Patrick Y. S. Lam

8.8k total citations · 3 hit papers
100 papers, 6.6k citations indexed

About

Patrick Y. S. Lam is a scholar working on Organic Chemistry, Cardiology and Cardiovascular Medicine and Hematology. According to data from OpenAlex, Patrick Y. S. Lam has authored 100 papers receiving a total of 6.6k indexed citations (citations by other indexed papers that have themselves been cited), including 37 papers in Organic Chemistry, 28 papers in Cardiology and Cardiovascular Medicine and 26 papers in Hematology. Recurrent topics in Patrick Y. S. Lam's work include Blood Coagulation and Thrombosis Mechanisms (26 papers), HIV/AIDS drug development and treatment (21 papers) and Catalytic Cross-Coupling Reactions (18 papers). Patrick Y. S. Lam is often cited by papers focused on Blood Coagulation and Thrombosis Mechanisms (26 papers), HIV/AIDS drug development and treatment (21 papers) and Catalytic Cross-Coupling Reactions (18 papers). Patrick Y. S. Lam collaborates with scholars based in United States, Germany and Sweden. Patrick Y. S. Lam's co-authors include Charles G. Clark, Jennifer X. Qiao, Andrew P. Combs, Simon Saubern, Dominic M. T. Chan, Ruth R. Wexler, Robert M. Knabb, Prabhakar K. Jadhav, Michael P. Winters and Joseph M. Luettgen and has published in prestigious journals such as Science, Proceedings of the National Academy of Sciences and Journal of the American Chemical Society.

In The Last Decade

Patrick Y. S. Lam

100 papers receiving 6.4k citations

Hit Papers

align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

New aryl/heteroaryl CN bond cross-coupling reactions via arylboronic acid/cupric acetate arylation

1998 893 citations Patrick Y. S. Lam, Charles G. Clark et al. profile →
Rational Design of Potent, Bioavailable, Nonpeptide Cyclic Ureas as HIV Protease Inhibitors

1994 680 citations Patrick Y. S. Lam, Lee T. Bacheler et al. profile →
Copper-Promoted Carbon-Heteroatom Bond Cross-Coupling with Boronic Acids and Derivatives

2010 486 citations Jennifer X. Qiao, Patrick Y. S. Lam profile →

Peers

Countries citing papers authored by Patrick Y. S. Lam

Since Specialization

Citations

This map shows the geographic impact of Patrick Y. S. Lam's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Patrick Y. S. Lam with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Patrick Y. S. Lam more than expected).

Fields of papers citing papers by Patrick Y. S. Lam

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Patrick Y. S. Lam. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Patrick Y. S. Lam. The network helps show where Patrick Y. S. Lam may publish in the future.

Co-authorship network of co-authors of Patrick Y. S. Lam

This figure shows the co-authorship network connecting the top 25 collaborators of Patrick Y. S. Lam. A scholar is included among the top collaborators of Patrick Y. S. Lam based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Patrick Y. S. Lam. Patrick Y. S. Lam is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

#	Work	Indexed citations
1	Survey of rodent-borne pathogens in Singapore reveals the circulation of Leptospira spp., Seoul hantavirus, and Rickettsia typhi 2022 ·Scientific Reports ·Jane Griffiths, Hui Ling Yeo, Grace Yap, Diyar Mailepessov, (unknown), (unknown), (unknown), Patrick Y. S. Lam, Lee Ching Ng	12
2	Discovery of a first-in-class inhibitor of sulfide:quinone oxidoreductase that protects against adverse cardiac remodelling and heart failure 2021 ·Cardiovascular Research ·Michael R. Jackson, (unknown), Simon D. P. Baugh, (unknown), Adel A. Rashad, Patrick Y. S. Lam, Boris Polyak, Marilyn Schuman Jörns	17
3	Synthesis of 4-oxotetrahydropyrimidine-1(2H)-carboxamides derivatives as capsid assembly modulators of hepatitis B virus 2021 ·Medicinal Chemistry Research ·(unknown), (unknown), Junjun Chen, Julia Ma, Hui Liu, Patrick Y. S. Lam, John L. Kulp, Stephan Menne, Jinhong Chang, Ju‐Tao Guo, Yanming Du	6
4	Orally bioavailable amine-linked macrocyclic inhibitors of factor XIa 2020 ·Bioorganic & Medicinal Chemistry Letters ·Tianan Fang, James R. Corte, Paul J. Gilligan, Yoon Jeon, (unknown), Karen A. Rossi, Joseph E. Myers, S. Sheriff, Zhen Lou, Joanna J. Zheng, Timothy W. Harper, Jeffrey M. Bozarth, Yiming Wu, Joseph M. Luettgen, Dietmar Seiffert, Ruth R. Wexler, Patrick Y. S. Lam	3
5	Macrocyclic inhibitors of Factor XIa: Discovery of alkyl-substituted macrocyclic amide linkers with improved potency 2017 ·Bioorganic & Medicinal Chemistry Letters ·James R. Corte, Wu Yang, Tianan Fang, Yufeng Wang, (unknown), (unknown), William R. Ewing, Karen A. Rossi, Joseph E. Myers, S. Sheriff, Zhen Lou, Joanna J. Zheng, Timothy W. Harper, Jeffrey M. Bozarth, Yiming Wu, Joseph M. Luettgen, Dietmar Seiffert, Mimi L. Quan, Ruth R. Wexler, Patrick Y. S. Lam	12
6	2-Amino-1,3,4-thiadiazoles in the 7-hydroxy-N-neopentyl spiropiperidine indolinyl series as potent P2Y1 receptor antagonists 2014 ·Bioorganic & Medicinal Chemistry Letters ·(unknown), Jennifer X. Qiao, Ying Han, Tammy C. Wang, Ji Hua, Laura A. Price, (unknown), Hong Shen, Christine Huang, Robert Rehfuss, Ruth R. Wexler, Patrick Y. S. Lam	8
7	Orally bioavailable factor Xa inhibitors containing alpha-substituted gem-dimethyl P4 moieties 2014 ·Bioorganic & Medicinal Chemistry Letters ·Michael J. Orwat, Jennifer X. Qiao, Kan He, Alan R. Rendina, Joseph M. Luettgen, Karen A. Rossi, Baomin Xin, Robert M. Knabb, Ruth R. Wexler, Patrick Y. S. Lam, Donald Pinto	7
8	Discovery of diarylurea P2Y1 antagonists with improved aqueous solubility 2013 ·Bioorganic & Medicinal Chemistry Letters ·Tammy C. Wang, Jennifer X. Qiao, Charles G. Clark, (unknown), Laura A. Price, (unknown), Ming Chang, Joanna J. Zheng, Christine Huang, (unknown), William A. Schumacher, Pancras C. Wong, Dietmar Seiffert, (unknown), Jeffrey S. Bostwick, Earl J. Crain, Carol A. Watson, Robert Rehfuss, Ruth R. Wexler, Patrick Y. S. Lam	14
9	Preclinical pharmacokinetics and pharmacodynamics of apixaban, a potent and selective factor Xa inhibitor 2011 ·European Journal of Drug Metabolism and Pharmacokinetics ·Kan He, Joseph M. Luettgen, Donglu Zhang, Bing He, James E. Grace, Baomin Xin, Donald Pinto, Pancras C. Wong, Robert M. Knabb, Patrick Y. S. Lam, Ruth R. Wexler, Scott Grossman	71
10	SAR and X-ray structures of enantiopure 1,2-cis-(1R,2S)-cyclopentyldiamine and cyclohexyldiamine derivatives as inhibitors of coagulation Factor Xa 2007 ·Bioorganic & Medicinal Chemistry Letters ·Jennifer X. Qiao, Chong‐Hwan Chang, Daniel L. Cheney, Paul E. Morin, (unknown), (unknown), Tammy C. Wang, Alan R. Rendina, Joseph M. Luettgen, Robert M. Knabb, Ruth R. Wexler, Patrick Y. S. Lam	29
11	Reductive Isoxazole Ring Opening of the Anticoagulant Razaxaban Is the Major Metabolic Clearance Pathway in Rats and Dogs 2007 ·Drug Metabolism and Disposition ·Donglu Zhang, Nirmala Raghavan, Shiang-Yuan Chen, Haiying Zhang, Mimi L. Quan, (unknown), (unknown), Patrick Y. S. Lam, Samuel J. Bonacorsi, Robert M. Knabb, Gary L. Skiles, Kan He	46
12	Razaxaban, a direct factor Xa inhibitor, in combination with aspirin and/or clopidogrel improves low-dose antithrombotic activity without enhancing bleeding liability in rabbits 2007 ·Journal of Thrombosis and Thrombolysis ·Pancras C. Wong, Earl J. Crain, Carol A. Watson, Ruth R. Wexler, Patrick Y. S. Lam, Mimi L. Quan, Robert M. Knabb	28
13	Enantiopure five-membered cyclicdiamine derivatives as potent and selective inhibitors of factor Xa. Improving in vitro metabolic stability via core modifications 2007 ·Bioorganic & Medicinal Chemistry Letters ·Jennifer X. Qiao, Tammy C. Wang, (unknown), Daniel L. Cheney, Kan He, Alan R. Rendina, Baomin Xin, Joseph M. Luettgen, Robert M. Knabb, Ruth R. Wexler, Patrick Y. S. Lam	17
14	Structure–activity relationship and pharmacokinetic profile of 5-ketopyrazole factor Xa inhibitors 2007 ·Bioorganic & Medicinal Chemistry Letters ·Jeffrey Varnes, Dean A. Wacker, Donald Pinto, Michael J. Orwat, Jay Theroff, (unknown), (unknown), Joseph M. Luettgen, Robert M. Knabb, Steven Bai, Kan He, Patrick Y. S. Lam, Ruth R. Wexler	29
15	Pyrazole-based factor Xa inhibitors containing N-arylpiperidinyl P4 residues 2006 ·Bioorganic & Medicinal Chemistry Letters ·Jennifer X. Qiao, Xuhong Cheng, Joanne M. Smallheer, Robert A. Galemmo, (unknown), Donald Pinto, Daniel L. Cheney, Kan He, Pancras C. Wong, Joseph M. Luettgen, Robert M. Knabb, Ruth R. Wexler, Patrick Y. S. Lam	18
16	Nonbenzamidine isoxazoline derivatives as factor Xa inhibitors 2003 ·Bioorganic & Medicinal Chemistry Letters ·Mimi L. Quan, Christopher D. Ellis, (unknown), Ann Y. Liauw, Patrick Y. S. Lam, Karen A. Rossi, Robert M. Knabb, Joseph M. Luettgen, Matthew Wright, Pancras C. Wong, Ruth R. Wexler	17
17	Synthesis and SAR of benzamidine factor Xa inhibitors containing a vicinally-substituted heterocyclic core 2001 ·Bioorganic & Medicinal Chemistry Letters ·John M. Fevig, Donald Pinto, Qi Han, Mimi L. Quan, James R. Pruitt, (unknown), Robert A. Galemmo, Shuaige Wang, Michael J. Orwat, Lori L. Bostrom, Robert M. Knabb, Pancras C. Wong, Patrick Y. S. Lam, Ruth R. Wexler	31
18	De novo design, discovery and development of cyclic urea HIV protease inhibitors 1998 ·Drugs of the Future ·George V. De Lucca, Patrick Y. S. Lam	35
19	Design and selection of DMP 850 and DMP 851: the next generation of cyclic urea HIV protease inhibitors 1998 ·Chemistry & Biology ·James D. Rodgers, Patrick Y. S. Lam, Barry L. Johnson, Haisheng Wang, Soo S. Ko, Steven P. Seitz, George L. Trainor, Paul Anderson, Ronald M. Klabe, Lee T. Bacheler, Beverly C. Cordova, Sena Garber, Carol Reid, Matthew Wright, Chong‐Hwan Chang, Susan Erickson‐Viitanen	1
20	Three‐dimensional solution structure of the HIV‐1 protease complexed with DMP323, a novel cyclic urea‐type inhibitor, determined by nuclear magnetic resonance spectroscopy 1996 ·Protein Science ·Toshimasa Yamazaki, Andrew P. Hinck, Yun‐Xing Wang, Linda K. Nicholson, Dennis A. Torchia, Paul T. Wingfield, Stephen J. Stahl, Joshua D. Kaufman, Chong‐Hwan Chang, Peter J. Domaille, Patrick Y. S. Lam	64

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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