Tsuneya Ikezu

29.6k citations

132 papers · 9.2k indexed · 2 hit papers · h-index 51

Impact in

Neurology top 0.1%
- Neuroinflammation and Neurodegeneration Mechanisms
Biological Psychiatry top 0.5%
- Tryptophan and brain disorders

Papers in

Neurology 52
- Neuroinflammation and Neurodegeneration Mechanisms 50
Virology 14
- HIV Research and Treatment 14

Co-authors: Takashi Okamoto Seiko Ikezu Michael P. Lisanti Megan Varnum Tomomi Kiyota Howard E. Gendelman Benjamin Wolozin Maya E. Woodbury
Journals: Alzheimer s & Dementia (14 papers)Journal of Neuroimmune Pharmacology (12 papers)Journal of Biological Chemistry (7 papers)The Journal of Immunology (5 papers)Journal of Neuroscience (5 papers)
Partner nations: United States Japan Australia

In The Last Decade

Tsuneya Ikezu

130 papers receiving 9.2k citations

Hit Papers

align trajectories log scale

Depletion of microglia and inhibition of exosome synthesis halt tau propagation 2015 · 1.2k citations

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if any of the following hold:

it has ≥500 total citations;
it reaches ≥1.5× the top-1% citation threshold for papers in the same subfield and year (the threshold is the minimum needed to enter the top 1%, not the average within it);
it reaches the top citation threshold in at least one of its specific research topics.

2015 Nature Neuroscience
1997 Journal of Biological Chemistry

Peers

Countries citing papers authored by Tsuneya Ikezu

Since Specialization

Citations

This map shows the geographic impact of Tsuneya Ikezu's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Tsuneya Ikezu with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Tsuneya Ikezu more than expected).

Fields of papers citing papers by Tsuneya Ikezu

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Tsuneya Ikezu. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Tsuneya Ikezu. The network helps show where Tsuneya Ikezu may publish in the future.

Co-authors

The 25 scholars most cited alongside Tsuneya Ikezu, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Tsuneya Ikezu Line = papers co-authored together Tsuneya Ikezu links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

#	Work
1	Amyloid precursor protein and presenilin‐1 knock‐in immunodeficient mice exhibit intraneuronal Aβ pathology, microgliosis, and extensive neuronal loss Alzheimer s & Dementia ·Pravin Yeapuri, Jatin Machhi, Puji Raharja Santosa, Greta Cornaggia, G. C Marinho, Yaman Lu, Susmita Sil, Amer A. Sharif, Shefali Srivastava, Gulsara Imanova, Tsuneya Ikezu, Larisa Y. Poluektova, Howard E. Gendelman, R. Lee Mosley	2025	3
2	ATP1A3 as a target for isolating neuron‐specific extracellular vesicles from human brain and biofluids Alzheimer s & Dementia ·Zhengrong Zhang, Yang You, Nadia Sultana, Maria Ericsson, Yuka A. Martens, G. Jentsch, Takahisa Kanekiyo, Seiko Ikezu, Tsuneya Ikezu, Scott A. Shaffer	2024	0
3	Single‐extracellular vesicle (EV) analyses validate the use of L1 Cell Adhesion Molecule (L1CAM) as a reliable biomarker of neuron‐derived EVs Journal of Extracellular Vesicles ·Carlos Nogueras‐Ortiz, Erden Eren, Pamela J. Yao, Elizabeth Calzada, Christopher J. Dunn, Olga V. Volpert, Francheska Delgado‐Peraza, Maja Mustapić, Alexey E. Lyashkov, F. Javier Rubio, Michael Vreones, Lesley Cheng, Yang You, Andrew F. Hill, Tsuneya Ikezu, Stefanik Rl, Edward J. Goetzl, Dimitrios Kapogiannis	2024	41
4	Microglia and extracellular vesicle‐mediated spread of Tau pathology Alzheimer s & Dementia ·Tsuneya Ikezu	2024	1
5	Comparison of nanoimaging and nanoflow based detection of extracellular vesicles at a single particle resolution SHILAP Revista de lepidopterología ·Shihan Xu, Zhengrong Zhang, Ya. A. Afanas’eva, Dorota Chmielewska Łuczak, Seiko Ikezu, Tsuneya Ikezu	2024	6
6	ATP1A3 as a target for isolating neuron-specific extracellular vesicles from human brain and biofluids Science Advances ·Yang You, Zhengrong Zhang, Nadia Sultana, Maria Ericsson, Yuka A. Martens, G. Jentsch, Takahisa Kanekiyo, Seiko Ikezu, Scott A. Shaffer, Tsuneya Ikezu	2023	42
7	Antisense oligonucleotide-based targeting of Tau-tubulin kinase 1 prevents hippocampal accumulation of phosphorylated tau in PS19 tauopathy mice Acta Neuropathologica Communications ·Kayo Takamatsu-Yukawa, F Weigert, Jawahar Vishnu B, Christine Hong, Fredrik Kamme, Tsuneya Ikezu, Seiko Ikezu	2023	2
8	Comprehensive characterization of human brain‐derived extracellular vesicles using multiple isolation methods: Implications for diagnostic and therapeutic applications Journal of Extracellular Vesicles ·Zhengrong Zhang, Kaiwen Yu, Yang You, Peizhou Jiang, ChangminXu, Michael DeTure, Dennis W. Dickson, Seiko Ikezu, Junmin Peng, Tsuneya Ikezu	2023	39
9	Microglial WNT5A supports dendritic spines maturation and neuronal firing Brain Behavior and Immunity ·Hana Yeh, Maya E. Woodbury, Kaitlin L. Ingraham Dixie, Tsuneya Ikezu, Seiko Ikezu	2022	13
10	Integrative brain transcriptome analysis links complement component 4 and HSPA2 to the APOE ε2 protective effect in Alzheimer disease Molecular Psychiatry ·L. N. Tashninova, Alice Goyanes, Jaeyoon Chung, Congcong Zhu, Gaoyuan Meng, Weiming Xia, David A. Bennett, Kathryn L. Lunetta, Tsuneya Ikezu, Rhoda Au, Thor D. Stein, Lindsay A. Farrer, Gyungah Jun	2021	30
11	Plaque associated microglia hyper-secrete extracellular vesicles and accelerate tau propagation in a humanized APP mouse model Molecular Neurodegeneration ·Lihong YU, Jean-Christophe Delpech, Shawn Herron, Naotoshi Iwahara, Maria Ericsson, Takashi Saito, Takaomi C. Saido, Seiko Ikezu, Tsuneya Ikezu	2021	155
12	Alzheimer’s disease brain-derived extracellular vesicles spread tau pathology in interneurons Brain ·Zhi Ruan, Dhruba Pathak, Srinidhi Venkatesan Kalavai, Supanee Chounchay, Satoshi Muraoka, Nemil Bhatt, Kayo Takamatsu-Yukawa, Jianqiao Hu, Yuzhi Wang, Samuel Hersh, Maria Ericsson, Santhi Gorantla, Howard E. Gendelman, Rakez Kayed, Seiko Ikezu, Jennifer I. Luebke, Tsuneya Ikezu	2020	187
13	P2RX7 inhibitor suppresses exosome secretion and disease phenotype in P301S tau transgenic mice Molecular Neurodegeneration ·Zhi Ruan, Jean-Christophe Delpech, Srinidhi Venkatesan Kalavai, Daniele Bufalo, Jianqiao Hu, Seiko Ikezu, Tsuneya Ikezu	2020	102
14	Assessment of separation methods for extracellular vesicles from human and mouse brain tissues and human cerebrospinal fluids Methods ·Satoshi Muraoka, Weiwei Lin, Mei Chen, Samuel Hersh, Andrew Emili, Weiming Xia, Tsuneya Ikezu	2020	44
15	The anti-inflammatory glycoprotein, CD200, restores neurogenesis and enhances amyloid phagocytosis in a mouse model of Alzheimer's disease Neurobiology of Aging ·Megan Varnum, Tomomi Kiyota, Kaitlin L. Ingraham Dixie, Seiko Ikezu, Tsuneya Ikezu	2015	56
16	Pyroglutamate-3 Amyloid-β Deposition in the Brains of Humans, Non-Human Primates, Canines, and Alzheimer Disease–Like Transgenic Mouse Models American Journal Of Pathology ·Jeffrey L. Frost, Kevin X. Le, Holger Cynis, 正一永田, Martin Kleinschmidt, I. Czernichowski, Frank R. Ervin, Shikha Snigdha, Carl W. Cotman, Takaomi C. Saido, Robert Vassar, Peter St George‐Hyslop, Tsuneya Ikezu, Stephan Schilling, Hans-Ulrich Demuth, Cynthia A. Lemere	2013	92
17	P4‐040: Phosphorylation of collapsin response mediator protein‐2 and axonal degeneration in transgenic mice expressing a familial Alzheimer's disease mutant of APP and tau‐tubulin kinase 1 Alzheimer s & Dementia ·Hirohide Asai, Seiko Ikezu, Megan Varnum, Tsuneya Ikezu	2012	1
18	Cytokine-Mediated Inhibition of Fibrillar Amyloid-β Peptide Degradation by Human Mononuclear Phagocytes The Journal of Immunology ·Masaru Yamamoto, Tomomi Kiyota, Shannon M. Walsh, Jianuo Liu, Jonathan Kipnis, Tsuneya Ikezu	2008	78
19	Copolymer-1 Induces Adaptive Immune Anti-inflammatory Glial and Neuroprotective Responses in a Murine Model of HIV-1 Encephalitis The Journal of Immunology ·Santhi Gorantla, Лилия Амировна Рябишина, V. V. Streltsova, Huanyu Dou, Adelina Holguin, 安達敬武, Tsuneya Ikezu, David J. Volsky, Larisa Y. Poluektova, Howard E. Gendelman	2007	33
20	Molecular Characterization of a Putative Antiretroviral Transcriptional Factor, OTK18 The Journal of Immunology ·Kimberly A. Carlson, Gerry Leisman, Jenae Limoges, D. Rittschof, Masahide Horiba, James L. Buescher, Howard E. Gendelman, Tsuneya Ikezu	2004	31

About Tsuneya Ikezu

Tsuneya Ikezu is a scholar working on Neurology, Virology, Developmental Neuroscience, Physiology and Biological Psychiatry, having authored 132 papers that have together received 9.2k indexed citations. Recurring topics across this work include Neuroinflammation and Neurodegeneration Mechanisms (50 papers), Alzheimer's disease research and treatments (49 papers), Extracellular vesicles in disease (33 papers), HIV Research and Treatment (14 papers), Immune cells in cancer (11 papers), MicroRNA in disease regulation (10 papers), Neuroscience and Neuropharmacology Research (9 papers) and Neurogenesis and neuroplasticity mechanisms (9 papers). The work is most often cited by research in Neurology (3.1k citations), Biological Psychiatry (605 citations), Physiology (3.1k citations), Developmental Neuroscience (465 citations) and Cell Biology (1.8k citations). Tsuneya Ikezu has collaborated with scholars based in United States, Japan and Australia. Frequent co-authors include Takashi Okamoto, Seiko Ikezu, Michael P. Lisanti, Megan Varnum, Tomomi Kiyota, Howard E. Gendelman, Benjamin Wolozin, Maya E. Woodbury, Jacques Couët and Shengwen Calvin Li. Their work appears in journals such as Alzheimer s & Dementia, Journal of Neuroimmune Pharmacology, Journal of Biological Chemistry, The Journal of Immunology and Journal of Neuroscience.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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