Thomas O’Brien

6.6k citations

62 papers · 3.6k indexed · h-index 31

Impact in

Geriatrics and Gerontology top 1%
- Sirtuins and Resveratrol in Medicine
Physiology top 2%

Papers in

Geriatrics and Gerontology 12
- Sirtuins and Resveratrol in Medicine 12
Physiology 7
- Calcium signaling and nucleotide metabolism 6

Co-authors: John T. Lis Daniel A. Erlanson Robert S. McDowell Robert Tjian S. E. Hardin Arno L. Greenleaf Joni W. Lam Deepak Sampath
Journals: Cancer Research (6 papers)Molecular and Cellular Biology (4 papers)Neoplasia (3 papers)Bioorganic & Medicinal Chemistry Letters (3 papers)Journal of Medicinal Chemistry (3 papers)
Partner nations: United States France United Kingdom

In The Last Decade

Thomas O’Brien

59 papers receiving 3.5k citations

Peers

Countries citing papers authored by Thomas O’Brien

Since Specialization

Citations

This map shows the geographic impact of Thomas O’Brien's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Thomas O’Brien with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Thomas O’Brien more than expected).

Fields of papers citing papers by Thomas O’Brien

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Thomas O’Brien. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Thomas O’Brien. The network helps show where Thomas O’Brien may publish in the future.

Co-authorship network

The 25 scholars most cited alongside Thomas O’Brien, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Thomas O’Brien Line = papers co-authored together Thomas O’Brien links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

#	Work
1	Pharmacological Inhibition of the Histone Lysine Demethylase KDM1A Suppresses the Growth of Multiple Acute Myeloid Leukemia Subtypes Cancer Research ·John P. McGrath, Kaylyn E. Williamson, Srividya Balasubramanian, Shobu Odate, Shilpi Arora, Charlie Hatton, Thomas M. Edwards, Thomas O’Brien, Steven Magnuson, David Stokoe, Danette L. Daniels, Barbara M. Bryant, Patrick Trojer	2016	70
2	Cardiotoxicity Associated with Nicotinamide Phosphoribosyltransferase Inhibitors in Rodents and in Rat and Human-Derived Cells Lines Cardiovascular Toxicology ·Dinah Misner, M. Ariel Kauss, Jatinder Singh, Hirdesh Uppal, Andrew Bruening‐Wright, Bianca M. Liederer, Tori Lin, Zeinab A. Elabdein, Amrutha. P. B, Trung Van Nguyen, Deepak Sampath, Peter S. Dragovich, Thomas O’Brien, Tanja S. Zabka	2016	18
3	Structural Basis for Resistance to Diverse Classes of NAMPT Inhibitors PLoS ONE ·Weiru Wang, Kristi Elkins, Angela Oh, Yen‐Ching Ho, Jian Wu, Hong Li, Yang Xiao, Mandy Kwong, Mary Coons, Bobby Brillantes, Eric Cheng, Lisa Crocker, Peter S. Dragovich, Deepak Sampath, Xiaozhang Zheng, Kenneth W. Bair, Thomas O’Brien, Lisa D. Belmont	2014	30
4	Depletion of the Central Metabolite NAD Leads to Oncosis-mediated Cell Death Journal of Biological Chemistry ·Christopher Del Nagro, Yang Xiao, Linda Rangell, Mike Reichelt, Thomas O’Brien	2014	64
5	Identification of Preferred Chemotherapeutics for Combining with a CHK1 Inhibitor Molecular Cancer Therapeutics ·Xiaohai Yang, Daniel Rodrigues, Amélie Bonard, Christopher Del Nagro, Shiva Malek, Marie Evangelista, Elizabeth Blackwood, Peter K. Jackson, Thomas O’Brien	2013	48
6	Loss of NAPRT1 Expression by Tumor-Specific Promoter Methylation Provides a Novel Predictive Biomarker for NAMPT Inhibitors Clinical Cancer Research ·David S. Shames, Kristi Elkins, Kimberly Walter, Thomas Holcomb, Pan Du, Dane Mohl, Yang Xiao, 황홍구, Peter M. Haverty, Bianca M. Liederer, Xiaorong Liang, Robert L. Yauch, Thomas O’Brien, Richard Bourgon, Hartmut Koeppen, Lisa D. Belmont	2013	59
7	Combination Drug Scheduling Defines a “Window of Opportunity” for Chemopotentiation of Gemcitabine by an Orally Bioavailable, Selective ChK1 Inhibitor, GNE-900 Molecular Cancer Therapeutics ·Elizabeth Blackwood, Jennifer Epler, Ivana Yen, Michael Flagella, Thomas O’Brien, Marie Evangelista, Dikshith Shetty, Xiaohai Yang, Jonathan Choi, Amélie Bonard, Daniel Rodrigues, Käthe Protze, Diana Jakubiak, Sharon Yee, Gary Cain, Lewis Gazzard, Karen Williams, Jason Halladay, Peter K. Jackson, Shiva Malek	2013	22
8	Dependence of Tumor Cell Lines and Patient-Derived Tumors on the NAD Salvage Pathway Renders Them Sensitive to NAMPT Inhibition with GNE-618 Neoplasia ·Yang Xiao, Kristi Elkins, Jenni Durieux, Leslie Lee, Jason Oeh, Lulu Yang, Xiaorong Liang, Sadaf M Basheer, Jarrod R. Tremayne, Mandy Kwong, Bianca M. Liederer, Peter K. Jackson, Lisa D. Belmont, Deepak Sampath, Thomas O’Brien	2013	64
9	Oncogene expression profiles in K6/ODC mouse skin and papillomas following a chronic exposure to monomethylarsonous acid Journal of Biochemical and Molecular Toxicology ·Don A. Delker, David R. Geter, Barbara C. Roop, William O. Ward, Gene J. Ahlborn, James W. Allen, Gail M. Nelson, Ming Ouyang, William J. Welsh, Yan Chen, Thomas O’Brien, Kirk T. Kitchin	2009	10
10	Genetic Variations in CC Chemokine Receptors and Hypertension American Journal of Hypertension ·Feni Risal Alala, Kristin G. Ardlie, Sholom Wacholder, Richard M. Welch, Stephen J. Chanock, Thomas O’Brien	2006	8
11	Structural analysis of caspase-1 inhibitors derived from Tethering Acta Crystallographica Section F Structural Biology and Crystallization Communications ·Thomas O’Brien, Bruce J. Fahr, Widya Hendrastiti, Joni W. Lam, Nathan D. Waal, Brian C. Raimundo, Hans E. Purkey, IRAN FERREIRA DE MELO, M.J. Romanowski	2005	16
12	Tethering identifies fragment that yields potent inhibitors of human caspase-1 Bioorganic & Medicinal Chemistry Letters ·Bruce J. Fahr, Thomas O’Brien, IRAN FERREIRA DE MELO, Nathan D. Waal, Subramanian Baskaran, Brian C. Raimundo, Joni W. Lam, Widya Hendrastiti, Hans E. Purkey, M.J. Romanowski	2005	19
13	Discovery of an allosteric site in the caspases Proceedings of the National Academy of Sciences ·Jeanne A. Hardy, Joni W. Lam, Jack Nguyen, Thomas O’Brien, James A. Wells	2004	188
14	Crystal Structures of a Ligand-free and Malonate-Bound Human Caspase-1 Structure ·M.J. Romanowski, Justin M. Scheer, Thomas O’Brien, Robert S. McDowell	2004	47
15	The two-week-wait cancer initiative in urology: useful modernization? Journal of the Royal Society of Medicine ·Darrell Allen, Rick Popert, Thomas O’Brien	2004	16
16	Prospects for Caspase Inhibitors Mini-Reviews in Medicinal Chemistry ·Thomas O’Brien, Dennis Lee	2004	45
17	Functional Analysis of the Human TAFII250 N-Terminal Kinase Domain Molecular Cell ·Thomas O’Brien, Robert Tjian	1998	48
18	15 Structure and Regulation of Heat Shock Gene Promoters Cold Spring Harbor Monograph Archive ·Mary Fernandes, Thomas O’Brien, John T. Lis	1994	11
19	Phosphorylation of RNA polymerase II C-terminal domain and transcriptional elongation Nature ·Thomas O’Brien, S. E. Hardin, Arno L. Greenleaf, John T. Lis	1994	295
20	RNA Polymerase II Pauses at the 5′ End of the Transcriptionally Induced Drosophila hsp70 Gene Molecular and Cellular Biology ·Thomas O’Brien, John T. Lis	1991	46

About Thomas O’Brien

Thomas O’Brien is a scholar working on Geriatrics and Gerontology, Physiology, Oncology, Aging and Molecular Biology, having authored 62 papers that have together received 3.6k indexed citations. Recurring topics across this work include Sirtuins and Resveratrol in Medicine (12 papers), PARP inhibition in cancer therapy (11 papers), Autophagy in Disease and Therapy (7 papers), Cell death mechanisms and regulation (6 papers), Calcium signaling and nucleotide metabolism (6 papers), Heat shock proteins research (6 papers), RNA Research and Splicing (6 papers) and Cancer-related Molecular Pathways (5 papers). The work is most often cited by research in Geriatrics and Gerontology (351 citations), Physiology (180 citations), Molecular Biology (2.7k citations), Oncology (743 citations) and Aging (44 citations). Thomas O’Brien has collaborated with scholars based in United States, France and United Kingdom. Frequent co-authors include John T. Lis, Daniel A. Erlanson, Robert S. McDowell, Robert Tjian, S. E. Hardin, Arno L. Greenleaf, Joni W. Lam, Deepak Sampath, Adam G. Eldridge and Peter S. Dragovich. Their work appears in journals such as Cancer Research, Molecular and Cellular Biology, Neoplasia, Bioorganic & Medicinal Chemistry Letters and Journal of Medicinal Chemistry.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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