James G. Herman

109.0k citations

399 papers · 65.8k indexed · 27 hit papers · h-index 119

Molecular Biology top 0.01%
Oncology top 0.02%
Cancer Research top 0.01%
Pathology and Forensic Medicine top 0.02%
Pulmonary and Respiratory Medicine top 0.1%

Co-authors: Stephen B. Baylin Manel Esteller Jeremy R. Graff S B Baylin Sanna Myöhänen Jean‐Pierre J. Issa B D Nelkin David Sidransky
Topics: Epigenetics and DNA Methylation (255 papers)Cancer-related gene regulation (141 papers)RNA modifications and cancer (73 papers)
Cited by: Cancer Research Molecular Biology Oncology
Journals: Nature New England Journal of Medicine Proceedings of the National Academy of Sciences
Partner nations: United States China Netherlands

In The Last Decade

James G. Herman

392 papers receiving 64.6k citations

Hit Papers

5 papers align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands.

1996 4.8k citations James G. Herman et al. profile →
Gene Silencing in Cancer in Association with Promoter Hypermethylation

2003 2.6k citations James G. Herman, Stephen B. Baylin profile →
CpG island methylator phenotype in colorectal cancer

1999 2.0k citations Nita Ahuja, James G. Herman et al. profile →
Inactivation of the DNA-Repair GeneMGMTand the Clinical Response of Gliomas to Alkylating Agents

2000 1.7k citations Stephen B. Baylin, James G. Herman et al. profile →
5′ CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancers

1995 1.7k citations James G. Herman, Stephen B. Baylin et al. profile →
A gene hypermethylation profile of human cancer.

2001 1.7k citations Stephen B. Baylin, James G. Herman et al. profile →
Alterations in DNA Methylation: A Fundamental Aspect of Neoplasia

1997 1.6k citations James G. Herman et al. profile →
Synergy of demethylation and histone deacetylase inhibition in the re-expression of genes silenced in cancer

1999 1.6k citations James G. Herman et al. profile →
Incidence and functional consequences of hMLH1 promoter hypermethylation in colorectal carcinoma

1998 1.5k citations James G. Herman, Nita Ahuja et al. profile →
DNA hypermethylation in tumorigenesis: epigenetics joins genetics

2000 1.3k citations Stephen B. Baylin, James G. Herman profile →
Silencing of the VHL tumor-suppressor gene by DNA methylation in renal carcinoma.

1994 1.3k citations James G. Herman et al. profile →
Inactivation of the CDKN2/p16/MTS1 gene is frequently associated with aberrant DNA methylation in all common human cancers.

1995 1.2k citations James G. Herman, Stephen B. Baylin et al. profile →
Inactivation of the DNA repair gene O6-methylguanine-DNA methyltransferase by promoter hypermethylation is a common event in primary human neoplasia.

1999 1.0k citations James G. Herman et al. profile →
Epigenetic inactivation of SFRP genes allows constitutive WNT signaling in colorectal cancer

2004 858 citations Kornel E. Schuebel, Manon van Engeland et al. profile →
Dysfunctional KEAP1–NRF2 Interaction in Non-Small-Cell Lung Cancer

2006 855 citations James G. Herman, Stephen B. Baylin et al. profile →
A stem cell–like chromatin pattern may predispose tumor suppressor genes to DNA hypermethylation and heritable silencing

2007 805 citations Joyce E. Ohm, Kelly M. McGarvey et al. profile →
Aberrant methylation of p16 ^INK4a is an early event in lung cancer and a potential biomarker for early diagnosis

1998 773 citations Steven A. Belinsky, Stephen B. Baylin et al. profile →
Detection of aberrant promoter hypermethylation of tumor suppressor genes in serum DNA from non-small cell lung cancer patients.

1999 770 citations Stephen B. Baylin, James G. Herman et al. profile →
Inactivation of the apoptosis effector Apaf-1 in malignant melanoma

2001 769 citations James G. Herman et al. profile →
A genomic screen for genes upregulated by demethylation and histone deacetylase inhibition in human colorectal cancer

2002 701 citations Manon van Engeland, Matty P. Weijenberg et al. profile →
E-cadherin expression is silenced by DNA hypermethylation in human breast and prostate carcinomas.

1995 668 citations James G. Herman, Stephen B. Baylin et al. profile →
Correlation of O⁶-Methylguanine Methyltransferase (MGMT) Promoter Methylation With Clinical Outcomes in Glioblastoma and Clinical Strategies to Modulate MGMT Activity

2008 658 citations James G. Herman et al. profile →
Predicting lung cancer by detecting aberrant promoter methylation in sputum.

2000 649 citations Stephen B. Baylin, James G. Herman et al. profile →
SOCS-1, a negative regulator of the JAK/STAT pathway, is silenced by methylation in human hepatocellular carcinoma and shows growth-suppression activity

2001 578 citations Curtis C. Harris, James G. Herman et al. profile →
Cancer as an epigenetic disease: DNA methylation and chromatin alterations in human tumours

2001 557 citations James G. Herman et al. profile →
Frequent inactivation of PTEN/MMAC1 in primary prostate cancer.

1997 552 citations James G. Herman et al. profile →
Analysis of DNA methylation in cancer: location revisited

2018 491 citations Sophie C. Joosten, Muriel X.G. Draht et al. profile →

Peers

Countries citing papers authored by James G. Herman

Since Specialization

Citations

This map shows the geographic impact of James G. Herman's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by James G. Herman with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites James G. Herman more than expected).

Fields of papers citing papers by James G. Herman

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by James G. Herman. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by James G. Herman. The network helps show where James G. Herman may publish in the future.

Co-authorship network of co-authors of James G. Herman

This figure shows the co-authorship network connecting the top 25 collaborators of James G. Herman. A scholar is included among the top collaborators of James G. Herman based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with James G. Herman. James G. Herman is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

#	Work	Indexed citations
1	BRCA1 Promoter Methylation Is Linked to Defective Homologous Recombination Repair and Elevated miR-155 to Disrupt Myeloid Differentiation in Myeloid Malignancies 2019 ·Clinical Cancer Research ·Weijie Poh,Robert L. Dilley,Alison R. Moliterno,Jaroslaw P. Maciejewski,Keith W. Pratz,Michael A. McDevitt,James G. Herman	10
2	Early Detection of Lung Cancer Using DNA Promoter Hypermethylation in Plasma and Sputum 2016 ·Clinical Cancer Research ·Alicia Hulbert,Ignacio Jusué-Torres,Alejandro Stark,Chen Chen,Kristen Rodgers,Beverly Lee,(unknown),Andrew Yang,Peng Huang,John Wrangle,Steven A. Belinsky,Tza‐Huei Wang,Stephen C. Yang,Stephen B. Baylin,Malcolm V. Brock,James G. Herman	198
3	A Phase I Study of Topotecan, Carboplatin and the PARP Inhibitor Veliparib in Acute Leukemias, Aggressive Myeloproliferative Neoplasms, and Chronic Myelomonocytic Leukemia 2016 ·Clinical Cancer Research ·Keith W. Pratz,Michelle A. Rudek,Ivana Gojo,Mark R. Litzow,Michael A. McDevitt,Jiuping Ji,Larry M. Karnitz,James G. Herman,Robert J. Kinders,B. Douglas Smith,Steven D. Gore,Hetty E. Carraway,Margaret M. Showel,Douglas E. Gladstone,Mark J. Levis,Hua-Ling Tsai,Gary L. Rosner,Alice P. Chen,Scott H. Kaufmann,Judith E. Karp	38
4	WRN Promoter CpG Island Hypermethylation Does Not Predict More Favorable Outcomes for Patients with Metastatic Colorectal Cancer Treated with Irinotecan-Based Therapy 2016 ·Clinical Cancer Research ·Linda J.W. Bosch,Yanxin Luo,Victoria Valinluck Lao,Pétur Snæbjörnsson,Geert Trooskens,Ilse Vlassenbroeck,Sandra Mongera,Weiliang Tang,Piri Welcsh,James G. Herman,Miriam Koopman,Irıs D. Nagtegaal,Cornelis J.A. Punt,Wim Van Criekinge,Gerrit A. Meijer,Raymond J. Monnat,Beatriz Carvalho,William M. Grady	6
5	A Four-Gene Promoter Methylation Marker Panel Consisting of GREM1, NEURL, LAD1, and NEFH Predicts Survival of Clear Cell Renal Cell Cancer Patients 2016 ·Clinical Cancer Research ·Iris J.H. van Vlodrop,Sophie C. Joosten,Tim De Meyer,Kim M. Smits,Leander Van Neste,Veerle Melotte,Marcella Baldewijns,Leo J. Schouten,Piet A. van den Brandt,Jana Jeschke,Joo Mi Yi,Kornel E. Schuebel,Nita Ahuja,James G. Herman,Maureen J.B. Aarts,Fred T. Bosman,Wim Van Criekinge,Manon van Engeland	44
6	Promoter Methylation of CDO1 Identifies Clear-Cell Renal Cell Cancer Patients with Poor Survival Outcome 2015 ·Clinical Cancer Research ·Ivette A.G. Deckers,Leo J. Schouten,Leander Van Neste,Iris J.H. van Vlodrop,Patricia M.M.B. Soetekouw,Marcella Baldewijns,Jana Jeschke,Nita Ahuja,James G. Herman,Piet A. van den Brandt,Manon van Engeland	49
7	CHFR Promoter Methylation Indicates Poor Prognosis in Stage II Microsatellite Stable Colorectal Cancer 2014 ·Clinical Cancer Research ·Arjen H.G. Cleven,Sarah Derks,Muriel X.G. Draht,Kim M. Smits,Veerle Melotte,Leander Van Neste,(unknown),Valérie Jooste,Caroline Chapusot,Matty P. Weijenberg,James G. Herman,Adriaan P. de Bruı̈ne,Manon van Engeland	30
8	Spectrin Repeat Containing Nuclear Envelope 1 and Forkhead Box Protein E1 Are Promising Markers for the Detection of Colorectal Cancer in Blood 2014 ·Cancer Prevention Research ·Veerle Melotte,Joo Mi Yi,Marjolein H.F.M. Lentjes,Kim M. Smits,Leander Van Neste,Hanneke E.C. Niessen,Kristien Wouters,Joost Louwagie,Kornel E. Schuebel,James G. Herman,Stephen B. Baylin,Wim Van Criekinge,Gerrit A. Meijer,Nita Ahuja,Manon van Engeland	31
9	Novel Methylation Biomarker Panel for the Early Detection of Pancreatic Cancer 2013 ·Clinical Cancer Research ·Joo Mi Yi,Angela A. Guzzetta,Vasudev J. Bailey,Stephanie R. Downing,Leander Van Neste,Katherine B. Chiappinelli,Brian P. Keeley,Alejandro Stark,(unknown),Christopher L. Wolfgang,Emmanouil P. Pappou,Christine A. Iacobuzio–Donahue,Michael Goggins,James G. Herman,Tza‐Huei Wang,Stephen B. Baylin,Nita Ahuja	118
10	CHFR Protein Expression Predicts Outcomes to Taxane-Based First Line Therapy in Metastatic NSCLC 2013 ·Clinical Cancer Research ·Rathi N. Pillai,(unknown),Gabriel Sica,Shaojin You,Ge Li,Dana Nickleach,Yuan Liu,Vijay Varma,Dacian Bonta,James G. Herman,(unknown),(unknown),Suresh S. Ramalingam,Taofeek K. Owonikoko,Fadlo R. Khuri,Johann C. Brandes	22
11	Defining a Gene Promoter Methylation Signature in Sputum for Lung Cancer Risk Assessment 2012 ·Clinical Cancer Research ·Shuguang Leng,Kieu Do,Christin M. Yingling,Maria A. Picchi,Holly J. Wolf,Timothy C. Kennedy,William J. Feser,Anna E. Barón,Wilbur A. Franklin,Malcolm V. Brock,James G. Herman,Stephen B. Baylin,Tim Byers,Christine A. Stidley,Steven A. Belinsky	78
12	Combination Epigenetic Therapy Has Efficacy in Patients with Refractory Advanced Non–Small Cell Lung Cancer 2011 ·Cancer Discovery ·Rosalyn A. Juergens,John Wrangle,Frank P. Vendetti,Sara C. Murphy,Ming Zhao,Barbara Coleman,Rosa Sebree,Kristen Rodgers,Craig M. Hooker,Noreli Franco,Beverly Lee,Salina Tsai,(unknown),Michelle A. Rudek,Steven A. Belinsky,James G. Herman,Stephen B. Baylin,Malcolm V. Brock,Charles M. Rudin	498
13	Aberrant Silencing of Cancer-Related Genes by CpG Hypermethylation Occurs Independently of Their Spatial Organization in the Nucleus 2010 ·Cancer Research ·Hariharan Easwaran,Leander Van Neste,Leslie Cope,Subhojit Sen,Helai P. Mohammad,(unknown),Jeanne B. Lawrence,James G. Herman,Kornel E. Schuebel,Stephen B. Baylin	23
14	Progressive Chromatin Repression and Promoter Methylation of CTNNA1 Associated with Advanced Myeloid Malignancies 2009 ·Cancer Research ·Ying Ye,Michael A. McDevitt,Mingzhou Guo,Wei Zhang,Oliver Galm,Steven D. Gore,Judith E. Karp,Jaroslaw P. Maciejewski,Jeanne Kowalski,Hua-Ling Tsai,Lukasz P. Gondek,Hsing-Chen Tsai,Xiaofei Wang,Craig M. Hooker,B. Douglas Smith,Hetty E. Carraway,James G. Herman	35
15	Lung Cancer in Never Smokers: Molecular Profiles and Therapeutic Implications 2009 ·Clinical Cancer Research ·Charles M. Rudin,Érika Ávila-Tang,Curtis C. Harris,James G. Herman,Fred R. Hirsch,William Pao,Ann G. Schwartz,Kirsi Vähäkangas,Jonathan M. Samet	123
16	Alcohol Consumption and the Risk of Nasopharyngeal Carcinoma: A Systematic Review 2008 ·Nutrition and Cancer ·Li‐Wei Chen,Lisa Gallicchio,(unknown),Xuguang Tao,Karen A. Robinson,Tram Kim Lam,James G. Herman,Laura E. Caulfield,Eliseo Güallar,Anthony J. Alberg	48
17	Promoter Hypermethylation of Hallmark Cancer Genes in Atypical Adenomatous Hyperplasia of the Lung 2008 ·Clinical Cancer Research ·Julien Licchesi,William H. Westra,Craig M. Hooker,James G. Herman	91
18	Abnormal DNA Methylation of CD133 in Colorectal and Glioblastoma Tumors 2008 ·Cancer Research ·Joo Mi Yi,Hsing-Chen Tsai,Sabine C. Glöckner,Steven H. Lin,Joyce E. Ohm,Hariharan Easwaran,C. David James,J Costello,Gregory J. Riggins,Charles G. Eberhart,John Laterra,Angelo L. Vescovi,Nita Ahuja,James G. Herman,Kornel E. Schuebel,Stephen B. Baylin	115
19	Defining a Chromatin Pattern that Characterizes DNA-Hypermethylated Genes in Colon Cancer Cells 2008 ·Cancer Research ·Kelly M. McGarvey,Leander Van Neste,Leslie Cope,Joyce E. Ohm,James G. Herman,Wim Van Criekinge,Kornel E. Schuebel,Stephen B. Baylin	94
20	Hypermethylation of ASC/TMS1 Is a Sputum Marker for Late-Stage Lung Cancer 2006 ·Cancer Research ·Emi Ota Machida,Malcolm V. Brock,Craig M. Hooker,Jun Nakayama,Akiko Ishida,Jun Amano,Maria A. Picchi,Steven A. Belinsky,James G. Herman,Shun’ichiro Taniguchi,Stephen B. Baylin	77

About James G. Herman

James G. Herman is a scholar working on Cancer Research, Molecular Biology and Pathology and Forensic Medicine, having authored 399 papers that have together received 65.8k indexed citations. Recurring topics across this work include Epigenetics and DNA Methylation (255 papers), Cancer-related gene regulation (141 papers) and RNA modifications and cancer (73 papers). The work is most often cited by research in Cancer Research (13.6k citations), Molecular Biology (50.9k citations) and Oncology (15.1k citations). James G. Herman has collaborated with scholars based in United States, China and Netherlands. Frequent co-authors include Stephen B. Baylin, Manel Esteller, Jeremy R. Graff, S B Baylin, Sanna Myöhänen, Jean‐Pierre J. Issa, B D Nelkin, David Sidransky, Edward Gabrielson and Paul G. Corn. Their work appears in journals such as Nature, New England Journal of Medicine and Proceedings of the National Academy of Sciences.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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