Shawn M. O’Connell

5.9k citations

32 papers · 4.7k indexed · 1 hit paper · h-index 25

Impact in

Behavioral Neuroscience top 1%
- Stress Responses and Cortisol
Endocrinology, Diabetes and Metabolism top 0.5%
- Growth Hormone and Insulin-like Growth Factors

Papers in

Aging 1
Developmental Neuroscience 2

Co-authors: Michael G. Rosenfeld Aimee K. Ryan Daniel P. Szeto Anatoli S. Gleiberman Mathias Treier Chia-Ping Chang Richard V. Pearse Jeremy S. Dasen
Journals: Bioorganic & Medicinal Chemistry Letters (8 papers)Genes & Development (3 papers)Proceedings of the National Academy of Sciences (3 papers)ACS Medicinal Chemistry Letters (2 papers)Nature (2 papers)
Partner nations: United States Italy Japan

In The Last Decade

Shawn M. O’Connell

31 papers receiving 4.6k citations

Hit Papers

align trajectories log scale

Pituitary lineage determination by the Prophet of Pit-1 homeodomain factor defective in Ames dwarfism 1996 · 615 citations

Peers

Countries citing papers authored by Shawn M. O’Connell

Since Specialization

Citations

This map shows the geographic impact of Shawn M. O’Connell's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Shawn M. O’Connell with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Shawn M. O’Connell more than expected).

Fields of papers citing papers by Shawn M. O’Connell

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Shawn M. O’Connell. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Shawn M. O’Connell. The network helps show where Shawn M. O’Connell may publish in the future.

Co-authors

The 25 scholars most cited alongside Shawn M. O’Connell, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Shawn M. O’Connell Line = papers co-authored together Shawn M. O’Connell links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

#	Work
1	Histone lysine acetyltransferase inhibitors: an emerging class of drugs for cancer therapy Trends in Pharmacological Sciences ·Jeffrey D. White, Frederick A. Derheimer, Kristen Jensen-Pergakes, Shawn M. O’Connell, Shikhar Sharma, Noah Spiegel, Thomas A. Paul	2024	28
2	Design, synthesis and biological evaluation of novel 4-phenylisoquinolinone BET bromodomain inhibitors Bioorganic & Medicinal Chemistry Letters ·Malcolm J. Bennett, Yiqin Wu, Amogh Boloor, Ages Shiel, Shawn M. O’Connell, Lihong Shi, Ryan Stansfield, W. H. Bruning, James M. Veal, David J. Hosfield, Jiangchun Xu, Stephen W. Kaldor, Jeffrey A. Stafford, Juan M. Betancort	2018	7
3	Structure-based design and discovery of potent and selective KDM5 inhibitors Bioorganic & Medicinal Chemistry Letters ·Zhe Nie, Lihong Shi, Chon Lai, Shawn M. O’Connell, Jiangchun Xu, Ryan Stansfield, David J. Hosfield, James M. Veal, Jeffrey A. Stafford	2018	32
4	Antitumor Activity of the MEK Inhibitor TAK-733 against Melanoma Cell Lines and Patient-Derived Tumor Explants Molecular Cancer Therapeutics ·張允瀞, John J. Tentler, Aik Choon Tan, Heather M. Selby, منیره فرضی شوب, Johra Neervoort, S. Lindsey Davis, Luiz Filipe Oliveira Mansão, Todd M. Pitts, Catherine Ayuma Ocholla, G Pisa, Shawn M. O’Connell, Patrick W. Vincent, S. Gail Eckhardt	2014	21
5	Discovery of novel benzo[b][1,4]oxazin-3(4H)-ones as poly(ADP-ribose)polymerase inhibitors Bioorganic & Medicinal Chemistry Letters ·Anthony R. Gangloff, Jason W. Brown, Ron de Jong, Douglas R. Dougan, Charles E. Grimshaw, Mark S. Hixon, Andy Jennings, Ruhi Kamran, Andre A. Kiryanov, Shawn M. O’Connell, Ewan R. Taylor, Dieter Burger	2013	28
6	Design and synthesis of orally available MEK inhibitors with potent in vivo antitumor efficacy Bioorganic & Medicinal Chemistry Letters ·Mark E. Adams, Michael B. Wallace, Toufike Kanouni, Gyula Szvák, Shawn M. O’Connell, Hiroshi Miyake, Lihong Shi, Jacques Claveau, Anne Fransas, Qing Dong	2012	15
7	Abstract 3739: TAK-733, an investigational, selective MEK1/2 inhibitor, in combination with alisertib (MLN8237), an investigational, selective Aurora A kinase inhibitor is tolerated and results in additive to synergistic antitumor activity: Results from In Vivo Studies Cancer Research ·G Pisa, Shawn M. O’Connell, Andrew Stanton, Arijit Chakravarty, Catherine Ayuma Ocholla, 隆宏山浦, Jodi Zarycki, Patrick W. Vincent	2012	2
8	Discovery of TAK-733, a potent and selective MEK allosteric site inhibitor for the treatment of cancer Bioorganic & Medicinal Chemistry Letters ·Qing Dong, Douglas R. Dougan, Xianchang Gong, Jacques Claveau, H.J. Park, Toufike Kanouni, Shawn M. O’Connell, Gyula Szvák, Lihong Shi, Michael B. Wallace, Feng Zhou	2011	93
9	Structure-based design and synthesis of pyrrole derivatives as MEK inhibitors Bioorganic & Medicinal Chemistry Letters ·Michael B. Wallace, Mark E. Adams, Toufike Kanouni, Clifford D. Mol, Douglas R. Dougan, Victoria A. Feher, Shawn M. O’Connell, Lihong Shi, Jacques Claveau, Qing Dong	2010	51
10	Benzimidazole and imidazole inhibitors of histone deacetylases: Synthesis and biological activity Bioorganic & Medicinal Chemistry Letters ·Jerome C. Bressi, Ron de Jong, Yiqin Wu, Andy Jennings, Jason W. Brown, Shawn M. O’Connell, Leslie W. Tari, R.J. Skene, Dieter Burger, Marc Navre, Xiaodong Cao, Anthony R. Gangloff	2010	47
11	Exploration of the HDAC2 foot pocket: Synthesis and SAR of substituted N-(2-aminophenyl)benzamides Bioorganic & Medicinal Chemistry Letters ·Jerome C. Bressi, Andy Jennings, R.J. Skene, Yiqin Wu, Erkki Hannula, Ron de Jong, Shawn M. O’Connell, Charles E. Grimshaw, Marc Navre, Anthony R. Gangloff	2010	213
12	Identification of Genes That Are Downregulated in the Absence of the POU Domain Transcription Factor pou3f1 (Oct-6, Tst-1, SCIP) in Sciatic Nerve Journal of Neuroscience ·John R. Bermingham, Susan Shumas, Madeleine Garros, Erich E. Sirkowski, Shawn M. O’Connell, Steven S. Scherer, Michael G. Rosenfeld	2002	36
13	A POU Domain Transcription Factor–Dependent Program Regulates Axon Pathfinding in the Vertebrate Visual System Neuron ·Linda Erkman, Paul Yates, Todd McLaughlin, Robert J. McEvilly, Thomas R. Whisenhunt, Shawn M. O’Connell, Anna Krones, Michael A. Kirby, David Rapaport, John R. Bermingham, Dennis D.M. O’Leary, Michael G. Rosenfeld	2000	133
14	Reciprocal Interactions of Pit1 and GATA2 Mediate Signaling Gradient–Induced Determination of Pituitary Cell Types Cell ·Jeremy S. Dasen, Shawn M. O’Connell, Sarah E. Flynn, Mathias Treier, Anatoli S. Gleiberman, Daniel P. Szeto, Farideh Hooshmand, Aneel K. Aggarwal, Michael G. Rosenfeld	1999	246
15	Mutations in PROP1 cause familial combined pituitary hormone deficiency Nature Genetics ·Wei Wu, Joy D. Cogan, Roland Pfäffle, Jeremy S. Dasen, H Frisch, Shawn M. O’Connell, Sarah E. Flynn, Milton R. Brown, Mia Elisabeth Drabløs, John S. Parks, John A. Phillips, Michael G. Rosenfeld	1998	382
16	A Novel Family of Cys-Cys, His-Cys Zinc Finger Transcription Factors Expressed in Developing Nervous System and Pituitary Gland Journal of Biological Chemistry ·K. Büttinghaus, Victor C. Yu, Frank Buchholz, Shawn M. O’Connell, Simon J. Rhodes, Aqsa Arooj Safdar, Yu-Rong Xia, Aldons J. Lusis, Michael G. Rosenfeld	1996	59
17	Pituitary lineage determination by the Prophet of Pit-1 homeodomain factor defective in Ames dwarfism Nature ·W. A. W., Wei Wu, Jeremy S. Dasen, Sarah E. Flynn, Deborah J. Norman, Shawn M. O’Connell, Ilya Gukovsky, Catherine Carrière, Aimee K. Ryan, Andrew P. Miller, Lin Zuo, Anatoli S. Gleiberman, Bogi Andersen, W G Beamer, Michael G. Rosenfeld Hit paper breakdown →	1996	615
18	Role of transcription factors a Brn-3.1 and Brn-3.2 in auditory and visual system development Nature ·Linda Erkman, Robert J. McEvilly, Lin Luo, Aimee K. Ryan, Farideh Hooshmand, Shawn M. O’Connell, Elizabeth M. Keithley, David Rapaport, Sophie Byrne, Michael G. Rosenfeld	1996	428
19	Development and survival of the endocrine hypothalamus and posterior pituitary gland requires the neuronal POU domain factor Brn-2. Genes & Development ·Marcus D. Schonemann, Aimee K. Ryan, Robert J. McEvilly, Shawn M. O’Connell, Carlos Arias, K A Kalla, Pan Li, P.E. Sawchenko, Michael G. Rosenfeld	1995	242
20	Identification of a seven transmembrane helix receptor for corticotropin-releasing factor and sauvagine in mammalian brain Neuron ·Chia-Ping Chang, Richard V. Pearse, Shawn M. O’Connell, Michael G. Rosenfeld	1993	458

About Shawn M. O’Connell

Shawn M. O’Connell is a scholar working on Aging, Developmental Neuroscience, Endocrinology, Diabetes and Metabolism, Molecular Biology and Endocrine and Autonomic Systems, having authored 32 papers that have together received 4.7k indexed citations. Recurring topics across this work include Histone Deacetylase Inhibitors Research (7 papers), Growth Hormone and Insulin-like Growth Factors (6 papers), Epigenetics and DNA Methylation (5 papers), Melanoma and MAPK Pathways (5 papers), Protein Degradation and Inhibitors (4 papers), Cancer Mechanisms and Therapy (3 papers), Hedgehog Signaling Pathway Studies (3 papers) and Renal and related cancers (3 papers). The work is most often cited by research in Behavioral Neuroscience (374 citations), Endocrinology, Diabetes and Metabolism (1.4k citations), Aging (99 citations), Developmental Neuroscience (231 citations) and Sensory Systems (245 citations). Shawn M. O’Connell has collaborated with scholars based in United States, Italy and Japan. Frequent co-authors include Michael G. Rosenfeld, Aimee K. Ryan, Daniel P. Szeto, Anatoli S. Gleiberman, Mathias Treier, Chia-Ping Chang, Richard V. Pearse, Jeremy S. Dasen, Robert J. McEvilly and Sarah E. Flynn. Their work appears in journals such as Bioorganic & Medicinal Chemistry Letters, Genes & Development, Proceedings of the National Academy of Sciences, ACS Medicinal Chemistry Letters and Nature.

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