Michael A. Mohutsky

959 citations

34 papers · 716 indexed · h-index 18

Pharmacology top 0.5%
- Pharmacogenetics and Drug Metabolism 27
- Drug-Induced Hepatotoxicity and Protection 10
Complementary and alternative medicine top 10%
Oncology
- Drug Transport and Resistance Mechanisms 15
Pharmaceutical Science top 10%
Computational Theory and Mathematics top 5%
- Computational Drug Discovery Methods 6
Pediatrics, Perinatology and Child Health
- Pharmacological Effects and Toxicity Studies 5
Spectroscopy
- Analytical Chemistry and Chromatography 4
Biomedical Engineering
- Innovative Microfluidic and Catalytic Techniques Innovation 2
Biomaterials
- Phytochemistry and Bioactive Compounds 2

Co-authors: Steven Wrighton Stephen D. Hall Gary W. Elmer Annie Lam Barbara J. Ring Jenny Y. Chien John Harrelson Jialin Mao
Cited by: Pharmacology Complementary and alternative medicine Oncology
Journals: Journal of Pharmacology and Experimental Therapeutics (1 paper)International Journal of Pharmaceutics (1 paper)Biochemical Pharmacology (1 paper)
Partner nations: United States United Kingdom Singapore

In The Last Decade

Michael A. Mohutsky

33 papers receiving 689 citations

Peers

Countries citing papers authored by Michael A. Mohutsky

Since Specialization

Citations

This map shows the geographic impact of Michael A. Mohutsky's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Michael A. Mohutsky with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Michael A. Mohutsky more than expected).

Fields of papers citing papers by Michael A. Mohutsky

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Michael A. Mohutsky. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Michael A. Mohutsky. The network helps show where Michael A. Mohutsky may publish in the future.

Co-authorship network

The 25 scholars most cited alongside Michael A. Mohutsky, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Michael A. Mohutsky Line = papers co-authored together Michael A. Mohutsky links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

#	Work
1	Profiling RNA metabolism to understand tissue and subcellular clearance of therapeutic RNA Drug Metabolism and Disposition ·Harvey M. Andersen,Ryan Hill,Alec Bell,Shane Lowery,Anthony Murphy,Michael Huskin,Michael A. Mohutsky,Christopher M. Wiethoff	2026	0
2	The Effect of Promiscuous Aggregation on in Vitro Drug Metabolism Assays Pharmaceutical Research ·Francesco Tres,Maria M. Posada,Stephen D. Hall,Michael A. Mohutsky,Lynne S. Taylor	2019	1
3	Mechanistic understanding of the phase behavior of supersaturated solutions of poorly water-soluble drugs International Journal of Pharmaceutics ·Francesco Tres,Maria M. Posada,Stephen D. Hall,Michael A. Mohutsky,Lynne S. Taylor	2018	25
4	In Vitro and In Vivo Correlation of Hepatic Fraction of Metabolism by P450 in Dogs Journal of Pharmaceutical Sciences ·Xin Zhou,Yu‐Hua Hui,Loyd Hudson,Kishore Katyayan,Michael A. Mohutsky,Junliang Hao,Douglas A. Schober,Erik J. Hembre	2018	2
5	Hepatic Organic Anion Transporting Polypeptide–Mediated Clearance in the Beagle Dog: Assessing In Vitro–In Vivo Relationships and Applying Cross-Species Empirical Scaling Factors to Improve Prediction of Human Clearance Drug Metabolism and Disposition ·Norikazu Matsunaga,Ayşe Ufuk,Bridget L. Morse,David W. Bedwell,Jingqi Bao,Michael A. Mohutsky,Kathleen M. Hillgren,Stephen D. Hall,J. Brian Houston,Aleksandra Galetin	2018	17
6	Considerations from the IQ Induction Working Group in Response to Drug-Drug Interaction Guidance from Regulatory Agencies: Focus on Downregulation, CYP2C Induction, and CYP2B6 Positive Control Drug Metabolism and Disposition ·Niresh Hariparsad,Diane Ramsden,Jairam Palamanda,Joshua G. DeKeyser,Odette A. Fahmi,Jane R. Kenny,Heidi J. Einolf,Michael A. Mohutsky,Magalie Pardon,Y. Amy Siu,Liangfu Chen,Michael Sinz,Barry Jones,Robert L. Walsky,Shannon Dallas,Suresh K. Balani,George Zhang,David B. Buckley,Donald Tweedie	2017	33
7	The Impact of the Hepatocyte-to-Plasma pH Gradient on the Prediction of Hepatic Clearance and Drug-Drug Interactions for CYP2C9 and CYP3A4 Substrates Drug Metabolism and Disposition ·L. R. A. Rougee,Michael A. Mohutsky,David W. Bedwell,Kenneth J. Ruterbories,Stephen D. Hall	2017	14
8	The Impact of the Hepatocyte-to-Plasma pH Gradient on the Prediction of Hepatic Clearance and Drug-Drug Interactions for CYP2D6 Substrates Drug Metabolism and Disposition ·L. R. A. Rougee,Michael A. Mohutsky,David W. Bedwell,Kenneth J. Ruterbories,Stephen D. Hall	2016	17
9	Investigational Small-Molecule Drug Selectively Suppresses Constitutive CYP2B6 Activity at the Gene Transcription Level: Physiologically Based Pharmacokinetic Model Assessment of Clinical Drug Interaction Risk Drug Metabolism and Disposition ·Maciej J. Zamek‐Gliszczynski,Michael A. Mohutsky,Jessica Rehmel,Alice Ke	2014	16
10	Reversible Mechanisms of Enzyme Inhibition and Resulting Clinical Significance Methods in molecular biology ·Barbara J. Ring,Steven Wrighton,Michael A. Mohutsky	2014	35
11	Predictions of Cytochrome P450-Mediated Drug-Drug Interactions Using Cryopreserved Human Hepatocytes: Comparison of Plasma and Protein-Free Media Incubation Conditions Drug Metabolism and Disposition ·Jialin Mao,Michael A. Mohutsky,John Harrelson,Steven Wrighton,Stephen D. Hall	2012	30
12	Metabolic‐intermediate complex formation with cytochrome P450: Theoretical studies in elucidating the reaction pathway for the generation of reactive nitroso intermediate Journal of Computational Chemistry ·Nikhil Taxak,Prashant Desai,Bhargav A. Patel,Michael A. Mohutsky,Valentine J. Klimkowski,Vijay K. Gombar,Prasad V. Bharatam	2012	32
13	Prediction of CYP3A-Mediated Drug-Drug Interactions Using Human Hepatocytes Suspended in Human Plasma Drug Metabolism and Disposition ·Jialin Mao,Michael A. Mohutsky,John Harrelson,Steven Wrighton,Stephen D. Hall	2011	45
14	Potentially increasing the metabolic stability of drug candidates via computational site of metabolism prediction by CYP2C9: The utility of incorporating protein flexibility via an ensemble of structures European Journal of Medicinal Chemistry ·Matthew L. Danielson,Prashant Desai,Michael A. Mohutsky,Steven Wrighton,Markus A. Lill	2011	20
15	Apparent High CYP3A5 Expression Is Required for Significant Metabolism of Vincristine by Human Cryopreserved Hepatocytes Journal of Pharmacology and Experimental Therapeutics ·Jennifer B. Dennison,Michael A. Mohutsky,Robert J. Barbuch,Steven Wrighton,Stephen D. Hall	2008	28
16	Identification of human UDP-glucuronosyltransferases catalyzing hepatic 1α,25-dihydroxyvitamin D3 conjugation Biochemical Pharmacology ·Takanori Hashizume,Yang Xu,Michael A. Mohutsky,Jeffrey J. Alberts,Chad E. Hadden,Thomas F. Kalhorn,Nina Isoherranen,Margaret C. Shuhart,Kenneth E. Thummel	2007	24
17	Ginkgo biloba: Evaluation of CYP2C9 Drug Interactions In Vitro and In Vivo American Journal of Therapeutics ·Michael A. Mohutsky,Gail D. Anderson,John W. Miller,Gary W. Elmer	2006	54
18	Predictions of the In Vivo Clearance of Drugs from Rate of Loss Using Human Liver Microsomes for Phase I and Phase II Biotransformations Pharmaceutical Research ·Michael A. Mohutsky,Jenny Y. Chien,Barbara J. Ring,Steven Wrighton	2006	40
19	THE USE OF A SUBSTRATE CASSETTE STRATEGY TO IMPROVE THE CAPACITY AND THROUGHPUT OF CYTOCHROME P450 INDUCTION STUDIES IN HUMAN HEPATOCYTES Drug Metabolism and Disposition ·Michael A. Mohutsky,David Petullo,Steven Wrighton	2005	7
20	Physiological Approaches to the Prediction of Drug-Drug Interactions in Study Populations Current Drug Metabolism ·Jenny Y. Chien,Michael A. Mohutsky,Steven Wrighton	2003	17

About Michael A. Mohutsky

Michael A. Mohutsky is a scholar working on Pharmacology, Oncology and Pharmaceutical Science, having authored 34 papers that have together received 716 indexed citations. Recurring topics across this work include Pharmacogenetics and Drug Metabolism (27 papers), Drug Transport and Resistance Mechanisms (15 papers), Drug-Induced Hepatotoxicity and Protection (10 papers), Computational Drug Discovery Methods (6 papers), Pharmacological Effects and Toxicity Studies (5 papers), Analytical Chemistry and Chromatography (4 papers), Innovative Microfluidic and Catalytic Techniques Innovation (2 papers) and Phytochemistry and Bioactive Compounds (2 papers). The work is most often cited by research in Pharmacology (437 citations), Complementary and alternative medicine (69 citations) and Oncology (210 citations). Michael A. Mohutsky has collaborated with scholars based in United States, United Kingdom and Singapore. Frequent co-authors include Steven Wrighton, Stephen D. Hall, Gary W. Elmer, Annie Lam, Barbara J. Ring, Jenny Y. Chien, John Harrelson, Jialin Mao, John W. Miller and Gail D. Anderson. Their work appears in journals such as Journal of Pharmacology and Experimental Therapeutics, International Journal of Pharmaceutics and Biochemical Pharmacology.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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