Melanie H. Cobb

44.3k citations

278 papers · 37.1k indexed · 14 hit papers · h-index 93

Molecular Biology top 0.05%
Cell Biology top 0.05%
Oncology top 0.2%
Immunology top 0.5%
Cancer Research top 0.2%

Co-authors: Elizabeth J. Goldsmith Megan J. Robinson Teri G. Boulton David J. Robbins Gray W. Pearson Bing-e Xu Fred L. Robinson Mahesh Karandikar
Topics: Melanoma and MAPK Pathways (102 papers)Protein Kinase Regulation and GTPase Signaling (98 papers)Pancreatic function and diabetes (42 papers)
Cited by: Molecular Biology Cell Biology Aging
Journals: Nature Science Cell
Partner nations: United States Germany Japan

In The Last Decade

Melanie H. Cobb

275 papers receiving 36.4k citations

Hit Papers

5 papers align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Mitogen-Activated Protein (MAP) Kinase Pathways: Regulation and Physiological Functions*

2001 3.4k citations Gray W. Pearson, Melanie H. Cobb et al. profile →
Mitogen-activated protein kinase pathways

1997 2.2k citations Megan J. Robinson, Melanie H. Cobb Current Opinion in Cell Biology profile →
ERKs: A family of protein-serine/threonine kinases that are activated and tyrosine phosphorylated in response to insulin and NGF

1991 1.7k citations David J. Robbins, Melanie H. Cobb et al. profile →
How MAP Kinases Are Regulated

1995 1.6k citations Melanie H. Cobb, Elizabeth J. Goldsmith Journal of Biological Chemistry profile →
Differential regulation and properties of MAPKs

2007 1.2k citations Melanie H. Cobb et al. profile →
Modulation of the dynamic instability of tubulin assembly by the microtubule-associated protein tau.

1992 779 citations Melanie H. Cobb et al. Molecular Biology of the Cell profile →
MAP kinase pathways

1999 739 citations Melanie H. Cobb profile →
MAP Kinases

2001 704 citations Gray W. Pearson, Melanie H. Cobb et al. profile →
Activation Mechanism of the MAP Kinase ERK2 by Dual Phosphorylation

1997 611 citations Melanie H. Cobb, Elizabeth J. Goldsmith et al. profile →
An Insulin-Stimulated Protein Kinase Similar to Yeast Kinases Involved in Cell Cycle Control

1990 600 citations Melanie H. Cobb et al. profile →
ERK phosphorylation potentiates Elk-1-mediated ternary complex formation and transactivation.

1995 584 citations Melanie H. Cobb et al. profile →
Phosphorylation of the MAP Kinase ERK2 Promotes Its Homodimerization and Nuclear Translocation

1998 576 citations Megan J. Robinson, Elizabeth J. Goldsmith et al. profile →
Atomic structure of the MAP kinase ERK2 at 2.3 Å resolution

1994 500 citations David J. Robbins, Melanie H. Cobb et al. profile →
Phosphorylation activates the insulin receptor tyrosine protein kinase.

1983 485 citations Melanie H. Cobb et al. Proceedings of the National Academy of Sciences profile →

Peers

Countries citing papers authored by Melanie H. Cobb

Since Specialization

Citations

This map shows the geographic impact of Melanie H. Cobb's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Melanie H. Cobb with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Melanie H. Cobb more than expected).

Fields of papers citing papers by Melanie H. Cobb

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Melanie H. Cobb. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Melanie H. Cobb. The network helps show where Melanie H. Cobb may publish in the future.

Co-authorship network of co-authors of Melanie H. Cobb

This figure shows the co-authorship network connecting the top 25 collaborators of Melanie H. Cobb. A scholar is included among the top collaborators of Melanie H. Cobb based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Melanie H. Cobb. Melanie H. Cobb is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

#	Work	Indexed citations
1	ERK1/2-MAPK signaling: Metabolic, organellar, and cytoskeletal interactions 2025 ·Current Opinion in Cell Biology ·(unknown),Melanie H. Cobb	2
2	Testis-specific serine kinase 6 (TSSK6) is abnormally expressed in colorectal cancer and promotes oncogenic behaviors 2024 ·Journal of Biological Chemistry ·(unknown),(unknown),Steve Stippec,Kathleen McGlynn,Melanie H. Cobb,Angelique W. Whitehurst	3
3	Hydrostatic Pressure Sensing by WNK kinases 2023 ·Molecular Biology of the Cell ·John M. Humphreys,(unknown),Radha Akella,Haixia He,(unknown),(unknown),(unknown),(unknown),Jenny Jiou,Kelly A. Servage,Kim Orth,Łukasz A. Joachimiak,Josep Rizo,Melanie H. Cobb,Chad A. Brautigam,Aylin R. Rodan,Elizabeth J. Goldsmith	4
4	Modulating p38 MAPK signaling by proteostasis mechanisms supports tissue integrity during growth and aging 2023 ·Nature Communications ·Yuan Wang,Yi M. Weaver,Svetlana Earnest,Clinton A. Taylor,Melanie H. Cobb,Benjamin P. Weaver	20
5	WNK1 controls endosomal trafficking through TRIM27-dependent regulation of actin assembly 2023 ·Proceedings of the National Academy of Sciences ·Ji-Ung Jung,Melanie H. Cobb	9
6	ERK2 Mutations Affect Interactions, Localization, and Dimerization 2023 ·Biochemistry ·Clinton A. Taylor,(unknown),(unknown),Svetlana Earnest,Steve Stippec,Chonlarat Wichaidit,Melanie H. Cobb	2
7	Small Molecule-mediated Insulin Hypersecretion Induces Transient ER Stress Response and Loss of Beta Cell Function 2022 ·Endocrinology ·(unknown),(unknown),Derk D. Binns,Magdalena Grzemska,Luiz F. Barella,(unknown),Melissa K. McCoy,(unknown),(unknown),Bruce A. Posner,Melanie H. Cobb,Michael A. Kalwat	2
8	WNK1 Enhances Migration and Invasion in Breast Cancer Models 2021 ·Molecular Cancer Therapeutics ·(unknown),Ji-Ung Jung,Pravat Kumar Parida,Tuyen T. Dang,Chonlarat Wichaidit,(unknown),Svetlana Earnest,Elizabeth J. Goldsmith,Gray W. Pearson,Srinivas Malladi,Melanie H. Cobb	33
9	Subtype-specific secretomic characterization of pulmonary neuroendocrine tumor cells 2019 ·Nature Communications ·Xudong Wang,Rongkuan Hu,Qing Ding,Trisha K. Savage,Kenneth E. Huffman,Noelle S. Williams,Melanie H. Cobb,John D. Minna,Jane E. Johnson,Yonghao Yu	28
10	The Epithelial Sodium Channel (αENaC) Is a Downstream Therapeutic Target of ASCL1 in Pulmonary Neuroendocrine Tumors 2018 ·Translational Oncology ·Min He,Shanshan Liu,Sachith Gallolu Kankanamalage,Mark D. Borromeo,Luc Girard,Adi F. Gazdar,John D. Minna,Jane E. Johnson,Melanie H. Cobb	14
11	Amino Acids Regulate mTORC1 by an Obligate Two-step Mechanism 2016 ·Journal of Biological Chemistry ·Julia Dyachok,Svetlana Earnest,(unknown),Melanie H. Cobb,Elliott M. Ross	55
12	Menin determines K-RAS proliferative outputs in endocrine cells 2014 ·Journal of Clinical Investigation ·Chester E. Chamberlain,David Scheel,Kathleen McGlynn,Hail Kim,Takeshi Miyatsuka,Juehu Wang,Vinh Nguyen,Shuhong Zhao,Anastasia Mavropoulos,Aswin Abraham,Eric O’Neill,Gregory Ku,Melanie H. Cobb,Gail R. Martin,Michael S. German	55
13	NeuroD1 mediates nicotine-induced migration and invasion via regulation of the nicotinic acetylcholine receptor subunits in a subset of neural and neuroendocrine carcinomas 2014 ·Molecular Biology of the Cell ·Jihan K. Osborne,Marcy L. Guerra,(unknown),Elizabeth A. McMillan,John D. Minna,Melanie H. Cobb	11
14	Regulation of OSR1 and the sodium, potassium, two chloride cotransporter by convergent signals 2013 ·Proceedings of the National Academy of Sciences ·(unknown),(unknown),Svetlana Earnest,Steve Stippec,Xiaofeng Guo,David C. Trudgian,Hamid Mirzaei,Melanie H. Cobb	23
15	WNK1 and OSR1 regulate the Na ⁺ , K ⁺ , 2Cl ⁻ cotransporter in HeLa cells 2006 ·Proceedings of the National Academy of Sciences ·Anthony Anselmo,Svetlana Earnest,Wei Chen,Yu‐Chi Juang,Sung Chan Kim,Yingming Zhao,Melanie H. Cobb	152
16	Activation of MEKK1 by Rho GTPases 2006 ·Methods in enzymology on CD-ROM/Methods in enzymology ·Zhui Chen,Melanie H. Cobb	5
17	Structural Analysis of the MAP Kinase ERK2 and Studies of MAP Kinase Regulatory Pathways 1996 ·Advances in pharmacology ·Melanie H. Cobb,Shuichan Xu,Mangeng Cheng,(unknown),David J. Robbins,Elizabeth J. Goldsmith,Megan J. Robinson	24
18	Products of the TAL2 oncogene in leukemic T cells: bHLH phosphoproteins with DNA-binding activity. 1994 ·PubMed ·Ying Xia,(unknown),Melanie H. Cobb,Richard Baer	26
19	The MAP kinase phosphorylation site of TAL1 occurs within a transcriptional activation domain. 1994 ·PubMed ·I Wadman,(unknown),Melanie H. Cobb,Richard Baer	31
20	Proposed conformation of glutamic acid bound to the GSH receptor 1978 ·Federation Proceedings ·Melanie H. Cobb,Garland R. Marshall,Wyrta Heagy	1

About Melanie H. Cobb

Melanie H. Cobb is a scholar working on Cell Biology, Molecular Biology and Aging, having authored 278 papers that have together received 37.1k indexed citations. Recurring topics across this work include Melanoma and MAPK Pathways (102 papers), Protein Kinase Regulation and GTPase Signaling (98 papers) and Pancreatic function and diabetes (42 papers). The work is most often cited by research in Molecular Biology (27.3k citations), Cell Biology (5.7k citations) and Aging (593 citations). Melanie H. Cobb has collaborated with scholars based in United States, Germany and Japan. Frequent co-authors include Elizabeth J. Goldsmith, Megan J. Robinson, Teri G. Boulton, David J. Robbins, Gray W. Pearson, Bing-e Xu, Fred L. Robinson, Mahesh Karandikar, Tara Beers Gibson and Kevin Berman. Their work appears in journals such as Nature, Science and Cell.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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