Steven Wrighton

22.3k total citations · 2 hit papers
172 papers, 17.1k citations indexed

About

Steven Wrighton is a scholar working on Pharmacology, Oncology and Molecular Biology. According to data from OpenAlex, Steven Wrighton has authored 172 papers receiving a total of 17.1k indexed citations (citations by other indexed papers that have themselves been cited), including 134 papers in Pharmacology, 85 papers in Oncology and 40 papers in Molecular Biology. Recurrent topics in Steven Wrighton's work include Pharmacogenetics and Drug Metabolism (131 papers), Drug Transport and Resistance Mechanisms (74 papers) and Drug-Induced Hepatotoxicity and Protection (31 papers). Steven Wrighton is often cited by papers focused on Pharmacogenetics and Drug Metabolism (131 papers), Drug Transport and Resistance Mechanisms (74 papers) and Drug-Induced Hepatotoxicity and Protection (31 papers). Steven Wrighton collaborates with scholars based in United States, United Kingdom and Japan. Steven Wrighton's co-authors include Barbara J. Ring, Paul B. Watkins, Jeffrey Stevens, Mark VandenBranden, Erin G. Schuetz, Philip S. Guzelian, Stephen D. Hall, Sean Ekins, Kenneth E. Thummel and David T. Molowa and has published in prestigious journals such as Proceedings of the National Academy of Sciences, Journal of Biological Chemistry and Journal of Clinical Investigation.

In The Last Decade

Steven Wrighton

172 papers receiving 16.5k citations

Hit Papers

align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Sequence diversity in CYP3A promoters and characterization of the genetic basis of polymorphic CYP3A5 expression

2001 1.8k citations Jatinder K. Lamba, Paul B. Watkins et al. profile →
The Human Hepatic Cytochromes P450 Involved in Drug Metabolism

1992 784 citations Steven Wrighton, Jeffrey Stevens Critical Reviews in Toxicology profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name	h						Papers	Cites
Steven Wrighton United States	71	11.1k	6.7k	3.9k	2.6k	1.8k	172	17.1k
John O. Miners Australia	71	10.1k 0.9×	5.6k 0.8×	4.6k 1.2×	2.6k 1.0×	2.5k 1.4×	287	16.6k
Ulrich M. Zanger Germany	74	10.1k 0.9×	6.8k 1.0×	5.1k 1.3×	3.1k 1.2×	1.7k 0.9×	197	19.8k
Kenneth E. Thummel United States	73	11.5k 1.0×	7.2k 1.1×	3.1k 0.8×	4.7k 1.8×	1.8k 1.0×	263	20.2k
Paul B. Watkins United States	73	11.5k 1.0×	6.2k 0.9×	3.5k 0.9×	3.2k 1.2×	2.2k 1.2×	246	19.9k
Philippe Beaune France	75	9.2k 0.8×	5.7k 0.9×	5.1k 1.3×	2.3k 0.9×	1.6k 0.9×	352	18.7k
Michel Eichelbaum Germany	87	12.0k 1.1×	11.4k 1.7×	4.7k 1.2×	6.8k 2.6×	2.6k 1.5×	335	25.4k
Allan E. Rettie United States	61	8.6k 0.8×	3.3k 0.5×	3.0k 0.8×	1.4k 0.5×	1.7k 0.9×	214	12.9k
Tsuyoshi Yokoi Japan	67	7.2k 0.6×	4.8k 0.7×	6.2k 1.6×	1.7k 0.6×	1.6k 0.9×	369	16.2k
Tsutomu Shimada Japan	75	11.0k 1.0×	5.0k 0.7×	6.7k 1.7×	1.1k 0.4×	1.6k 0.9×	317	20.2k
Ann K. Daly United Kingdom	74	9.9k 0.9×	4.5k 0.7×	4.3k 1.1×	2.3k 0.9×	1.9k 1.1×	282	20.5k

Countries citing papers authored by Steven Wrighton

Since Specialization

Citations

This map shows the geographic impact of Steven Wrighton's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Steven Wrighton with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Steven Wrighton more than expected).

Fields of papers citing papers by Steven Wrighton

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Steven Wrighton. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Steven Wrighton. The network helps show where Steven Wrighton may publish in the future.

Co-authorship network of co-authors of Steven Wrighton

This figure shows the co-authorship network connecting the top 25 collaborators of Steven Wrighton. A scholar is included among the top collaborators of Steven Wrighton based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Steven Wrighton. Steven Wrighton is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

Sort: Min cites: Since: Top N: Style:

20 of 20 papers shown

Ring, Barbara J., Steven Wrighton, & Michael A. Mohutsky. (2014). Reversible Mechanisms of Enzyme Inhibition and Resulting Clinical Significance. Methods in molecular biology. 1113. 37–56. 35 indexed citations

Wickremsinhe, Enaksha, Anne H. Dantzig, Stephen D. Hall, et al.. (2012). Pharmacogenomics of Gemcitabine Metabolism: Functional Analysis of Genetic Variants in Cytidine Deaminase and Deoxycytidine Kinase. Drug Metabolism and Disposition. 41(3). 541–545. 32 indexed citations

Mao, Jialin, Michael A. Mohutsky, John Harrelson, Steven Wrighton, & Stephen D. Hall. (2011). Prediction of CYP3A-Mediated Drug-Drug Interactions Using Human Hepatocytes Suspended in Human Plasma. Drug Metabolism and Disposition. 39(4). 591–602. 45 indexed citations

Williams, Eric T., Mariam Ehsani, Xiliang Wang, et al.. (2007). Effect of buffer components and carrier solvents on in vitro activity of recombinant human carboxylesterases. Journal of Pharmacological and Toxicological Methods. 57(2). 138–144. 22 indexed citations

Mohutsky, Michael A., Jenny Y. Chien, Barbara J. Ring, & Steven Wrighton. (2006). Predictions of the In Vivo Clearance of Drugs from Rate of Loss Using Human Liver Microsomes for Phase I and Phase II Biotransformations. Pharmaceutical Research. 23(4). 654–662. 40 indexed citations

Lamba, Vishal, Jatinder K. Lamba, Kazuto Yasuda, et al.. (2003). Hepatic CYP2B6 Expression: Gender and Ethnic Differences and Relationship to CYP2B6 Genotype and CAR (Constitutive Androstane Receptor) Expression. Journal of Pharmacology and Experimental Therapeutics. 307(3). 906–922. 320 indexed citations

Ring, Barbara J., Jennifer S. Gillespie, James A. Eckstein, & Steven Wrighton. (2002). Identification of the Human Cytochromes P450 Responsible for Atomoxetine Metabolism. Drug Metabolism and Disposition. 30(3). 319–323. 110 indexed citations

Ekins, Sean, William Crumb, R. Dustan Sarazan, James H. Wikel, & Steven Wrighton. (2002). Three-Dimensional Quantitative Structure-Activity Relationship for Inhibition of Human Ether-a-Go-Go-Related Gene Potassium Channel. Journal of Pharmacology and Experimental Therapeutics. 301(2). 427–434. 211 indexed citations

Ekins, Sean, et al.. (2000). Present and future in vitro approaches for drug metabolism. Journal of Pharmacological and Toxicological Methods. 44(1). 313–324. 157 indexed citations

10.

Wrighton, Steven & Barbara J. Ring. (1999). PREDICTING DRUG INTERACTIONS AND PHARMACOKINETIC VARIABILITY WITH IN VITRO METHODS: THE OLANZAPINE EXPERIENCE*. Drug Metabolism Reviews. 31(1). 15–28. 16 indexed citations

11.

Fisher, Jeannine M., Steven Wrighton, Justina C. Calamia, et al.. (1999). Midazolam Metabolism by Modified Caco-2 Monolayers: Effects of Extracellular Protein Binding. Journal of Pharmacology and Experimental Therapeutics. 289(2). 1143–1150. 35 indexed citations

12.

Wrighton, Steven, et al.. (1999). The effect of estrogen replacement therapy on CYP3A activity1. Clinical Pharmacology & Therapeutics. 65(2). 192–192. 1 indexed citations

13.

Wrighton, Steven, Mark VandenBranden, & Barbara J. Ring. (1996). The human drug metabolizing cytochromes P450. Journal of Pharmacokinetics and Biopharmaceutics. 24(5). 461–473. 139 indexed citations

14.

Kolars, Joseph C., Kenneth S. Lown, Phyllissa Schmiedlin‐Ren, et al.. (1994). CYP3A gene expression in human gut epithelium. Pharmacogenetics. 4(5). 247–259. 321 indexed citations

15.

Stevens, Jeffrey, Lisa A. Shipley, John R. Cashman, Mark VandenBranden, & Steven Wrighton. (1993). Comparison of human and rhesus monkey in vitro phase I and phase II hepatic drug metabolism activities.. Drug Metabolism and Disposition. 21(5). 753–760. 62 indexed citations

16.

Wrighton, Steven, Jeffrey Stevens, Gerald W. Becker, & Mark VandenBranden. (1993). Isolation and Characterization of Human Liver Cytochrome P450 2C19: Correlation between 2C19 and S-Mephenytoin 4′-Hydroxylation. Archives of Biochemistry and Biophysics. 306(1). 240–245. 252 indexed citations

17.

Wrighton, Steven & Jeffrey Stevens. (1992). The Human Hepatic Cytochromes P450 Involved in Drug Metabolism. Critical Reviews in Toxicology. 22(1). 1–21. 784 indexed citations breakdown →

18.

Watkins, Paul B., et al.. (1989). Erythromycin breath test as an assay of glucocorticoid-inducible liver cytochromes P-450. Studies in rats and patients.. Journal of Clinical Investigation. 83(2). 688–697. 316 indexed citations

19.

Wrighton, Steven & Mark VandenBranden. (1989). Isolation and characterization of human fetal liver cytochrome P450HLp2: A third member of the P450III gene family. Archives of Biochemistry and Biophysics. 268(1). 144–151. 69 indexed citations

20.

Wrighton, Steven, Paul E. Thomas, Dene E. Ryan, & Wayne Levin. (1987). Purification and characterization of ethanol-inducible human hepatic cytochrome P-450HLj. Archives of Biochemistry and Biophysics. 258(1). 292–297. 97 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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