Dene E. Ryan

10.7k citations

106 papers · 9.5k indexed · 2 hit papers · h-index 51

Impact in

Pharmacology top 0.01%
- Pharmacogenetics and Drug Metabolism
- Drug-Induced Hepatotoxicity and Protection
Biochemistry top 0.1%
- Eicosanoids and Hypertension Pharmacology

Papers in ⓘ

Pharmacology 79
- Pharmacogenetics and Drug Metabolism 77
Biochemistry 25
- Eicosanoids and Hypertension Pharmacology 18

Co-authors: Wayne Levin (105 shared papers)Paul E. Thomas (43 shared papers)Thomas K. H. Chang (35 shared papers)Linda M. Reik (21 shared papers)Alexander W. Wood (16 shared papers)Anthony Y.H. Lu (14 shared papers)Stelvio M. Bandiera (12 shared papers)Susan West (11 shared papers)
Journals: Journal of Biological Chemistry (28 papers)Archives of Biochemistry and Biophysics (22 papers)Molecular Pharmacology (9 papers)Biochemistry (7 papers)Biochemical and Biophysical Research Communications (6 papers)
Partner nations: United States Switzerland Poland

In The Last Decade

Dene E. Ryan

106 papers receiving 8.8k citations

Hit Papers

align trajectories log scale

Separation and characterization of highly purified forms of liver microsomal cytochrome P-450 from rats treated with polychlorinated biphenyls, phenobarbital, and 3-methylcholanthrene. 1979 · 516 citations

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if any of the following hold:

it has ≥500 total citations;
it reaches ≥1.5× the top-1% citation threshold for papers in the same subfield and year (the threshold is the minimum needed to enter the top 1%, not the average within it);
it reaches the top citation threshold in at least one of its specific research topics.

1979 Journal of Biological Chemistry
1976 Analytical Biochemistry

Peers

Countries citing papers authored by Dene E. Ryan

Since Specialization

Citations

This map shows the geographic impact of Dene E. Ryan's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Dene E. Ryan with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Dene E. Ryan more than expected).

Fields of papers citing papers by Dene E. Ryan

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Dene E. Ryan. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Dene E. Ryan. The network helps show where Dene E. Ryan may publish in the future.

Co-authors

The 25 scholars most cited alongside Dene E. Ryan, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Dene E. Ryan Line = papers co-authored together Dene E. Ryan links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

Showing the 20 most-cited of 106 papers — load more, or switch the sort, to bring in the rest.

#	Work
1	An improved staining procedure for the detection of the peroxidase activity of cytochrome P-450 on sodium dodecyl sulfate polyacrylamide gels Analytical Biochemistry ·Paul E. Thomas, Dene E. Ryan, Wayne Levin Hit paper breakdown →	1976	952
2	Separation and characterization of highly purified forms of liver microsomal cytochrome P-450 from rats treated with polychlorinated biphenyls, phenobarbital, and 3-methylcholanthrene. Journal of Biological Chemistry ·Dene E. Ryan, Thomas K. H. Chang, Daria Korzeniowski, Wayne Levin Hit paper breakdown →	1979	516
3	Purification and characterization of hepatic microsomal cytochrome P-450 Pharmacology & Therapeutics ·Dene E. Ryan, Wayne Levin	1990	335
4	Induction of two immunochemically related rat liver cytochrome P-450 isozymes, cytochromes P-450c and P-450d, by structurally diverse xenobiotics. Journal of Biological Chemistry ·Thomas K. H. Chang, Linda M. Reik, Dene E. Ryan, Wayne Levin	1983	315
5	Regio- and stereoselective metabolism of two C19 steroids by five highly purified and reconstituted rat hepatic cytochrome P-450 isozymes. Journal of Biological Chemistry ·Alexander W. Wood, Dene E. Ryan, Thomas K. H. Chang, Wayne Levin	1983	314
6	Regulation of three forms of cytochrome P-450 and epoxide hydrolase in rat liver microsomes. Effects of age, sex, and induction. Journal of Biological Chemistry ·Thomas K. H. Chang, Linda M. Reik, Dene E. Ryan, Wayne Levin	1981	282
7	Immunochemical quantitation of cytochrome P-450 isozymes and epoxide hydrolase in liver microsomes from polychlorinated or polybrominated biphenyl-treated rats. A study of structure-activity relationships. Journal of Biological Chemistry ·A. Parkinson, Stephen Safe, Larry W. Robertson, Thomas K. H. Chang, Dene E. Ryan, Linda M. Reik, Wayne Levin	1983	282
8	Characterization of three highly purified cytochromes P-450 from hepatic microsomes of adult male rats. Journal of Biological Chemistry ·Dene E. Ryan, Satoshi Iida, Alexander W. Wood, Thomas K. H. Chang, C S Lieber, Wayne Levin	1984	281
9	Hepatic microsomal cytochrome P-450 from rats treated with isosafrole. Purification and characterization of four enzymic forms. Journal of Biological Chemistry ·Dene E. Ryan, Thomas K. H. Chang, Wayne Levin	1980	271
10	Characterization of a major form of rat hepatic microsomal cytochrome P-450 induced by isoniazid. Journal of Biological Chemistry ·Dene E. Ryan, Lata Ramanathan, Satoshi Iida, Thomas K. H. Chang, Mitsuru Haniu, John E. Shively, C S Lieber, Wayne Levin	1985	270
11	Purification, characterization and regulation of five rat hepatic microsomal cytochrome P-450 isozymes Xenobiotica ·Dene E. Ryan, Thomas K. H. Chang, Linda M. Reik, Wayne Levin	1982	243
12	PCBs: Structure-Function Relationships and Mechanism of Action Environmental Health Perspectives ·Stephen Safe, Stelvio M. Bandiera, T. Sawyer, Larry W. Robertson, L. Safe, Andrew Parkinson, Paul E. Thomas, Dene E. Ryan, Linda M. Reik, Wayne Levin, Mary Anne Denommé, Toshio Fujita	1985	239
13	Purification and characterization of a minor form of hepatic microsomal cytochrome P-450 from rats treated with polychlorinated biphenyls Archives of Biochemistry and Biophysics ·Dene E. Ryan, Paul E. Thomas, Wayne Levin	1982	205
14	Regulation of cytochrome P-450j, a high-affinity N-nitrosodimethylamine demethylase, in rat hepatic microsomes Biochemistry ·Paul E. Thomas, Stelvio M. Bandiera, Sarah L. Maines, Dene E. Ryan, Wayne Levin	1987	187
15	Reconstituted Liver Microsomal Enzyme System That Hydroxylates Drugs, Other Foreign Compounds, and Endogenous Substrates Journal of Biological Chemistry ·Anthony Y.H. Lu, Wayne Levin, Susan West, Martin Jacobson, Dene E. Ryan, R. Kuntzman, Allan H. Conney	1973	174
16	Preparation of monospecific antibodies against two forms of rat liver cytochrome P-450 and quantitation of these antigens in microsomes Archives of Biochemistry and Biophysics ·Paul E. Thomas, Daria Korzeniowski, Dene E. Ryan, Wayne Levin	1979	164
17	Highly purified cytochrome P-448 and P-450 from rat liver microsomes Biochemical and Biophysical Research Communications ·Dene E. Ryan, Anthony Y.H. Lu, Joseph C. Kawalek, Susan West, Wayne Levin	1975	157
18	A simple, non-chromatographic purification procedure for monoclonal antibodies Isolation of monoclonal antibodies against cytochrome P450 isozymes Journal of Immunological Methods ·Linda M. Reik, Sarah L. Maines, Dene E. Ryan, Wayne Levin, Stelvio M. Bandiera, Paul E. Thomas	1987	154
19	Evidence that isoniazid and ethanol induce the same microsomal cytochrome P-450 in rat liver, an isozyme homologous to rabbit liver cytochrome P-450 isozyme 3a Archives of Biochemistry and Biophysics ·Dene E. Ryan, Dennis R. Koop, Paul E. Thomas, Minor J. Coon, Wayne Levin	1986	142
20	Amino acid compositions and partial amino acid sequences of three highly purified forms of liver microsomal cytochrome P-450 from rats treated with polychlorinated biphenyls, phenobarbital, or 3-methylcholanthrene. Journal of Biological Chemistry ·L Botelho, Dene E. Ryan, Wayne Levin	1979	134

About Dene E. Ryan

Dene E. Ryan is a scholar working on Pharmacology, Biochemistry, Clinical Biochemistry, Oncology and Cancer Research, having authored 106 papers that have together received 9.5k indexed citations. Recurring topics across this work include Pharmacogenetics and Drug Metabolism (77 papers), Drug Transport and Resistance Mechanisms (27 papers), Metabolomics and Mass Spectrometry Studies (22 papers), Eicosanoids and Hypertension Pharmacology (18 papers), Hormonal and reproductive studies (10 papers), Metabolism and Genetic Disorders (9 papers), Carcinogens and Genotoxicity Assessment (8 papers) and Hormonal Regulation and Hypertension (7 papers). The work is most often cited by research in Pharmacology (6.0k citations), Biochemistry (1.3k citations), Cancer Research (1.4k citations), Oncology (2.3k citations) and Health, Toxicology and Mutagenesis (1.1k citations). Dene E. Ryan has collaborated with scholars based in United States, Switzerland and Poland. Frequent co-authors include Wayne Levin, Paul E. Thomas, Thomas K. H. Chang, Linda M. Reik, Alexander W. Wood, Anthony Y.H. Lu, Stelvio M. Bandiera, Susan West, Allan H. Conney and John E. Shively. Their work appears in journals such as Journal of Biological Chemistry, Archives of Biochemistry and Biophysics, Molecular Pharmacology, Biochemistry and Biochemical and Biophysical Research Communications.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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