Tasuku Honjo

95.8k citations

582 papers · 72.1k indexed · 64 hit papers · h-index 129

Immunology top 0.01%
Molecular Biology top 0.05%
Oncology top 0.01%
Radiology, Nuclear Medicine and Imaging top 0.05%
Genetics top 0.1%

Co-authors: Taku Okazaki Masamichi Muramatsu Sidonia Fagarasan Kazuo Kinoshita Nagahiro Minato Yoshiko Iwai Hiroyuki Nishimura Yasumasa Ishida
Topics: T-cell and B-cell Immunology (181 papers)Immune Cell Function and Interaction (168 papers)Monoclonal and Polyclonal Antibodies Research (95 papers)
Cited by: Immunology Oncology Molecular Biology
Journals: Nature Science Cell
Partner nations: Japan United States Sweden

In The Last Decade

Tasuku Honjo

579 papers receiving 70.4k citations

Hit Papers

5 papers align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Engagement of the Pd-1 Immunoinhibitory Receptor by a Novel B7 Family Member Leads to Negative Regulation of Lymphocyte Activation

2000 4.2k citations Taku Okazaki, Tasuku Honjo et al. profile →
Class Switch Recombination and Hypermutation Require Activation-Induced Cytidine Deaminase (AID), a Potential RNA Editing Enzyme

2000 2.6k citations Masamichi Muramatsu, Kazuo Kinoshita et al. profile →
Involvement of PD-L1 on tumor cells in the escape from host immune system and tumor immunotherapy by PD-L1 blockade

2002 2.4k citations Yoshimasa Tanaka, Taku Okazaki et al. Proceedings of the National Academy of Sciences profile →
Induced expression of PD-1, a novel member of the immunoglobulin gene superfamily, upon programmed cell death.

1992 2.4k citations Tasuku Honjo et al. The EMBO Journal profile →
Development of Lupus-like Autoimmune Diseases by Disruption of the PD-1 Gene Encoding an ITIM Motif-Carrying Immunoreceptor

1999 2.1k citations Nagahiro Minato, Tasuku Honjo et al. profile →
Autoimmune Dilated Cardiomyopathy in PD-1 Receptor-Deficient Mice

2001 1.5k citations Taku Okazaki, Yoshimasa Tanaka et al. Science profile →
Expression of the PD-1 antigen on the surface of stimulated mouse T and B lymphocytes

1996 1.2k citations Tasuku Honjo et al. profile →
Programmed cell death 1 ligand 1 and tumor-infiltrating CD8 ⁺ T lymphocytes are prognostic factors of human ovarian cancer

2007 1.2k citations Junzo Hamanishi, Masaki Mandai et al. Proceedings of the National Academy of Sciences profile →
Notch signalling controls pancreatic cell differentiation

1999 930 citations Tasuku Honjo et al. profile →
Specific Expression of Activation-induced Cytidine Deaminase (AID), a Novel Member of the RNA-editing Deaminase Family in Germinal Center B Cells

1999 904 citations Masamichi Muramatsu, Kazuo Kinoshita et al. Journal of Biological Chemistry profile →
Instruction of Distinct CD4 T Helper Cell Fates by Different Notch Ligands on Antigen-Presenting Cells

2004 729 citations Tasuku Honjo et al. profile →
A rheostat for immune responses: the unique properties of PD-1 and their advantages for clinical application

2013 713 citations Taku Okazaki, Shunsuke Chikuma et al. profile →
Generation of Lymphohematopoietic Cells from Embryonic Stem Cells in Culture

1994 679 citations Tasuku Honjo et al. Science profile →
PD-1 immunoreceptor inhibits B cell receptor-mediated signaling by recruiting src homology 2-domain-containing tyrosine phosphatase 2 to phosphotyrosine

2001 676 citations Taku Okazaki, Tasuku Honjo et al. Proceedings of the National Academy of Sciences profile →
Signal Sequence Trap: a Cloning Strategy for Secreted Proteins and Type I Membrane Proteins

1993 612 citations Tasuku Honjo et al. Science profile →
PD-L1/B7H-1 Inhibits the Effector Phase of Tumor Rejection by T Cell Receptor (TCR) Transgenic CD8+ T Cells

2004 609 citations Tasuku Honjo et al. profile →
The PD-1–PD-L pathway in immunological tolerance

2006 581 citations Taku Okazaki, Tasuku Honjo profile →
Aberrant expansion of segmented filamentous bacteria in IgA-deficient gut

2004 563 citations Keiichiro Suzuki, Masamichi Muramatsu et al. Proceedings of the National Academy of Sciences profile →
PD-1:PD-L inhibitory pathway affects both CD4+ and CD8+ T cells and is overcome by IL-2

2002 548 citations Tasuku Honjo et al. profile →
Autoantibodies against cardiac troponin I are responsible for dilated cardiomyopathy in PD-1-deficient mice

2003 544 citations Taku Okazaki, Yoshimasa Tanaka et al. profile →
Tumor cell expression of programmed cell death‐1 ligand 1 is a prognostic factor for malignant melanoma

2010 537 citations Tasuku Honjo, Taku Okazaki et al. profile →
Structure and Chromosomal Localization of the Human Stromal Cell-Derived Factor 1 (SDF1) Gene

1995 525 citations Tasuku Honjo et al. profile →
Conservation of the Notch signalling pathway in mammalian neurogenesis

1997 513 citations Tasuku Honjo et al. profile →
Fibulin-5/DANCE is essential for elastogenesis in vivo

2002 493 citations Tasuku Honjo et al. profile →
Cancer immunotherapies targeting the PD-1 signaling pathway

2017 488 citations Junzo Hamanishi, Kenji Chamoto et al. profile →
Molecular Mechanism of Class Switch Recombination: Linkage with Somatic Hypermutation

2002 481 citations Tasuku Honjo, Kazuo Kinoshita et al. profile →
Inducible gene knockout of transcription factor recombination signal binding protein‐J reveals its essential role in T versus B lineage decision

2002 480 citations Hua Han, Tasuku Honjo et al. profile →
Molecular cloning of cDNA encoding human interleukin-2 receptor

1984 478 citations Tasuku Honjo et al. profile →
Critical Roles of Activation-Induced Cytidine Deaminase in the Homeostasis of Gut Flora

2002 474 citations Sidonia Fagarasan, Masamichi Muramatsu et al. Science profile →
Preferential Generation of Follicular B Helper T Cells from Foxp3 ⁺ T Cells in Gut Peyer's Patches

2009 463 citations Masayuki Tsuji, Noriko Komatsu et al. Science profile →
Diphtheria Toxin-dependent Adenosine Diphosphate Ribosylation of Aminoacyl Transferase II and Inhibition of Protein Synthesis

1968 435 citations Tasuku Honjo et al. Journal of Biological Chemistry profile →
Plasma elevation of stromal cell–derived factor-1 induces mobilization of mature and immature hematopoietic progenitor and stem cells

2001 434 citations Tasuku Honjo et al. Blood profile →
Resting dendritic cells induce peripheral CD8+ T cell tolerance through PD-1 and CTLA-4

2005 432 citations Taku Okazaki, Tasuku Honjo et al. profile →
Disruption of the mouse RBP-Jк gene results in early embryonic death

1995 419 citations Tasuku Honjo et al. profile →
Haploinsufficient lethality and formation of arteriovenous malformations in Notch pathway mutants

2004 418 citations Tasuku Honjo, Thomas Gridley et al. profile →
AID is required to initiate Nbs1/γ-H2AX focus formation and mutations at sites of class switching

2001 409 citations Masamichi Muramatsu, Tasuku Honjo et al. profile →
Notch–RBP-J signaling is involved in cell fate determination of marginal zone B cells

2002 402 citations Hua Han, Masaya Ikegawa et al. profile →
Cloning of cDNA encoding the murine IgG1 induction factor by a novel strategy using SP6 promoter

1986 396 citations Tasuku Honjo et al. profile →
Physical interaction between a novel domain of the receptor Notch and the transcription factor RBP-Jκ/Su(H)

1995 395 citations Yoshihito Taniguchi, Tasuku Honjo et al. profile →
Intestinal IgA synthesis: regulation of front-line body defences

2003 383 citations Sidonia Fagarasan, Tasuku Honjo profile →
Helicobacter pylori infection triggers aberrant expression of activation-induced cytidine deaminase in gastric epithelium

2007 380 citations Kazuo Kinoshita, Il‐mi Okazaki et al. profile →
Alymphoplasia is caused by a point mutation in the mouse gene encoding Nf-κb-inducing kinase

1999 379 citations Reiko Shinkura, Tasuku Honjo et al. profile →
AID Is Required for c-myc/IgH Chromosome Translocations In Vivo

2004 367 citations Masamichi Muramatsu, Tasuku Honjo et al. profile →
Establishment of NOD-Pdcd1^-/-mice as an efficient animal model of type I diabetes

2005 365 citations Taku Okazaki, Tasuku Honjo et al. Proceedings of the National Academy of Sciences profile →
Constitutive Expression of AID Leads to Tumorigenesis

2003 360 citations Il‐mi Okazaki, Naoki Kakazu et al. profile →
The PD-1/PD-L1 complex resembles the antigen-binding Fv domains of antibodies and T cell receptors

2008 353 citations Yoshimasa Tanaka, Masashi Iwasaki et al. Proceedings of the National Academy of Sciences profile →
Forebrain ependymal cells are Notch-dependent and generate neuroblasts and astrocytes after stroke

2009 352 citations Tasuku Honjo et al. profile →
B-cell apoptosis induced by antigen receptor crosslinking is blocked by a T-cell signal through CD40

1993 345 citations Tasuku Honjo et al. profile →
B1b Lymphocytes Confer T Cell-Independent Long-Lasting Immunity

2004 330 citations Masamichi Muramatsu, Tasuku Honjo et al. profile →
TCGF (IL 2)-receptor inducing factor(s). I. Regulation of IL 2 receptor on a natural killer-like cell line (YT cells).

1985 330 citations Tasuku Honjo, Nagahiro Minato et al. profile →
In situ class switching and differentiation to IgA-producing cells in the gut lamina propria

2001 329 citations Sidonia Fagarasan, Kazuo Kinoshita et al. profile →
Cloning of complementary DNA encoding T-cell replacing factor and identity with B-cell growth factor II

1986 320 citations Tasuku Honjo et al. profile →
Loss of intestinal crypt progenitor cells owing to inactivation of both Notch1 and Notch2 is accompanied by derepression of CDK inhibitors p27 ^Kip1 and p57 ^Kip2

2008 315 citations Tasuku Honjo, Freddy Radtke et al. profile →
Mitochondrial activation chemicals synergize with surface receptor PD-1 blockade for T cell-dependent antitumor activity

2017 314 citations Kenji Chamoto, Partha S. Chowdhury et al. Proceedings of the National Academy of Sciences profile →
Inhibition of Carnitine Palmitoyltransferase I Augments Sphingolipid Synthesis and Palmitate-induced Apoptosis

1997 305 citations Masamichi Muramatsu, Tasuku Honjo et al. Journal of Biological Chemistry profile →
IFN-α Directly Promotes Programmed Cell Death-1 Transcription and Limits the Duration of T Cell-Mediated Immunity

2011 278 citations Shunsuke Chikuma, Taku Okazaki et al. profile →
Structure and physical map of 64 variable segments in the 3′ 0.8–megabase region of the human immunoglobulin heavy–chain locus

1993 276 citations Hitoshi Nagaoka, Tasuku Honjo et al. profile →
PPAR-Induced Fatty Acid Oxidation in T Cells Increases the Number of Tumor-Reactive CD8+ T Cells and Facilitates Anti–PD-1 Therapy

2018 268 citations Partha S. Chowdhury, Kenji Chamoto et al. Cancer Immunology Research profile →
Organization of the constant-region gene family of the mouse immunoglobulin heavy chain

1982 265 citations Tasuku Honjo et al. profile →
Immunoglobulin Genes

1983 260 citations Tasuku Honjo profile →
PD-1 and LAG-3 inhibitory co-receptors act synergistically to prevent autoimmunity in mice

2011 255 citations Taku Okazaki, Il‐mi Okazaki et al. profile →
Organization of immunoglobulin heavy chain genes and allelic deletion model.

1978 247 citations Tasuku Honjo et al. Proceedings of the National Academy of Sciences profile →
Predominant recognition of human T cell leukemia virus type I (HTLV-I) pX gene products by human CD8+ cytotoxic T cells directed against HTLV-I-infected cells

1991 223 citations Tasuku Honjo et al. profile →
Insights from a 30-year journey: function, regulation and therapeutic modulation of PD1

2023 95 citations Kenji Chamoto, Masaki Tajima et al. profile →

Peers

Countries citing papers authored by Tasuku Honjo

Since Specialization

Citations

This map shows the geographic impact of Tasuku Honjo's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Tasuku Honjo with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Tasuku Honjo more than expected).

Fields of papers citing papers by Tasuku Honjo

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Tasuku Honjo. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Tasuku Honjo. The network helps show where Tasuku Honjo may publish in the future.

Co-authorship network of co-authors of Tasuku Honjo

This figure shows the co-authorship network connecting the top 25 collaborators of Tasuku Honjo. A scholar is included among the top collaborators of Tasuku Honjo based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Tasuku Honjo. Tasuku Honjo is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

#	Work	Indexed citations
1	Chemoproteomic Identification of Spermidine-Binding Proteins and Antitumor-Immunity Activators 2024 ·Journal of the American Chemical Society ·(unknown),(unknown),(unknown),(unknown),Shin‐ichi Sato,Tasuku Honjo,Kenji Chamoto,Motonari Uesugi	7
2	Spermidine – an old molecule with a new age-defying immune function 2023 ·Trends in Cell Biology ·Kenji Chamoto,Baihao Zhang,Masaki Tajima,Tasuku Honjo,Sidonia Fagarasan	34
3	Phf5a regulates DNA repair in class switch recombination via p400 and histone H2A variant deposition 2021 ·The EMBO Journal ·Nasim A. Begum,Farazul Haque,Andre Stanlie,Afzal Husain,Samiran Mondal,Mikiyo Nakata,Takako Taniguchi,Hisaaki Taniguchi,Tasuku Honjo	20
4	RNA-binding motifs of hnRNP K are critical for induction of antibody diversification by activation-induced cytidine deaminase 2020 ·Proceedings of the National Academy of Sciences ·(unknown),Maki Kobayashi,Wenjun Hu,Koichi Higashi,Nasim A. Begum,Ken Kurokawa,Tasuku Honjo	12
5	SAMHD 1‐mediated dNTP degradation is required for efficient DNA repair during antibody class switch recombination 2020 ·The EMBO Journal ·Afzal Husain,Jianliang Xu,Hodaka Fujii,Mikiyo Nakata,Maki Kobayashi,Ji‐Yang Wang,Jan Rehwinkel,Tasuku Honjo,Nasim A. Begum	16
6	PPAR-Induced Fatty Acid Oxidation in T Cells Increases the Number of Tumor-Reactive CD8+ T Cells and Facilitates Anti–PD-1 Therapybreakdown → 2018 ·Cancer Immunology Research ·Partha S. Chowdhury,Kenji Chamoto,Alok Kumar,Tasuku Honjo	268
7	C-terminal region of activation-induced cytidine deaminase (AID) is required for efficient class switch recombination and gene conversion 2014 ·Proceedings of the National Academy of Sciences ·(unknown),Maki Kobayashi,Nasim A. Begum,Jianliang Xu,Kouji Hirota,Tasuku Honjo	21
8	Programmed cell death 1 inhibits inflammatory helper T-cell development through controlling the innate immune response 2013 ·Proceedings of the National Academy of Sciences ·(unknown),Tasuku Honjo,Shunsuke Chikuma	45
9	Oncogenic activation of the Notch1 gene by deletion of its promoter in Ikaros-deficient T-ALL 2010 ·Blood ·Robin Jeannet,Jérôme Mastio,(unknown),Attila Oravecz,Todd Ashworth,(unknown),Bernard Jost,Stéphanie Le Gras,Jacques Ghysdael,Thomas Gridley,Tasuku Honjo,Freddy Radtke,Jon C. Aster,Susan Chan,Philippe Kastner	65
10	X4 and R5 HIV-1 Have Distinct Post-entry Requirements for Uracil DNA Glycosylase during Infection of Primary Cells 2010 ·Journal of Biological Chemistry ·Kate Jones,Michael Roche,Michael P. Gantier,Nasim A. Begum,Tasuku Honjo,Salvatore J. Caradonna,Bryan R.G. Williams,Johnson Mak	26
11	Preferential Generation of Follicular B Helper T Cells from Foxp3 ⁺ T Cells in Gut Peyer's Patchesbreakdown → 2009 ·Science ·Masayuki Tsuji,Noriko Komatsu,Shimpei Kawamoto,Keiichiro Suzuki,Osami Kanagawa,Tasuku Honjo,Shohei Hori,Sidonia Fagarasan	463
12	Effects of hypoxia on behavior and mortality of pen shell (Atrina lischkeana) 2009 ·(unknown),(unknown),Hidetoshi Matsui,(unknown),(unknown),(unknown),(unknown),Ik Joon Kang,Yohei Shimasaki,Tasuku Honjo	3
13	Programmed cell death 1 ligand 1 and tumor-infiltrating CD8 ⁺ T lymphocytes are prognostic factors of human ovarian cancerbreakdown → 2007 ·Proceedings of the National Academy of Sciences ·Junzo Hamanishi,Masaki Mandai,Masashi Iwasaki,Taku Okazaki,Yoshimasa Tanaka,Ken Yamaguchi,Toshihiro Higuchi,Haruhiko Yagi,Kenji Takakura,Nagahiro Minato,Tasuku Honjo,Shingo Fujii	1155
14	Role of AID in Tumorigenesis 2007 ·Advances in immunology ·Il‐mi Okazaki,Ai Kotani,Tasuku Honjo	111
15	A target selection of somatic hypermutations is regulated similarly between T and B cells upon activation-induced cytidine deaminase expression 2005 ·Proceedings of the National Academy of Sciences ·Ai Kotani,Il‐mi Okazaki,Masamichi Muramatsu,Kazuo Kinoshita,Nasim A. Begum,Toshiharu Nakajima,Hirohisa Saito,Tasuku Honjo	60
16	Uracil DNA Glycosylase Activity Is Dispensable for Immunoglobulin Class Switch 2004 ·Science ·Nasim A. Begum,Kazuo Kinoshita,Naoki Kakazu,Masamichi Muramatsu,Hitoshi Nagaoka,Reiko Shinkura,Detlev Biniszkiewicz,Laurie A. Boyer,Rudolf Jaenisch,Tasuku Honjo	91
17	De novo protein synthesis is required for the activation-induced cytidine deaminase function in class-switch recombination 2003 ·Proceedings of the National Academy of Sciences ·Tomomitsu Doi,Kazuo Kinoshita,Masaya Ikegawa,Masamichi Muramatsu,Tasuku Honjo	94
18	AID Enzyme-Induced Hypermutation in an Actively Transcribed Gene in Fibroblasts 2002 ·Science ·Kiyotsugu Yoshikawa,Il‐mi Okazaki,(unknown),Kazuo Kinoshita,Masamichi Muramatsu,Hitoshi Nagaoka,Tasuku Honjo	312
19	LIM Protein KyoT2 Negatively Regulates Transcription by Association with the RBP-J DNA-Binding Protein 1998 ·Molecular and Cellular Biology ·Yoshihito Taniguchi,(unknown),(unknown),Hua Han,Tasuku Honjo	153
20	The shortest path from the surface to the nucleus: RBP‐Jκ/Su(H) transcription factor 1996 ·Genes to Cells ·Tasuku Honjo	175

About Tasuku Honjo

Tasuku Honjo is a scholar working on Immunology, Radiology, Nuclear Medicine and Imaging and Molecular Biology, having authored 582 papers that have together received 72.1k indexed citations. Recurring topics across this work include T-cell and B-cell Immunology (181 papers), Immune Cell Function and Interaction (168 papers) and Monoclonal and Polyclonal Antibodies Research (95 papers). The work is most often cited by research in Immunology (39.3k citations), Oncology (23.2k citations) and Molecular Biology (24.8k citations). Tasuku Honjo has collaborated with scholars based in Japan, United States and Sweden. Frequent co-authors include Taku Okazaki, Masamichi Muramatsu, Sidonia Fagarasan, Kazuo Kinoshita, Nagahiro Minato, Yoshiko Iwai, Hiroyuki Nishimura, Yasumasa Ishida, Hiroshi Hiai and Yasutoshi Agata. Their work appears in journals such as Nature, Science and Cell.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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