Shiva Malek

7.4k total citations · 3 hit papers
35 papers, 3.1k citations indexed

About

Shiva Malek is a scholar working on Molecular Biology, Cancer Research and Oncology. According to data from OpenAlex, Shiva Malek has authored 35 papers receiving a total of 3.1k indexed citations (citations by other indexed papers that have themselves been cited), including 27 papers in Molecular Biology, 8 papers in Cancer Research and 7 papers in Oncology. Recurrent topics in Shiva Malek's work include Melanoma and MAPK Pathways (8 papers), Protein Kinase Regulation and GTPase Signaling (8 papers) and Cancer therapeutics and mechanisms (7 papers). Shiva Malek is often cited by papers focused on Melanoma and MAPK Pathways (8 papers), Protein Kinase Regulation and GTPase Signaling (8 papers) and Cancer therapeutics and mechanisms (7 papers). Shiva Malek collaborates with scholars based in United States, France and Canada. Shiva Malek's co-authors include Gourisankar Ghosh, Tom Huxford, Scott Rosenberg, Amanda R. Moore, Frank McCormick, D. Huang, S.G. Hymowitz, Anthony M. Giannetti, Yi Chen and Joachim Rudolph and has published in prestigious journals such as Science, Cell and Proceedings of the National Academy of Sciences.

In The Last Decade

Shiva Malek

35 papers receiving 3.0k citations

Hit Papers

align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

RAS-targeted therapies: is the undruggable drugged?

2020 690 citations Amanda R. Moore, Scott Rosenberg et al. Nature Reviews Drug Discovery profile →
The Crystal Structure of the IκBα/NF-κB Complex Reveals Mechanisms of NF-κB Inactivation

1998 501 citations Tom Huxford, Shiva Malek et al. profile →
Small-molecule ligands bind to a distinct pocket in Ras and inhibit SOS-mediated nucleotide exchange activity

2012 479 citations Shiva Malek, Peter K. Jackson et al. profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name	h						Papers	Cites
Shiva Malek United States	23	2.2k	849	774	605	248	35	3.1k
Marzia Pennati Italy	32	2.4k 1.1×	735 0.9×	906 1.2×	327 0.5×	365 1.5×	64	3.4k
Heng Liang United States	18	4.3k 2.0×	838 1.0×	700 0.9×	768 1.3×	120 0.5×	28	4.9k
Angelika M. Burger United States	37	2.7k 1.2×	684 0.8×	981 1.3×	297 0.5×	273 1.1×	81	4.1k
Louis F. Stancato United States	33	2.3k 1.1×	335 0.4×	872 1.1×	872 1.4×	152 0.6×	66	3.3k
Peter Mullen United Kingdom	34	1.9k 0.8×	1.1k 1.3×	773 1.0×	246 0.4×	374 1.5×	84	3.3k
Laura Sepp‐Lorenzino United States	36	3.6k 1.6×	788 0.9×	1.0k 1.3×	502 0.8×	198 0.8×	78	4.9k
Celia R. Berkers Netherlands	31	3.9k 1.8×	1.2k 1.4×	1.4k 1.8×	714 1.2×	229 0.9×	76	5.3k
Warren Fiskus United States	48	5.1k 2.3×	468 0.6×	1.2k 1.5×	511 0.8×	332 1.3×	141	6.3k
Simon Bergqvist United States	25	1.5k 0.7×	327 0.4×	599 0.8×	315 0.5×	305 1.2×	35	2.3k
Vincent L. Giranda United States	40	2.5k 1.2×	552 0.7×	2.1k 2.8×	361 0.6×	402 1.6×	115	4.4k

Countries citing papers authored by Shiva Malek

Since Specialization

Citations

This map shows the geographic impact of Shiva Malek's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Shiva Malek with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Shiva Malek more than expected).

Fields of papers citing papers by Shiva Malek

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Shiva Malek. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Shiva Malek. The network helps show where Shiva Malek may publish in the future.

Co-authorship network of co-authors of Shiva Malek

This figure shows the co-authorship network connecting the top 25 collaborators of Shiva Malek. A scholar is included among the top collaborators of Shiva Malek based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Shiva Malek. Shiva Malek is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

Rosenberg, Scott, Fergus Shanahan, Sayumi Yamazoe, et al.. (2023). Ternary complex dissociation kinetics contribute to mutant-selective EGFR degradation. Cell chemical biology. 30(2). 175–187.e15. 10 indexed citations

Moore, Amanda R., Scott Rosenberg, Frank McCormick, & Shiva Malek. (2021). RAS-targeted therapies. Nature Reviews Drug Discovery. 18 indexed citations

Hagenbeek, Thijs J., Ho-June Lee, Jason Li, et al.. (2020). Machine-Learning and Chemicogenomics Approach Defines and Predicts Cross-Talk of Hippo and MAPK Pathways. Cancer Discovery. 11(3). 778–793. 37 indexed citations

Liau, Nicholas P. D., Avinashnarayan Venkatanarayan, John G. Quinn, et al.. (2020). Dimerization Induced by C-Terminal 14–3–3 Binding Is Sufficient for BRAF Kinase Activation. Biochemistry. 59(41). 3982–3992. 26 indexed citations

Liau, Nicholas P. D., Timothy J. Wendorff, John G. Quinn, et al.. (2020). Negative regulation of RAF kinase activity by ATP is overcome by 14-3-3-induced dimerization. Nature Structural & Molecular Biology. 27(2). 134–141. 66 indexed citations

Moore, Amanda R., Scott Rosenberg, Frank McCormick, & Shiva Malek. (2020). RAS-targeted therapies: is the undruggable drugged?. Nature Reviews Drug Discovery. 19(8). 533–552. 690 indexed citations breakdown →

Yen, Ivana, Fergus Shanahan, Mark Merchant, et al.. (2018). Pharmacological Induction of RAS-GTP Confers RAF Inhibitor Sensitivity in KRAS Mutant Tumors. Cancer Cell. 34(4). 611–625.e7. 47 indexed citations

Hymowitz, S.G. & Shiva Malek. (2018). Targeting the MAPK Pathway in RAS Mutant Cancers. Cold Spring Harbor Perspectives in Medicine. 8(11). a031492–a031492. 45 indexed citations

Foster, Scott A., Christiaan Klijn, & Shiva Malek. (2016). Tissue-Specific Mutations in BRAF and EGFR Necessitate Unique Therapeutic Approaches. Trends in cancer. 2(12). 699–701. 4 indexed citations

10.

Hanan, Emily J., Marian C. Bryan, Yuan Chen, et al.. (2015). 4-Aminoindazolyl-dihydrofuro[3,4-d]pyrimidines as non-covalent inhibitors of mutant epidermal growth factor receptor tyrosine kinase. Bioorganic & Medicinal Chemistry Letters. 26(2). 534–539. 39 indexed citations

11.

Yang, Xiaohai, Christopher Del Nagro, Shiva Malek, et al.. (2013). Identification of Preferred Chemotherapeutics for Combining with a CHK1 Inhibitor. Molecular Cancer Therapeutics. 12(11). 2285–2295. 48 indexed citations

12.

Blackwood, Elizabeth, Jennifer Epler, Ivana Yen, et al.. (2013). Combination Drug Scheduling Defines a “Window of Opportunity” for Chemopotentiation of Gemcitabine by an Orally Bioavailable, Selective ChK1 Inhibitor, GNE-900. Molecular Cancer Therapeutics. 12(10). 1968–1980. 22 indexed citations

13.

Lee, Wendy, Daniel F. Ortwine, Philippe Bergeron, et al.. (2013). A hit to lead discovery of novel N-methylated imidazolo-, pyrrolo-, and pyrazolo-pyrimidines as potent and selective mTOR inhibitors. Bioorganic & Medicinal Chemistry Letters. 23(18). 5097–5104. 26 indexed citations

14.

Estrada, Anthony A., Daniel G. Shore, Elizabeth Blackwood, et al.. (2013). Pyrimidoaminotropanes as Potent, Selective, and Efficacious Small Molecule Kinase Inhibitors of the Mammalian Target of Rapamycin (mTOR). Journal of Medicinal Chemistry. 56(7). 3090–3101. 25 indexed citations

15.

Lee, Ho‐June, Gabriele Schaefer, Timothy P. Heffron, et al.. (2012). Noncovalent Wild-type–Sparing Inhibitors of EGFR T790M. Cancer Discovery. 3(2). 168–181. 68 indexed citations

16.

Malek, Shiva, Yi Chen, Tom Huxford, & Gourisankar Ghosh. (2001). IκBβ, but Not IκBα, Functions as a Classical Cytoplasmic Inhibitor of NF-κB Dimers by Masking Both NF-κB Nuclear Localization Sequences in Resting Cells. Journal of Biological Chemistry. 276(48). 45225–45235. 144 indexed citations

17.

Phelps, Christopher B., Lei Lei Sengchanthalangsy, Shiva Malek, & Gourisankar Ghosh. (2000). Mechanism of κB DNA binding by Rel/NF-κB dimers. Journal of Biological Chemistry. 275(32). 24392–24399. 111 indexed citations

18.

Huxford, Tom, Shiva Malek, & Gourisankar Ghosh. (1999). Structure and Mechanism in NF- B/I B Signaling. Cold Spring Harbor Symposia on Quantitative Biology. 64(0). 533–540. 61 indexed citations

19.

Wang, Enxin, Shiva Malek, & Juli Feigon. (1992). Structure of G.cntdot.T.cntdot.A triplet in an intramolecular DNA triplex. Biochemistry. 31(20). 4838–4846. 50 indexed citations

20.

Malek, Shiva, et al.. (1991). Structure and stability of X.G.C mismatches in the third strand of intramolecular triplexes. Science. 254(5029). 270–274. 19 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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