Umut Özcan

11.6k citations

34 papers · 9.2k indexed · 4 hit papers · h-index 23

Impact in

Cell Biology top 0.1%
- Endoplasmic Reticulum Stress and Disease
Endocrine and Autonomic Systems top 0.5%
- Regulation of Appetite and Obesity

Papers in

Cell Biology 18
- Endoplasmic Reticulum Stress and Disease 18
Endocrine and Autonomic Systems 4
- Regulation of Appetite and Obesity 4

Co-authors: Gökhan S. Hotamışlıgil Erkan Yılmaz Cem Z. Görgün Lale Özcan Jaemin Lee Ann–Hwee Lee Qiong Cao Neal N. Iwakoshi
Journals: Cell Metabolism (5 papers)Nature Medicine (5 papers)Cell (2 papers)Journal of Clinical Investigation (2 papers)Science (2 papers)
Partner nations: United States France Türkiye

In The Last Decade

Umut Özcan

33 papers receiving 9.0k citations

Hit Papers

align trajectories log scale

Treatment of Obesity with Celastrol 2015 · 591 citations

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if any of the following hold:

it has ≥500 total citations;
it reaches ≥1.5× the top-1% citation threshold for papers in the same subfield and year (the threshold is the minimum needed to enter the top 1%, not the average within it);
it reaches the top citation threshold in at least one of its specific research topics.

2015 Cell
2009 Cell Metabolism
2006 Science
2004 Science

Peers

Countries citing papers authored by Umut Özcan

Since Specialization

Citations

This map shows the geographic impact of Umut Özcan's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Umut Özcan with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Umut Özcan more than expected).

Fields of papers citing papers by Umut Özcan

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Umut Özcan. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Umut Özcan. The network helps show where Umut Özcan may publish in the future.

Co-authorship network

The 25 scholars most cited alongside Umut Özcan, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Umut Özcan Line = papers co-authored together Umut Özcan links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

#	Work
1	Central inhibition of HDAC6 re-sensitizes leptin signaling during obesity to induce profound weight loss Cell Metabolism ·Dongxian Guan, Yuqin Men, H Musilová, Mario Andrés Salazar Hernández, Jie Xu, Alderman Walton Smith, H. Buske, Dong Kong, Ralph Mazitschek, Umut Özcan	2024	9
2	FKBP11 rewires UPR signaling to promote glucose homeostasis in type 2 diabetes and obesity Cell Metabolism ·Hilde Herrema, Dongxian Guan, Cristiane Lionço Zeferino, Xudong Feng, Mario Andrés Salazar Hernández, 古橋嘉一, Annelie Ramsbrock, Aldo Di, Rongya Tao, Hyonho Chun, Umut Özcan	2022	22
3	IL1R1 is required for celastrol’s leptin-sensitization and antiobesity effects Nature Medicine ·Xudong Feng, Dongxian Guan, Annelie Ramsbrock, Jae Won Choi, Mario Andrés Salazar Hernández, Jaemin Lee, Hyonho Chun, 古橋嘉一, Michael Massis, Zachary T. Herbert, Kyle D. Copps, Umut Özcan	2019	105
4	Lipocalin 2 Does Not Play A Role in Celastrol-Mediated Reduction in Food Intake and Body Weight Scientific Reports ·Xudong Feng, Dongxian Guan, Annelie Ramsbrock, Jae Won Choi, Ігор Гулейков, 古橋嘉一, Kyle D. Copps, Umut Özcan	2019	7
5	PGC-1α functions as a co-suppressor of XBP1s to regulate glucose metabolism Molecular Metabolism ·Jaemin Lee, Mario Andrés Salazar Hernández, Annelie Ramsbrock, Patrick Mucka, Justin Lee, Umut Özcan	2017	28
6	Withaferin A is a leptin sensitizer with strong antidiabetic properties in mice Nature Medicine ·Jaemin Lee, Junli Liu, Xudong Feng, Mario Andrés Salazar Hernández, Patrick Mucka, Dorina Ibi, Jae Won Choi, Umut Özcan	2016	175
7	XBP1s Is an Anti-lipogenic Protein Journal of Biological Chemistry ·Hilde Herrema, Yingjiang Zhou, Dongyan Zhang, Justin Lee, Mario Andrés Salazar Hernández, Gerald I. Shulman, Umut Özcan	2016	60
8	Inflammation Improves Glucose Homeostasis through IKKβ-XBP1s Interaction Cell ·Junli Liu, Dorina Ibi, Koji Taniguchi, Jaemin Lee, Hilde Herrema, Bedia Akosman, Patrick Mucka, Mario Andrés Salazar Hernández, Sung-Ho Rhyu, Sang Won Park, Michael Karin, Umut Özcan	2016	79
9	Treatment of Obesity with Celastrol Cell ·Jun‐Li Liu, Jaemin Lee, Mario Andrés Salazar Hernández, Ralph Mazitschek, Umut Özcan Hit paper breakdown →	2015	591
10	BRD7 Regulates XBP1s’ Activity and Glucose Homeostasis through Its Interaction with the Regulatory Subunits of PI3K Cell Metabolism ·Sang Won Park, Hilde Herrema, S. Aravind Shankar, Işın Çakır, Serkan Cabi, Dayana Desireé Avendaño Moreno, Yu‐Hsin Chiu, Lewis C. Cantley, Umut Özcan	2014	1
11	Potential for therapeutic manipulation of the UPR in disease Seminars in Immunopathology ·Sang Won Park, Umut Özcan	2013	74
12	Epinephrine deficiency results in intact glucose counter-regulation, severe hepatic steatosis and possible defective autophagy in fasting mice The International Journal of Biochemistry & Cell Biology ·Rana Sharara‐Chami, Yingjiang Zhou, Steven N. Ebert, Karel Pacák, Umut Özcan, Joseph A. Majzoub	2012	17
13	Regulation of glucose homeostasis through a XBP-1–FoxO1 interaction Nature Medicine ·Yingjiang Zhou, Justin Lee, Candace M. Reno, Cheng Sun, Sang Won Park, Jason Chung, Jaemin Lee, Simon J. Fisher, Morris F. White, Sudha B. Biddinger, Umut Özcan	2011	229
14	p38 MAPK–mediated regulation of Xbp1s is crucial for glucose homeostasis Nature Medicine ·Jaemin Lee, Cheng Sun, Yingjiang Zhou, Justin Lee, Deniz Gökalp, Hilde Herrema, Sang Won Park, Roger J. Davis, Umut Özcan	2011	176
15	Endoplasmic Reticulum Stress Plays a Central Role in Development of Leptin Resistance Cell Metabolism ·Lale Özcan, Marion Briend, Allen Lu, Jason Chung, Sumit Sarkar, Duyu Nie, Martin G. Myers, Umut Özcan Hit paper breakdown →	2009	713
16	Expected treatment benefits of percutaneous transluminal coronary angioplasty: the patient’s perspective International journal of cardiac imaging ·Orhan Veli Özkan, Chen Hanbai, Umut Özcan	2008	10
17	Loss of the Tuberous Sclerosis Complex Tumor Suppressors Triggers the Unfolded Protein Response to Regulate Insulin Signaling and Apoptosis Molecular Cell ·Umut Özcan, Lale Özcan, Erkan Yılmaz, Katrin Düvel, Mustafa Şahin, Brendan D. Manning, Gökhan S. Hotamışlıgil	2008	353
18	Alterations in growth and apoptosis of insulin receptor substrate-1-deficient β-cells American Journal of Physiology-Endocrinology and Metabolism ·Anita M. Hennige, Umut Özcan, Terumasa Okada, Ulupi S. Jhala, Markus Schubert, Morris F. White, Rohit Kulkarni	2005	35
19	Endoplasmic Reticulum Stress Links Obesity, Insulin Action, and Type 2 Diabetes Science ·Umut Özcan, Qiong Cao, Erkan Yılmaz, Ann–Hwee Lee, Neal N. Iwakoshi, Гринберг Светлана Николаевна, Gürol Tuncman, Cem Z. Görgün, Laurie H. Glimcher, Gökhan S. Hotamışlıgil Hit paper breakdown →	2004	3035
20	β-cell–specific deletion of the Igf1 receptor leads to hyperinsulinemia and glucose intolerance but does not alter β-cell mass Nature Genetics ·Rohit Kulkarni, Martin Holzenberger, David Q. Shih, Umut Özcan, Markus Stoffel, Mark A. Magnuson, C. Ronald Kahn	2002	293

About Umut Özcan

Umut Özcan is a scholar working on Cell Biology, Endocrine and Autonomic Systems, Complementary and alternative medicine, Surgery and Epidemiology, having authored 34 papers that have together received 9.2k indexed citations. Recurring topics across this work include Endoplasmic Reticulum Stress and Disease (18 papers), Pancreatic function and diabetes (15 papers), Autophagy in Disease and Therapy (8 papers), Metabolism, Diabetes, and Cancer (6 papers), Diabetes and associated disorders (5 papers), Regulation of Appetite and Obesity (4 papers), Natural Compounds in Disease Treatment (3 papers) and Protein Degradation and Inhibitors (2 papers). The work is most often cited by research in Cell Biology (4.2k citations), Endocrine and Autonomic Systems (799 citations), Epidemiology (3.3k citations), Physiology (2.4k citations) and Aging (156 citations). Umut Özcan has collaborated with scholars based in United States, France and Türkiye. Frequent co-authors include Gökhan S. Hotamışlıgil, Erkan Yılmaz, Cem Z. Görgün, Lale Özcan, Jaemin Lee, Ann–Hwee Lee, Qiong Cao, Neal N. Iwakoshi, Laurie H. Glimcher and Gürol Tuncman. Their work appears in journals such as Cell Metabolism, Nature Medicine, Cell, Journal of Clinical Investigation and Science.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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