Patrick Y. S. Lam

8.8k total citations · 3 hit papers
100 papers, 6.6k citations indexed

About

Patrick Y. S. Lam is a scholar working on Organic Chemistry, Cardiology and Cardiovascular Medicine and Hematology. According to data from OpenAlex, Patrick Y. S. Lam has authored 100 papers receiving a total of 6.6k indexed citations (citations by other indexed papers that have themselves been cited), including 37 papers in Organic Chemistry, 28 papers in Cardiology and Cardiovascular Medicine and 26 papers in Hematology. Recurrent topics in Patrick Y. S. Lam's work include Blood Coagulation and Thrombosis Mechanisms (26 papers), HIV/AIDS drug development and treatment (21 papers) and Catalytic Cross-Coupling Reactions (18 papers). Patrick Y. S. Lam is often cited by papers focused on Blood Coagulation and Thrombosis Mechanisms (26 papers), HIV/AIDS drug development and treatment (21 papers) and Catalytic Cross-Coupling Reactions (18 papers). Patrick Y. S. Lam collaborates with scholars based in United States, Germany and Sweden. Patrick Y. S. Lam's co-authors include Charles G. Clark, Jennifer X. Qiao, Andrew P. Combs, Simon Saubern, Dominic M. T. Chan, Ruth R. Wexler, Robert M. Knabb, Prabhakar K. Jadhav, Michael P. Winters and Joseph M. Luettgen and has published in prestigious journals such as Science, Proceedings of the National Academy of Sciences and Journal of the American Chemical Society.

In The Last Decade

Patrick Y. S. Lam

100 papers receiving 6.4k citations

Hit Papers

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What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

New aryl/heteroaryl CN bond cross-coupling reactions via arylboronic acid/cupric acetate arylation

1998 893 citations Patrick Y. S. Lam, Charles G. Clark et al. profile →
Rational Design of Potent, Bioavailable, Nonpeptide Cyclic Ureas as HIV Protease Inhibitors

1994 680 citations Patrick Y. S. Lam, Prabhakar K. Jadhav et al. profile →
Copper-Promoted Carbon-Heteroatom Bond Cross-Coupling with Boronic Acids and Derivatives

2010 486 citations Jennifer X. Qiao, Patrick Y. S. Lam profile →

Author Peers

Peers are selected by citation overlap in the author's most active subfields. citations · hero ref

Author						Papers	Cites
Patrick Y. S. Lam	3.6k	2.0k	856	758	597	100	6.6k
David J. Maloney	991 0.3×	3.3k 1.6×	175 0.2×	196 0.3×	89 0.1×	140	5.6k
Lawrence C. Kuo	450 0.1×	1.6k 0.8×	1.5k 1.8×	932 1.2×	691 1.2×	91	4.7k
Fabrizio Giordanetto	807 0.2×	2.7k 1.3×	305 0.4×	154 0.2×	28 0.0×	73	4.1k
C. A. A. VAN BOECKEL	3.3k 0.9×	3.8k 1.9×	235 0.3×	76 0.1×	17 0.0×	162	5.4k
Jeanne A. Stuckey	1.8k 0.5×	7.1k 3.5×	181 0.2×	339 0.4×	63 0.1×	142	9.9k
Pierre Sînaÿ	7.9k 2.2×	7.1k 3.5×	188 0.2×	125 0.2×	15 0.0×	293	10.5k
Peter J. Tummino	529 0.1×	2.7k 1.3×	761 0.9×	549 0.7×	166 0.3×	76	4.8k
K. C. Nicolaou	7.7k 2.1×	4.4k 2.1×	185 0.2×	81 0.1×	12 0.0×	156	11.7k
Diane Joseph‐McCarthy	310 0.1×	1.7k 0.9×	509 0.6×	148 0.2×	13 0.0×	78	2.8k
Melinda G. Hollingshead	1.1k 0.3×	3.9k 1.9×	50 0.1×	301 0.4×	221 0.4×	167	6.9k

Countries citing papers authored by Patrick Y. S. Lam

Since Specialization

Citations

This map shows the geographic impact of Patrick Y. S. Lam's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Patrick Y. S. Lam with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Patrick Y. S. Lam more than expected).

Fields of papers citing papers by Patrick Y. S. Lam

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Patrick Y. S. Lam. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Patrick Y. S. Lam. The network helps show where Patrick Y. S. Lam may publish in the future.

Co-authorship network of co-authors of Patrick Y. S. Lam

This figure shows the co-authorship network connecting the top 25 collaborators of Patrick Y. S. Lam. A scholar is included among the top collaborators of Patrick Y. S. Lam based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Patrick Y. S. Lam. Patrick Y. S. Lam is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

Griffiths, Jane, Hui Ling Yeo, Grace Yap, et al.. (2022). Survey of rodent-borne pathogens in Singapore reveals the circulation of Leptospira spp., Seoul hantavirus, and Rickettsia typhi. Scientific Reports. 12(1). 2692–2692. 12 indexed citations

Jackson, Michael R., Simon D. P. Baugh, Adel A. Rashad, et al.. (2021). Discovery of a first-in-class inhibitor of sulfide:quinone oxidoreductase that protects against adverse cardiac remodelling and heart failure. Cardiovascular Research. 118(7). 1771–1784. 17 indexed citations

Li, Mei-Zhi Irene, Diyar Mailepessov, Indra Vythilingam, et al.. (2021). Prevalence of simian malaria parasites in macaques of Singapore. PLoS neglected tropical diseases. 15(1). e0009110–e0009110. 19 indexed citations

Corte, James R., Wu Yang, Tianan Fang, et al.. (2017). Macrocyclic inhibitors of Factor XIa: Discovery of alkyl-substituted macrocyclic amide linkers with improved potency. Bioorganic & Medicinal Chemistry Letters. 27(16). 3833–3839. 12 indexed citations

Chen, Xueqing, Kevin Stefanski, Hong Shen, et al.. (2014). Oral Delivery of Highly Lipophilic Poorly Water-Soluble Drugs: Spray-Dried Dispersions to Improve Oral Absorption and Enable High-Dose Toxicology Studies of a P2Y1 Antagonist. Journal of Pharmaceutical Sciences. 103(12). 3924–3931. 14 indexed citations

Wang, Tammy C., Jennifer X. Qiao, Charles G. Clark, et al.. (2013). Discovery of diarylurea P2Y1 antagonists with improved aqueous solubility. Bioorganic & Medicinal Chemistry Letters. 23(11). 3239–3243. 14 indexed citations

Wong, Pancras C., Earl J. Crain, Ruth R. Wexler, et al.. (2008). Apixaban, an oral, direct and highly selective factor Xa inhibitor: in vitro, antithrombotic and antihemostatic studies. Journal of Thrombosis and Haemostasis. 6(5). 820–829. 246 indexed citations

Qiao, Jennifer X., Kan He, Pancras C. Wong, et al.. (2008). Highly efficacious factor Xa inhibitors containing α-substituted phenylcycloalkyl P4 moieties. Bioorganic & Medicinal Chemistry Letters. 19(2). 462–468. 14 indexed citations

Qiao, Jennifer X., Daniel L. Cheney, Richard Alexander, et al.. (2008). Achieving structural diversity using the perpendicular conformation of alpha-substituted phenylcyclopropanes to mimic the bioactive conformation of ortho-substituted biphenyl P4 moieties: Discovery of novel, highly potent inhibitors of Factor Xa. Bioorganic & Medicinal Chemistry Letters. 18(14). 4118–4123. 49 indexed citations

10.

Zhang, Donglu, Nirmala Raghavan, Shiang-Yuan Chen, et al.. (2007). Reductive Isoxazole Ring Opening of the Anticoagulant Razaxaban Is the Major Metabolic Clearance Pathway in Rats and Dogs. Drug Metabolism and Disposition. 36(2). 303–315. 46 indexed citations

11.

Varnes, Jeffrey, Dean A. Wacker, Donald Pinto, et al.. (2007). Structure–activity relationship and pharmacokinetic profile of 5-ketopyrazole factor Xa inhibitors. Bioorganic & Medicinal Chemistry Letters. 18(2). 749–754. 29 indexed citations

12.

Qiao, Jennifer X., Chong‐Hwan Chang, Daniel L. Cheney, et al.. (2007). SAR and X-ray structures of enantiopure 1,2-cis-(1R,2S)-cyclopentyldiamine and cyclohexyldiamine derivatives as inhibitors of coagulation Factor Xa. Bioorganic & Medicinal Chemistry Letters. 17(16). 4419–4427. 29 indexed citations

13.

Qiao, Jennifer X., Tammy C. Wang, Daniel L. Cheney, et al.. (2007). Enantiopure five-membered cyclicdiamine derivatives as potent and selective inhibitors of factor Xa. Improving in vitro metabolic stability via core modifications. Bioorganic & Medicinal Chemistry Letters. 17(18). 5041–5048. 17 indexed citations

14.

Qiao, Jennifer X., Xuhong Cheng, Joanne M. Smallheer, et al.. (2006). Pyrazole-based factor Xa inhibitors containing N-arylpiperidinyl P4 residues. Bioorganic & Medicinal Chemistry Letters. 17(5). 1432–1437. 18 indexed citations

15.

Li, Yunlong, John M. Fevig, Joseph Cacciola, et al.. (2006). Preparation of 1-(3-aminobenzo[d]isoxazol-5-yl)-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-ones as potent, selective, and efficacious inhibitors of coagulation factor Xa. Bioorganic & Medicinal Chemistry Letters. 16(19). 5176–5182. 24 indexed citations

16.

Lam, Patrick Y. S., Charles G. Clark, William J. Calhoun, et al.. (2003). Discovery of 3-Amino-4-Chlorophenyl P1 as a novel and potent benzamidine mimic via solid-phase synthesis of an isoxazoline library. Bioorganic & Medicinal Chemistry Letters. 13(10). 1795–1799. 23 indexed citations

17.

Fevig, John M., Donald Pinto, Qi Han, et al.. (2001). Synthesis and SAR of benzamidine factor Xa inhibitors containing a vicinally-substituted heterocyclic core. Bioorganic & Medicinal Chemistry Letters. 11(5). 641–645. 31 indexed citations

18.

Lucca, George V. De & Patrick Y. S. Lam. (1998). De novo design, discovery and development of cyclic urea HIV protease inhibitors. Drugs of the Future. 23(9). 987–987. 35 indexed citations

19.

Rodgers, James D., Patrick Y. S. Lam, Barry L. Johnson, et al.. (1998). Design and selection of DMP 850 and DMP 851: the next generation of cyclic urea HIV protease inhibitors. Chemistry & Biology. 5(11). R312–R312. 1 indexed citations

20.

Nicholson, Linda K., Toshimasa Yamazaki, Stephan Grzesiek, et al.. (1995). Flexibility and function in HIV-1 protease. Nature Structural & Molecular Biology. 2(4). 274–280. 190 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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