Alexander Poltorak

13.8k total citations · 5 hit papers
66 papers, 11.0k citations indexed

About

Alexander Poltorak is a scholar working on Immunology, Molecular Biology and Infectious Diseases. According to data from OpenAlex, Alexander Poltorak has authored 66 papers receiving a total of 11.0k indexed citations (citations by other indexed papers that have themselves been cited), including 44 papers in Immunology, 35 papers in Molecular Biology and 8 papers in Infectious Diseases. Recurrent topics in Alexander Poltorak's work include Immune Response and Inflammation (26 papers), interferon and immune responses (19 papers) and Inflammasome and immune disorders (17 papers). Alexander Poltorak is often cited by papers focused on Immune Response and Inflammation (26 papers), interferon and immune responses (19 papers) and Inflammasome and immune disorders (17 papers). Alexander Poltorak collaborates with scholars based in United States, Russia and Germany. Alexander Poltorak's co-authors include Bruce Beutler, Irina Smirnova, Xin Du, Paola Ricciardi‐Castagnoli, Marina A. Freudenberg, Erica Alejos, Christophe Van Huffel, Chris Galanos, Xiaolong He and Maria João Silva and has published in prestigious journals such as Science, Proceedings of the National Academy of Sciences and Journal of Biological Chemistry.

In The Last Decade

Alexander Poltorak

65 papers receiving 10.8k citations

Hit Papers

5 papers align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Defective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in Tlr4 Gene

1998 6.3k citations Alexander Poltorak, Xiaolong He et al. Science profile →
Caspase-8 induces cleavage of gasdermin D to elicit pyroptosis during Yersinia infection

2018 684 citations Joseph Sarhan, Beiyun C. Liu et al. profile →
Three novel mammalian toll-like receptors: gene structure, expression, and evolution.

2000 374 citations Xin Du, Alexander Poltorak et al. PubMed profile →
Physical contact between lipopolysaccharide and Toll-like receptor 4 revealed by genetic complementation

2000 367 citations Alexander Poltorak, Paola Ricciardi‐Castagnoli et al. profile →
Genetic and Physical Mapping of theLpsLocus: Identification of the Toll-4 Receptor as a Candidate Gene in the Critical Region

1998 306 citations Alexander Poltorak, Irina Smirnova et al. Blood Cells Molecules and Diseases profile →

Peers

Alexander Poltorak

IMMUN

EPIDE

MICRO

Kelly D. Smith United States

John C. Mathison United States

Xin Du United States

Gregory M. Barton United States

Tomohiko Ogawa Japan

Haruhiko Takada Japan

Kasper Hoebe United States

Irina Smirnova United States

Brian G. Monks United States

Philippe Georgel France

Kelly D. Smith United States

Alexander Poltorak

7.7k ×1.0

IMMUN

3.4k ×1.0

2.1k ×1.1

EPIDE

849 ×0.7

1.4k ×1.3

MICRO

Citations per year, relative to Alexander Poltorak Alexander Poltorak (= 1×) peers Kelly D. Smith

Countries citing papers authored by Alexander Poltorak

Since Specialization

Citations

This map shows the geographic impact of Alexander Poltorak's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Alexander Poltorak with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Alexander Poltorak more than expected).

Fields of papers citing papers by Alexander Poltorak

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Alexander Poltorak. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Alexander Poltorak. The network helps show where Alexander Poltorak may publish in the future.

Co-authorship network of co-authors of Alexander Poltorak

This figure shows the co-authorship network connecting the top 25 collaborators of Alexander Poltorak. A scholar is included among the top collaborators of Alexander Poltorak based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Alexander Poltorak. Alexander Poltorak is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

Sort: Min cites: Since: Top N: Style:

20 of 20 papers shown

Bayer, Abraham, Zoie Magri, Hayley I. Muendlein, Alexander Poltorak, & Pilar Alcaide. (2025). MyD88 determines T cell fate through BCAP-PI3K signaling. The Journal of Immunology. 214(3). 433–445. 1 indexed citations

Magri, Zoie, David Jetton, Hayley I. Muendlein, et al.. (2024). CD14 is a decision-maker between Fas-mediated death and inflammation. Cell Reports. 43(9). 114685–114685. 1 indexed citations

Magri, Zoie & Alexander Poltorak. (2023). You had me at PELO: a “Ribosome Rescuer” induces NLR inflammasome assembly. Cellular and Molecular Immunology. 21(1). 1–2.

Muendlein, Hayley I., Wilson M. Connolly, Zoie Magri, et al.. (2021). ZBP1 promotes LPS-induced cell death and IL-1β release via RHIM-mediated interactions with RIPK1. Nature Communications. 12(1). 86–86. 79 indexed citations

Muendlein, Hayley I., David Jetton, Wilson M. Connolly, et al.. (2020). cFLIP _L protects macrophages from LPS-induced pyroptosis via inhibition of complex II formation. Science. 367(6484). 1379–1384. 109 indexed citations

Muendlein, Hayley I. & Alexander Poltorak. (2020). Flipping the Switch from Inflammation to Cell Death. Trends in Immunology. 41(8). 648–651. 4 indexed citations

Liu, Beiyun C., Joseph Sarhan, & Alexander Poltorak. (2018). Host-Intrinsic Interferon Status in Infection and Immunity. Trends in Molecular Medicine. 24(8). 658–668. 13 indexed citations

Poltorak, Alexander, et al.. (2016). Stimulator of interferon genes (STING): A “new chapter” in virus-associated cancer research. Lessons from wild-derived mouse models of innate immunity. Cytokine & Growth Factor Reviews. 29. 83–91. 14 indexed citations

Schworer, Stephen A., Irina Smirnova, Trent Fowler, et al.. (2014). Toll-like Receptor-mediated Down-regulation of the Deubiquitinase Cylindromatosis (CYLD) Protects Macrophages from Necroptosis in Wild-derived Mice. Journal of Biological Chemistry. 289(20). 14422–14433. 31 indexed citations

10.

Smith, Patrick M., Mara G. Shainheit, Lindsey E. Bazzone, et al.. (2009). Genetic Control of Severe Egg-Induced Immunopathology and IL-17 Production in Murine Schistosomiasis. The Journal of Immunology. 183(5). 3317–3323. 30 indexed citations

11.

Smirnova, Irina, et al.. (2006). Genetic analysis of the innate immune responses in wild‐derived inbred strains of mice. European Journal of Immunology. 37(1). 212–223. 20 indexed citations

12.

Smirnova, Irina, et al.. (2006). Mice expressing high levels of soluble CD14 retain LPS in the circulation and are resistant to LPS‐induced lethality. European Journal of Immunology. 36(11). 3007–3016. 22 indexed citations

13.

Poltorak, Alexander, Thomas Merlin, Peter Nielsen, et al.. (2001). A Point Mutation in the IL-12R β2 Gene Underlies the IL-12 Unresponsiveness of Lps- Defective C57BL/10ScCr Mice. The Journal of Immunology. 167(4). 2106–2111. 62 indexed citations

14.

Beutler, Bruce & Alexander Poltorak. (2001). Sepsis and evolution of the innate immune response. Critical Care Medicine. 29(7 Suppl). S2–S6. 129 indexed citations

15.

Smirnova, Irina, Alexander Poltorak, Edward K. L. Chan, Colleen M. McBride, & Bruce Beutler. (2000). Phylogenetic variation and polymorphism at the Toll-like receptor 4 locus (TLR4). Genome biology. 1(1). RESEARCH002–RESEARCH002. 147 indexed citations

16.

Rehli, Michael, Alexander Poltorak, Lucia Schwarzfischer, et al.. (2000). PU.1 and Interferon Consensus Sequence-binding Protein Regulate the Myeloid Expression of the Human Toll-like Receptor 4 Gene. Journal of Biological Chemistry. 275(13). 9773–9781. 212 indexed citations

17.

Poltorak, Alexander, et al.. (2000). Analysis of Tlr4-Mediated LPS Signal Transduction in Macrophages by Mutational Modification of the Receptor. Blood Cells Molecules and Diseases. 26(1). 9–9. 8 indexed citations

18.

Poltorak, Alexander, Irina Smirnova, Christophe Van Huffel, et al.. (1999). Defective LPS signaling in C3 H/HeJ and C57 BL/10 ScCr mice: Mutations in Tlr4 Gene. Pneumologie. 53(9). 257 indexed citations

19.

Poltorak, Alexander, Irina Smirnova, Xiaolong He, et al.. (1998). Genetic and Physical Mapping of theLpsLocus: Identification of the Toll-4 Receptor as a Candidate Gene in the Critical Region. Blood Cells Molecules and Diseases. 24(3). 340–355. 306 indexed citations breakdown →

20.

Włodarski, Paweł, et al.. (1971). Irradiation and the bone induction properties of epithelial cells.. PubMed. 19(12). 821–5. 5 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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