Gary W. Cline

40.1k total citations · 17 hit papers
215 papers, 31.3k citations indexed

About

Gary W. Cline is a scholar working on Molecular Biology, Physiology and Surgery. According to data from OpenAlex, Gary W. Cline has authored 215 papers receiving a total of 31.3k indexed citations (citations by other indexed papers that have themselves been cited), including 119 papers in Molecular Biology, 109 papers in Physiology and 69 papers in Surgery. Recurrent topics in Gary W. Cline's work include Adipose Tissue and Metabolism (74 papers), Pancreatic function and diabetes (62 papers) and Metabolism, Diabetes, and Cancer (50 papers). Gary W. Cline is often cited by papers focused on Adipose Tissue and Metabolism (74 papers), Pancreatic function and diabetes (62 papers) and Metabolism, Diabetes, and Cancer (50 papers). Gary W. Cline collaborates with scholars based in United States, Denmark and Italy. Gary W. Cline's co-authors include Gerald I. Shulman, Kitt Falk Petersen, Douglas L. Rothman, Sylvie Dufour, Dongyan Zhang, Douglas E. Befroy, Richard G. Kibbey, Michael Roden, Charlotte E. Ariyan and Gianluca Perseghin and has published in prestigious journals such as Nature, Science and New England Journal of Medicine.

In The Last Decade

Gary W. Cline

215 papers receiving 30.7k citations

Hit Papers

5 papers align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Functional polarization of tumour-associated macrophages by tumour-derived lactic acid

2014 2.2k citations Gary W. Cline et al. profile →
Mitochondrial Dysfunction in the Elderly: Possible Role in Insulin Resistance

2003 1.7k citations Kitt Falk Petersen, Douglas E. Befroy et al. profile →
Mechanism by Which Fatty Acids Inhibit Insulin Activation of Insulin Receptor Substrate-1 (IRS-1)-associated Phosphatidylinositol 3-Kinase Activity in Muscle

2002 1.2k citations Chunli Yu, Gary W. Cline et al. Journal of Biological Chemistry profile →
Mechanism of free fatty acid-induced insulin resistance in humans.

1996 1.2k citations Douglas L. Rothman, Gary W. Cline et al. Journal of Clinical Investigation profile →
Acetate mediates a microbiome–brain–β-cell axis to promote metabolic syndrome

2016 989 citations Rachel J. Perry, Gary W. Cline et al. profile →
Effects of free fatty acids on glucose transport and IRS-1–associated phosphatidylinositol 3-kinase activity

1999 974 citations Sylvie Dufour, Gary W. Cline et al. Journal of Clinical Investigation profile →
Metformin suppresses gluconeogenesis by inhibiting mitochondrial glycerophosphate dehydrogenase

2014 961 citations Derek M. Erion, Sanjay Bhanot et al. profile →
Free fatty acid-induced insulin resistance is associated with activation of protein kinase C theta and alterations in the insulin signaling cascade.

1999 955 citations Gary W. Cline, Gerald I. Shulman et al. profile →
Leptin reverses insulin resistance and hepatic steatosis in patients with severe lipodystrophy

2002 581 citations Kitt Falk Petersen, Elif A Oral et al. Journal of Clinical Investigation profile →
UCP2 mediates ghrelin’s action on NPY/AgRP neurons by lowering free radicals

2008 579 citations Derek M. Erion, Gary W. Cline et al. profile →
The role of skeletal muscle insulin resistance in the pathogenesis of the metabolic syndrome

2007 558 citations Kitt Falk Petersen, Sylvie Dufour et al. Proceedings of the National Academy of Sciences profile →
Hepatic Acetyl CoA Links Adipose Tissue Inflammation to Hepatic Insulin Resistance and Type 2 Diabetes

2015 536 citations Rachel J. Perry, Dongyan Zhang et al. Cell profile →
The Effects of Rosiglitazone on Insulin Sensitivity, Lipolysis, and Hepatic and Skeletal Muscle Triglyceride Content in Patients With Type 2 Diabetes

2002 536 citations Sylvie Dufour, Vincent Lebon et al. profile →
Increased Glucose Transport–Phosphorylation and Muscle Glycogen Synthesis after Exercise Training in Insulin-Resistant Subjects

1996 520 citations Kitt Falk Petersen, Gary W. Cline et al. profile →
Impaired Glucose Transport as a Cause of Decreased Insulin-Stimulated Muscle Glycogen Synthesis in Type 2 Diabetes

1999 515 citations Gary W. Cline, Kitt Falk Petersen et al. profile →
Leptin reverses insulin resistance and hepatic steatosis in patients with severe lipodystrophy

2002 503 citations Kitt Falk Petersen, Elif A Oral et al. Journal of Clinical Investigation profile →
A Forward Chemical Genetic Screen Reveals Gut Microbiota Metabolites That Modulate Host Physiology

2019 256 citations Gary W. Cline et al. Cell profile →

Peers

Countries citing papers authored by Gary W. Cline

Since Specialization

Citations

This map shows the geographic impact of Gary W. Cline's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Gary W. Cline with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Gary W. Cline more than expected).

Fields of papers citing papers by Gary W. Cline

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Gary W. Cline. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Gary W. Cline. The network helps show where Gary W. Cline may publish in the future.

Co-authorship network of co-authors of Gary W. Cline

This figure shows the co-authorship network connecting the top 25 collaborators of Gary W. Cline. A scholar is included among the top collaborators of Gary W. Cline based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Gary W. Cline. Gary W. Cline is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

#	Work	Indexed citations
1	MMAB promotes negative feedback control of cholesterol homeostasis 2021 ·Nature Communications ·Leigh Goedeke, Alberto Canfrán‐Duque, Noemí Rotllán, Balkrishna Chaube, Bonne M. Thompson, Richard Lee, Gary W. Cline, Jeffrey G. McDonald, Gerald I. Shulman, Miguel A. Lasunción, Yajaira Suárez, Carlos Fernández‐Hernando	16
2	Metabolic control analysis of hepatic glycogen synthesis in vivo 2020 ·Proceedings of the National Academy of Sciences ·Yuichi Nozaki, Max C. Petersen, Dongyan Zhang, Daniel F. Vatner, Rachel J. Perry, Abudukadier Abulizi, Sofie Hædersdal, Xian‐Man Zhang, Gina M. Butrico, Varman T. Samuel, Graeme F. Mason, Gary W. Cline, Kitt Falk Petersen, Douglas L. Rothman, Gerald I. Shulman	64
3	Effect of a ketogenic diet on hepatic steatosis and hepatic mitochondrial metabolism in nonalcoholic fatty liver disease 2020 ·Proceedings of the National Academy of Sciences ·Panu K. Luukkonen, Sylvie Dufour, Kun Lyu, (unknown), Antti Hakkarainen, Tiina E. Lehtimäki, Gary W. Cline, Kitt Falk Petersen, Gerald I. Shulman, Hannele Yki‐Järvinen	178
4	Adaptive Protein Translation by the Integrated Stress Response Maintains the Proliferative and Migratory Capacity of Lung Adenocarcinoma Cells 2019 ·Molecular Cancer Research ·(unknown), (unknown), Wesley L. Cai, Anna Arnal Estape, Gary W. Cline, Zongzhi Liu, Minghui Zhao, Paul D. Cao, Malaiyalam Mariappan, Don X. Nguyen	14
5	Leptin Mediates a Glucose-Fatty Acid Cycle to Maintain Glucose Homeostasis in Starvation 2018 ·Cell ·Rachel J. Perry, Yongliang Wang, Gary W. Cline, Aviva Rabin-Court, Joongyu D. Song, Sylvie Dufour, Xian Man Zhang, Kitt Falk Petersen, Gerald I. Shulman	126
6	Role of Gut Microbiota and Short Chain Fatty Acids in Modulating Energy Harvest and Fat Partitioning in Youth 2016 ·The Journal of Clinical Endocrinology & Metabolism ·Martina Goffredo, (unknown), Elizabeth J. Parks, David A. Wagner, (unknown), Joerg Graf, Mary Savoye, Bridget Pierpont, Gary W. Cline, Nicola Santoro	128
7	cAMP-responsive Element-binding Protein (CREB)-regulated Transcription Coactivator 2 (CRTC2) Promotes Glucagon Clearance and Hepatic Amino Acid Catabolism to Regulate Glucose Homeostasis 2013 ·Journal of Biological Chemistry ·Derek M. Erion, Maya E. Kotas, (unknown), Shin Yonemitsu, Jennifer J. Hsiao, Yoshio Nagai, Takanori Iwasaki, Susan F. Murray, Sanjay Bhanot, Gary W. Cline, Varman T. Samuel, Gerald I. Shulman, Matthew P. Gillum	18
8	Reversal of muscle insulin resistance by weight reduction in young, lean, insulin-resistant offspring of parents with type 2 diabetes 2012 ·Proceedings of the National Academy of Sciences ·Kitt Falk Petersen, Sylvie Dufour, Katsutaro Morino, Peter S. Yoo, Gary W. Cline, Gerald I. Shulman	65
9	Synthesis and evaluation of [(18)F]Exendin (9-39) as a potential biomarker to measure pancreatic beta-cell mass 2011 ·PubMed Central ·Yi Wang, Keunpoong Lim, Marc D. Normandin, Xiaojian Zhao, Gary W. Cline, Yu‐Shin Ding	1
10	Altered Brain Mitochondrial Metabolism in Healthy Aging as Assessed by in vivo Magnetic Resonance Spectroscopy 2009 ·Journal of Cerebral Blood Flow & Metabolism ·Fawzi Boumezbeur, Graeme F. Mason, Robin A. de Graaf, Kevin L. Behar, Gary W. Cline, Gerald I. Shulman, Douglas L. Rothman, Kitt Falk Petersen	182
11	Paradoxical effects of increased expression of PGC-1α on muscle mitochondrial function and insulin-stimulated muscle glucose metabolism 2008 ·Proceedings of the National Academy of Sciences ·Cheol Soo Choi, Douglas E. Befroy, Roberto Codella, Sheene Kim, (unknown), Yu-Jin Hwang, Zhenxiang Liu, Hui‐Young Lee, Alberto Distefano, Varman T. Samuel, Dongyan Zhang, Gary W. Cline, Christoph Handschin, Jiandie D. Lin, Kitt Falk Petersen, Bruce M. Spiegelman, Gerald I. Shulman	228
12	The role of skeletal muscle insulin resistance in the pathogenesis of the metabolic syndrome breakdown → 2007 ·Proceedings of the National Academy of Sciences ·Kitt Falk Petersen, Sylvie Dufour, David B. Savage, Stefan Bilz, (unknown), Shin Yonemitsu, Gary W. Cline, Douglas E. Befroy, Laura Zemany, Barbara B. Kahn, Xenophon Papademetris, Douglas L. Rothman, Gerald I. Shulman	558
13	PKC-θ knockout mice are protected from fat-induced insulin resistance 2004 ·Journal of Clinical Investigation ·Jason K. Kim, Jonathan J. Fillmore, Mary Jean Sunshine, (unknown), Takamasa Higashimori, Dong‐Wook Kim, Zhenxiang Liu, Timothy Soos, Gary W. Cline, (unknown), Dan R. Littman, Gerald I. Shulman	371
14	PKC-θ knockout mice are protected from fat-induced insulin resistance 2004 ·Journal of Clinical Investigation ·Jason K. Kim, Jonathan J. Fillmore, Mary Jean Sunshine, (unknown), Takamasa Higashimori, Dongwook Kim, Zhenxiang Liu, Timothy Soos, Gary W. Cline, (unknown), Dan R. Littman, Gerald I. Shulman	341
15	Inactivation of fatty acid transport protein 1 prevents fat-induced insulin resistance in skeletal muscle 2004 ·Journal of Clinical Investigation ·Jason K. Kim, Ruth E. Gimeno, Takamasa Higashimori, Hyo‐Jeong Kim, Hyejeong Choi, Sandhya Punreddy, Robin L. Mozell, (unknown), Alain Stricker‐Krongrad, David J. Hirsch, Jonathan J. Fillmore, Zhenxiang Liu, Jianying Dong, Gary W. Cline, Andreas Stahl, Harvey F. Lodish, Gerald I. Shulman	179
16	Leptin reverses insulin resistance and hepatic steatosis in patients with severe lipodystrophy 2002 ·Journal of Clinical Investigation ·Kitt Falk Petersen, Elif A Oral, Sylvie Dufour, Douglas E. Befroy, Charlotte E. Ariyan, (unknown), Gary W. Cline, Alex M. DePaoli, Simeon I. Taylor, Phillip Görden, Gerald I. Shulman	44
17	Leptin reverses insulin resistance and hepatic steatosis in patients with severe lipodystrophy breakdown → 2002 ·Journal of Clinical Investigation ·Kitt Falk Petersen, Elif A Oral, Sylvie Dufour, Douglas E. Befroy, Charlotte E. Ariyan, Chunli Yu, Gary W. Cline, Alex M. DePaoli, Simeon I. Taylor, Phillip Görden, Gerald I. Shulman	503
18	Effect of triiodothyronine on mitochondrial energy coupling in human skeletal muscle 2001 ·Journal of Clinical Investigation ·Vincent Lebon, Sylvie Dufour, Kitt Falk Petersen, Jianming Ren, Beat M. Jucker, Lori A. Slezak, Gary W. Cline, Douglas L. Rothman, Gerald I. Shulman	124
19	Effect of triiodothyronine on mitochondrial energy coupling in human skeletal muscle 2001 ·Journal of Clinical Investigation ·Vincent Lebon, Sylvie Dufour, Kitt Falk Petersen, Jianming Ren, Beat M. Jucker, Lori A. Slezak, Gary W. Cline, Douglas L. Rothman, Gerald I. Shulman	133
20	Sources of carbon for hepatic glycogen synthesis in the conscious dog. 1991 ·Journal of Clinical Investigation ·Mary Courtney Moore, Alan D. Cherrington, Gary W. Cline, Michael J. Pagliassotti, Elizabeth M. Jones, Doss W. Neal, (unknown), Gerald I. Shulman	101

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