Tom Huxford

3.4k citations

50 papers · 2.7k indexed · 2 hit papers · h-index 20

Molecular Biology top 5%
Cancer Research top 1%
Immunology top 2%
Oncology top 10%
Cellular and Molecular Neuroscience top 10%

Co-authors: Gourisankar Ghosh Shiva Malek D. Huang Yves Bourne Gerlind Sulzenbacher P. Marchot Palmer Taylor Scott B. Hansen
Topics: NF-κB Signaling Pathways (30 papers)Immune Response and Inflammation (19 papers)interferon and immune responses (11 papers)
Cited by: Cancer Research Immunology Molecular Biology
Journals: Cell Proceedings of the National Academy of Sciences Journal of the American Chemical Society
Partner nations: United States France Macao

In The Last Decade

Tom Huxford

48 papers receiving 2.7k citations

Hit Papers

align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Structures of Aplysia AChBP complexes with nicotinic agonists and antagonists reveal distinctive binding interfaces and conformations

2005 550 citations Scott B. Hansen, Gerlind Sulzenbacher et al. profile →
The Crystal Structure of the IκBα/NF-κB Complex Reveals Mechanisms of NF-κB Inactivation

1998 501 citations Tom Huxford, D. Huang et al. profile →

Peers

Countries citing papers authored by Tom Huxford

Since Specialization

Citations

This map shows the geographic impact of Tom Huxford's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Tom Huxford with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Tom Huxford more than expected).

Fields of papers citing papers by Tom Huxford

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Tom Huxford. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Tom Huxford. The network helps show where Tom Huxford may publish in the future.

Co-authorship network of co-authors of Tom Huxford

This figure shows the co-authorship network connecting the top 25 collaborators of Tom Huxford. A scholar is included among the top collaborators of Tom Huxford based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Tom Huxford. Tom Huxford is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

#	Work	Indexed citations
1	Dual-specific autophosphorylation of kinase IKK2 enables phosphorylation of substrate IκBα through a phosphoenzyme intermediate 2025 ·eLife ·(unknown),Tapan Biswas,(unknown),(unknown),Swasti Raychaudhuri,Tom Huxford,Saikat Chakrabarti,Gourisankar Ghosh,Smarajit Polley	0
2	Structural and biochemical analyses of the nuclear IκBζ protein in complex with the NF-κB p50 homodimer 2024 ·Genes & Development ·(unknown),William E. Rogers,David K. Heidary,Tom Huxford	3
3	X-ray Crystallographic Study of Preferred Spacing by the NF-κB p50 Homodimer on κB DNA 2023 ·Biomolecules ·(unknown),(unknown),(unknown),(unknown),(unknown),Eric Rogers,(unknown),Tom Huxford	3
4	TWEAK–Fn14–RelB Signaling Cascade Promotes Stem Cell–like Features that Contribute to Post-Chemotherapy Ovarian Cancer Relapse 2022 ·Molecular Cancer Research ·(unknown),(unknown),Samuel F. Gilbert,(unknown),Jennifer A. Waters,(unknown),(unknown),(unknown),(unknown),(unknown),(unknown),(unknown),(unknown),Benjamin G. Bitler,Tom Huxford,Carrie D. House	14
5	Dimers of isatin derived α-methylene-γ-butyrolactone as potent anti-cancer agents 2022 ·Bioorganic & Medicinal Chemistry Letters ·Sandeep Rana,Smit Kour,Smitha Kizhake,(unknown),Jayapal Reddy Mallareddy,Adam J. Case,Tom Huxford,Amarnath Natarajan	7
6	X-ray Crystallographic and Molecular Dynamic Analyses of Drosophila melanogaster Embryonic Muscle Myosin Define Domains Responsible for Isoform-Specific Properties 2019 ·Journal of Molecular Biology ·(unknown),(unknown),Ross C. Walker,Sanford I. Bernstein,Tom Huxford	6
7	Protein Cofactors Are Essential for High-Affinity DNA Binding by the Nuclear Factor κB RelA Subunit 2018 ·Biochemistry ·María Carmen Mulero,(unknown),Myung S. Ko,Jamie M. Schiffer,D. Huang,Vivien Ya‐Fan Wang,Rommie E. Amaro,Tom Huxford,Gourisankar Ghosh	13
8	X-ray Crystal Structure of the UCS Domain-Containing UNC-45 Myosin Chaperone from Drosophila melanogaster 2011 ·Structure ·(unknown),Arthur V. Hauenstein,(unknown),(unknown),(unknown),Banumathi Sankaran,Sanford I. Bernstein,Tom Huxford	30
9	Understanding the Logic of IκB:NF-κB Regulation in Structural Terms 2010 ·Current topics in microbiology and immunology ·Tom Huxford,Alexander Hoffmann,Gourisankar Ghosh	22
10	A Structural Guide to Proteins of the NF- B Signaling Module 2009 ·Cold Spring Harbor Perspectives in Biology ·Tom Huxford,Gourisankar Ghosh	102
11	The Nuclear IκB Protein IκBζ Specifically Binds NF-κB p50 Homodimers and Forms a Ternary Complex on κB DNA 2008 ·Journal of Molecular Biology ·(unknown),(unknown),(unknown),Brian Kim,Tom Huxford	58
12	Structural Characterization of Agonist and Antagonist-Bound Acetylcholine-Binding Protein From Aplysia californica 2006 ·Journal of Molecular Neuroscience ·Scott B. Hansen,Gerlind Sulzenbacher,Tom Huxford,P. Marchot,Yves Bourne,Palmer Taylor	13
13	Inhibition of Transcription Factor NF‐κB Activation by κB‐Ras 2006 ·Methods in enzymology on CD-ROM/Methods in enzymology ·Tom Huxford,Gourisankar Ghosh	8
14	Thermodynamics Reveal that Helix Four in the NLS of NF-κB p65 Anchors IκBα, Forming a Very Stable Complex 2006 ·Journal of Molecular Biology ·Simon Bergqvist,Carrie H. Croy,Magnus Kjærgaard,Tom Huxford,Gourisankar Ghosh,Elizabeth A. Komives	64
15	Structures of Aplysia AChBP complexes with nicotinic agonists and antagonists reveal distinctive binding interfaces and conformations 2005 ·EMBO Reports ·Scott B. Hansen,Gerlind Sulzenbacher,Tom Huxford,P. Marchot,Palmer Taylor,Yves Bourne	5
16	Biophysical characterization of the free IκBα ankyrin repeat domain in solution 2004 ·Protein Science ·Carrie H. Croy,Simon Bergqvist,Tom Huxford,Gourisankar Ghosh,Elizabeth A. Komives	92
17	IκBβ, but Not IκBα, Functions as a Classical Cytoplasmic Inhibitor of NF-κB Dimers by Masking Both NF-κB Nuclear Localization Sequences in Resting Cells 2001 ·Journal of Biological Chemistry ·Shiva Malek,Yi Chen,Tom Huxford,Gourisankar Ghosh	144
18	Mechanism of IκBα Binding to NF-κB Dimers 2000 ·Journal of Biological Chemistry ·Christopher B. Phelps,Lei Lei Sengchanthalangsy,Tom Huxford,Gourisankar Ghosh	92
19	Structure and Mechanism in NF- B/I B Signaling 1999 ·Cold Spring Harbor Symposia on Quantitative Biology ·Tom Huxford,Shiva Malek,Gourisankar Ghosh	61
20	The role of DNA in the mechanism of NFκB dimer formation: crystal structures of the dimerization domains of the p50 and p65 subunits 1997 ·Structure ·D. Huang,Tom Huxford,Yongqing Chen,Gourisankar Ghosh	69

About Tom Huxford

Tom Huxford is a scholar working on Cancer Research, Immunology and Molecular Biology, having authored 50 papers that have together received 2.7k indexed citations. Recurring topics across this work include NF-κB Signaling Pathways (30 papers), Immune Response and Inflammation (19 papers) and interferon and immune responses (11 papers). The work is most often cited by research in Cancer Research (1.1k citations), Immunology (966 citations) and Molecular Biology (1.7k citations). Tom Huxford has collaborated with scholars based in United States, France and Macao. Frequent co-authors include Gourisankar Ghosh, Shiva Malek, D. Huang, Yves Bourne, Gerlind Sulzenbacher, P. Marchot, Palmer Taylor, Scott B. Hansen, María Carmen Mulero and Yi Chen. Their work appears in journals such as Cell, Proceedings of the National Academy of Sciences and Journal of the American Chemical Society.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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