Éric Therrien

1.5k citations

34 papers · 1.1k indexed · h-index 21

Impact in

Computational Theory and Mathematics top 2%
- Computational Drug Discovery Methods
Organic Chemistry top 5%
- Click Chemistry and Applications
- Synthetic Organic Chemistry Methods

Papers in

Computational Theory and Mathematics 10
- Computational Drug Discovery Methods 10
Organic Chemistry 14
- Synthesis and Catalytic Reactions 5
- Synthetic Organic Chemistry Methods 4
- Carbohydrate Chemistry and Synthesis 4

Co-authors: Stephen Hanessian Nicolas Moitessier Joshua Pottel Christopher R. Corbeil Valérie Campágna‐Slater Ingemar Nilsson Silvana Leit Nathanaël Weill
Journals: Bioorganic & Medicinal Chemistry Letters (12 papers)Journal of Chemical Information and Modeling (5 papers)Journal of Medicinal Chemistry (4 papers)Current Pharmaceutical Design (2 papers)The Journal of Organic Chemistry (2 papers)
Partner nations: Canada United States Sweden

In The Last Decade

Éric Therrien

34 papers receiving 1.0k citations

Peers

Countries citing papers authored by Éric Therrien

Since Specialization

Citations

This map shows the geographic impact of Éric Therrien's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Éric Therrien with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Éric Therrien more than expected).

Fields of papers citing papers by Éric Therrien

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Éric Therrien. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Éric Therrien. The network helps show where Éric Therrien may publish in the future.

Co-authors

The 25 scholars most cited alongside Éric Therrien, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Éric Therrien Line = papers co-authored together Éric Therrien links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

#	Work
1	In Silico Enabled Discovery of KAI-11101, a Preclinical DLK Inhibitor for the Treatment of Neurodegenerative Disease and Neuronal Injury Journal of Medicinal Chemistry ·H. Rachel Lagiakos, Yefen Zou, Hideyuki Igawa, Éric Therrien, Morgan Lawrenz, Mitsunori Kato, Mats Svensson, Felicia Gray, Kristian Jensen, Markus K. Dahlgren, Robert Pelletier, Karen H. Dingley, Jeffrey A. Bell, Zhijian Liu, Yuansong Jiang, Hua Zhou, R.J. Skene, Zhe Nie	2024	4
2	A Computational Physics-based Approach to Predict Unbound Brain-to-Plasma Partition Coefficient, K _p,uu Journal of Chemical Information and Modeling ·Morgan Lawrenz, Mats Svensson, Mitsunori Kato, Karen H. Dingley, Jackson Chief Elk, Zhe Nie, Yefen Zou, Zachary Kaplan, H. Rachel Lagiakos, Hideyuki Igawa, Éric Therrien	2023	11
3	An Allosteric Inhibitory Site Conserved in the Ectodomain of P2X Receptor Channels Frontiers in Cellular Neuroscience ·Ariel R. Ase, Éric Therrien, Philippe Séguéla	2019	26
4	An allosteric mechanism for potent inhibition of human ATP-citrate lyase Nature ·Wei Jia, Silvana Leit, Jun Kuai, Éric Therrien, Salma B. Rafi, H. James Harwood, Byron DeLaBarre, Liang Tong	2019	122
5	Discovery of bicyclic pyrazoles as class III histone deacetylase SIRT1 and SIRT2 inhibitors Bioorganic & Medicinal Chemistry Letters ·Éric Therrien, Guillaume Larouche, Natalie Nguyen, Jubrail Rahil, Anne‐Marie Lemieux, Zuomei Li, Marielle Fournel, Theresa P. Yan, Anne-Julie Landry, Sylvain Lefèbvre, Jinru Wang, Kyle J. MacBeth, Carla Heise, Aaron Nguyen, Jeffrey M. Besterman, Robert Déziel, Amal Wahhab	2015	23
6	Design and synthesis of close analogs of LCRF-0004, a potent and selective RON receptor tyrosine kinase inhibitor Bioorganic & Medicinal Chemistry Letters ·Stéphane Raeppel, Franck Raeppel, Éric Therrien	2015	18
7	Design, synthesis and RON receptor tyrosine kinase inhibitory activity of new head groups analogs of LCRF-0004 Bioorganic & Medicinal Chemistry Letters ·Franck Raeppel, Stéphane Raeppel, Éric Therrien	2015	9
8	Design and synthesis of constrained analogs of LCRF-0004 as potent RON tyrosine kinase inhibitors Bioorganic & Medicinal Chemistry Letters ·Stéphane Raeppel, Éric Therrien, Franck Raeppel	2015	6
9	Methods for Docking Small Molecules to Macromolecules: A User’s Perspective. 2. Applications Current Pharmaceutical Design ·Valérie Campágna‐Slater, Éric Therrien, Nathanaël Weill, Nicolas Moitessier	2014	8
10	Methods for Docking Small Molecules to Macromolecules: A User’s Perspective. 1. The Theory Current Pharmaceutical Design ·Nathanaël Weill, Éric Therrien, Valérie Campágna‐Slater, Nicolas Moitessier	2014	16
11	Docking Ligands into Flexible and Solvated Macromolecules. 7. Impact of Protein Flexibility and Water Molecules on Docking-Based Virtual Screening Accuracy Journal of Chemical Information and Modeling ·Éric Therrien, Nathanaël Weill, Anna Tomberg, Christopher R. Corbeil, Devin Lee, Nicolas Moitessier	2014	33
12	1,2-Diamines as inhibitors of co-activator associated arginine methyltransferase 1 (CARM1) Bioorganic & Medicinal Chemistry Letters ·Éric Therrien, Guillaume Larouche, Sukhdev Manku, Martin Allan, Natalie Nguyen, Sylvia Styhler, Marie‐France Robert, Anne-Christine Goulet, Jeffrey M. Besterman, Hannah Nguyen, Amal Wahhab	2009	36
13	From natural products to achiral drug prototypes: Potent thrombin inhibitors based on P2/P3 dihydropyrid-2-one core motifs Bioorganic & Medicinal Chemistry Letters ·Stephen Hanessian, Éric Therrien, Jianbin Zhang, Willem A. L. van Otterlo, Yafeng Xue, David Gustafsson, Ingemar Nilsson, Ola Fjellström	2009	9
14	Synthesis and evaluation of lysine derived sulfamides as histone deacetylase inhibitors Bioorganic & Medicinal Chemistry Letters ·Sukhdev Manku, Martin Allan, Natalie Nguyen, Alain Ajamian, Jacques Rodrigue, Éric Therrien, Jinru Wang, Jingzhong Guo, Jubrail Rahil, Andrea J. Petschner, Alina Nicolescu, Sylvain Lefèbvre, Zuomei Li, Marielle Fournel, Jeffrey M. Besterman, Robert Déziel, Amal Wahhab	2009	17
15	Sulfamides as novel histone deacetylase inhibitors Bioorganic & Medicinal Chemistry Letters ·Amal Wahhab, David Smil, Alain Ajamian, Martin Allan, Yves Chantigny, Éric Therrien, Natalie Nguyen, Sukhdev Manku, Silvana Leit, Jubrail Rahil, Andrea J. Petschner, Aihua Lu, Alina Nicolescu, Sylvain Lefèbvre, Samuel Montcalm, Marielle Fournel, Theresa P. Yan, Zuomei Li, Jeffrey M. Besterman, Robert Déziel	2008	26
16	N-Benzyl-1-heteroaryl-3-(trifluoromethyl)-1H-pyrazole-5-carboxamides as inhibitors of co-activator associated arginine methyltransferase 1 (CARM1) Bioorganic & Medicinal Chemistry Letters ·Martin Allan, Sukhdev Manku, Éric Therrien, Natalie Nguyen, Sylvia Styhler, Marie‐France Robert, Anne-Christine Goulet, Andrea J. Petschner, Gabi Rahil, A. Robert MacLeod, Robert Déziel, Jeffrey M. Besterman, Hannah Nguyen, Amal Wahhab	2008	69
17	Design, synthesis, and thrombin-inhibitory activity of pyridin-2-ones as P2/P3 core motifs Bioorganic & Medicinal Chemistry Letters ·Stephen Hanessian, Daniel Simard, Malken Bayrakdarian, Éric Therrien, Ingemar Nilsson, Ola Fjellström	2008	25
18	Phenolic P2/P3 core motif as thrombin inhibitors—Design, synthesis, and X-ray co-crystal structure Bioorganic & Medicinal Chemistry Letters ·Stephen Hanessian, Éric Therrien, Willem A. L. van Otterlo, Malken Bayrakdarian, Ingemar Nilsson, Ola Fjellström, Yafeng Xue	2005	15
19	Targeting thrombin and factor VIIa: design, synthesis, and inhibitory activity of functionally relevant indolizidinones Bioorganic & Medicinal Chemistry Letters ·Stephen Hanessian, Éric Therrien, Kenneth L. Granberg, Ingemar Nilsson	2002	44
20	A comparative docking study and the design of potentially selective MMP inhibitors Journal of Computer-Aided Molecular Design ·Stephen Hanessian, Nicolas Moitessier, Éric Therrien	2001	26

About Éric Therrien

Éric Therrien is a scholar working on Computational Theory and Mathematics, Organic Chemistry, Molecular Biology, Hematology and Geriatrics and Gerontology, having authored 34 papers that have together received 1.1k indexed citations. Recurring topics across this work include Computational Drug Discovery Methods (10 papers), Chemical Synthesis and Analysis (8 papers), Enzyme function and inhibition (5 papers), Synthesis and Catalytic Reactions (5 papers), Synthetic Organic Chemistry Methods (4 papers), Carbohydrate Chemistry and Synthesis (4 papers), Peptidase Inhibition and Analysis (4 papers) and Histone Deacetylase Inhibitors Research (3 papers). The work is most often cited by research in Computational Theory and Mathematics (237 citations), Organic Chemistry (411 citations), Molecular Biology (649 citations), Physiology (30 citations) and Cancer Research (88 citations). Éric Therrien has collaborated with scholars based in Canada, United States and Sweden. Frequent co-authors include Stephen Hanessian, Nicolas Moitessier, Joshua Pottel, Christopher R. Corbeil, Valérie Campágna‐Slater, Ingemar Nilsson, Silvana Leit, Nathanaël Weill, Wei Jia and Byron DeLaBarre. Their work appears in journals such as Bioorganic & Medicinal Chemistry Letters, Journal of Chemical Information and Modeling, Journal of Medicinal Chemistry, Current Pharmaceutical Design and The Journal of Organic Chemistry.

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