Klaus Ley

77.4k total citations · 22 hit papers
457 papers, 55.9k citations indexed

About

Klaus Ley is a scholar working on Immunology, Immunology and Allergy and Molecular Biology. According to data from OpenAlex, Klaus Ley has authored 457 papers receiving a total of 55.9k indexed citations (citations by other indexed papers that have themselves been cited), including 269 papers in Immunology, 235 papers in Immunology and Allergy and 116 papers in Molecular Biology. Recurrent topics in Klaus Ley's work include Cell Adhesion Molecules Research (234 papers), Atherosclerosis and Cardiovascular Diseases (106 papers) and Immune Response and Inflammation (78 papers). Klaus Ley is often cited by papers focused on Cell Adhesion Molecules Research (234 papers), Atherosclerosis and Cardiovascular Diseases (106 papers) and Immune Response and Inflammation (78 papers). Klaus Ley collaborates with scholars based in United States, Germany and Brazil. Klaus Ley's co-authors include Elena Galkina, Alexander Zarbock, Yuqing Huo, Myron I. Cybulsky, Carlo Laudanna, Sussan Nourshargh, Timothy S. Olson, Marco Orecchioni, Steffen Jung and Ali Hafezi‐Moghadam and has published in prestigious journals such as Nature, Science and Proceedings of the National Academy of Sciences.

In The Last Decade

Klaus Ley

443 papers receiving 55.1k citations

Hit Papers

5 papers align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Getting to the site of inflammation: the leukocyte adhesion cascade updated

2007 3.2k citations Klaus Ley et al. Nature reviews. Immunology profile →
Development of Monocytes, Macrophages, and Dendritic Cells

2010 2.3k citations Steffen Jung, Klaus Ley et al. profile →
Macrophage Polarization: Different Gene Signatures in M1(LPS+) vs. Classically and M2(LPS–) vs. Alternatively Activated Macrophages

2019 1.5k citations Marco Orecchioni, Yanal Ghosheh et al. profile →
Interaction of oestrogen receptor with the regulatory subunit of phosphatidylinositol-3-OH kinase

2000 1.2k citations Klaus Ley et al. profile →
Immune and Inflammatory Mechanisms of Atherosclerosis

2009 1.1k citations Klaus Ley et al. profile →
Anti-inflammatory Properties of Cytochrome P450 Epoxygenase-Derived Eicosanoids

1999 1.0k citations Yuqing Huo, Klaus Ley et al. profile →
Circulating activated platelets exacerbate atherosclerosis in mice deficient in apolipoprotein E

2002 809 citations Yuqing Huo, S. Bradley Forlow et al. profile →
Phagocytosis of Apoptotic Neutrophils Regulates Granulopoiesis via IL-23 and IL-17

2005 760 citations Yuqing Huo, Tracy L. Burcin et al. profile →
Lymphocyte homing and leukocyte rolling and migration are impaired in L-selectin-deficient mice

1994 706 citations Klaus Ley et al. profile →
Vascular Adhesion Molecules in Atherosclerosis

2007 641 citations Klaus Ley et al. profile →
Single-Cell RNA-Seq Reveals the Transcriptional Landscape and Heterogeneity of Aortic Macrophages in Murine Atherosclerosis

2018 609 citations Holger Winkels, Klaus Ley et al. Circulation Research profile →
Severe reduction in leukocyte adhesion and monocyte extravasation in mice deficient in CC chemokine receptor 2

1997 573 citations Klaus Ley et al. profile →
Interleukin-17 Signaling in Inflammatory, Kupffer Cells, and Hepatic Stellate Cells Exacerbates Liver Fibrosis in Mice

2012 561 citations Klaus Ley et al. profile →
Chemokines and chemokine receptors in leukocyte trafficking

2002 543 citations Timothy S. Olson, Klaus Ley profile →
The role of selectins in inflammation and disease

2003 520 citations Klaus Ley profile →
Platelet-neutrophil-interactions: Linking hemostasis and inflammation

2006 511 citations Alexander Zarbock, Klaus Ley et al. profile →
T cell subsets and functions in atherosclerosis

2020 476 citations Holger Winkels, Klaus Ley et al. profile →
Bacterial colonization factors control specificity and stability of the gut microbiota

2013 467 citations Klaus Ley et al. profile →
Atherosclerosis

2018 400 citations Kouji Kobiyama, Klaus Ley Circulation Research profile →
Atlas of the Immune Cell Repertoire in Mouse Atherosclerosis Defined by Single-Cell RNA-Sequencing and Mass Cytometry

2018 381 citations Holger Winkels, Erik Ehinger et al. Circulation Research profile →
How the immune system shapes atherosclerosis: roles of innate and adaptive immunity

2021 340 citations Payel Roy, Marco Orecchioni et al. Nature reviews. Immunology profile →
Integrin-based therapeutics: biological basis, clinical use and new drugs

2016 313 citations Klaus Ley, Jesús Rivera–Nieves et al. profile →

Peers

Countries citing papers authored by Klaus Ley

Since Specialization

Citations

This map shows the geographic impact of Klaus Ley's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Klaus Ley with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Klaus Ley more than expected).

Fields of papers citing papers by Klaus Ley

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Klaus Ley. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Klaus Ley. The network helps show where Klaus Ley may publish in the future.

Co-authorship network of co-authors of Klaus Ley

This figure shows the co-authorship network connecting the top 25 collaborators of Klaus Ley. A scholar is included among the top collaborators of Klaus Ley based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Klaus Ley. Klaus Ley is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

#	Work	Indexed citations
1	Single Cell High Dimensional Analysis of Human Peripheral Blood Mononuclear Cells Reveals Unique Intermediate Monocyte Subsets Associated with Sex Differences in Coronary Artery Disease 2024 ·International Journal of Molecular Sciences ·(unknown), (unknown), Christopher P. Durant, Runpei Wu, Chantel McSkimming, (unknown), (unknown), (unknown), Yury I. Miller, Coleen A. McNamara, Klaus Ley, Angela M. Taylor, Ahmad Alimadadi, Catherine C. Hedrick	5
2	Identification of human exTreg cells as CD16+CD56+ cytotoxic CD4+ T cells 2023 ·Nature Immunology ·(unknown), Payel Roy, (unknown), (unknown), Sunil Kumar, Marco Orecchioni, Amal J. Ali, Amir Khan, Jeffrey Makings, (unknown), Holger Winkels, Erpei Wang, Christopher P. Durant, Yanal Ghosheh, (unknown), Felix Sebastian Nettersheim, Klaus Ley	31
3	V₄C₃ MXene Immune Profiling and Modulation of T Cell‐Dendritic Cell Function and Interaction 2023 ·Small Methods ·Laura Fusco, Arianna Gazzi, Christopher E. Shuck, Marco Orecchioni, Eiman I. Ahmed, (unknown), Barbara Zavan, Açelya Yılmazer, Klaus Ley, Davide Bedognetti, Yury Gogotsi, Lucia Gemma Delogu	22
4	Neuroinflammation Plays a Critical Role in Cerebral Cavernous Malformation Disease 2022 ·Circulation Research ·(unknown), (unknown), (unknown), (unknown), Marco Orecchioni, (unknown), (unknown), Hao Sun, Omar A. Mesarwi, Klaus Ley, Brendan Gongol, Miguel Alejandro Lopez‐Ramirez	23
5	Immune Profiling and Multiplexed Label‐Free Detection of 2D MXenes by Mass Cytometry and High‐Dimensional Imaging 2022 ·Advanced Materials ·Laura Fusco, Arianna Gazzi, Christopher E. Shuck, Marco Orecchioni, (unknown), (unknown), Darawan Rinchai, Eiman I. Ahmed, Ofer Elhanani, Martina Rauner, Barbara Zavan, Jean‐Charles Grivel, Leeat Keren, Giulia Pasqual, Davide Bedognetti, Klaus Ley, Yury Gogotsi, Lucia Gemma Delogu	25
6	Immunodominant MHC-II (Major Histocompatibility Complex II) Restricted Epitopes in Human Apolipoprotein B 2022 ·Circulation Research ·Payel Roy, John Sidney, Cecilia S. Lindestam Arlehamn, Elizabeth J. Phillips, S. Mallal, (unknown), (unknown), Paul Rubiro, Daniel Marrama, (unknown), Jenifer Vallejo, (unknown), Marco Orecchioni, Jeffrey Makings, Paul Kim, Coleen A. McNamara, Bjoern Peters, Alessandro Sette, Klaus Ley	12
7	Thymus-Derived CD4+CD8+ Cells Reside in Mediastinal Adipose Tissue and the Aortic Arch 2021 ·The Journal of Immunology ·Holger Winkels, Yanal Ghosheh, Kouji Kobiyama, William B. Kiosses, Marco Orecchioni, Erik Ehinger, (unknown), Sara Herrera de la Mata, (unknown), Thomas Riffelmacher, (unknown), Mitchell Kronenberg, Dennis Wolf, Grégory Seumois, Pandurangan Vijayanand, Klaus Ley	1
8	How the immune system shapes atherosclerosis: roles of innate and adaptive immunity breakdown → 2021 ·Nature reviews. Immunology ·Payel Roy, Marco Orecchioni, Klaus Ley	340
9	Neutrophils: New insights and open questions 2018 ·Science Immunology ·Klaus Ley, Hal M. Hoffman, Paul Kubes, Marco A. Cassatella, Arturo Zychlinsky, Catherine C. Hedrick, Sergio Catz	371
10	The PSGL-1–L-selectin signaling complex regulates neutrophil adhesion under flow 2013 ·The Journal of Experimental Medicine ·Anika Stadtmann, Giulia Germena, Helena Block, (unknown), Jan Rossaint, Prithu Sundd, Craig T. Lefort, Charles I. Fisher, Konrad Buscher, (unknown), Ana Urzainqui, Volker Gerke, Klaus Ley, Alexander Zarbock	87
11	Distinct roles for talin-1 and kindlin-3 in LFA-1 extension and affinity regulation 2012 ·Blood ·Craig T. Lefort, Jan Rossaint, Markus Moser, Brian G. Petrich, Alexander Zarbock, Susan J. Monkley, David R. Critchley, Mark H. Ginsberg, Reinhard Fässler, Klaus Ley	188
12	PSGL-1 engagement by E-selectin signals through Src kinase Fgr and ITAM adapters DAP12 and FcRγ to induce slow leukocyte rolling 2008 ·The Journal of Experimental Medicine ·Alexander Zarbock, Clare L. Abram, Matthias Hundt, Amnon Altman, Clifford A. Lowell, Klaus Ley	172
13	Adhesion Molecules: Function and Inhibition 2007 ·Birkhäuser Basel eBooks ·Klaus Ley	36
14	Mechanisms and Consequences of Neutrophil Interaction with the Endothelium 2007 ·American Journal Of Pathology ·Alexander Zarbock, Klaus Ley	157
15	Critical role of endothelial P-selectin glycoprotein ligand 1 in chronic murine ileitis 2006 ·The Journal of Experimental Medicine ·Jesús Rivera–Nieves, Tracy L. Burcin, Timothy S. Olson, Margaret Morris, Marcia McDuffie, Fabio Cominelli, Klaus Ley	73
16	Analysis of Leukocyte Rolling In Vivo and In Vitro 2006 ·Methods in enzymology on CD-ROM/Methods in enzymology ·Markus Sperandio, J.E. Pickard, Sunil Unnikrishnan, Scott T. Acton, Klaus Ley	51
17	Expanded B cell population blocks regulatory T cells and exacerbates ileitis in a murine model of Crohn disease 2004 ·Journal of Clinical Investigation ·Timothy S. Olson, Giorgos Bamias, Makoto Naganuma, Jesús Rivera–Nieves, Tracy L. Burcin, William A. Ross, Margaret Morris, Theresa T. Pizarro, Peter B. Ernst, Fabio Cominelli, Klaus Ley	78
18	P-selectin glycoprotein ligand-1–deficient mice have impaired leukocyte tethering to E-selectin under flow 2002 ·Journal of Clinical Investigation ·Lijun Xia, Markus Sperandio, Tadayuki Yago, J. Michael McDaniel, Richard D. Cummings, Sonia Pearson‐White, Klaus Ley, Rodger P. McEver	180
19	The chemokine KC, but not monocyte chemoattractant protein-1, triggers monocyte arrest on early atherosclerotic endothelium 2001 ·Journal of Clinical Investigation ·Yuqing Huo, Christian Weber, (unknown), Markus Sperandio, Jayant Thatte, Matthias Mack, Steffen Jung, Dan R. Littman, Klaus Ley	17
20	The chemokine KC, but not monocyte chemoattractant protein-1, triggers monocyte arrest on early atherosclerotic endothelium 2001 ·Journal of Clinical Investigation ·Yuqing Huo, Christian Weber, S. Bradley Forlow, Markus Sperandio, Jayant Thatte, Matthias Mack, Steffen Jung, Dan R. Littman, Klaus Ley	226

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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