Tsutomu Shimada

24.0k total citations · 4 hit papers
317 papers, 20.2k citations indexed

About

Tsutomu Shimada is a scholar working on Pharmacology, Molecular Biology and Oncology. According to data from OpenAlex, Tsutomu Shimada has authored 317 papers receiving a total of 20.2k indexed citations (citations by other indexed papers that have themselves been cited), including 166 papers in Pharmacology, 87 papers in Molecular Biology and 79 papers in Oncology. Recurrent topics in Tsutomu Shimada's work include Pharmacogenetics and Drug Metabolism (154 papers), Drug Transport and Resistance Mechanisms (65 papers) and Carcinogens and Genotoxicity Assessment (56 papers). Tsutomu Shimada is often cited by papers focused on Pharmacogenetics and Drug Metabolism (154 papers), Drug Transport and Resistance Mechanisms (65 papers) and Carcinogens and Genotoxicity Assessment (56 papers). Tsutomu Shimada collaborates with scholars based in Japan, United States and South Korea. Tsutomu Shimada's co-authors include F. Peter Guengerich, Hiroshi Yamazaki, Yukiharu Inui, Mayumi Mimura, Kiyoshi Inoue, Yoshiaki Fujii‐Kuriyama, Elizabeth M. J. Gillam, Yune‐Fang Ueng, Chul‐Ho Yun and Thomas R. Sutter and has published in prestigious journals such as Proceedings of the National Academy of Sciences, Nucleic Acids Research and Journal of Biological Chemistry.

In The Last Decade

Tsutomu Shimada

313 papers receiving 19.5k citations

Hit Papers

align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians.

1994 2.4k citations Tsutomu Shimada, Hiroshi Yamazaki et al. Journal of Pharmacology and Experimental Therapeutics profile →
Oxidation of toxic and carcinogenic chemicals by human cytochrome P-450 enzymes

1991 854 citations F. Peter Guengerich, Tsutomu Shimada profile →
Activation of chemically diverse procarcinogens by human cytochrome P-450 1B1.

1996 693 citations Tsutomu Shimada, Hiroshi Yamazaki et al. PubMed profile →
Metabolic activation of polycyclic aromatic hydrocarbons to carcinogens by cytochromes P450 1A1 and1B1

2004 624 citations Tsutomu Shimada et al. profile →

Peers

Countries citing papers authored by Tsutomu Shimada

Since Specialization

Citations

This map shows the geographic impact of Tsutomu Shimada's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Tsutomu Shimada with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Tsutomu Shimada more than expected).

Fields of papers citing papers by Tsutomu Shimada

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Tsutomu Shimada. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Tsutomu Shimada. The network helps show where Tsutomu Shimada may publish in the future.

Co-authorship network of co-authors of Tsutomu Shimada

This figure shows the co-authorship network connecting the top 25 collaborators of Tsutomu Shimada. A scholar is included among the top collaborators of Tsutomu Shimada based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Tsutomu Shimada. Tsutomu Shimada is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

#	Work	Indexed citations
1	Risk factors for oxaliplatin-induced vascular pain in patients with colorectal cancer and comparison of the efficacy of preventive methods 2018 ·Journal of Pharmaceutical Health Care and Sciences ·Yukio Suga, (unknown), Manami Maeda, (unknown), Tsutomu Shimada, (unknown), Hironori Kitade, (unknown), Morihiro Okada, Junko Ishizaki, Yoshimichi Sai, Ryo Matsushita	4
2	A Dietary Restriction Influences the Progression But Not the Initiation of MSG-Induced Nonalcoholic Steatohepatitis 2014 ·Journal of Medicinal Food ·Makoto Fujimoto, Koichi Tsuneyama, Yuko Nakanishi, Thucydides L. Salunga, Kazuhiro Nomoto, Yoshiyuki Sasaki, Seiichi Iizuka, Mitsunobu Nagata, Wataru Suzuki, Tsutomu Shimada, Masaki Aburada, Yutaka Shimada, M. Eric Gershwin, Carlo Selmi	22
3	Prediction of Glomerular Filtration Rate in Cancer Patients by an Equation for Japanese Estimated Glomerular Filtration Rate 2013 ·Japanese Journal of Clinical Oncology ·Yohei Funakoshi, Yutaka Fujiwara, Naomi Kiyota, Toru Mukohara, Tsutomu Shimada, Masanori Toyoda, Yoshinori Imamura, Naoko Chayahara, (unknown), Naoki Otsuki, Ken‐ichi Nibu, Hironobu Minami	18
4	Docking and QSAR comparative studies of polycyclic aromatic hydrocarbons and other procarcinogen interactions with cytochromes P450 1A1 and 1B1 2011 ·SAR and QSAR in environmental research ·(unknown), Nathalie Marchand-Geneste, J.L. Giraudel, Tsutomu Shimada	17
5	Site-dependent contributions of P-glycoprotein and CYP3A to cyclosporin A absorption, and effect of dexamethasone in small intestine of mice 2006 ·Biochemical Pharmacology ·Mingji Jin, Tsutomu Shimada, Koiçhi Yokogawa, Masaaki Nomura, Junko Ishizaki, Yingshi Piao, Yukio Kato, Akira Tsuji, Ken‐ichi Miyamoto	20
6	Identification of Cytochrome P450 Isoforms Involved in Citalopram N-Demethylation by Human Liver Microsomes 1997 ·Journal of Pharmacology and Experimental Therapeutics ·Kaoru Kobayashi, Kan Chiba, (unknown), Tsutomu Shimada, (unknown), Toru Horie, Masayoshi Tani, Toshinori Yamamoto, Takashi Ishizaki, Yukio Kuroiwa	117
7	3A-02 Effects of co-administration of food antioxidants and naturally occurring components, flavonoids on the activation of mutagens 1997 ·The Journal of Toxicological Sciences ·Tsutomu Shimada, Hiroshi Yamazaki	1
8	Comparison of reconstitution conditions for recombinant human P450 2C9 with systems containing P450S 1A1, 1A2, 2D6, 2E1, and 3A4. Effects of P450-P450 and P450-b(5) interactions 1997 ·The FASEB Journal ·(unknown), Elizabeth M. J. Gillam, Dong, (unknown), (unknown), Tsutomu Shimada	1
9	Reconstitution of Recombinant Cytochrome P450 2C10(2C9) and Comparison with Cytochrome P450 3A4 and Other Forms: Effects of Cytochrome P450–P450 and Cytochrome P450–b5Interactions 1997 ·Archives of Biochemistry and Biophysics ·Hiroshi Yamazaki, Elizabeth M. J. Gillam, Mi‐Sook Dong, William W. Johnson, F. Peter Guengerich, Tsutomu Shimada	114
10	New Applications of Bacterial Systems to Problems in Toxicology 1996 ·Critical Reviews in Toxicology ·F. Peter Guengerich, Elizabeth M. J. Gillam, Tsutomu Shimada	86
11	Mutagenic Activation of 3-Methoxy-4-aminoazobenzene by Mouse Renal Cytochrome-P450 CYP4B1: Cloning and Characterization of Mouse CYP4B1 1995 ·Archives of Biochemistry and Biophysics ·Susumu Imaoka, Toyoko Hiroi, Yasuhisa Tamura, Hiroshi Yamazaki, Tsutomu Shimada, Naoka Komori, Masakuni Degawa, Yoshihiko Funae	33
12	Use of a newly developed tester strain Salmonella typhimurium NM2009 for the study of metabolic activation of carcinogenic aromatic amines by rat liver microsomal cytochrome P-450 enzymes 1992 ·Mutation Research/Environmental Mutagenesis and Related Subjects ·Hiroshi Yamazaki, Yoshimitsu Oda, Tsutomu Shimada	21
13	Purification and Characterization of Human Liver Microsomal Cytochrome P-450 2A6 1991 ·Molecular Pharmacology ·Chul‐Ho Yun, Tsutomu Shimada, F. Peter Guengerich	243
14	Cytochrome P-450 Oxidations and the Generation of Biologically Reactive Intermediates 1991 ·Advances in experimental medicine and biology ·F. Peter Guengerich, Tsutomu Shimada, Arnaud Bondon, Timothy L. Macdonald	10
15	Lidocaine metabolism by human cytochrome P-450s purified from hepatic microsomes: comparison of those with rat hepatic cytochrome P-450s. 1990 ·Journal of Pharmacology and Experimental Therapeutics ·Susumu Imaoka, Keiichi Enomoto, Yutaka Oda, Akira Asada, Maiko Fujimori, Tsutomu Shimada, S. Fujita, F. Peter Guengerich, Yoshihiko Funae	127
16	Potentiation by a biscoclaurine alkaloid, cepharanthine, of the toxicity of conjugates of epidermal growth factor with Pseudomonas exotoxin in HeLa cells. 1988 ·PubMed ·Norio Shiraishi, Tsutomu Shimada, (unknown), Kimitoshi Kohno, Michio Kobayashi, M Kuwano, Shin‐ichi Akiyama	7
17	Lipid composition of the plasma membrane isolated from normal and precancerous rat bladder epithelium 1987 ·Urological Research ·Hiromitsu Mimata, Jun Ogata, M Takeshita, Tsutomu Shimada	3
18	Review of the use of the dynamic CT scan on cases of ultra-early revascularization performed within 6 hours after a cerebral ischemic attack 1983 ·Tsutomu Shimada, Mitsuo Kaneko, (unknown), (unknown)	1
19	Recovery from toxicological and biochemical effects of rats intoxicated with polychlorinated biphenyls. 1977 ·Folia Pharmacologica Japonica ·Tsutomu Shimada, Yoshiki Nunoura, (unknown), (unknown), Yasuko Mizuta	3
20	Induction of mouse and rat liver microsomal enzymes by polychlorinated biphenyls in relation to the PCB levels in tissue 1976 ·Folia Pharmacologica Japonica ·Tsutomu Shimada, Yoshiki Nunoura, (unknown), (unknown), Yasuko Mizuta	6

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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