Hiroshi Hiai

16.1k total citations · 7 hit papers
148 papers, 12.0k citations indexed

About

Hiroshi Hiai is a scholar working on Molecular Biology, Immunology and Oncology. According to data from OpenAlex, Hiroshi Hiai has authored 148 papers receiving a total of 12.0k indexed citations (citations by other indexed papers that have themselves been cited), including 85 papers in Molecular Biology, 33 papers in Immunology and 22 papers in Oncology. Recurrent topics in Hiroshi Hiai's work include Immune Cell Function and Interaction (18 papers), Glutathione Transferases and Polymorphisms (12 papers) and DNA Repair Mechanisms (11 papers). Hiroshi Hiai is often cited by papers focused on Immune Cell Function and Interaction (18 papers), Glutathione Transferases and Polymorphisms (12 papers) and DNA Repair Mechanisms (11 papers). Hiroshi Hiai collaborates with scholars based in Japan, United States and United Kingdom. Hiroshi Hiai's co-authors include Tasuku Honjo, Nagahiro Minato, Shinya Toyokuni, Hiroyuki Nishimura, Masato Nose, Keisei Okamoto, Taku Okazaki, Junji Yodoi, Yoshimasa Tanaka and Akira Mizoguchi and has published in prestigious journals such as Science, Proceedings of the National Academy of Sciences and Journal of Clinical Investigation.

In The Last Decade

Hiroshi Hiai

148 papers receiving 11.7k citations

Hit Papers

5 papers align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Development of Lupus-like Autoimmune Diseases by Disruption of the PD-1 Gene Encoding an ITIM Motif-Carrying Immunoreceptor

1999 2.1k citations Hiroyuki Nishimura, Masato Nose et al. Immunity profile →
Autoimmune Dilated Cardiomyopathy in PD-1 Receptor-Deficient Mice

2001 1.5k citations Hiroyuki Nishimura, Taku Okazaki et al. profile →
Persistent oxidative stress in cancer

1995 1.0k citations Shinya Toyokuni, Keisei Okamoto et al. profile →
Autoantibodies against cardiac troponin I are responsible for dilated cardiomyopathy in PD-1-deficient mice

2003 544 citations Taku Okazaki, Hiroshi Hiai et al. profile →
Critical Roles of Activation-Induced Cytidine Deaminase in the Homeostasis of Gut Flora

2002 474 citations Hiroshi Hiai, Tasuku Honjo et al. profile →
Establishment of NOD-Pdcd1^-/-mice as an efficient animal model of type I diabetes

2005 365 citations Taku Yoshida, Fumio Nakaki et al. profile →
Constitutive Expression of AID Leads to Tumorigenesis

2003 360 citations Il‐mi Okazaki, Hiroshi Hiai et al. The Journal of Experimental Medicine profile →

Peers

Countries citing papers authored by Hiroshi Hiai

Since Specialization

Citations

This map shows the geographic impact of Hiroshi Hiai's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Hiroshi Hiai with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Hiroshi Hiai more than expected).

Fields of papers citing papers by Hiroshi Hiai

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Hiroshi Hiai. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Hiroshi Hiai. The network helps show where Hiroshi Hiai may publish in the future.

Co-authorship network of co-authors of Hiroshi Hiai

This figure shows the co-authorship network connecting the top 25 collaborators of Hiroshi Hiai. A scholar is included among the top collaborators of Hiroshi Hiai based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Hiroshi Hiai. Hiroshi Hiai is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

#	Work	Indexed citations
1	Pthlh, a promising cancer modifier gene in rat tongue carcinogenesis 2013 ·Oncology Reports ·Hirohiko Suwa, Masato Hirano, (unknown), Motohiko Nagayama, (unknown), (unknown), Hayase Shisa, Aiko Sugiyama, Masahiro Sugimoto, Hiroshi Hiai, Motoo Kitano, Jun‐ichi Tanuma	6
2	The Drosophila DOCK family protein sponge is involved in differentiation of R7 photoreceptor cells 2013 ·Experimental Cell Research ·Koichi Eguchi, (unknown), Hideki Yoshida, (unknown), Seiji Miyata, Hiroshi Hiai, Masamitsu Yamaguchi	10
3	PD-1 deficiency results in the development of fatal myocarditis in MRL mice 2010 ·International Immunology ·Jian Wang, Il‐mi Okazaki, Taku Yoshida, Shunsuke Chikuma, Yu Kato, Fumio Nakaki, Hiroshi Hiai, Tasuku Honjo, Taku Okazaki	220
4	Mutation of Dock5, a member of the guanine exchange factor Dock180 superfamily, in the rupture of lens cataract mouse 2008 ·Experimental Eye Research ·Natsue Omi, Etsuko Kiyokawa, Michiyuki Matsuda, Kazuo Kinoshita, Shuichi Yamada, Kazumi Yamada, Yoshibumi Matsushima, Yun Wang, Jun Kawai, Masanori Suzuki, Yoshihide Hayashizaki, Hiroshi Hiai	22
5	Bone marrow pre-B expansion by SL/Kh-Bomb1 locus: Not sufficient for lymphomagenesis 2007 ·Leukemia Research ·(unknown), Tatsuaki Tsuruyama, Richard H. Kaszynski, Kohei Kometani, Nagahiro Minato, Takuro Nakamura, Keiji Tamaki, Hiroshi Hiai	6
6	Hydronephrosis associated with antiurothelial and antinuclear autoantibodies in BALB/c-Fcgr2b −/− Pdcd1 −/− mice 2005 ·The Journal of Experimental Medicine ·Taku Okazaki, (unknown), Jian Wang, Hiroshi Hiai, Toshiyuki Takai, Jeffrey V. Ravetch, Tasuku Honjo	41
7	Notch/RBP-J Signaling Regulates Epidermis/Hair Fate Determination of Hair Follicular Stem Cells 2003 ·Current Biology ·Norio Yamamoto, Kenji Tanigaki, Hua Han, Hiroshi Hiai, Tasuku Honjo	109
8	Peroxynitrite-mediated stress is associated with proliferation of human metastatic colorectal carcinoma in the liver 2002 ·Cancer Letters ·Shohei Kondo, Shinya Toyokuni, Tatsuaki Tsuruyama, Munetaka Ozeki, Tsuyoshi Tachibana, (unknown), Hiroshi Hiai, Hisashi Onodera, Masayuki Imamura	19
9	Identification of xanthine dehydrogenase/xanthine oxidase as a rat Paneth cell zinc-binding protein 2001 ·Biochimica et Biophysica Acta (BBA) - Molecular Cell Research ·Yukari Morita, Mitsutaka Sawada, Hiroshi Seno, Shigeo Takaishi, Hiroaki Fukuzawa, Naoki Miyake, Hiroshi Hiai, (unknown)	19
10	Development of Lupus-like Autoimmune Diseases by Disruption of the PD-1 Gene Encoding an ITIM Motif-Carrying Immunoreceptor breakdown → 1999 ·Immunity ·Hiroyuki Nishimura, Masato Nose, Hiroshi Hiai, Nagahiro Minato, Tasuku Honjo	2093
11	High incidence of allelic loss on chromosome 5 and inactivation of p15INK4B and p16INK4A tumor suppressor genes in oxystress-induced renal cell carcinoma of rats 1999 ·Oncogene ·Tomoyuki Tanaka, Yoko Iwasa, Shohei Kondo, Hiroshi Hiai, Shinya Toyokuni	97
12	Development of High‐grade Renal Cell Carcinomas in Rats Independently of Somatic Mutations in the Tsc2 and VHL Tumor Suppressor Genes 1998 ·Japanese Journal of Cancer Research ·Shinya Toyokuni, K. Okada, Shohei Kondo, Hiroaki Nishioka, Tomoyuki Tanaka, Yasuyuki Nishiyama, Okio Hino, Hiroshi Hiai	21
13	Overexpression of Integrin–associated Protein (CD47) in Rat Kidney Treated with a Renal Carcinogen, Ferric Nitrilotriacetate 1997 ·Japanese Journal of Cancer Research ·Yasuyuki Nishiyama, Tomoyuki Tanaka, Hiroshi Naitoh, Chisato Mori, Manabu Fukumoto, Hiroshi Hiai, Shinya Toyokuni	19
14	Rupture of Lens Cataract: A Novel Hereditary Recessive Cataract Model in the Mouse 1997 ·Experimental Eye Research ·(unknown), Yoshibumi Matsushima, Hiroshi Hiai, Shigekazu Uga, Yoshihito Honda	26
15	A Quantitative Trait Locus in Major Histocompatibility Complex Determining Latent Period of Mouse Lymphomas 1996 ·Japanese Journal of Cancer Research ·Toshiyuki Kamoto, Hayase Shisa, Abujiang Pataer, Л. Лу, Osamu Yoshida, Yoshihiro Yamada, Hiroshi Hiai	5
16	Autoimmune disease of exocrine organs in immunodeficient alymphoplasia mice: a spontaneous model for Sjören's syndrome 1996 ·European Journal of Immunology ·(unknown), Takeshi Tsubata, Hiroshi Hiai, Reiko Shinkura, Ryutaro Matsumura, Takayuki Sumida, Shigeki Miyawaki, Hiroshi Ishida, Shunichi Kumagai, Kazuwa Nakao, Tasuku Honjo	69
17	Low Incidence of Point Mutations in H‐, K‐ and N‐ras Oncogenes and p53 Tumor Suppressor Gene in Renal Cell Carcinoma and Peritoneal Mesothelioma of Wistar Rats Induced by Ferric Nitrilotriacetate 1995 ·Japanese Journal of Cancer Research ·Yasuyuki Nishiyama, Hirofumi Suwa, Keisei Okamoto, Manabu Fukumoto, Hiroshi Hiai, Shinya Toyokuni	61
18	Expression of metastasis-related nm23-H1 and nm23-H2 genes in ovarian carcinomas: correlation with clinicopathology, EGFR, c-erbB-2, and c-erbB-3 genes, and sex steroid receptor expression. 1994 ·PubMed ·Masaki Mandai, Ikuo Konishi, Masafumi Koshiyama, Takahide Mori, Shinji Arao, Hironori Tashiro, Hitoshi Okamura, Hiroshi Nomura, Hiroshi Hiai, Manabu Fukumoto	100
19	SL/Kh strain of mice: A model of spontaneous pre-B-lymphomas 1993 ·Leukemia Research ·Masako Shimada, Yoshihiro Yamada, (unknown), Keisei Okamoto, Manabu Fukumoto, Tasuku Honjo, Hiroshi Hiai	21
20	Nuclear Localization of Antigens Detected by a Monoclonal Antibody Against a Synthetic Peptide of rfp Finger Protein 1990 ·Hybridoma ·Takashi Kikuchi, Masahide Takahashi, Ryuzo Ueda, (unknown), Tsutomu Seito, Hiroshi Hiai, Izumi Nakashima, Takashi Takahashi	2

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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