurt R. Weiss, Rebecca Watters, Tullia C. Bruno, Dario A.A. Vignali, Kelly M. Bailey	51
9	Antibodies targeting conserved non-canonical antigens and endemic coronaviruses associate with favorable outcomes in severe COVID-19 2022 ·Cell Reports ·(unknown), Syed A. Rahman, Anthony R. Cillo, (unknown), Ashwin Somasundaram, Creg J. Workman, William Bain, Bryan J. McVerry, Barbara A. Methé, Janet Lee, Prabir Ray, Anuradha Ray, Tullia C. Bruno, Dario A.A. Vignali, Georgios D. Kitsios, Alison Morris, Harinder Singh, Aniruddh Sarkar, Jishnu Das	12
10	The Great Immune Escape: Understanding the Divergent Immune Response in Breast Cancer Subtypes 2022 ·Cancer Discovery ·Sayali Onkar, Neil Carleton, Peter C. Lucas, Tullia C. Bruno, Adrian V. Lee, Dario A.A. Vignali, Steffi Oesterreich	133
11	Metabolic support of tumour-infiltrating regulatory T cells by lactic acid breakdown → 2021 ·Nature ·McLane J. Watson, Paolo Vignali, Steven J. Mullett, Abigail E. Overacre-Delgoffe, Ronal M. Peralta, Stephanie Grebinoski, Ashley V. Menk, Natalie Rittenhouse, Kristin DePeaux, Ryan D. Whetstone, Dario A.A. Vignali, Timothy W. Hand, Amanda C. Poholek, Brett M. Morrison, Jeffrey D. Rothstein, Stacy G. Wendell, Greg M. Delgoffe	817
12	Cancer-associated MSC drive tumor immune exclusion and resistance to immunotherapy, which can be overcome by Hedgehog inhibition 2021 ·Science Advances ·Sandra Cascio, Chelsea Chandler, (unknown), (unknown), Bingsi Gao, Sayali Onkar, Tullia C. Bruno, Dario A.A. Vignali, Haider Mahdi, Hatice U. Osmanbeyoglu, Anda Vlad, Lan Coffman, Ronald J. Buckanovich	54
13	B cell–Derived IL35 Drives STAT3-Dependent CD8+ T-cell Exclusion in Pancreatic Cancer 2020 ·Cancer Immunology Research ·Bhalchandra Mirlekar, Daniel Michaud, Samuel Lee, Nancy P. Kren, (unknown), Kevin G. Greene, Emily C. Goldman, Gaorav P. Gupta, Ryan C. Fields, William G. Hawkins, David G. DeNardo, Naim U. Rashid, Jen Jen Yeh, Autumn J. McRee, Benjamin G. Vincent, Dario A.A. Vignali, Yuliya Pylayeva‐Gupta	92
14	Interleukin-33 activates regulatory T cells to suppress innate γδ T cell responses in the lung 2020 ·Nature Immunology ·Lucas Faustino, Jason W. Griffith, Rod A. Rahimi, (unknown), Daniel L. Hamilos, (unknown), Benjamin D. Medoff, James J. Moon, Dario A.A. Vignali, Andrew D. Luster	76
15	PD-1 restraint of regulatory T cell suppressive activity is critical for immune tolerance 2020 ·The Journal of Experimental Medicine ·(unknown), Juhi R. Kuchroo, Peter T. Sage, Dan Liang, Loise M. Francisco, Jessica N. Buck, Youg Raj Thaker, Qianxia Zhang, Shannon McArdel, Vikram R. Juneja, Sun Jung Lee, Scott B. Lovitch, Christine G. Lian, George F. Murphy, Bruce R. Blazar, Dario A.A. Vignali, Gordon J. Freeman, Arlene H. Sharpe	181
16	LAG3 limits regulatory T cell proliferation and function in autoimmune diabetes 2017 ·Science Immunology ·Qianxia Zhang, Maria Chikina, Andrea L. Szymczak-Workman, William Horne, Jay K. Kolls, Kate M. Vignali, Daniel P. Normolle, Maria Bettini, Creg J. Workman, Dario A.A. Vignali	120
17	Cutting Edge: CD3 ITAM Diversity Is Required for Optimal TCR Signaling and Thymocyte Development 2017 ·The Journal of Immunology ·Matthew L. Bettini, (unknown), Clifford S. Guy, Thomas Lee, Kate M. Vignali, Dario A.A. Vignali	35
18	Prevention of Autoimmune Diabetes by Ectopic Pancreatic β-Cell Expression of Interleukin-35 2012 ·Diabetes ·Maria Bettini, Ashley Castellaw, Greig P. Lennon, Amanda R. Burton, Dario A.A. Vignali	100
19	PD-L1 blockade effectively restores strong graft-versus-leukemia effects without graft-versus-host disease after delayed adoptive transfer of T-cell receptor gene-engineered allogeneic CD8+ T cells 2010 ·Blood ·(unknown), Martin Hapke, Jessica Herbst, Christoph Klein, Karl Welte, (unknown), Andrew Flatley, Dario A.A. Vignali, Matthias Hardtke‐Wolenski, Elmar Jaeckel, Bruce R. Blazar, Martin G. Sauer	63
20	Essential Cytoplasmic Translocation of a Cytokine Receptor–Assembled Signaling Complex 2008 ·Science ·Atsushi Matsuzawa, Ping‐Hui Tseng, Sivakumar Vallabhapurapu, Jun‐Li Luo, Weizhou Zhang, Haopeng Wang, Dario A.A. Vignali, Ewen Gallagher, Michael Karin	179

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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