Bruce Beutler

82.7k total citations · 56 hit papers
406 papers, 64.5k citations indexed

About

Bruce Beutler is a scholar working on Immunology, Molecular Biology and Epidemiology. According to data from OpenAlex, Bruce Beutler has authored 406 papers receiving a total of 64.5k indexed citations (citations by other indexed papers that have themselves been cited), including 243 papers in Immunology, 133 papers in Molecular Biology and 60 papers in Epidemiology. Recurrent topics in Bruce Beutler's work include Immune Response and Inflammation (163 papers), Immune Cell Function and Interaction (82 papers) and T-cell and B-cell Immunology (36 papers). Bruce Beutler is often cited by papers focused on Immune Response and Inflammation (163 papers), Immune Cell Function and Interaction (82 papers) and T-cell and B-cell Immunology (36 papers). Bruce Beutler collaborates with scholars based in United States, France and Germany. Bruce Beutler's co-authors include Anthony Cerami, Xin Du, Kasper Hoebe, Alexander Poltorak, Christophe Van Huffel, Flavia Bazzoni, Irina Smirnova, Amanda L. Blasius, Paola Ricciardi‐Castagnoli and Marina A. Freudenberg and has published in prestigious journals such as Nature, Science and New England Journal of Medicine.

In The Last Decade

Bruce Beutler

401 papers receiving 62.8k citations

Hit Papers

Defective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice:... 1985 2026 1998 2012 1998 1986 1985 1989 1986 2.0k 4.0k 6.0k
What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

  1. Defective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in Tlr4 Gene
    1998 6.3k citations Irina Smirnova, Xin Du et al. Science profile →
  2. Shock and Tissue Injury Induced by Recombinant Human Cachectin
    1986 2.1k citations Bruce Beutler et al. Science profile →
  3. Passive Immunization Against Cachectin/Tumor Necrosis Factor Protects Mice from Lethal Effect of Endotoxin
    1985 1.9k citations Bruce Beutler et al. Science profile →
  4. The Biology of Cachectin/TNF -- A Primary Mediator of the Host Response
    1989 1.4k citations Bruce Beutler et al. profile →
  5. Cachectin and tumour necrosis factor as two sides of the same biological coin
    1986 1.4k citations Bruce Beutler et al. profile →
  6. Identification of a common nucleotide sequence in the 3'-untranslated region of mRNA molecules specifying inflammatory mediators.
    1986 1.4k citations Bruce Beutler et al. Proceedings of the National Academy of Sciences profile →
  7. Tumor necrosis factor (cachectin) is an endogenous pyrogen and induces production of interleukin 1.
    1986 1.3k citations Bruce Beutler et al. The Journal of Experimental Medicine profile →
  8. Cachectin: More Than a Tumor Necrosis Factor
    1987 1.2k citations Bruce Beutler et al. profile →
  9. Inferences, questions and possibilities in Toll-like receptor signalling
    2004 1.2k citations Bruce Beutler profile →
  10. Control of Cachectin (Tumor Necrosis Factor) Synthesis: Mechanisms of Endotoxin Resistance
    1986 1.1k citations Bruce Beutler et al. Science profile →
  11. Cachectin/tumor necrosis factor stimulates collagenase and prostaglandin E2 production by human synovial cells and dermal fibroblasts.
    1985 1.1k citations Bruce Beutler et al. The Journal of Experimental Medicine profile →
  12. Innate immune sensing and its roots: the story of endotoxin
    2003 1.0k citations Bruce Beutler et al. profile →
  13. Intracellular Toll-like Receptors
    2010 1.0k citations Bruce Beutler et al. profile →
  14. The Tumor Necrosis Factor Ligand and Receptor Families
    1996 1.0k citations Bruce Beutler et al. profile →
  15. Identification of Lps2 as a key transducer of MyD88-independent TIR signalling
    2003 1.0k citations Xin Du, Koichi Tabeta et al. profile →
  16. TYPE I INTERFERONS (α/β) IN IMMUNITY AND AUTOIMMUNITY
    2004 973 citations Argyrios N. Theofilopoulos, Roberto Baccalà et al. profile →
  17. Essential role of mda-5 in type I IFN responses to polyriboinosinic:polyribocytidylic acid and encephalomyocarditis picornavirus
    2006 926 citations Bruce Beutler et al. Proceedings of the National Academy of Sciences profile →
  18. Innate immunity: an overview
    2003 902 citations Bruce Beutler profile →
  19. Exogenous and endogenous glycolipid antigens activate NKT cells during microbial infections
    2005 895 citations Bruce Beutler et al. profile →
  20. Identity of tumour necrosis factor and the macrophage-secreted factor cachectin
    1985 884 citations Bruce Beutler, Richard J. Ulevitch et al. profile →
  21. Toll-like receptors 9 and 3 as essential components of innate immune defense against mouse cytomegalovirus infection
    2004 759 citations Koichi Tabeta, Xin Du et al. Proceedings of the National Academy of Sciences profile →
  22. TUMOR NECROSIS, CACHEXIA, SHOCK, AND INFLAMMATION: A COMMON MEDIATOR
    1988 729 citations Bruce Beutler et al. profile →
  23. Purification of cachectin, a lipoprotein lipase-suppressing hormone secreted by endotoxin-induced RAW 264.7 cells.
    1985 702 citations Bruce Beutler et al. The Journal of Experimental Medicine profile →
  24. CD36 is a sensor of diacylglycerides
    2005 693 citations Xin Du, Suzanne Mudd et al. profile →
  25. The interface between innate and adaptive immunity
    2004 657 citations Bruce Beutler et al. profile →
  26. TLRs and innate immunity
    2008 656 citations Bruce Beutler Blood profile →
  27. Cachectin/tumor necrosis factor: production, distribution, and metabolic fate in vivo.
    1985 655 citations Bruce Beutler et al. profile →
  28. Tlr4: central component of the sole mammalian LPS sensor
    2000 644 citations Bruce Beutler profile →
  29. GENETIC ANALYSIS OF HOST RESISTANCE: Toll-Like Receptor Signaling and Immunity at Large
    2006 625 citations Bruce Beutler, Karine Crozat et al. profile →
  30. Cachectin/tumor necrosis factor induces cachexia, anemia, and inflammation.
    1988 612 citations Bruce Beutler et al. The Journal of Experimental Medicine profile →
  31. The Unc93b1 mutation 3d disrupts exogenous antigen presentation and signaling via Toll-like receptors 3, 7 and 9
    2006 553 citations Koichi Tabeta, Xin Du et al. profile →
  32. CD14 is required for MyD88-independent LPS signaling
    2005 534 citations Xin Du, Suzanne Mudd et al. profile →
  33. The evolution and genetics of innate immunity
    2001 510 citations Bruce Beutler et al. profile →
  34. Natural killer T cells recognize diacylglycerol antigens from pathogenic bacteria
    2006 496 citations Gary D. Ainge, Gavin F. Painter et al. profile →
  35. Macrophages secrete a novel heparin-binding protein with inflammatory and neutrophil chemokinetic properties.
    1988 477 citations Bruce Beutler et al. The Journal of Experimental Medicine profile →
  36. How we detect microbes and respond to them: the Toll-like receptors and their transducers
    2003 475 citations Bruce Beutler, Xin Du et al. profile →
  37. Adjuvant-Enhanced Antibody Responses in the Absence of Toll-Like Receptor Signaling
    2006 469 citations Bruce Beutler et al. Science profile →
  38. A Common Dominant TLR5 Stop Codon Polymorphism Abolishes Flagellin Signaling and Is Associated with Susceptibility to Legionnaires' Disease
    2003 467 citations Bruce Beutler et al. The Journal of Experimental Medicine profile →
  39. A Macrophage Factor Inhibits Adipocyte Gene Expression: An in Vitro Model of Cachexia
    1985 451 citations Bruce Beutler et al. Science profile →
  40. The Serine Protease TMPRSS6 Is Required to Sense Iron Deficiency
    2008 443 citations Xin Du, Terri Gelbart et al. Science profile →
  41. Endotoxin-responsive sequences control cachectin/tumor necrosis factor biosynthesis at the translational level.
    1990 439 citations Bruce Beutler et al. The Journal of Experimental Medicine profile →
  42. Dexamethasone and pentoxifylline inhibit endotoxin-induced cachectin/tumor necrosis factor synthesis at separate points in the signaling pathway.
    1990 437 citations Bruce Beutler et al. The Journal of Experimental Medicine profile →
  43. Toll-like receptors
    2011 392 citations Eva Marie Y. Moresco, Bruce Beutler et al. profile →
  44. Innate and Adaptive Immunity Cooperate Flexibly to Maintain Host-Microbiota Mutualism
    2009 383 citations Emma Slack, Siegfried Hapfelmeier et al. Science profile →
  45. TLR-dependent and TLR-independent pathways of type I interferon induction in systemic autoimmunity
    2007 379 citations Roberto Baccalà, Dwight H. Kono et al. profile →
  46. Upregulation of costimulatory molecules induced by lipopolysaccharide and double-stranded RNA occurs by Trif-dependent and Trif-independent pathways
    2003 374 citations Bruce Beutler et al. profile →
  47. Three novel mammalian toll-like receptors: gene structure, expression, and evolution.
    2000 374 citations Xin Du, Bruce Beutler et al. profile →
  48. Unraveling Function in the TNF Ligand and Receptor Families
    1994 370 citations Bruce Beutler et al. Science profile →
  49. Physical contact between lipopolysaccharide and Toll-like receptor 4 revealed by genetic complementation
    2000 367 citations Bruce Beutler et al. Proceedings of the National Academy of Sciences profile →
  50. The interaction between the ER membrane protein UNC93B and TLR3, 7, and 9 is crucial for TLR signaling
    2007 354 citations Bruce Beutler et al. profile →
  51. Cachectin/tumor necrosis factor induces lethal shock and stress hormone responses in the dog.
    1987 341 citations Bruce Beutler et al. profile →
  52. Genetic and Physical Mapping of theLpsLocus: Identification of the Toll-4 Receptor as a Candidate Gene in the Critical Region
    1998 306 citations Irina Smirnova, Xin Du et al. profile →
  53. Tumor Necrosis Factor: The molecules and Their Emerging Role in Medicine
    1992 300 citations Bruce Beutler et al. profile →
  54. The role of cachectin/TNF in endotoxic shock and cachexia
    1988 283 citations Bruce Beutler et al. profile →
  55. Cachectin/tumor necrosis factor-alpha formation in human decidua. Potential role of cytokines in infection-induced preterm labor.
    1989 272 citations Bruce Beutler et al. profile →
  56. Correlation of interleukin-1β and cachectin concentrations in cerebrospinal fluid and outcome from bacterial meningitis
    1989 241 citations Bruce Beutler et al. profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name h Career Trend Papers Cites
Bruce Beutler United States 112 38.1k 17.2k 10.8k 6.0k 5.6k 406 64.5k
Taro Kawai Japan 83 46.7k 1.2× 20.2k 1.2× 12.5k 1.2× 8.7k 1.5× 5.3k 1.0× 177 67.0k
Siamon Gordon United Kingdom 133 41.2k 1.1× 22.0k 1.3× 10.6k 1.0× 3.6k 0.6× 6.7k 1.2× 455 78.1k
Douglas T. Golenbock United States 112 30.7k 0.8× 15.2k 0.9× 10.7k 1.0× 4.5k 0.7× 2.7k 0.5× 288 51.0k
Luke O'neill Ireland 124 32.5k 0.9× 23.7k 1.4× 8.3k 0.8× 11.2k 1.9× 4.3k 0.8× 392 61.3k
Ruslan Medzhitov United States 114 61.3k 1.6× 27.9k 1.6× 13.4k 1.2× 8.9k 1.5× 7.3k 1.3× 227 97.2k
Osamu Takeuchi Japan 109 55.9k 1.5× 24.1k 1.4× 15.3k 1.4× 10.0k 1.7× 6.7k 1.2× 352 81.5k
Kiyoshi Takeda Japan 118 57.1k 1.5× 27.9k 1.6× 14.7k 1.4× 10.5k 1.8× 9.7k 1.7× 463 92.8k
Yoichiro Iwakura Japan 126 32.8k 0.9× 18.2k 1.1× 8.7k 0.8× 3.1k 0.5× 7.8k 1.4× 694 61.6k
Gabriel Núñez United States 131 33.2k 0.9× 46.9k 2.7× 10.6k 1.0× 6.3k 1.0× 8.9k 1.6× 383 82.2k
Nico van Rooijen Netherlands 146 38.1k 1.0× 21.4k 1.2× 13.1k 1.2× 3.5k 0.6× 10.0k 1.8× 838 80.5k

Countries citing papers authored by Bruce Beutler

Since Specialization
Citations

This map shows the geographic impact of Bruce Beutler's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Bruce Beutler with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Bruce Beutler more than expected).

Fields of papers citing papers by Bruce Beutler

Since Specialization
Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Bruce Beutler. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Bruce Beutler. The network helps show where Bruce Beutler may publish in the future.

Co-authorship network of co-authors of Bruce Beutler

This figure shows the co-authorship network connecting the top 25 collaborators of Bruce Beutler. A scholar is included among the top collaborators of Bruce Beutler based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Bruce Beutler. Bruce Beutler is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

20 of 20 papers shown
1.
Zhong, Xue, James J. Moresco, Jeffrey A. SoRelle, et al.. (2024). Disruption of the ZFP574–THAP12 complex suppresses B cell malignancies in mice. Proceedings of the National Academy of Sciences. 121(31). e2409232121–e2409232121. 2 indexed citations
2.
Zhong, Xue, James J. Moresco, Jianhui Wang, et al.. (2024). Viable mutations of mouse midnolin suppress B cell malignancies. The Journal of Experimental Medicine. 221(6). 11 indexed citations
3.
Zhang, Zhao, Shunxing Rong, Jeffrey A. SoRelle, et al.. (2022). Loss of immunity-related GTPase GM4951 leads to nonalcoholic fatty liver disease without obesity. Nature Communications. 13(1). 4136–4136. 12 indexed citations
4.
Su, Lijing, Muhammad Athamna, Ying Wang, et al.. (2021). Sulfatides are endogenous ligands for the TLR4–MD-2 complex. Proceedings of the National Academy of Sciences. 118(30). 40 indexed citations
5.
Zhang, Zhao, T. F. Gallagher, Philipp E. Scherer, & Bruce Beutler. (2020). Tissue-specific disruption of Kbtbd2 uncovers adipocyte-intrinsic and -extrinsic features of the teeny lipodystrophy syndrome. Proceedings of the National Academy of Sciences. 117(21). 11829–11835. 6 indexed citations
6.
Su, Lijing, Ying Wang, Junmei Wang, et al.. (2019). Structural Basis of TLR2/TLR1 Activation by the Synthetic Agonist Diprovocim. Journal of Medicinal Chemistry. 62(6). 2938–2949. 65 indexed citations
7.
McAlpine, William, Jin Huk Choi, Sara Ludwig, et al.. (2018). The class I myosin MYO1D binds to lipid and protects against colitis. Disease Models & Mechanisms. 11(9). 9 indexed citations
8.
Choi, Jin Huk, Kuan-Wen Wang, Duanwu Zhang, et al.. (2017). IgD class switching is initiated by microbiota and limited to mucosa-associated lymphoid tissue in mice. Proceedings of the National Academy of Sciences. 114(7). E1196–E1204. 40 indexed citations
9.
Zhang, Zhao, Emre E. Turer, Xiaohong Li, et al.. (2016). Insulin resistance and diabetes caused by genetic or diet-induced KBTBD2 deficiency in mice. Proceedings of the National Academy of Sciences. 113(42). E6418–E6426. 33 indexed citations
10.
Jimenez-Dalmaroni, Maximiliano, Catherine M. Radcliffe, David J. Harvey, et al.. (2014). Soluble human TLR2 ectodomain binds diacylglycerol from microbial lipopeptides and glycolipids. Innate Immunity. 21(2). 175–193. 17 indexed citations
11.
Narni-Mancinelli, Émilie, Baptiste N. Jaeger, Claire Bernat, et al.. (2012). Tuning of Natural Killer Cell Reactivity by NKp46 and Helios Calibrates T Cell Responses. Science. 335(6066). 344–348. 150 indexed citations
12.
Siggs, Owen M., Xiaohong Li, Yu Xia, & Bruce Beutler. (2011). ZBTB1 is a determinant of lymphoid development. The Journal of Experimental Medicine. 209(1). 19–27. 33 indexed citations
13.
Krebs, Philippe, Karine Crozat, Daniel L. Popkin, Michael B. A. Oldstone, & Bruce Beutler. (2011). Disruption of MyD88 signaling suppresses hemophagocytic lymphohistiocytosis in mice. Blood. 117(24). 6582–6588. 48 indexed citations
14.
Siggs, Owen M., Bernd Schnabl, Bill D. Webb, & Bruce Beutler. (2011). X-linked cholestasis in mouse due to mutations of the P4-ATPase ATP11C. Proceedings of the National Academy of Sciences. 108(19). 7890–7895. 52 indexed citations
15.
Arnold, Carrie, Yu Xia, Pei Lin, et al.. (2010). Rapid Identification of a Disease Allele in Mouse Through Whole Genome Sequencing and Bulk Segregation Analysis. Genetics. 187(3). 633–641. 46 indexed citations
16.
Kono, Dwight H., Brian R. Lawson, K. Michael Pollard, et al.. (2009). Endosomal TLR signaling is required for anti-nucleic acid and rheumatoid factor autoantibodies in lupus. Proceedings of the National Academy of Sciences. 106(29). 12061–12066. 127 indexed citations
17.
Slack, Emma, Siegfried Hapfelmeier, Bärbel Stecher, et al.. (2009). Innate and Adaptive Immunity Cooperate Flexibly to Maintain Host-Microbiota Mutualism. Science. 325(5940). 617–620. 383 indexed citations breakdown →
18.
Du, Xin, Terri Gelbart, Jaroslav Truksa, et al.. (2008). The Serine Protease TMPRSS6 Is Required to Sense Iron Deficiency. Science. 320(5879). 1088–1092. 443 indexed citations breakdown →
19.
Meehan, Thomas P., et al.. (2006). Point mutations in the melanocortin-4 receptor cause variable obesity in mice. Mammalian Genome. 17(12). 1162–1171. 18 indexed citations
20.
Smirnova, Irina, Navjiwan Mann, Annemiek Dols, et al.. (2003). Assay of locus-specific genetic load implicates rare Toll-like receptor 4 mutations in meningococcal susceptibility. Proceedings of the National Academy of Sciences. 100(10). 6075–6080. 178 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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