Xi He

38.1k total citations · 15 hit papers
158 papers, 28.2k citations indexed

About

Xi He is a scholar working on Molecular Biology, Oncology and Genetics. According to data from OpenAlex, Xi He has authored 158 papers receiving a total of 28.2k indexed citations (citations by other indexed papers that have themselves been cited), including 133 papers in Molecular Biology, 22 papers in Oncology and 21 papers in Genetics. Recurrent topics in Xi He's work include Wnt/β-catenin signaling in development and cancer (84 papers), Cancer-related gene regulation (54 papers) and Kruppel-like factors research (17 papers). Xi He is often cited by papers focused on Wnt/β-catenin signaling in development and cancer (84 papers), Cancer-related gene regulation (54 papers) and Kruppel-like factors research (17 papers). Xi He collaborates with scholars based in United States, China and United Kingdom. Xi He's co-authors include Keiko Tamai, Bryan T. MacDonald, Mikhail A. Semenov, Raymond Habas, Linheng Li, Chunming Liu, Yoichi Kato, Igor B. Dawid, Xin Zeng and He Huang and has published in prestigious journals such as Nature, Science and Cell.

In The Last Decade

Xi He

154 papers receiving 27.8k citations

Hit Papers

5 papers align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Wnt/β-Catenin Signaling: Components, Mechanisms, and Diseases

2009 4.5k citations Bryan T. MacDonald, Keiko Tamai et al. profile →
Control of β-Catenin Phosphorylation/Degradation by a Dual-Kinase Mechanism

2002 1.7k citations Chunming Liu, Xi He et al. profile →
TSC2 Integrates Wnt and Energy Signals via a Coordinated Phosphorylation by AMPK and GSK3 to Regulate Cell Growth

2006 1.1k citations Yuko Harada, Xi He et al. profile →
LDL-receptor-related proteins in Wnt signal transduction

2000 1.1k citations Keiko Tamai, Yoichi Kato et al. Nature profile →
LDL receptor-related proteins 5 and 6 in Wnt/β-catenin signaling:Arrows point the way

2004 859 citations Xi He, Keiko Tamai et al. Development profile →
BMP signaling inhibits intestinal stem cell self-renewal through suppression of Wnt–β-catenin signaling

2004 821 citations Xi He, Jiwang Zhang et al. profile →
Wnt/Frizzled Activation of Rho Regulates Vertebrate Gastrulation and Requires a Novel Formin Homology Protein Daam1

2001 660 citations Raymond Habas, Yoichi Kato et al. profile →
A dual-kinase mechanism for Wnt co-receptor phosphorylation and activation

2005 650 citations Xin Zeng, Keiko Tamai et al. Nature profile →
PTEN maintains haematopoietic stem cells and acts in lineage choice and leukaemia prevention

2006 640 citations Jiwang Zhang, Justin C. Grindley et al. Nature profile →
SOST Is a Ligand for LRP5/LRP6 and a Wnt Signaling Inhibitor

2005 611 citations Keiko Tamai, Xi He et al. Journal of Biological Chemistry profile →
Head inducer Dickkopf-1 is a ligand for Wnt coreceptor LRP6

2001 591 citations Keiko Tamai, Xi He et al. profile →
Frizzled and LRP5/6 Receptors for Wnt/ -Catenin Signaling

2012 496 citations Bryan T. MacDonald, Xi He profile →
FoxM1 Promotes β-Catenin Nuclear Localization and Controls Wnt Target-Gene Expression and Glioma Tumorigenesis

2011 473 citations He Huang, Xi He et al. profile →
Megakaryocytes maintain homeostatic quiescence and promote post-injury regeneration of hematopoietic stem cells

2014 438 citations Meng Zhao, John M. Perry et al. profile →
Impaired TFEB-Mediated Lysosome Biogenesis and Autophagy Promote Chronic Ethanol-Induced Liver Injury and Steatosis in Mice

2018 270 citations Xi He, Linheng Li et al. profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name	h						Papers	Cites
Xi He United States	74	22.0k	4.1k	3.7k	3.6k	2.3k	158	28.2k
Akira Kikuchi Japan	88	20.4k 0.9×	3.3k 0.8×	2.3k 0.6×	6.2k 1.7×	1.7k 0.7×	463	26.8k
Raphael Kopan United States	77	17.5k 0.8×	2.7k 0.7×	2.8k 0.7×	3.7k 1.0×	1.9k 0.8×	163	25.2k
John M. Chirgwin United States	49	18.4k 0.8×	5.9k 1.4×	4.9k 1.3×	2.4k 0.7×	2.6k 1.1×	122	31.4k
Tetsuo Noda Japan	80	15.6k 0.7×	2.9k 0.7×	2.3k 0.6×	2.7k 0.8×	2.6k 1.1×	260	24.3k
Richard Treisman United Kingdom	70	19.1k 0.9×	3.8k 0.9×	3.2k 0.8×	4.2k 1.2×	2.5k 1.1×	116	25.1k
Hong‐Gang Wang United States	73	17.2k 0.8×	4.6k 1.1×	1.2k 0.3×	3.1k 0.9×	2.6k 1.1×	320	24.8k
Johji Inazawa Japan	75	13.1k 0.6×	4.2k 1.0×	2.8k 0.7×	2.0k 0.6×	4.8k 2.0×	410	20.6k
M. Luisa Iruela‐Arispe United States	82	12.5k 0.6×	3.1k 0.7×	1.6k 0.4×	3.2k 0.9×	5.0k 2.1×	202	21.4k
Calvin J. Kuo United States	67	10.9k 0.5×	5.1k 1.2×	2.3k 0.6×	1.8k 0.5×	2.3k 1.0×	139	20.9k
Keiko Nakayama Japan	71	15.7k 0.7×	6.9k 1.7×	1.8k 0.5×	2.7k 0.7×	2.5k 1.0×	286	23.3k

Countries citing papers authored by Xi He

Since Specialization

Citations

This map shows the geographic impact of Xi He's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Xi He with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Xi He more than expected).

Fields of papers citing papers by Xi He

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Xi He. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Xi He. The network helps show where Xi He may publish in the future.

Co-authorship network of co-authors of Xi He

This figure shows the co-authorship network connecting the top 25 collaborators of Xi He. A scholar is included among the top collaborators of Xi He based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Xi He. Xi He is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

Sort: Min cites: Since: Top N: Style:

20 of 20 papers shown

Zheng, Jing, et al.. (2025). Wnt induces FZD5/8 endocytosis and degradation and the involvement of RSPO-ZNRF3/RNF43 and DVL. PubMed. 14. 1 indexed citations

Karwacki-Neisius, Violetta, Ahram Jang, Engin Cukuroglu, et al.. (2024). WNT signalling control by KDM5C during development affects cognition. Nature. 627(8004). 594–603. 12 indexed citations

Dong, Ruochen, Kate Hall, Sarah E. Smith, et al.. (2021). Using Spatial Transcriptomics to Reveal Fetal Liver Hematopoietic Stem Cell-Niche Interactions. Blood. 138(Supplement 1). 3284–3284. 2 indexed citations

Ma, Wenzhe, Maorong Chen, Hong Mo Kang, et al.. (2020). Single-molecule dynamics of Dishevelled at the plasma membrane and Wnt pathway activation. Proceedings of the National Academy of Sciences. 117(28). 16690–16701. 47 indexed citations

Chen, Maorong, Nathália G. Amado, Jieqiong Tan, et al.. (2020). TMEM79/MATTRIN defines a pathway for Frizzled regulation and is required for Xenopus embryogenesis. eLife. 9. 12 indexed citations

Chen, Peng, Liang Tao, Tianyu Wang, et al.. (2018). Structural basis for recognition of frizzled proteins by Clostridium difficile toxin B. Science. 360(6389). 664–669. 102 indexed citations

Qian, Pengxu, Xi He, Ariel Paulson, et al.. (2015). The Dlk1-Gtl2 Locus Preserves LT-HSC Function by Inhibiting the PI3K-mTOR Pathway to Restrict Mitochondrial Metabolism. Cell stem cell. 18(2). 214–228. 131 indexed citations

Kim, Sung‐Eun, He Huang, Ming Zhao, et al.. (2013). Wnt Stabilization of β-Catenin Reveals Principles for Morphogen Receptor-Scaffold Assemblies. Science. 340(6134). 867–870. 190 indexed citations

Nusse, Roel, Xi He, & Renée van Amerongen. (2013). Wnt signaling : a subject collection from Cold Spring Harbor Perspectives in Biology. 12 indexed citations

10.

Zebisch, M., Yang Xu, Bryan T. MacDonald, et al.. (2013). Structural and molecular basis of ZNRF3/RNF43 transmembrane ubiquitin ligase inhibition by the Wnt agonist R-spondin. Nature Communications. 4(1). 2787–2787. 149 indexed citations

11.

Zhong, Hanbing, Haixia Zou, Mikhail V. Semënov, et al.. (2009). Characterization and development of novel small-molecules inhibiting GSK3 and activating Wntsignaling. Molecular BioSystems. 5(11). 1356–1360. 34 indexed citations

12.

Zeng, Xin, He Huang, Keiko Tamai, et al.. (2007). Initiation of Wnt signaling: control of Wnt coreceptor Lrp6 phosphorylation/activation via frizzled, dishevelled and axin functions. Development. 135(2). 367–375. 27 indexed citations

13.

Harada, Yuko, Chika Yokota, Raymond Habas, Diane C. Slusarski, & Xi He. (2007). Retinoic acid-inducible G protein-coupled receptors bind to frizzled receptors and may activate non-canonical Wnt signaling. Biochemical and Biophysical Research Communications. 358(4). 968–975. 15 indexed citations

14.

Zhang, Wen, Xi Chen, Yoichi Kato, et al.. (2006). Novel Cross Talk of Krüppel-Like Factor 4 and β-Catenin Regulates Normal Intestinal Homeostasis and Tumor Repression. Molecular and Cellular Biology. 26(6). 2055–2064. 120 indexed citations

15.

Zhang, Jiwang, Justin C. Grindley, Tong Yin, et al.. (2006). PTEN maintains haematopoietic stem cells and acts in lineage choice and leukaemia prevention. Nature. 441(7092). 518–522. 640 indexed citations breakdown →

16.

Habas, Raymond & Xi He. (2006). Activation of Rho and Rac by Wnt/Frizzled Signaling. Methods in enzymology on CD-ROM/Methods in enzymology. 406. 500–511. 22 indexed citations

17.

Zhang, Yi, et al.. (2002). Casein Kinase I and Casein Kinase II Differentially Regulate Axin Function in Wnt and JNK Pathways. Journal of Biological Chemistry. 277(20). 17706–17712. 41 indexed citations

18.

Akashi, Koichi, Xi He, Jie Chen, et al.. (2002). Transcriptional accessibility for genes of multiple tissues and hematopoietic lineages is hierarchically controlled during early hematopoiesis. Blood. 101(2). 383–389. 293 indexed citations

19.

Capelluto, Daniel G. S., Tatiana G. Kutateladze, Raymond Habas, et al.. (2002). The DIX domain targets dishevelled to actin stress fibres and vesicular membranes. Nature. 419(6908). 726–729. 156 indexed citations

20.

He, Xi, Jean‐Pierre Saint‐Jeannet, James R. Woodgett, Harold Varmus, & Igor B. Dawid. (1995). Glycogen synthase kinase-3 and dorsoventral patterning in Xenopus embryos. Nature. 374(6523). 617–622. 431 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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