Byron Caughey

27.5k total citations · 8 hit papers
244 papers, 20.4k citations indexed

About

Byron Caughey is a scholar working on Molecular Biology, Neurology and Nutrition and Dietetics. According to data from OpenAlex, Byron Caughey has authored 244 papers receiving a total of 20.4k indexed citations (citations by other indexed papers that have themselves been cited), including 218 papers in Molecular Biology, 115 papers in Neurology and 81 papers in Nutrition and Dietetics. Recurrent topics in Byron Caughey's work include Prion Diseases and Protein Misfolding (206 papers), Neurological diseases and metabolism (113 papers) and Trace Elements in Health (81 papers). Byron Caughey is often cited by papers focused on Prion Diseases and Protein Misfolding (206 papers), Neurological diseases and metabolism (113 papers) and Trace Elements in Health (81 papers). Byron Caughey collaborates with scholars based in United States, Italy and United Kingdom. Byron Caughey's co-authors include Gregory J. Raymond, Peter T. Lansbury, Bruce Chesebro, Richard Race, Gerald S. Baron, Andrew G. Hughson, David A. Kocisko, D Ernst, Suzette A. Priola and Christina D. Orrú and has published in prestigious journals such as Nature, Science and New England Journal of Medicine.

In The Last Decade

Byron Caughey

242 papers receiving 19.8k citations

Hit Papers

5 papers align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

PROTOFIBRILS, PORES, FIBRILS, AND NEURODEGENERATION: Separating the Responsible Protein Aggregates from The Innocent Bystanders

2003 1.4k citations Byron Caughey, Peter T. Lansbury profile →
The most infectious prion protein particles

2005 717 citations Jay R. Silveira, Gregory J. Raymond et al. Nature profile →
Secondary structure analysis of the scrapie-associated protein PrP 27-30 in water by infrared spectroscopy

1991 695 citations Byron Caughey et al. profile →
Cell-free formation of protease-resistant prion protein

1994 694 citations David A. Kocisko, Suzette A. Priola et al. Nature profile →
The scrapie-associated form of PrP is made from a cell surface precursor that is both protease- and phospholipase-sensitive.

1991 527 citations Byron Caughey, Gregory J. Raymond profile →
Anchorless Prion Protein Results in Infectious Amyloid Disease Without Clinical Scrapie

2005 500 citations Bruce Chesebro, Richard Race et al. profile →
Rapid and ultra-sensitive quantitation of disease-associated α-synuclein seeds in brain and cerebrospinal fluid by αSyn RT-QuIC

2018 285 citations Bradley R. Groveman, Christina D. Orrú et al. Acta Neuropathologica Communications profile →
Biomarkers and diagnostic guidelines for sporadic Creutzfeldt-Jakob disease

2021 171 citations Byron Caughey, Alison Green et al. profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name	h						Papers	Cites
Byron Caughey United States	76	17.4k	8.8k	6.3k	4.2k	2.8k	244	20.4k
John Collinge United Kingdom	72	19.8k 1.1×	10.6k 1.2×	7.0k 1.1×	3.6k 0.9×	2.0k 0.7×	332	22.0k
David Westaway Canada	61	11.7k 0.7×	6.4k 0.7×	4.9k 0.8×	4.5k 1.1×	1.2k 0.4×	188	16.3k
Claudio Soto United States	79	13.4k 0.8×	4.4k 0.5×	2.8k 0.4×	8.4k 2.0×	2.9k 1.0×	239	21.5k
Giuseppe Legname Italy	50	7.8k 0.4×	3.7k 0.4×	2.8k 0.4×	1.9k 0.5×	1.1k 0.4×	209	10.0k
Blas Frangione United States	91	15.0k 0.9×	4.3k 0.5×	1.9k 0.3×	16.0k 3.8×	3.0k 1.1×	355	27.9k
Darlene Groth United States	49	12.9k 0.7×	7.0k 0.8×	5.8k 0.9×	1.3k 0.3×	581 0.2×	69	13.3k
Witold K. Surewicz United States	65	11.3k 0.7×	2.4k 0.3×	2.7k 0.4×	3.1k 0.8×	510 0.2×	174	13.9k
Holger Wille United States	42	6.4k 0.4×	2.7k 0.3×	2.3k 0.4×	1.9k 0.5×	453 0.2×	121	7.5k
Jiri Safar United States	40	6.0k 0.3×	3.0k 0.3×	2.3k 0.4×	1.3k 0.3×	655 0.2×	107	7.0k
Ronald Melki France	65	7.1k 0.4×	3.0k 0.3×	576 0.1×	5.2k 1.2×	7.1k 2.6×	212	15.1k

Countries citing papers authored by Byron Caughey

Since Specialization

Citations

This map shows the geographic impact of Byron Caughey's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Byron Caughey with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Byron Caughey more than expected).

Fields of papers citing papers by Byron Caughey

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Byron Caughey. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Byron Caughey. The network helps show where Byron Caughey may publish in the future.

Co-authorship network of co-authors of Byron Caughey

This figure shows the co-authorship network connecting the top 25 collaborators of Byron Caughey. A scholar is included among the top collaborators of Byron Caughey based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Byron Caughey. Byron Caughey is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

Parveen, Sabiha, Parvez Alam, Christina D. Orrú, et al.. (2025). A same day α-synuclein RT-QuIC seed amplification assay for synucleinopathy biospecimens. PubMed. 2(1). 8–8. 4 indexed citations

Alam, Parvez, Forrest Hoyt, Efrosini Artikis, et al.. (2024). Cryo-EM structure of a natural prion: chronic wasting disease fibrils from deer. Acta Neuropathologica. 148(1). 56–56. 11 indexed citations

Koga, Shunsuke, Michael A. Metrick, Lawrence I. Golbe, et al.. (2023). Case report of a patient with unclassified tauopathy with molecular and neuropathological features of both progressive supranuclear palsy and corticobasal degeneration. Acta Neuropathologica Communications. 11(1). 88–88. 7 indexed citations

Vascellari, Sarah, Christina D. Orrú, Bradley R. Groveman, et al.. (2023). α-Synuclein seeding activity in duodenum biopsies from Parkinson’s disease patients. PLoS Pathogens. 19(6). e1011456–e1011456. 15 indexed citations

Aguilar‐Calvo, Patricia, Daniel R. Sandoval, Christopher V. Barback, et al.. (2023). Neuronal Ndst1 depletion accelerates prion protein clearance and slows neurodegeneration in prion infection. PLoS Pathogens. 19(9). e1011487–e1011487. 2 indexed citations

Hall, Sara, Christina D. Orrú, Geidy E. Serrano, et al.. (2022). Performance of αSynuclein RT-QuIC in relation to neuropathological staging of Lewy body disease. Acta Neuropathologica Communications. 10(1). 90–90. 78 indexed citations

Ferreira, Natalia, Andrew G. Hughson, Jason R. Hollister, et al.. (2017). A Promising Antiprion Trimethoxychalcone Binds to the Globular Domain of the Cellular Prion Protein and Changes Its Cellular Location. Antimicrobial Agents and Chemotherapy. 62(2). 14 indexed citations

Wang, Fei, Xinhe Wang, Christina D. Orrú, et al.. (2017). Self-propagating, protease-resistant, recombinant prion protein conformers with or without in vivo pathogenicity. PLoS Pathogens. 13(7). e1006491–e1006491. 32 indexed citations

Caughey, Byron, Christina D. Orrú, Bradley R. Groveman, et al.. (2017). Amplified Detection of Prions and Other Amyloids by RT-QuIC in Diagnostics and the Evaluation of Therapeutics and Disinfectants. Progress in molecular biology and translational science. 375–388. 16 indexed citations

10.

Hopping, Gene, et al.. (2016). Peptides Composed of Alternating L- and D-Amino Acids Inhibit Amyloidogenesis in Three Distinct Amyloid Systems Independent of Sequence. Journal of Molecular Biology. 428(11). 2317–2328. 50 indexed citations

11.

Orrú, Christina D., Bradley R. Groveman, Lynne D. Raymond, et al.. (2015). Bank Vole Prion Protein As an Apparently Universal Substrate for RT-QuIC-Based Detection and Discrimination of Prion Strains. PMC. 1 indexed citations

12.

Tan, Bo, Sonya Agarwal, Byron Caughey, et al.. (2012). Analysis of BSE-infected sheep tissues and plasma using the real-time quaking induced conversion (RT-QuIC) assay. Prion. 6. 2 indexed citations

13.

Vascellari, Sarah, Christina D. Orrú, Andrew G. Hughson, et al.. (2012). Prion Seeding Activities of Mouse Scrapie Strains with Divergent PrPSc Protease Sensitivities and Amyloid Plaque Content Using RT-QuIC and eQuIC. PLoS ONE. 7(11). e48969–e48969. 52 indexed citations

14.

McGuire, Lynne I., Alexander Peden, N. E. J. Appleford, et al.. (2011). Prion seeding activity in cerebrospinal fluid from sporadic Creutzfeldt-Jakob disease patients using real-time QuIC analysis: a potential new diagnostic test?. Prion. 5. 2 indexed citations

15.

Silveira, Jay R., Gregory J. Raymond, Andrew G. Hughson, et al.. (2005). The most infectious prion protein particles. Nature. 437(7056). 257–261. 717 indexed citations breakdown →

16.

Caughey, Byron. (2001). Interactions between prion protein isoforms: the kiss of death?. Trends in Biochemical Sciences. 26(4). 235–242. 107 indexed citations

17.

Caughey, Byron. (2000). Formation of Protease-Resistant Prion Protein in Cell-Free Systems. Current Issues in Molecular Biology. 2(3). 95–101. 10 indexed citations

18.

Caughey, Byron, Gregory J. Raymond, Suzette A. Priola, et al.. (1999). Methods for Studying Prion Protein (PrP) Metabolism and the Formation of Protease-Resistant PrP in Cell Culture and Cell-Free Systems: An Update. Molecular Biotechnology. 13(1). 45–56. 26 indexed citations

19.

Caughey, Byron, et al.. (1994). Binding of the protease-sensitive form of PrP (prion protein) to sulfated glycosaminoglycan and congo red [corrected]. Journal of Virology. 68(4). 2135–2141. 201 indexed citations

20.

Caughey, Byron, et al.. (1978). Growth of infective forms of Trypanosoma (T.) brucei on buffalo lung and Chinese hamster lung tissue culture cells.. Munich Personal RePEc Archive (Ludwig Maximilian University of Munich). 35(3). 201–7. 23 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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