R.J. Skene

4.2k citations

34 papers · 2.5k indexed · h-index 22

Impact in

Oncology top 5%
- Peptidase Inhibition and Analysis
- HER2/EGFR in Cancer Research
Endocrinology, Diabetes and Metabolism top 2%
- Diabetes Treatment and Management

Papers in

Oncology 13
- Peptidase Inhibition and Analysis 8
Endocrinology, Diabetes and Metabolism 7
- Diabetes Treatment and Management 5

Co-authors: Bi‐Ching Sang Duncan E. McRee Hua Zou G. Snell Andy Jennings Michelle L. Kraus Douglas R. Dougan Kathleen Aertgeerts
Journals: Bioorganic & Medicinal Chemistry Letters (8 papers)Journal of Medicinal Chemistry (6 papers)Journal of Biological Chemistry (5 papers)Bioorganic & Medicinal Chemistry (3 papers)Proceedings of the National Academy of Sciences (2 papers)
Partner nations: United States Japan Canada

In The Last Decade

R.J. Skene

33 papers receiving 2.5k citations

Peers

Countries citing papers authored by R.J. Skene

Since Specialization

Citations

This map shows the geographic impact of R.J. Skene's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by R.J. Skene with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites R.J. Skene more than expected).

Fields of papers citing papers by R.J. Skene

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by R.J. Skene. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by R.J. Skene. The network helps show where R.J. Skene may publish in the future.

Co-authors

The 25 scholars most cited alongside R.J. Skene, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with R.J. Skene Line = papers co-authored together R.J. Skene links everyone, so they are left out of the graph.

All Works

Sort: Min cites: Since: Top N: Style:

20 of 20 papers shown

#	Work
1	Design and identification of brain-penetrant, potent, and selective 1,3-oxazole-based cholesterol 24-hydroxylase (CH24H) inhibitors Bioorganic & Medicinal Chemistry ·Y. ITO, Eiji Kimura, Izumi Nomura, Etsurou Watanabe, Jason K. Yano, R.J. Skene, Maki Miyamoto, Tsuyoshi Ishii, Toshiya Nishi, Tatsuki Koike	2025	0
2	In Silico Enabled Discovery of KAI-11101, a Preclinical DLK Inhibitor for the Treatment of Neurodegenerative Disease and Neuronal Injury Journal of Medicinal Chemistry ·H. Rachel Lagiakos, Yefen Zou, Hideyuki Igawa, Éric Therrien, Morgan Lawrenz, Mitsunori Kato, Mats Svensson, Felicia Gray, Kristian Jensen, Markus K. Dahlgren, Robert Pelletier, Karen H. Dingley, Jeffrey A. Bell, Zhijian Liu, Yuansong Jiang, Hua Zhou, R.J. Skene, Zhe Nie	2024	4
3	Efficient synthesis of tert-butyl 3-cyano-3-cyclopropyl-2-oxopyrrolidine-4-carboxylates: Highly functionalized 2-pyrrolidinone enabling access to novel macrocyclic Tyk2 inhibitors Bioorganic & Medicinal Chemistry Letters ·Yusuke Sasaki, Hidekazu Tokuhara, Yusuke Ohba, Atsutoshi Okabe, Masaaki Nakayama, Hideyuki Nakagawa, R.J. Skene, Isaac Hoffman, Hua Zou, Masato Yoshida	2020	14
4	Identification of novel quinazolinedione derivatives as RORγt inverse agonist Bioorganic & Medicinal Chemistry ·Yoshiyuki Fukase, Ayumu Sato, Yoshihide Tomata, Atsuko Ochida, Mitsunori Kono, Kazuko Yonemori, Keiko Koga, Toshitake Okui, Masashi Yamasaki, Yasushi Fujitani, Hideyuki Nakagawa, Ryoukichi Koyama, Masaaki Nakayama, R.J. Skene, Bi‐Ching Sang, Isaac Hoffman, Junya Shirai, Satoshi Yamamoto	2017	17
5	Identification of a new class of potent Cdc7 inhibitors designed by putative pharmacophore model: Synthesis and biological evaluation of 2,3-dihydrothieno[3,2-d]pyrimidin-4(1H)-ones Bioorganic & Medicinal Chemistry ·Osamu Kurasawa, Yuya Oguro, T. Miyazaki, Misaki Homma, Kouji Mori, Kenichi Iwai, Hideto Hara, R.J. Skene, Isaac Hoffman, Akihiro Ohashi, Sei Yoshida, Tomoyasu Ishikawa, Nobuo Cho	2017	14
6	Structure-based design and SAR development of 5,6-dihydroimidazolo[1,5-f]pteridine derivatives as novel Polo-like kinase-1 inhibitors Bioorganic & Medicinal Chemistry Letters ·Andre A. Kiryanov, Srinivasa Reddy Natala, Benjamin Jones, Christopher M. McBride, Victoria A. Feher, Betty Lam, Yan Liu, Kouhei Honda, Noriko Uchiyama, Tomohiro Kawamoto, Yuichi Hikichi, Lilly Zhang, David J. Hosfield, R.J. Skene, Hua Zou, Jeffrey A. Stafford, Xiaodong Cao, Takashi Ichikawa	2016	13
7	Structure-based optimization of 1H-imidazole-2-carboxamides as Axl kinase inhibitors utilizing a Mer mutant surrogate Bioorganic & Medicinal Chemistry Letters ·Walter Keung, Amogh Boloor, Jason W. Brown, Andre A. Kiryanov, Anthony R. Gangloff, J. David Lawson, R.J. Skene, Isaac Hoffman, Josephine M. Atienza, Jason A. Kahana, Ron de Jong, Pamela Farrell, Deepika Balakrishna, Petro Halkowycz	2016	10
8	Structure-based design of pyridopyrimidinediones as dipeptidyl peptidase IV inhibitors Bioorganic & Medicinal Chemistry Letters ·Betty Lam, Zhiyuan Zhang, Jeffery A. Stafford, R.J. Skene, Lihong Shi, Stephen L. Gwaltney	2012	21
9	Discovery and characterization of novel allosteric FAK inhibitors European Journal of Medicinal Chemistry ·Misa Iwatani, Hidehisa Iwata, Atsutoshi Okabe, R.J. Skene, Naoki Tomita, Yoko Hayashi, Yoshio Aramaki, David J. Hosfield, Akira Hori, Atsuo Baba, Hiroshi Miki	2012	42
10	Structural Analysis of the Mechanism of Inhibition and Allosteric Activation of the Kinase Domain of HER2 Protein Journal of Biological Chemistry ·Kathleen Aertgeerts, R.J. Skene, Jason K. Yano, Bi‐Ching Sang, Hua Zou, Gyorgy Snell, Andy Jennings, Keiji Iwamoto, Noriyuki Habuka, Aki Hirokawa, Tomoyasu Ishikawa, Toshimasa Tanaka, Hiroshi Miki, Yoshikazu Ohta, Satoshi Sogabe	2011	310
11	Benzimidazole and imidazole inhibitors of histone deacetylases: Synthesis and biological activity Bioorganic & Medicinal Chemistry Letters ·Jerome C. Bressi, Ron de Jong, Yiqin Wu, Andy Jennings, Jason W. Brown, Shawn M. O’Connell, Leslie W. Tari, R.J. Skene, Phong Vu, Marc Navre, Xiaodong Cao, Anthony R. Gangloff	2010	47
12	Exploration of the HDAC2 foot pocket: Synthesis and SAR of substituted N-(2-aminophenyl)benzamides Bioorganic & Medicinal Chemistry Letters ·Jerome C. Bressi, Andy Jennings, R.J. Skene, Yiqin Wu, Robert Melkus, Ron de Jong, Shawn M. O’Connell, Charles E. Grimshaw, Marc Navre, Anthony R. Gangloff	2010	213
13	Structure-based design and synthesis of benzimidazole derivatives as dipeptidyl peptidase IV inhibitors Bioorganic & Medicinal Chemistry Letters ·Michael B. Wallace, Jun Feng, Zhiyuan Zhang, R.J. Skene, Lihong Shi, Christopher L. Caster, Daniel B. Kassel, Rongda Xu, Stephen L. Gwaltney	2008	50
14	Functional and Crystal Structure Analysis of Active Site Adaptations of a Potent Anti-Angiogenic Human tRNA Synthetase Structure ·Xiang‐Lei Yang, Min Guo, Mili Kapoor, Karla L. Ewalt, Francella J. Otero, R.J. Skene, Duncan E. McRee, Paul Schimmel	2007	40
15	Two conformations of a crystalline human tRNA synthetase–tRNA complex: implications for protein synthesis The EMBO Journal ·Xiang‐Lei Yang, Francella J. Otero, Karla L. Ewalt, Jianming Liu, Manal A. Swairjo, Caroline Köhrer, Uttam L. RajBhandary, R.J. Skene, Duncan E. McRee, Paul Schimmel	2006	50
16	Crystal structure of human dipeptidyl peptidase IV in complex with a decapeptide reveals details on substrate specificity and tetrahedral intermediate formation Protein Science ·Kathleen Aertgeerts, Sheng Ye, Mike Tennant, Michelle L. Kraus, Joe Rogers, Bi‐Ching Sang, R.J. Skene, David R. Webb, G. Sridhar Prasad	2004	162
17	Alanyl-tRNA Synthetase Crystal Structure and Design for Acceptor-Stem Recognition Molecular Cell ·Manal A. Swairjo, Francella J. Otero, Xiang‐Lei Yang, Martha A. Lovato, R.J. Skene, Duncan E. McRee, Lluı́s Ribas de Pouplana, Paul Schimmel	2004	45
18	Conformational Flexibility in Crystal Structures of Human 11β-Hydroxysteroid Dehydrogenase Type I Provide Insights into Glucocorticoid Interconversion and Enzyme Regulation Journal of Biological Chemistry ·David J. Hosfield, Yiqin Wu, R.J. Skene, M.T. Hilgers, Andy Jennings, G. Snell, Kathleen Aertgeerts	2004	93
19	Crystal Structure of Pasteurella haemolytica Ferric Ion-binding Protein A Reveals a Novel Class of Bacterial Iron-binding Proteins Journal of Biological Chemistry ·Stephen R. Shouldice, Douglas R. Dougan, Pamela A. Williams, R.J. Skene, G. Snell, Daniel Scheibe, Shane D. Kirby, David J. Hosfield, Duncan E. McRee, Anthony B. Schryvers, Leslie W. Tari	2003	23
20	High Resolution Structure of an Alternate Form of the Ferric Ion Binding Protein from Haemophilus influenzae Journal of Biological Chemistry ·Stephen R. Shouldice, Douglas R. Dougan, R.J. Skene, Leslie W. Tari, Duncan E. McRee, Rong‐hua Yu, Anthony B. Schryvers	2003	29

About R.J. Skene

R.J. Skene is a scholar working on Oncology, Endocrinology, Diabetes and Metabolism, Molecular Biology, Immunology and Allergy and Cellular and Molecular Neuroscience, having authored 34 papers that have together received 2.5k indexed citations. Recurring topics across this work include RNA and protein synthesis mechanisms (8 papers), Peptidase Inhibition and Analysis (8 papers), RNA modifications and cancer (7 papers), Neuropeptides and Animal Physiology (6 papers), Diabetes Treatment and Management (5 papers), Bacterial Genetics and Biotechnology (3 papers), Hemoglobin structure and function (3 papers) and RNA Research and Splicing (3 papers). The work is most often cited by research in Oncology (816 citations), Endocrinology, Diabetes and Metabolism (455 citations), Gastroenterology (129 citations), Molecular Biology (1.4k citations) and Hematology (203 citations). R.J. Skene has collaborated with scholars based in United States, Japan and Canada. Frequent co-authors include Bi‐Ching Sang, Duncan E. McRee, Hua Zou, G. Snell, Andy Jennings, Michelle L. Kraus, Douglas R. Dougan, Kathleen Aertgeerts, Marc Navre and Paul Schimmel. Their work appears in journals such as Bioorganic & Medicinal Chemistry Letters, Journal of Medicinal Chemistry, Journal of Biological Chemistry, Bioorganic & Medicinal Chemistry and Proceedings of the National Academy of Sciences.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

Explore authors with similar magnitude of impact