Marcel Spaargaren

11.8k citations

98 papers · 5.8k indexed · 1 hit paper · h-index 43

Impact in

Genetics top 0.5%
- Chronic Lymphocytic Leukemia Research
Hematology top 1%
- Multiple Myeloma Research and Treatments

Papers in

Hematology 27
- Multiple Myeloma Research and Treatments 17
Genetics 20
- Chronic Lymphocytic Leukemia Research 19

Co-authors: Steven T. Pals James R. Bischoff Patrick W.B. Derksen David J. J. de Gorter Alfred Wittinghofer Esther A. Beuling Annemieke Kuil Eric Eldering
Journals: Blood (20 papers)Leukemia (6 papers)Journal of Biological Chemistry (6 papers)The Journal of Immunology (5 papers)Haematologica (4 papers)
Partner nations: Netherlands United States France

In The Last Decade

Marcel Spaargaren

97 papers receiving 5.7k citations

Hit Papers

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The clinically active BTK inhibitor PCI-32765 targets B-cell receptor– and chemokine-controlled adhesion and migration in chronic lymphocytic leukemia 2012 · 407 citations

Peers

Countries citing papers authored by Marcel Spaargaren

Since Specialization

Citations

This map shows the geographic impact of Marcel Spaargaren's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Marcel Spaargaren with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Marcel Spaargaren more than expected).

Fields of papers citing papers by Marcel Spaargaren

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Marcel Spaargaren. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Marcel Spaargaren. The network helps show where Marcel Spaargaren may publish in the future.

Co-authors

The 25 scholars most cited alongside Marcel Spaargaren, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Marcel Spaargaren Line = papers co-authored together Marcel Spaargaren links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

#	Work
1	DNA damage–induced p53 downregulates expression of RAG1 through a negative feedback loop involving miR-34a and FOXP1 Journal of Biological Chemistry ·Katarina Ochodnicka‐Mackovicova, Martine van Keimpema, Marcel Spaargaren, Carel J.M. van Noesel, Jeroen E. J. Guikema	2024	1
2	Negligible role of TRAIL death receptors in cell death upon endoplasmic reticulum stress in B-cell malignancies Oncogenesis ·Francesca Favaro, Demi Both, Ingrid A. M. Derks, Marcel Spaargaren, Cristina Muñoz‐Pinedo, Eric Eldering	2023	3
3	Endothelial ICAM-1 Adhesome Recruits CD44 for Optimal Transcellular Migration of Human CTLs The Journal of Immunology ·Abraham C.I. van Steen, Max L.B. Grönloh, Sander P.J. Joosten, Floris van Alphen, Maartje van den Biggelaar, Martijn A. Nolte, Marcel Spaargaren, Jaap D. van Buul, Rouven Schoppmeyer	2023	17
4	Redirecting T-cell Activity with Anti-BCMA/Anti-CD3 Bispecific Antibodies in Chronic Lymphocytic Leukemia and Other B-cell Lymphomas Cancer Research Communications ·Anne W. J. Martens, Joanne M. Rietveld, Renate de Boer, Fleur S. Peters, An Ngo‐Huang, Lotte W.H.G. van Mil, Koen de Heer, Marcel Spaargaren, Christie P.M. Verkleij, Niels W.C.J. van de Donk, Homer Adams, Eric Eldering, Carel J.M. van Noesel, Raluca Verona, Arnon P. Kater	2022	9
5	Syndecan-1 and stromal heparan sulfate proteoglycans: key moderators of plasma cell biology and myeloma pathogenesis Blood ·Zemin Ren, Marcel Spaargaren, Steven T. Pals	2021	19
6	AKT signaling restrains tumor suppressive functions of FOXO transcription factors and GSK3 kinase in multiple myeloma Blood Advances ·Timon A. Bloedjes, Guus de Wilde, Chiel Maas, Eric Eldering, Richard J. Bende, Carel J.M. van Noesel, Steven T. Pals, Marcel Spaargaren, Jeroen E. J. Guikema	2020	28
7	BTK inhibitors in chronic lymphocytic leukemia: a glimpse to the future Oncogene ·Marcel Spaargaren, Martin F. M. de Rooij, Arnon P. Kater, Eric Eldering	2014	22
8	Egress of CD19+CD5+ cells into peripheral blood following treatment with the Bruton tyrosine kinase inhibitor ibrutinib in mantle cell lymphoma patients Blood ·Betty Chang, Michelle Francesco, Martin F. M. de Rooij, Padmaja Magadala, Susanne Steggerda, Min Huang, Annemieke Kuil, Sarah E. M. Herman, Stella Chang, Steven T. Pals, Wyndham H. Wilson, Adrian Wiestner, Marcel Spaargaren, Joseph J. Buggy, Laurence Elias	2013	159
9	Disruption of heparan sulfate proteoglycan conformation perturbs B-cell maturation and APRIL-mediated plasma cell survival Blood ·Rogier M. Reijmers, Richard W.J. Groen, Annemieke Kuil, Kees Weijer, Fiona C. Kimberley, Jan Paul Medema, Toin H. Van Kuppevelt, Jin‐Ping Li, Marcel Spaargaren, Steven T. Pals	2011	45
10	Impaired Lymphoid Organ Development in Mice Lacking the Heparan Sulfate Modifying Enzyme Glucuronyl C5-Epimerase The Journal of Immunology ·Rogier M. Reijmers, Mark F. R. Vondenhoff, Ramon Roozendaal, Annemieke Kuil, Jin‐Ping Li, Marcel Spaargaren, Steven T. Pals, Reina E. Mebius	2010	22
11	Illegitimate WNT Pathway Activation by β-Catenin Mutation or Autocrine Stimulation in T-Cell Malignancies Cancer Research ·Richard W.J. Groen, Monique E.C.M. Oud, Esther J.M. Schilder-Tol, Marije B. Overdijk, Derk ten Berge, Roel Nusse, Marcel Spaargaren, Steven T. Pals	2008	38
12	Deletion of the WNT Target and Cancer Stem Cell Marker CD44 in Apc(Min/+) Mice Attenuates Intestinal Tumorigenesis Cancer Research ·Jurrit Zeilstra, Sander P.J. Joosten, Maarten Dokter, Eugène T.P. Verwiel, Marcel Spaargaren, Steven T. Pals	2008	146
13	The B Cell Antigen Receptor Controls AP-1 and NFAT Activity through Ras-Mediated Activation of Ral The Journal of Immunology ·David J. J. de Gorter, Johanna C. M. Vos, Steven T. Pals, Marcel Spaargaren	2007	31
14	Follicular Dendritic Cells Catalyze Hepatocyte Growth Factor (HGF) Activation in the Germinal Center Microenvironment by Secreting the Serine Protease HGF Activator The Journal of Immunology ·Esther P.M. Tjin, Richard J. Bende, Patrick W.B. Derksen, Anne-Pauline van Huijstee, Hiroaki Kataoka, Marcel Spaargaren, Steven T. Pals	2005	23
15	R-Ras Alters Ca2+ Homeostasis by Increasing the Ca2+ Leak across the Endoplasmic Reticular Membrane Journal of Biological Chemistry ·Werner J.H. Koopman, Remko R. Bosch, Sjenet E. van Emst‐de Vries, Marcel Spaargaren, J.J.H.H.M. De Pont, Peter H.G.M. Willems	2003	17
16	Human sprouty 4, a new ras antagonist on 5q31, interacts with the dual specificity kinase TESK1 European Journal of Biochemistry ·Onno Leeksma, Tanja A.E. van Achterberg, Yoshikazu Tsumura, Jiro Toshima, Eric Eldering, Wilma G. M. Kroes, Clemens Mellink, Marcel Spaargaren, Kensaku Mizuno, Hans Pannekoek, Carlie J.M. de Vries	2002	75
17	c-Cbl Is Involved in Met Signaling in B Cells and Mediates Hepatocyte Growth Factor-Induced Receptor Ubiquitination The Journal of Immunology ·Taher E.I. Taher, Esther P.M. Tjin, Esther A. Beuling, Jannie Borst, Marcel Spaargaren, Steven T. Pals	2002	57
18	Rab5 Induces Rac-independent Lamellipodia Formation and Cell Migration Molecular Biology of the Cell ·Marcel Spaargaren, Johannes L. Bos	1999	73
19	Cross-talk Between CD44 and c-Met in B cells Current topics in microbiology and immunology ·T.E.I. Taher, Robbert van der Voort, Linda Smit, Robert M. J. Keehnen, Esther J.M. Schilder-Tol, Marcel Spaargaren, Steven T. Pals	1999	14
20	Differential Interaction of the Ras Family GTP-binding Proteins H-Ras, Rap1A, and R-Ras with the Putative Effector Molecules Raf Kinase and Ral-Guanine Nucleotide Exchange Factor Journal of Biological Chemistry ·Christian Herrmann, Gudrun Horn, Marcel Spaargaren, Alfred Wittinghofer	1996	289

About Marcel Spaargaren

Marcel Spaargaren is a scholar working on Hematology, Genetics, Hepatology, Cell Biology and Pathology and Forensic Medicine, having authored 98 papers that have together received 5.8k indexed citations. Recurring topics across this work include Proteoglycans and glycosaminoglycans research (20 papers), Chronic Lymphocytic Leukemia Research (19 papers), Lymphoma Diagnosis and Treatment (19 papers), Multiple Myeloma Research and Treatments (17 papers), Liver physiology and pathology (14 papers), Glycosylation and Glycoproteins Research (11 papers), Protein Kinase Regulation and GTPase Signaling (11 papers) and Wnt/β-catenin signaling in development and cancer (10 papers). The work is most often cited by research in Genetics (1.2k citations), Hematology (1.0k citations), Pathology and Forensic Medicine (1.3k citations), Cell Biology (1.0k citations) and Immunology and Allergy (355 citations). Marcel Spaargaren has collaborated with scholars based in Netherlands, United States and France. Frequent co-authors include Steven T. Pals, James R. Bischoff, Patrick W.B. Derksen, David J. J. de Gorter, Alfred Wittinghofer, Esther A. Beuling, Annemieke Kuil, Eric Eldering, Harmen van Andel and Martin F. M. de Rooij. Their work appears in journals such as Blood, Leukemia, Journal of Biological Chemistry, The Journal of Immunology and Haematologica.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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