Sylvain Meloche

13.3k total citations · 3 hit papers
151 papers, 10.6k citations indexed

About

Sylvain Meloche is a scholar working on Molecular Biology, Oncology and Cardiology and Cardiovascular Medicine. According to data from OpenAlex, Sylvain Meloche has authored 151 papers receiving a total of 10.6k indexed citations (citations by other indexed papers that have themselves been cited), including 117 papers in Molecular Biology, 29 papers in Oncology and 22 papers in Cardiology and Cardiovascular Medicine. Recurrent topics in Sylvain Meloche's work include Melanoma and MAPK Pathways (45 papers), Protein Kinase Regulation and GTPase Signaling (34 papers) and Receptor Mechanisms and Signaling (12 papers). Sylvain Meloche is often cited by papers focused on Melanoma and MAPK Pathways (45 papers), Protein Kinase Regulation and GTPase Signaling (34 papers) and Receptor Mechanisms and Signaling (12 papers). Sylvain Meloche collaborates with scholars based in Canada, France and United States. Sylvain Meloche's co-authors include Jacques Pouysségur, Marc K. Saba-El-Leil, Gilles Pagès, Philippe Coulombe, Marc J. Servant, Christophe Frémin, Edith Giasson, Gilles L’Allemain, Philippe Lenormand and Jean‐Claude Chambard and has published in prestigious journals such as Cell, Proceedings of the National Academy of Sciences and Journal of Biological Chemistry.

In The Last Decade

Sylvain Meloche

149 papers receiving 10.5k citations

Hit Papers

align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Mitogen-activated protein kinases p42mapk and p44mapk are required for fibroblast proliferation.

1993 899 citations Gilles Pagès, Sylvain Meloche et al. Proceedings of the National Academy of Sciences profile →
The ERK1/2 mitogen-activated protein kinase pathway as a master regulator of the G1- to S-phase transition

2007 890 citations Sylvain Meloche, Jacques Pouysségur Oncogene profile →
FGF stimulation of the Erk1/2 signalling cascade triggers transition of pluripotent embryonic stem cells from self-renewal to lineage commitment

2007 606 citations Marc K. Saba-El-Leil, Sylvain Meloche et al. profile →

Peers

Countries citing papers authored by Sylvain Meloche

Since Specialization

Citations

This map shows the geographic impact of Sylvain Meloche's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Sylvain Meloche with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Sylvain Meloche more than expected).

Fields of papers citing papers by Sylvain Meloche

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Sylvain Meloche. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Sylvain Meloche. The network helps show where Sylvain Meloche may publish in the future.

Co-authorship network of co-authors of Sylvain Meloche

This figure shows the co-authorship network connecting the top 25 collaborators of Sylvain Meloche. A scholar is included among the top collaborators of Sylvain Meloche based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Sylvain Meloche. Sylvain Meloche is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

#	Work	Indexed citations
1	Brain-wide mapping of immune receptors uncovers a neuromodulatory role of IL-17E and the receptor IL-17RB 2025 ·Cell ·(unknown), Tomoe Ishikawa, Hyeseung Lee, Byeongjun Lee, Changhyeon Ryu, (unknown), Minjin Kim, (unknown), Yujin Hong, Mengyang Feng, Hainsworth Y. Shin, Sylvain Meloche, Richard M. Locksley, Ekaterina K. Koltsova, Sergei I. Grivennikov, Myriam Heiman, Gloria B. Choi, Jun R. Huh	10
2	CDK12 is hyperactivated and a synthetic-lethal target in BRAF-mutated melanoma 2022 ·Nature Communications ·Thibault Houlès, Geneviève Lavoie, Sami Nourreddine, Winnie Cheung, (unknown), (unknown), (unknown), Benoı̂t Grondin, Sichun Lin, Marc K. Saba-El-Leil, Stéphane Angers, Sylvain Meloche, Philippe P. Roux	23
3	Phosphoproteomic analysis identifies supervillin as an ERK3 substrate regulating cytokinesis and cell ploidy 2022 ·Journal of Cellular Physiology ·(unknown), Eugénie Goupil, Mathilde Soulez, Evgeny Kanshin, Antoine Bouchard, Ole Morten Seternes, Pierre Thibault, Jean‐Claude Labbé, Sylvain Meloche	4
4	Loss of interleukin-17 receptor D promotes chronic inflammation-associated tumorigenesis 2020 ·Oncogene ·(unknown), (unknown), Marie‐Josée Langlois, Sarah Pasquin, Marc K. Saba-El-Leil, Nathalie Rivard, Robert Friesel, Marc J. Servant, Jean‐François Gauchat, Sylvie Lesage, Sylvain Meloche	23
5	Towards the development of chromone-based MEK1/2 modulators 2014 ·European Journal of Medicinal Chemistry ·(unknown), Christine Dyrager, Carlos Solano, (unknown), Laure Voisin, David Bliman, Sylvain Meloche, Morten Grøtli	14
6	Tumor suppressor activity of the ERK/MAPK pathway by promoting selective protein degradation 2013 ·Genes & Development ·Xavier Deschênes‐Simard, Marie‐France Gaumont‐Leclerc, Véronique Bourdeau, Frédéric Lessard, Olga Moiseeva, Valérie Forest, Sebastian Igelmann, Frédérick A. Mallette, Marc K. Saba-El-Leil, Sylvain Meloche, Fred Saad, Anne‐Marie Mes‐Masson, Gerardo Ferbeyre	147
7	Sef Downregulation by Ras Causes MEK1/2 to Become Aberrantly Nuclear Localized Leading to Polyploidy and Neoplastic Transformation 2012 ·Cancer Research ·Stéphanie Duhamel, Josée Hébert, Louis Gaboury, Amélie Bouchard, Ronald Simon, Guido Sauter, Mark Basik, Sylvain Meloche	39
8	Proteomic Profiling of the TRAF3 Interactome Network Reveals a New Role for the ER-to-Golgi Transport Compartments in Innate Immunity 2012 ·PLoS Pathogens ·Wendy J. van Zuylen, (unknown), Jean-François Clément, Kashif Aziz Khan, (unknown), Florence Dô, (unknown), (unknown), Grégory Emery, Anne‐Claude Gingras, Sylvain Meloche, Marc J. Servant	47
9	Extracellular Signal-Regulated Kinases 1 and 2 Regulate the Balance Between Eccentric and Concentric Cardiac Growth 2010 ·Circulation Research ·Izhak Kehat, Jennifer Davis, Malte Tiburcy, Federica Accornero, Marc K. Saba-El-Leil, Marjorie Maillet, Allen J. York, John N. Lorenz, Wolfram H. Zimmermann, Sylvain Meloche, Jeffery D. Molkentin	197
10	From basic research to clinical development of MEK1/2 inhibitors for cancer therapy 2010 ·Journal of Hematology & Oncology ·Christophe Frémin, Sylvain Meloche	197
11	Genetic inhibition of cardiac ERK1/2 promotes stress-induced apoptosis and heart failure but has no effect on hypertrophy in vivo 2007 ·Proceedings of the National Academy of Sciences ·Nicole H. Purcell, Benjamin J. Wilkins, Allen J. York, Marc K. Saba-El-Leil, Sylvain Meloche, Jeffrey Robbins, Jeffery D. Molkentin	197
12	The ERK1/2 mitogen-activated protein kinase pathway as a master regulator of the G1- to S-phase transition breakdown → 2007 ·Oncogene ·Sylvain Meloche, Jacques Pouysségur	890
13	Atypical mitogen-activated protein kinases: Structure, regulation and functions 2006 ·Biochimica et Biophysica Acta (BBA) - Molecular Cell Research ·Philippe Coulombe, Sylvain Meloche	225
14	p107 inhibits G1 to S phase progression by down-regulating expression of the F-box protein Skp2 2005 ·The Journal of Cell Biology ·Geneviève Rodier, Constantin Makris, Philippe Coulombe, Anthony Scimè, Keiko Nakayama, Keiichi I. Nakayama, Sylvain Meloche	36
15	Expression of angiotensin type II receptor downregulates Cdk4 synthesis and inhibits cell-cycle progression 2003 ·Oncogene ·(unknown), Geneviève Rodier, Edith Giasson, Philippe Coulombe, Catherine Chassagne, Sylvain Meloche	8
16	Tissue-specific GATA factors are transcriptional effectors of the small GTPase RhoA 2001 ·Genes & Development ·Frédéric Charron, (unknown), (unknown), Lynda Robitaille, Qiangrong Liang, Jeffery D. Molkentin, Sylvain Meloche, Mona Nemer	198
17	Primary structure, expression and chromosomal locus of a human homolog of rat ERK3. 1996 ·PubMed ·Sylvain Meloche, (unknown), (unknown)	24
18	Functional expression and growth factor activation of an epitope-tagged p44 mitogen-activated protein kinase, p44mapk. 1992 ·Molecular Biology of the Cell ·Sylvain Meloche, Gilles Pagès, Jacques Pouysségur	145
19	Complement receptor 2 mediates enhancement of human immunodeficiency virus 1 infection in Epstein-Barr virus-carrying B cells. 1990 ·The Journal of Experimental Medicine ·Michel L. Tremblay, Sylvain Meloche, (unknown), Mark A. Wainberg	52
20	Distinct properties of atrial natriuretic factor receptor subpopulations in epithelial and fibroblast cell lines. 1989 ·Molecular Pharmacology ·James Féthière, Sylvain Meloche, Tina Nguyen, Hui Xin Ong, A. De Léan	43

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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