Jeffrey Varnes

920 citations

20 papers · 260 indexed · h-index 11

Impact in

Pharmaceutical Science top 10%
- Fluorine in Organic Chemistry
Organic Chemistry
- Catalytic C–H Functionalization Methods
- Synthesis and Biological Evaluation
- Cyclopropane Reaction Mechanisms

Papers in

Toxicology 2
Organic Chemistry 9
- Click Chemistry and Applications 3

Co-authors: Dean A. Wacker Robert M. KnabbBin YangSteven Bai Jeffrey S. Albert Kan He Ruth R. Wexler Patrick Y. S. Lam
Journals: Bioorganic & Medicinal Chemistry Letters (8 papers)ACS Medicinal Chemistry Letters (3 papers)Tetrahedron Letters (3 papers)Phytochemistry (1 paper)Molecular Pharmacology (1 paper)
Partner nations: United States United Kingdom Sweden

In The Last Decade

Jeffrey Varnes

20 papers receiving 258 citations

Peers

Countries citing papers authored by Jeffrey Varnes

Since Specialization

Citations

This map shows the geographic impact of Jeffrey Varnes's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Jeffrey Varnes with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Jeffrey Varnes more than expected).

Fields of papers citing papers by Jeffrey Varnes

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Jeffrey Varnes. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Jeffrey Varnes. The network helps show where Jeffrey Varnes may publish in the future.

Co-authors

The 25 scholars most cited alongside Jeffrey Varnes, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Jeffrey Varnes Line = papers co-authored together Jeffrey Varnes links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

#	Work
1	From Milligram to Kilogram Manufacture of AZD4573: Making It Possible by Application of Enzyme-, Iridium-, and Palladium-Catalyzed Key Transformations Organic Process Research & Development ·Staffan Karlsson, Cian O'Dalaigh, Calum Cook, Gordon S. Currie, K. N. Bhatia, Hans Emtenäs, Genli Xu, Rebecca E. Meadows, Peter D. Smith, Jeffrey Varnes	2021	5
2	Addition of Fluorine and a Late-Stage Functionalization (LSF) of the Oral SERD AZD9833 ACS Medicinal Chemistry Letters ·James S. Scott, Tom Moss, Bernard Barlaam, Paul R. J. Davey, Gary Fairley, Eric T. Gangl, Ryan Greenwood, Holia Hatoum‐Mokdad, Gary Windham, Cullen Olivia, Radosław Polański, S.P. Stokes, Michael Tucker, Jeffrey Varnes, Bin Yang	2020	12
3	Building Bridges in a Series of Estrogen Receptor Degraders: An Application of Metathesis in Medicinal Chemistry ACS Medicinal Chemistry Letters ·James S. Scott, J. Breed, Rodrigo J. Carbajo, Paul R. J. Davey, Ryan Greenwood, Hoan K. Huynh, Teresa Klinowska, Christopher J. Morrow, Tom Moss, Radosław Polański, J. Willem M. Nissink, Jeffrey Varnes, Bin Yang	2019	7
4	Preparation of highly functionalized 1,5-disubstituted tetrazoles via palladium-catalyzed Suzuki coupling Tetrahedron Letters ·Edward J. Hennessy, Mark Cornebise, Lakshmaiah Gingipalli, Tyler Grebe, Sudhir M. Hande, 広行高井, Hoan K. Huynh, Scott Throner, Jeffrey Varnes, Ye Wu	2017	12
5	Optimization of Highly Kinase Selective Bis-anilino Pyrimidine PAK1 Inhibitors ACS Medicinal Chemistry Letters ·William McCoull, Edward J. Hennessy, Kevin Blades, Claudio Chuaqui, James J. Dowling, Andrew D. Ferguson, Frederick W. Goldberg, M. T. Higazi, Christopher R. Jones, Paul D. Kemmitt, Gillian M. Lamont, Jeffrey Varnes, Richard A. Ward, Bin Yang	2016	20
6	Fragment-assisted hit investigation involving integrated HTS and fragment screening: Application to the identification of phosphodiesterase 10A (PDE10A) inhibitors Bioorganic & Medicinal Chemistry Letters ·Jeffrey Varnes, Stefan Geschwindner, Christopher R. Holmquist, Anissa Winarni, Xia Wang, Niek Dekker, Clay W. Scott, Gaochao Tian, Michael W. Wood, Jeffrey S. Albert	2015	8
7	Towards the next generation of dual Bcl-2/Bcl-xL inhibitors Bioorganic & Medicinal Chemistry Letters ·Jeffrey Varnes, Thomas W. Gero, Shan Huang, R. Bruce Diebold, В. Л. Пучков, Paul Grover, Mei Su, Prasenjit Mukherjee, Jamal Saeh, Terry Macintyre, Lucineide Bispo dos Reis, Keith Dillman, Kate F. Byth, Daniel Russell, Stephanos Ioannidis	2014	14
8	Identification and optimisation of 7-azaindole PAK1 inhibitors with improved potency and kinase selectivity MedChemComm ·William McCoull, Edward J. Hennessy, Kevin Blades, Matthew Box, Claudio Chuaqui, James J. Dowling, Edson Estarneck, Andrew D. Ferguson, Frederick W. Goldberg, M. T. Higazi, Paul D. Kemmitt, Gillian M. Lamont, Justin T. Lana, Claire McWhirter, Jeffrey Varnes, Richard A. Ward, Jason D. Williams, Bin Yang	2014	14
9	Biochemical characterization and in vitro activity of AZ513, a noncovalent, reversible, and noncompetitive inhibitor of fatty acid amide hydrolase European Journal of Pharmacology ·Clay W. Scott, Gaochao Tian, Xiao Yu, Kathy Paschetto, Chris B. A. Brook, Лопатина Алина Валентиновна, Chang Cao, Jeffrey Varnes, Philip D. Edwards	2011	9
10	Discovery of novel positive allosteric modulators of the metabotropic glutamate receptor 5 (mGlu5) Bioorganic & Medicinal Chemistry Letters ·Jeffrey Varnes, Andrew P. Marcus, Russell C. Mauger, Scott Throner, 広行高井, Tisha Celine Erika G. Ocampo, Xia Wang, Linda A. Sygowski, Nathan Spear, R.A. Gadient, Dean G. Brown, James B. Campbell	2011	21
11	Identification of N-(2-(azepan-1-yl)-2-phenylethyl)-benzenesulfonamides as novel inhibitors of GlyT1 Bioorganic & Medicinal Chemistry Letters ·Jeffrey Varnes, Anissa Winarni, Maria de Jesus Medina Arellano, Christopher R. Holmquist, Deidre Wilkins, Gaochao Tian, Gerald J. Jonak, Xia Wang, W. M. Potts, Michael W. Wood, Cristóbal Alhambra, Todd A. Brugel, Jeffrey S. Albert	2010	3
12	Efficient synthesis of a 7-azabicyclo[2.2.1]heptane based GlyT1 uptake inhibitor Tetrahedron Letters ·Hui Xiong, William E. Frietze, Donald W. Andisik, G Scatà, William E. Palmer, Peter Tyre, Jeffrey Varnes, Jeffrey S. Albert, Chris A. Veale	2010	3
13	Efficient preparation of 2,4-methanoproline Tetrahedron Letters ·Jeffrey Varnes, Liza Schillo, 石田かおる, Éric Cordier, Jeffrey S. Albert	2010	12
14	Position 5.46 of the Serotonin 5-HT2A Receptor Contributes to a Species-Dependent Variation for the 5-HT2C Agonist (R)-9-Ethyl-1,3,4,10b-tetrahydro-7-trifluoromethylpyrazino[2,1-a]isoindol-6(2H)-one: Impact on Selectivity and Toxicological Evaluation Molecular Pharmacology ·Keith J. Miller, Ginger Wu, Jeffrey Varnes, Paul Lévesque, V. Lyubin, Danshi Li, Jeffrey A. Robl, Karen A. Rossi, Dean A. Wacker	2009	8
15	Structure–activity relationship and pharmacokinetic profile of 5-ketopyrazole factor Xa inhibitors Bioorganic & Medicinal Chemistry Letters ·Jeffrey Varnes, Dean A. Wacker, Donald Pinto, Michael J. Orwat, Jay Theroff, Ananda Rizqi Johansyah, T. Hallina, Joseph M. Luettgen, Robert M. Knabb, Steven Bai, Kan He, Patrick Y. S. Lam, Ruth R. Wexler	2007	29
16	Design, structure–activity relationship, and pharmacokinetic profile of pyrazole-based indoline factor Xa inhibitors Bioorganic & Medicinal Chemistry Letters ·Jeffrey Varnes, Dean A. Wacker, 夏映雪, Mimi L. Quan, Christopher D. Ellis, Karen A. Rossi, Nedorezova Ai, Joseph M. Luettgen, Robert M. Knabb, Steven Bai, Kan He, Patrick Y. S. Lam, Ruth R. Wexler	2007	18
17	Discovery of N-propylurea 3-benzylpiperidines as selective CC chemokine receptor-3 (CCR3) antagonists Bioorganic & Medicinal Chemistry Letters ·Jeffrey Varnes, Daniel S. Gardner, Joseph B. Santella, John V. Duncia, Keyaki Yoichiro Miyasak, Paul S. Watson, Tara Suntum, Soo S. Ko, Lučka Lešnik, Maryanne Covington, Nicole Stowell, Eric Wadman, Paul Davies, Pilar Pérez Chaparro, Robert Newton, George L. Trainor, Carl P. Decicco, Dean A. Wacker	2004	21
18	CCR3 antagonists: a potential new therapy for the treatment of asthma. Discovery and structure–activity relationships Bioorganic & Medicinal Chemistry Letters ·Dean A. Wacker, Joseph B. Santella, Daniel S. Gardner, Jeffrey Varnes, Keyaki Yoichiro Miyasak, CD Cowper-Smith, Soo S. Ko, 哲夫長瀬, Paul S. Watson, Aslam Mohammad, Maryanne Covington, Nicole Stowell, Eric Wadman, Paul Davies, Kimberly A. Solomon, Robert Newton, George L. Trainor, Steven Friedman, Carl P. Decicco, John V. Duncia	2002	35
19	Choline conjugates of auxins. I. Direct evidence for the hydrolysis of choline-auxin conjugates by pea cholinesterase Plant Physiology and Biochemistry ·Richard A. Fluck, Phyllis A. Leber, Wahyu Wicaksono, Hannita Wijaya, Jeffrey Varnes, Melissa Vitale, E. Marciano	2000	7
20	A versatile and efficient methodology for the preparation of choline ester auxin conjugates Phytochemistry ·Kiki Yualiati, Richard A. Fluck, Juan Francisco Lasso Gaite, Phyllis A. Leber, Jeffrey Varnes	1995	2

About Jeffrey Varnes

Jeffrey Varnes is a scholar working on Toxicology, Organic Chemistry, Biochemistry, Pharmacology and Hematology, having authored 20 papers that have together received 260 indexed citations. Recurring topics across this work include Chemical Synthesis and Analysis (5 papers), Click Chemistry and Applications (3 papers), Neuroscience and Neuropharmacology Research (3 papers), Cholinesterase and Neurodegenerative Diseases (3 papers), Amino Acid Enzymes and Metabolism (2 papers), Computational Drug Discovery Methods (2 papers), Atrial Fibrillation Management and Outcomes (2 papers) and Protein Kinase Regulation and GTPase Signaling (2 papers). The work is most often cited by research in Pharmaceutical Science (31 citations), Organic Chemistry (122 citations), Cellular and Molecular Neuroscience (32 citations), Oncology (46 citations) and Pharmacology (28 citations). Jeffrey Varnes has collaborated with scholars based in United States, United Kingdom and Sweden. Frequent co-authors include Dean A. Wacker, Robert M. Knabb, Bin Yang, Steven Bai, Jeffrey S. Albert, Kan He, Ruth R. Wexler, Patrick Y. S. Lam, Joseph M. Luettgen and Soo S. Ko. Their work appears in journals such as Bioorganic & Medicinal Chemistry Letters, ACS Medicinal Chemistry Letters, Tetrahedron Letters, Phytochemistry and Molecular Pharmacology.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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