Tomohiko Maehama

9.4k total citations · 3 hit papers
66 papers, 7.6k citations indexed

About

Tomohiko Maehama is a scholar working on Molecular Biology, Cell Biology and Oncology. According to data from OpenAlex, Tomohiko Maehama has authored 66 papers receiving a total of 7.6k indexed citations (citations by other indexed papers that have themselves been cited), including 49 papers in Molecular Biology, 23 papers in Cell Biology and 13 papers in Oncology. Recurrent topics in Tomohiko Maehama's work include PI3K/AKT/mTOR signaling in cancer (19 papers), Hippo pathway signaling and YAP/TAZ (15 papers) and Protein Kinase Regulation and GTPase Signaling (14 papers). Tomohiko Maehama is often cited by papers focused on PI3K/AKT/mTOR signaling in cancer (19 papers), Hippo pathway signaling and YAP/TAZ (15 papers) and Protein Kinase Regulation and GTPase Signaling (14 papers). Tomohiko Maehama collaborates with scholars based in Japan, United States and Canada. Tomohiko Maehama's co-authors include Jack E. Dixon, Gregory S. Taylor, Yasunori Kanaho, Marco Muda, Brian A. Hemmings, Carolyn A. Worby, James C. Clemens, Jie‐Oh Lee, Haijuan Yang and Nikola P. Pavletich and has published in prestigious journals such as Cell, Proceedings of the National Academy of Sciences and Journal of Biological Chemistry.

In The Last Decade

Tomohiko Maehama

65 papers receiving 7.5k citations

Hit Papers

align trajectories sort by overperformance

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

The Tumor Suppressor, PTEN/MMAC1, Dephosphorylates the Lipid Second Messenger, Phosphatidylinositol 3,4,5-Trisphosphate

1998 2.6k citations Tomohiko Maehama, Jack E. Dixon Journal of Biological Chemistry profile →
Crystal Structure of the PTEN Tumor Suppressor

1999 851 citations Tomohiko Maehama, Jack E. Dixon et al. profile →
Use of double-stranded RNA interference in Drosophila cell lines to dissect signal transduction pathways

2000 719 citations Tomohiko Maehama, Jack E. Dixon et al. Proceedings of the National Academy of Sciences profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name	h						Papers	Cites
Tomohiko Maehama Japan	32	6.2k	1.5k	1.1k	937	798	66	7.6k
Anke Klippel United States	40	6.2k 1.0×	1.3k 0.9×	1.3k 1.1×	967 1.0×	831 1.0×	67	8.0k
Estela Jacinto United States	27	6.9k 1.1×	965 0.7×	906 0.8×	1.5k 1.6×	895 1.1×	45	8.9k
Shubha Bagrodia United States	27	5.5k 0.9×	2.3k 1.6×	1.3k 1.1×	753 0.8×	626 0.8×	39	7.4k
Alan P. Fields United States	54	6.1k 1.0×	1.4k 0.9×	1.8k 1.6×	612 0.7×	1.1k 1.3×	120	7.9k
Robert Latek United States	17	5.4k 0.9×	812 0.6×	936 0.8×	1.2k 1.3×	509 0.6×	31	7.6k
Roberto D. Polakiewicz United States	41	6.7k 1.1×	741 0.5×	1.4k 1.3×	948 1.0×	1.3k 1.6×	69	9.1k
Peter M. Finan United Kingdom	26	5.2k 0.8×	954 0.7×	1.2k 1.0×	1.4k 1.5×	1.2k 1.5×	40	7.6k
Davide Ruggero United States	48	9.9k 1.6×	1.3k 0.9×	1.6k 1.4×	1.1k 1.2×	1.7k 2.2×	91	11.9k
Ned Lamb France	49	7.5k 1.2×	1.8k 1.3×	1.8k 1.6×	715 0.8×	740 0.9×	90	9.4k
Piero Crespo Spain	38	5.6k 0.9×	1.4k 1.0×	1.3k 1.1×	987 1.1×	637 0.8×	97	7.2k

Countries citing papers authored by Tomohiko Maehama

Since Specialization

Citations

This map shows the geographic impact of Tomohiko Maehama's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Tomohiko Maehama with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Tomohiko Maehama more than expected).

Fields of papers citing papers by Tomohiko Maehama

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Tomohiko Maehama. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Tomohiko Maehama. The network helps show where Tomohiko Maehama may publish in the future.

Co-authorship network of co-authors of Tomohiko Maehama

This figure shows the co-authorship network connecting the top 25 collaborators of Tomohiko Maehama. A scholar is included among the top collaborators of Tomohiko Maehama based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Tomohiko Maehama. Tomohiko Maehama is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

Nishio, Miki, Junji Otani, Toshiko Sakuma, et al.. (2022). Hippo-TAZ signaling is the master regulator of the onset of triple-negative basal-like breast cancers. Proceedings of the National Academy of Sciences. 119(29). e2123134119–e2123134119. 14 indexed citations

Maehama, Tomohiko, Miki Nishio, Junji Otani, et al.. (2021). Alantolactone is a natural product that potently inhibits YAP1/TAZ through promotion of reactive oxygen species accumulation. Cancer Science. 112(10). 4303–4316. 22 indexed citations

Omori, Hirofumi, Miki Nishio, Muneyuki Masuda, et al.. (2020). YAP1 is a potent driver of the onset and progression of oral squamous cell carcinoma. Science Advances. 6(12). eaay3324–eaay3324. 91 indexed citations

Nishio, Miki, Tomohiko Maehama, Junji Otani, et al.. (2020). Endogenous YAP1 activation drives immediate onset of cervical carcinoma in situ in mice. Cancer Science. 111(10). 3576–3587. 24 indexed citations

Nakada‐Tsukui, Kumiko, et al.. (2020). Dynamism of PI4-Phosphate during Interactions with Human Erythrocytes in Entamoeba histolytica. Microorganisms. 8(7). 1050–1050. 4 indexed citations

Maehama, Tomohiko, Miki Nishio, Hiroki Goto, et al.. (2016). Targeting the Hippo signalling pathway for cancer treatment. The Journal of Biochemistry. 161(3). mvw074–mvw074. 40 indexed citations

Maehama, Tomohiko, Masayoshi Fukasawa, Tomoko Date, Takaji Wakita, & Kentaro Hanada. (2013). A class II phosphoinositide 3-kinase plays an indispensable role in hepatitis C virus replication. Biochemical and Biophysical Research Communications. 440(1). 150–156. 11 indexed citations

Tanaka, Masahiko, Hideyuki Hara, Hiroshi Nishina, et al.. (2010). An improved method for cell-to-cell transmission of infectious prion. Biochemical and Biophysical Research Communications. 397(3). 505–508. 1 indexed citations

Miyazaki, Hideyuki, Masakazu Yamazaki, Hiroshi Watanabe, et al.. (2005). The small GTPase ADP‐ribosylation factor 6 negatively regulates dendritic spine formation. FEBS Letters. 579(30). 6834–6838. 36 indexed citations

10.

Maehama, Tomohiko, et al.. (2004). Suppression of a phosphatidylinositol 3‐kinase signal by a specific spliced variant of Drosophila PTEN. FEBS Letters. 565(1-3). 43–47. 11 indexed citations

11.

Watanabe, Hiroshi, Takeaki Yokozeki, Masakazu Yamazaki, et al.. (2004). Essential Role for Phospholipase D2 Activation Downstream of ERK MAP Kinase in Nerve Growth Factor-stimulated Neurite Outgrowth from PC12 Cells. Journal of Biological Chemistry. 279(36). 37870–37877. 41 indexed citations

12.

Kanaho, Yasunori, et al.. (2004). Regulation of PTEN Phosphorylation and Stability by a Tumor Suppressor Candidate Protein. Journal of Biological Chemistry. 279(44). 45300–45303. 108 indexed citations

13.

Merlot, Sylvain, Ruedi Meili, David J. Pagliarini, et al.. (2003). A PTEN-related 5-Phosphatidylinositol Phosphatase Localized in the Golgi. Journal of Biological Chemistry. 278(41). 39866–39873. 27 indexed citations

14.

Yamazaki, Masakazu, Hideyuki Miyazaki, Hiroshi Watanabe, et al.. (2002). Phosphatidylinositol 4-Phosphate 5-Kinase Is Essential for ROCK-mediated Neurite Remodeling. Journal of Biological Chemistry. 277(19). 17226–17230. 66 indexed citations

15.

Gustin, Jason A., Tomohiko Maehama, Jack E. Dixon, & David B. Donner. (2001). The PTEN Tumor Suppressor Protein Inhibits Tumor Necrosis Factor-induced Nuclear Factor κB Activity. Journal of Biological Chemistry. 276(29). 27740–27744. 90 indexed citations

16.

Maehama, Tomohiko & Jack E. Dixon. (1998). The Tumor Suppressor, PTEN/MMAC1, Dephosphorylates the Lipid Second Messenger, Phosphatidylinositol 3,4,5-Trisphosphate. Journal of Biological Chemistry. 273(22). 13375–13378. 2551 indexed citations breakdown →

17.

Kurosu, Hiroshi, Tomohiko Maehama, Taro Okada, et al.. (1997). Heterodimeric Phosphoinositide 3-Kinase Consisting of p85 and p110β Is Synergistically Activated by the βγ Subunits of G Proteins and Phosphotyrosyl Peptide. Journal of Biological Chemistry. 272(39). 24252–24256. 229 indexed citations

18.

Maehama, Tomohiko & Toshiaki Katada. (1997). Molecular Characterization of Rat T Lymphocyte Alloantigen RT6.1 as an ADP-Ribosyltransferase. Advances in experimental medicine and biology. 419. 181–183. 1 indexed citations

19.

Maehama, Tomohiko, S. Hoshino, & Toshiaki Katada. (1996). Increase in ADP‐ribosyltransferase activity of rat T lymphocyte alloantigen RT6.1 by a single amino acid mutation. FEBS Letters. 388(2-3). 189–191. 17 indexed citations

20.

Nishina, Hiroshi, Iwao Kukimoto, Tomohiko Maehama, et al.. (1995). Significance of Thrl82 in the Nucleotide-Exchange and GTP-Hydrolysis Reactions of the Subunit of GTP-Binding Protein Gi2. The Journal of Biochemistry. 118(5). 1083–1089. 13 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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